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Abandoned Altitudes? Decrease and Expansion of Grassland in the Hinterland of Popayán, Southern Colombian Andes

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Journal of mountain Science 2015年第1期12卷 123-133页

作者： Andreas haller Oliver Bender Institute of Geography University of Innsbruck Institute for Interdisciplinary mountain Research Austrian Academy of Sciences Technikerstrasse 21a 6020 InnsbruckAustria

Due to their ecological disadvantages, many mountain regions have experienced land-use abandonment and shrub encroachment on former grassland at higher altitudinal zones--especially during recent decades of urbanization. But does this trend also apply to the hinterland of urban settlements？ By using the Southern Colombian example of Popay^n, a medium-sized city located in the Northern Andes, we can show that the landscape changes observed between 1989 and 2010 can hardly be related to agricultural abandonment. Hypsometric variations of land-cover change indicate that, until 2001, woods or shrubland expanded faster at the lower altitudinal range adjacent to the city than at the more remote higher zones. In contrast, after 2001 grassland areas increased on former woods or shrnbland at all altitudinal belts. Both periods thus present developments that can be interpreted as the result of land-use expansion below 2000 m asl and land-use persistence in the tierrafrla of the mountain city＇s hinterland.

关键词： Land-cover change Land-use change Rural-urban linkages Northern Andes

Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas haller Domenico BRANCA Deyvis CANO Institute for Interdisciplinary mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： mountain cities mountain agriculture Land use change Land cover change Rural-urban linkages montology

Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors

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World Journal of Gastroenterology 2014年第14期20卷 4017-4024页

作者： Valentin Becker Stefan Grotz Christoph Schlag Simon Nennstiel Analena Beitz Bernhard haller Roland m Schmid Alexander meining monther Bajbouj Ⅱ. medizinische Klinik und Poliklinik Technische Universit?t München Institut für medizinische Statistik und Epidemiologie Technische Universit?t München

AIm: To identify objective and subjective predictors for the reliable diagnosis of gastroesophageal reflux disease (GERD) and the response to proton pump inhibitor (PPI) therapy.

关键词： Gastroesophageal reflux Gastroesophageal reflux disease Non-erosive reflux disease Impedance pH measurement Follow-up Therapy Proton pump inhibitor

Cenozoic diatreme field in Chubut （Argentina） as evidence of phreatomagmatic volcanism accompanied with extensive Patagonian plateau basalt volcanism？

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Episodes 2007年第3期30卷 217-223页

作者： Karoly Nemeth Ulrike martin miguel J. haller Viviana I. Alric Institute of Natural Resources Volcanic Risk Solutions M_asse_y Uniyer_sity Palmerston North New Zealand. Department of mapping Geological Institute of Hungary Stefainia 14 Budapest H- 1143 Hungary. Geo-Zentrum an der KTB Am Bohrturm 2 92670 Windischeschenbach Germany. Universidad Nacional de la Patagonea San Juan Bosco Bvard Brown 3700 （9120） Puerto Ma.dryn Argentina. Centro Nacional Patagenico-CONICET Bvard. Brown 3500 （9120） Puerto Madryn Argentina.

In Patagonia, Argentina, at the northern border of the Patagonian Cenozoic mafic plateau lava fields, newly discovered diatremes stand about I00 m above the sur- rounding plain. These diatremes document phreato- magmatic episodes associated with the formation of the volcanic fields. The identified pyroclastic and intrusive rocks are exposed lower diatremes of former phreato- magmatic volcanoes and their feeding dyke systems. These remotely located erosional remnants cut through Paleozoic granitoids and Jurassic/Cretaceous alternating siliciclastic continental successions that are rela-

关键词：新生界火山地下水湿生植物玄武岩

C-X3-C motif chemokine ligand 1/receptor 1 regulates the m1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury

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Chronic Diseases and Translational medicine 2021年第4期7卷 254-265页

作者： Shuiming Guo Lei Dong Junhua Li Yuetao Chen Ying Yao Rui Zeng Nelli Shushakova Hermann haller Gang Xu Song Rong Department of Nephrology Division of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Respiratory Division of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Nephrology Hannover Medical SchoolHannover 30625Germany

Background:macrophages play an important role in renal ischemia reperfusion injury,but the functional changes of macrophages under hypoxia/reoxygenation and the related mechanism are unclear and need to be further ***:The effects of hypoxia/reoxygenation on functional characteristics of RAW264.7 macrophages were analyzed through the protein expression detection of pro-inflammatory factors TNF-αand CD80,anti-inflammatory factors ARG-1 and *** functional implications of C-X3-C motif chemokine receptor 1(CX3CR1)down-regulation in hypoxic macrophages were explored using small interfering RNA *** was assessed by the parametrict-test or nonparametric mann-Whitney test for two group comparisons,and a one-way ANOVA or the Kruskal-Wallis test for multiple group ***:Hypoxia/reoxygenation significantly increased the protein expression of m1-related pro-inflammatory factors TNF-α,CD80 and chemokine C-X3-C motif chemokine ligand 1(CX3CL1)/CX3CR1 and inhibited the protein expression of m2-related anti-inflammatory factors ARG-1 and CD206 in a time-dependent manner in RAW264.7 ***,the silencing of CX3CR1 in RAW264.7 cells using specific CX3CR1-siRNA,significantly attenuated the increase in protein expression of TNF-α(Pmigration(2.2-fold,Pmacrophages compared with the control group,and CX3CR1-siRNA had an inhibitory role(40%and 20%reduction,respectively).For elucidating the mechanism,we showed that the phosphorylation levels of ERK(P<0.01)and the p65 subunit of NF-κB(P<0.01)of the RAW264.7 cells in the hypoxic/reoxygenation group were significantly increased,which could be attenuated by down-regulation of CX3CR1 expression(P<0.01,both).ERK inhibitors also significantly bloc

