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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Surface morphology and impurity distribution of electron beam recrystallized silicon films on low cost substrates for solar cell absorber

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Rare metals 2006年第Z1期25卷 195-200页

作者： GROmBALL F müller j Department of mikrosystemtechnik Technische Universitt Hamburg-Harburg Hamburg 21073 Germany

A line shaped electron beam recrystallised polycrystalline silicon film on the low cost substrate was investigated for the use of the solar cell absorber. The applied EB energy density strongly influences the surface morphology of the film system. Lower EB energy density results in droplet morphology and the rougher SiO2 capping layer due to the low fluidity. With the energy increasing, the capping layer becomes smooth and continuous and less and small pinholes form in the silicon film. Tungstendisilicide (WSi2) is formed at the interface tungsten/silicon but also at the grain boundaries of the silicon. Because of the fast melting and cooling of the silicon film, the eutectic of silicon and tungstendisilicide mainly forms at the grain boundary of the primary silicon dendrites. The SEm-EDX analysis shows that there are no chlorine and hydrogen in the area surrounding a pinhole after recrystallization because of outgassing during the solidification.

关键词： polycrystalline silicon film solar cell recrystallization energy surface morphology outgassing

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Simulation and calibration of granules using the discrete element method

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Particuology 2014年第1期12卷 40-43页

作者： Peter müller jürgen Tomas Institute of Process Engineering Mechanical Process EngineeringOtto-von-Guericke University MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The discrete element method （DEm）, developed by Cundall and 5track to solve geomecnamcai problems, is used to simulate the mechanical behavior of granules. According to the DEm, an individ ual granule can be modeled as a realistic mechanical system consisting of primary particles bonded by interaction forces. Cranulometric properties of the model material, zeolite 4A, have been measured to determine their macro properties. To investigate the compression behavior, a compression test was performed using a strength tester on single granules between two pistons. A modeled granule consisting of more than 22,000 primary particles was generated. The micro properties of the modeled granule have been precisely set to allow its macro properties to be equivalent to the macro properties of zeolite 4A granules. To calibrate the mechanical properties, diametrical compression was simulated using two rigid walls stressed at a constant stressing velocity, The force-displacement curve of the modeled granule at compression has been calibrated by the experimental curve of zeolite 4A.

关键词： Discrete element method material behavior Granulation

The Projective Cover of the Trivial Representation for a Finite Group of Lie Type in Defining Characteristic

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Algebra Colloquium 2017年第3期24卷 439-452页

作者： Shigeo Koshitani jürgen müller Department of mathematics Graduate School of Science Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Fakult t für mathematik und Naturwissenschaften Bergische Universit t Wuppertal GauBstr. 20 D-42119 Wuppertal Germany

We give a lower bound of the Loewy length of the projective cover of the trivial module for the group algebra kG of a finite group G of Lie type defined over a finite field of odd characteristic p, where k is an arbit... 详细信息

关键词： modular representations projective cover of trivial module finite groups ofLie type in defining characteristic

Synthesis and electronic properties of expanded 5-(hetero)arylthien-2-yl substituted 3-ethynyl quinoxalines with AIE characteristics

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Science China Chemistry 2018年第8期61卷 909-924页

作者： Franziska K.merkt Thomas j.j.müller Institute of Organic Chemistry and macromolecular Chemistry Heinrich Heine University Düsseldorf

Expanded 5-(hetero)aryl-thien-2-yl substituted 3-ethynyl quinoxaline dyes with variable substitution pattern on the peripheral thiophene ring were synthesized in moderate to very good yields by Suzuki and Buchwald-Hartwig coupling of the corresponding brominated 3-ethynyl quinoxalines. Dumbbell-shaped bis(thienyl 3-ethynyl quinoxalines) are also accessible by the Suzuki protocol. The photophysical properties were investigated by UV and fluorescence spectroscopy. most of the obtained compounds display fluorescence in solution and some of them also in the solid state. Additionally, tuning of the emission color of the quinoxaline based chromophores can be conveniently accomplished by the remote substituent group. The determined absorption and emission maximum as well as the Stokes shifts strongly correlate with Hammett σp+parameters. Besides,photophysical properties of selected derivatives in the solid state, biphasic solutions, and PmmA films, along with their relationships, are comparatively investigated. moreover, two 5-(hetero)aryl-thien-2-yl substituted 3-ethynyl quinoxaline dyes are aggregation induced emission(AIE) chromophores indicated by restriction of molecular motions. A covalently restricted 3-ethynyl quinoxaline supports that the inhibition of molecular rotation is responsible for the significant enhancement of fluorescence in acetonitrile/water mixtures.

关键词： absorption aggregation induced emission cross-coupling fluorescence heterocycles palladium

神经精神药理学治疗药物监测共识指南:2017版

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实用药物与临床 2022年第1期25卷 1-20页

作者： C.Hiemke N.Bergemann H.W.Clement A.Conca j.Deckert K.Domschke G.Eckermann K.Egberts m.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.janssen E.jaquenoud G.Laux T.messer R.m ssner m.j.müller m.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis m.Schwarz m.Silva Gracia B.Stegmann W.Steimer j.C.Stingl m.Uhr S.Ulrich S.Unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(主译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(审校) 王传跃(审校) 王刚(审校) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory medicine University Medical Center of MainzMainzGermany Kitzberg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Servizio Psichiatrico del Comprensorio Sanitario di Bolzano BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and medical Devices(BfArm) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry Unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum münchen-Ost Psychiatric HospitalMunich-HaarGermany Department of

治疗药物监测(Therapeutic Drug monitoring,TDm)通过定量测定和解释血药浓度以优化药物治疗。TDm着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDm的主要患者群体包括少年儿童... 详细信息

治疗药物监测(Therapeutic Drug monitoring,TDm)通过定量测定和解释血药浓度以优化药物治疗。TDm着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDm的主要患者群体包括少年儿童、孕妇、老年患者、智障患者、药物滥用者、涉法精神病患者、已知或怀疑药代动力学异常的患者以及合并躯体疾病影响药代动力学的患者。常规剂量下治疗无效,用药依从性难以判断,药物耐受性不佳,以及可能存在药代动力学方面的药物-药物相互作用等情况都是治疗药物监测的典型指征。然而,只有将TDm充分整合到临床治疗过程中,才能发挥其优化药物治疗的潜在优势。为了向临床医生和实验室提供有效的TDm信息,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDm专家组在2004年发表了第一版《精神科治疗药物监测指南》。2011年进行了更新之后,现在再次更新。遵循新版指南,可能会改善神经精神药物治疗的效果,加快很多患者的康复,并降低医疗费用。

关键词：抗凝药物妊娠期静脉血栓栓塞疾病抗抑郁药抗癫痫药抗帕金森病药抗精神病药血药浓度共识指南药物分析基因型分析神经药物遗传药理学药代动力学表型分析血浆药物浓度精神药物参考范围血清药物浓度治疗药物监测治疗窗

Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International journal of mining Science and Technology 2018年第1期28卷 79-83页

作者： Denise müller Axel Preusse Faculty of Georesources and materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection modeling above caverns