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much Stronger Anti-Aβ Fibrillization Activities of bis(12)-hupyridone Than Its Natural Analogue

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Much Stronger Anti-Aβ Fibrillization Activities of bis(12)-...

第十四届全国中药和天然药物学术研讨会

作者： Shengquan Hu Rui Wang Wei Cui Shinghung mak Daping Xu Zaijun Zhang Chunglit Choi Paul R.Carlier Yifan Han The Hong kong Polytechnic University The Hong kong Polytechnic University Shenzhen Research Institute East China University of Science and Technology Jinan University University of macau Virginia Tech

The aggregation of p-amyloid protein(Ap)into fibrils contributes significantly to the pathogenesis of Alzheimer’s disease(AD),and hence the attractive therapeutic strategies focusing on the inhibition of Aβfibrillization are *** this study,the anti-APfibrillization effect of bis(12)-hupyridone,a multifunctional homo-dimer derived from huperzine

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香港地区婴幼儿的锌营养状况研究

中华儿科杂志 1991年第4期29卷 209-211页

作者：梁淑芳麦英达香港中文大学医学院儿科香港中文大学医学院病理化学科

1989年6~12月，我们对被纳入"婴幼儿生长与营养随访研究"的133例5岁儿童进行了锌营养状况的调查研究。利用已有的膳食调查资料，计算出生后2个月~5岁时的每日膳食锌摄入量。对其中70例测血浆梓含量，36例女童测发锌含量。结果表明，目... 详细信息

1989年6~12月，我们对被纳入"婴幼儿生长与营养随访研究"的133例5岁儿童进行了锌营养状况的调查研究。利用已有的膳食调查资料，计算出生后2个月~5岁时的每日膳食锌摄入量。对其中70例测血浆梓含量，36例女童测发锌含量。结果表明，目前香港地区婴幼儿的锌摄入量可基本满足锌的需要量。有无临界性缺锌，需进一步观察研究。

关键词：锌营养调查婴幼儿香港

含硫过渡金属基元的反应——Ⅱ.双膦及双齿巯基混合配位钴,镍化合物的合成和结构特征

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化学学报 1998年第1期56卷 58-67页

作者：康北笙陈忠宁高汉荣周忠远伍伯牧麦松威林璋中山大学化学系广州510275 香港中文大学化学系结构化学国家重点实验室和中国科学院福建物质结构研究所福州350002

双膦(P(?)P)和1,2-双齿巯基(S(?)X)混合与mCl_2(m=Co,Ni)反应,得到通式为m(S(?)X)(P(?)P)的产物.晶体结构测定表明,配合物Co(bdt)(dppe)(1),Ni(tdt)(dppm)(2)和Ni(tsal)(dppe)(3)中的金属均为SXP_2配位的四方平面构型,S,X,P原子分别来... 详细信息

关键词：膦巯钴配合物镍双齿双膦

Phenylketonuria in Hong kong Chinese： a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China

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Chinese medical Journal 2011年第16期000卷 2556-2558页

作者： Chloe miu mak Chun-hung ko Ching-wan Lam Wai-ling Lau Wai-kwan Siu Sammy Pak-lam Chen Chun-yiu Law Chi-kong Lai Chak-man Yu Albert Yan-wo Chan kowloon West Cluster Laboratory Genetic Service ChemicalPathology Laboratory Department of Pathology Princess MargaretHospital Hong Kong China Department of Paediatrics and Adolescent medicine CaritasMedical Centre Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine TheUniversity of Hong Kong Hong Kong China