关键词： macrophages Hypoxia/Reoxygenation C-X3-C motif chemokine ligand 1/receptor 1 Phenotypic polarization

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer Sabine Gerum Falk Roeder Stefan münch Stephanie E Combs Alexander B Philipp Enrico N De Toni martha m Kirstein Arndt Vogel Carolin mogler Bernhard haller Jens Neumann Rickmer F Braren marcus R makowski Philipp Paprottka markus Guba Fabian Geisler Roland m Schmid Andreas Umgelter Ursula Ehmer Internal medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation Oncology University of SalzburgSalzburg 5020Austria Department of Radiation Oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation Oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver *** explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and mann-Whitney-U *** Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests th

关键词： Hepatocellular carcinoma Transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation

methemoglobinemia—A biomarker and a link to ferric iron accumulation in Alzheimer’s disease

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Advances in Bioscience and Biotechnology 2014年第1期5卷 12-18页

作者： Lucijan mohorovic Anna m. Lavezzi Sanja Stifter George Perry Djulija malatestinic Vladimir micovic Eris materljan Herman haller Oleg Petrovic “Lino Rossi” Research Center Department of Biomedical Sur-gical and Dental Science University of Milan Milan Italy Department of Biology University of Texas at San Antonio San Antonio USA Department of Environmental medicine University of Rijeka School of Medicine Rijeka Croatia Department of Family medicine University of Rijeka School of Medicine Rijeka Croatia Department of Gynecology and Obstetrics University of Rijeka School of Medicine Rijeka Croatia Department of Pathology University of Rijeka School of Medi-cine Rijeka Croatia Department of Social medicine and Epidemiology University of Rijeka School of Medicine Rijeka Croatia

Understanding the mechanism of oxidative stress is likely to yield new insights regarding the pathogenesis of Alzheimer’s disease (AD). Our earlier work focused on the difference between hemoglobin and methemoglobin degradation, respectively leading to ferrous (Fe2+) iron, or ferric (Fe3+) iron. methemoglobin has the role of carrier, the donor of cytotoxic and redox-active ferric (Fe3+) iron, which can directly accumulate and increase the rate of capillary endothelial cell apoptosis, and may cross into the brain parenchyma, to the astrocytes, glia, neurons, and other neuronal cells (neurovascular unit). This supposition helps us to understand the transport and neuronal accumulation process of ferric iron, and determine how iron is transported and accumulated intracellularly, identifiable as “Brain rust”. Earlier research found that the incidences of neonatal jaundice (p = 0.034), heart murmur (p = 0.011) and disorders such as dyslalia and learning/memory impairments (p = 0.002) were significantly higher in those children born from mothers with methemoglobinemia. Our hypothesis suggests that prenatal iron abnormalities could lead to greater neuronal death, the disease ageing process, and neurodegenerative disorders such as AD and other neurodegenerative diseases.

关键词： Alzheimer’s Disease (AD) Apoptosis Blood-Brain Barrier (BBB) Brain Capillary Ferric Iron Deposition Hemoglobin and methemoglobin Catabolism Neurodegenerative Brain Disease SIDS

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膝关节损伤和疾病的影象检查

放射学实践 1990年第4期5卷 157-163页

作者： W.haller K.Lehner 李贵林 Orthopdische Klinik und Poliklinik und Institut fur Rontgendiagnostik des Klinikums rechts der Isar der Technischen Universitt mnchen 同济医科大学附属同济医院

影象检查是膝关节矫形外科诊断的重要组成部分,除了普通X线检查外,特殊检查法如超声检查、CT、磁共振检查(mRT)均日益增加其价值。

关键词：膝关节损伤膝关节疾病影象检查

Productivity of White and Yellow Grain Corns in Campeche, méxico

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Agricultural Sciences 2019年第9期10卷 1255-1269页

作者： Juan medina-méndez Jesús manuel Soto-Rocha Antonio Villalobos-González Víctor Hugo Volke-haller Joaquín Gómez-Tejero Campo Experimental Edzná Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Campeche México Postgrado en Edafología Colegio de Postgraduados Montecillo México

The present work took place in the central and northern regions of the state of Campeche, mexico. The grain yield was evaluated in a total of 46 materials, comprising 30 of white grain and 16 of yellow grain. The crop was supplied to a greater extent with rainwater from the months of July to November. The sowing was in trials designed to evaluate grain yield and technology validation lots established for demonstration purposes. To integrate a genetic material into this study, it was a fundamental requirement that it had at least four evaluations considering different locations or years. As a result of the above, it was determined that there are 27 hybrids of white grain and 14 of yellow grain, which constitute options for the producer with which it is possible to obtain yields of 4.1 to 6.0 t⋅ha−1 and that can make corn a profitable crop under the current conditions of technology application. Of the white grain hybrids, the group formed by SB-309, DK-395, DK-393, DAS-2382, SP-500, DK-390, P4082W, 9209W, P3966W, SORENTO, JC-25, LUCINO, and 9401W was considered as the high productivity stratum, whose average yield is 5.1 to 5.9 t⋅ha−1. Similarly, in the yellow grain hybrids, the group formed 9107Y, SP-525A, 2B688, DK-7500, P4226A, ImPACT and DK-7088, was considered as the high productivity stratum, whose average yield fluctuated from 5.0 to 5.9 t⋅ha−1.

关键词： White and Yellow maize Tropics Arable Soils