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The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite

Research in Astronomy and Astrophysics 2023年第9期23卷 66-78页

作者： Z.X.Ling X.j.Sun C.Zhang S.L.Sun G.jin S.N.Zhang X.F.Zhang j.B.Chang F.S.Chen Y.F.Chen Z.W.Cheng W.Fu Y.X.Han H.Li j.F.Li Y.Li Z.D.Li P.R.liu Y.H.Lv X.H.ma Y.j.Tang C.B.Wang R.j.Xie Y.L.Xue A.L.Yan Q.Zhang C.Y.Bao H.B.Cai H.Q.Cheng C.Z.Cui Y.F.Dai D.W.Fan H.B.Hu j.W.Hu m.H.Huang Z.Q.jia C.C.jin D.Y.Li j.Q.Li H.Y.liu m.j.liu Y.liu H.W.Pan Y.L.Qiu m.Sugizaki H.Sun W.X.Wang Y.L.Wang Q.Y.Wu X.P.Xu Y.F.Xu H.N.Yang X.Yang B.Zhang m.Zhang W.D.Zhang Z.Zhang D.H.Zhao X.Q.Cong B.W.jiang L.H.Li X.B.Qiu j.N.Sun D.T.Su j.Wang C.Wu Z.Xu X.m.Yang S.K.Zhang Z.Zhang N.Zhang Y.F.Zhu H.Y.Ban X.Z.Bi Z.m.Cai W.Chen X.Chen Y.H.Chen Y.Cui X.L.Duan Z.G Feng Y.Gao j.W.He T.He j.j.Huang F.Li j.S.Li T.j.Li T.T.Li H.Q.liu L.liu R.liu S.liu N.meng Q.Shi A.T.Sun Y.m.Wang Y.B.Wang H.C.Wu D.X Xu Y.Q Yang Y.Yang X.S.Yu K.X.Zhang Y.L.Zhang Y.H.Zhang Y.T.Zhang H.Zhou X.C.Zhu j.S.Cheng L.Qin L.Wang Q.L.Wang m.Bai R.L.Gao Z.ji Y.R.liu F.L.ma Y.j.Shi j.Su Y.Y.Tan j.Z.Tong H.T.Xu C.B.Xue G.F.Xue W.Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision Technology Co. LTDNanjing 211106China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Science and Technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National Space Science Center Chinese Academy of ScienceBeijing 100190China

The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 july *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art micro-Pore Optics(mPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is *** optical assembly composed of 36 mPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CmOS)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of FWHm)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CmOS sensors for X-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-X-rays genera

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对比增强光谱钼靶X线摄影影像组学诺模图预测乳腺癌腋窝淋巴结转移的多中心研究

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国际医学放射学杂志 2021年第1期44卷 122-122页

作者： N.mao P.Yin Q.Li Q.L.Wang m.j.liu H.ma 张坤

摘要目的本研究旨在建立和验证基于对比增强光谱钼靶摄影(CESm)的影像组学诺模图预测乳腺癌腋窝淋巴结(ALN)转移。方法这项回顾性研究包括在2家医院接受

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Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle liu munerah m.S.Almutairi jie ma Aisling Stewart Zhaohui Xing mengxia liu Bo Hou Yuljae Cho Um-SjTU joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying Wang jie liu Department of Life Sciences and medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(mAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of mAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the mAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FmT)from healthy donors alleviated CD symptoms,whereas FmT from CD patients exacerbated these ***,FmT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting mAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting mAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

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Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai liu Yong-Wei Yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCm)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCm and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer multicomponent multitarget Therapy

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： mingyi Yu Faith Teo En Ning Chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

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Neural Regeneration Research 2025年第5期20卷 1513-1520页

作者： Xueyun Shao Longfei He Yangyang liu Physical Education School Shenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Institute of Neuroscience ShenzhenGuangdong ProvinceChina

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(mD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67,

关键词： adolescents brain-derived neurotrophic factor children exercise meta-analysis randomized controlled trials

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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