Hyperphenylalaninemia is one of the commonest inborn errors of metabolism affecting approximately 1 in 15 000 live births. Among Chinese, BH4 deficiency leading to hyperphenylalaninemia is much commoner than in Caucasians. Exact diagnosis is important for the treatment and genetic counseling. In 2000, newborn screening for phenylketonuria is mandatory by law in China throughout the whole country. However, it is not yet included in the newborn screening program of the Hong kong Special Administrative Region, China. Published data on hyperphenylalaninemia among Hong kong Chinese are largely lacking. We report a 1-year-old Hong kong Chinese girl with severe 6-pyruvoyl-tetrahydropterin synthase （PTPS） deficiency. The patient presented with infantile hypotonia and was misdiagnosed as cerebral palsy. She had very mild hyperphenylalaninemia （95 IJmol/L）, significantly high phenylalnine-to-tyrosine ratio （3.1）, and ele~,ated prolactin of 1109 m lU/L. Genetic analysis confirmed a homozygous known disease-causing mutation PTS Nm_000317.1： c.259C〉T; NP_000308.1： p.P87S in the proband. In our local experience, while the estimated prevalence of hyperphenylalaninemia due to PTPS deficiency was reported to be 1 in 29 542 live births, not a single case of phenylalanine hydroxylase deficiency has been reported. Furthermore, there is a general lack of awareness of inherited metabolic diseases in the community as well as among the medical professionals. Very often, a low index of clinical suspicion will lead to delay in diagnosis, multiple unnecessary and costly investigations, prolonged morbidity and anxiety to the family affected. We strongly recommend that expanded newborn screening for hyperphenylalaninemia should be implemented for every baby born in the Hong kong Special Administrative Region, China.

关键词： Hong kong Chinese hyperphenylalaninemia newborn screening phenylketonuria 6-pyruvoyl-tetrahydropterin synthase deficiency

Panel discussion on Disp cher Training Simulator-A summary

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Electricity 1992年第1期 24-29页

作者： mr.k.C.Lo mr.C.m.mak (China light and Power kowloon,Hong kong.)mr.P.Selosse (Electricite de France,France)mr.L.P.Zhang (Electric Power Research Institute,China)mr.Y.C.Gu (Tsinghua University,China)Chairman:Prof.H.Glavitsch (ETH,Switzerland)mr.S.T.Fu (EPRI,China)

On the“International Conference on Power SystemTechnology,1991”,a panel discussion on Dis-patcher Training Simulator(DTS)was *** DTS is a very in-teresting topic both in China and abroad,not only many audienceswere attracted by this panel discussion,they also raised many inter-esting questions and discussed with the *** of thefour papers presented by panelists as well as their related discus-sions are summarized below.

关键词： discussion Training summary questions panel summarized disadvantage think restoration themselves

mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study

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Infectious Diseases of Poverty 2023年第2期12卷 125-125页

作者： Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai mingyu Si Jiaqi Fu Xu Chen mengmeng Jia Zhiwei Leng Dan Cui Winnie W.S.mak Liming Dong Xiaoyou Su School of Population medicine and Public Health Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Pulmonary and Critical Care medicine National Center for Respiratory Medicine Center of Respiratory Medicine National Clinical Research Center for Respiratory Diseases China-Japan Friendship Hospital Beijing China Department of Pulmonary and Critical Care medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin Medical University Harbin China Diversity and Well-Being Laboratory Department of Psychology The Chinese University of Hong Kong Hong Kong China

Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived *** from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the *** current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 *** The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,*** demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the *** analyses,Pearson correlation analysis and Structural Equation modeling were used to make data description and *** A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the *** stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,Pmatic stress disorder(PTSD)(r=0.384,Pmediated the association between perceived stigma and anxiety(β=0.020,Pmong COVID-19 *** Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 *** on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience.

关键词： COVID-19 Survivor mental health Resilience mediating affect Stigma

mindfulness-based online intervention on mental health and quality of life among COVID-19 patients in China: an intervention design

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Infectious Diseases of Poverty 2021年第3期10卷 62-71页

作者： ming-Yu Si Wei-Jun Xiao Chen Pan Hao Wang Yi-man Huang Jun Lian Winnie W.S.mak Zhi-Wei Leng Xiao-You Su Qiu-PingTang Yu Jiang Lu-Zhao Feng Wei-Zhong Yang Chen Wang School of Population medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College9 DongDanSanTiaoDongchengBeijingChina Department of Clinical Psychology The Third Xiangya Hospital of Central South UniversityNo.138 Tongzipo RoadYueluChangshaHunanChina Diversity and Well-Being Laboratory Department of PsychologyThe Chinese University of Hong KongShatinNTHong KongChina Chinese Academy of medical Sciences and Peking Union medical College BeijingChina National Clinical Research Center for Respiratory Diseases BeijingChina.

Background:COVID-19 can lead to increased psychological symptoms such as post-traumatic stress disorder(PTSD),depression,and anxiety among patients with *** on the previous mindfulness-based interventions proved to be effective,this protocol reports a design of a randomized controlled trial aiming to explore the efficacy and possible mechanism of a mindful living with challenge(mLWC)intervention developed for COVID-19 survivors in alleviating their psychological problems caused by both the disease and the ***:In April 2021,more than 1600 eligible participants from Hubei Province of China will be assigned 1:1 to an online mLWC intervention group or a waitlist control *** participants will be asked to complete online questionnaires at baseline,post-program,and 3-month *** differences of mental health status(***)and physical symptoms including fatigue and sleeplessness between the COVID-19 survivors who receiving the online mLWC intervention and the control group will be *** addition,the possible mediators and moderators of the link between the mLWC intervention and target outcomes will be evaluated by related verified scales,such as the Five Facets mindfulness *** will be analyzed based on an intention-to-t「eat approach,and SPSS software will be used to perform statistical ***:The efficacy and potential mechanism of mLWC intervention in improving the quality of life and psychological status of COVID-19 survivors in China are expected to be *** from this study will shed light on a novel and feasible model in improving the psychological well-being of people during such public health *** registration Chinese ClinicalTrial Registry(ChiCTR),ChiCTR2000037524;Registered on August 29,2020,http://***/***?proj=60034.

关键词： COVID-19 Internet mindfulness-based intervention mental health Randomized controlled trial China

Corrole光敏剂在光动力治疗中的重原子效应

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高等学校化学学报 2006年第7期27卷 1363-1365页

作者：刘海洋郭平叶江柏荣应晓廖世军麦乃歧张启光华南理工大学化学系广州510641 香港科技大学化学系华南理工大学应用物理系广州510641 香港浸会大学生物系

10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole([STHZ]1) was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang *** al.,Proc SPIE,2006,Vol.6139,p268).To explore the heavy-atom effect on corrole photosensitizer,an exact analogue of corole [STHZ]1[STBZ] with the modification of two heavy iodine atoms on its 10-phenyl group,10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole(2),were ***,the photocytoxicity of corrole 2 on NPC cell dropped sharply as compared to corole *** exhibited no significant PDT cytotoxicity even if its concentration reached 2 μmol/*** may be caused by the lowering of its singlet oxygen quantum yield in PDT, although the intersystem crossing of corrole 2 could be enhanced by iodine heavy-atom effect as indicated by the strong decrease of its fluorescence emission.

关键词： Corrole 光敏剂鼻咽癌光动力治疗重原子效应

Ventilation of air-conditioned residential buildings: A case study in Hong kong

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建筑节能 2016年第9期44卷 5-5页

作者： Z.T.Ai C.m.mak D.J.Cui P.Xue 侯恩哲 <建筑节能>杂志社

more and more studies reported that there were insufficient ventilation and excessive CO_2 concentration in air-conditioned residential buildings, but few solutions were provided. This study investigates the overnight evolution of CO_2 concentration in air-conditioned residential buildings and then focuses mainly on the evaluation of three ventilation strategies, including overnight natural ventilation, short-term mechanical ventilation and short-term natural ventilation. On-site measurements were conducted in a typical residential bedroom in Hong kong in September. The indoor and outdoor CO_2 concentration, air temperature and relative humidity as well as the outdoor wind speed during the measurements were analysed. Ventilation rates were calculated based on the time series of CO_2 concentration. This study confirms that additional ventilation is usually needed in air-conditioned residential buildings. Overnight natural ventilation with even a small opening is associated with excessive energy consumption and deteriorated indoor thermal environment. Short-term natural ventilation strategies are inefficient and uncontrollable. Compared to the best short-term natural ventilation strategy, a reasonably designed short-term mechanical ventilation strategy requires only a 41% of ventilation period to complete one full replacement of indoor air and to reach a lower indoor CO_2 concentration. Nighttime case studies and a theoretical analysis suggest that a few several-minute mechanical ventilation periods could potentially maintain an acceptable indoor air quality for a normal sleeping period of 8 h.

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