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Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

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Burns & Trauma 2016年第3期4卷 199-215页

作者： Jennifer m.hahn Kevin L.mcFarland Kelly A.Combs Dorothy m.Supp Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Department of Surgery University of Cincinnati College of MedicineCincinnatiOHUSA

Background:Keloids are an extreme form of abnormal scarring that result from a pathological fibroproliferative wound healing *** molecular mechanisms driving keloid pathology remain incompletely understood,hindering development of targeted,effective *** studies in our laboratory demonstrated that keloid keratinocytes exhibit adhesion abnormalities and display a transcriptional signature reminiscent of cells undergoing epithelial-mesenchymal transition(EmT),suggesting a role for EmT in keloid *** the current study,we further define the EmT-like phenotype of keloid scars and investigate regulation of EmT-related genes in ***:Primary keratinocytes from keloid scar and normal skin were cultured in the presence or absence of transforming growth factor beta 1(TGF-β1)+/-inhibitors of TGF-β1 and downstream signaling *** expression was measured using quantitative polymerase chain *** was analyzed using an in vitro wound healing *** in keloid scar and normal skin sections were localized by *** analyses utilized SigmaPlot(SyStat Software,San Jose,CA)or SAS?(SAS Institute,Cary,NC).Results:In keloid and normal keratinocytes,TGF-β1 regulated expression of EmT-related genes,including hyaluronan synthase 2,vimentin,cadherin-11,wingless-type mmTV integration site family,member 5A,frizzled 7,ADAm metallopeptidase domain 19,and *** of canonical TGF-β1 signaling in keloid keratinocytes significantly inhibited expression of these genes,and TGF-β1 stimulation of normal keratinocytes increased their *** inhibition of the extracellular signal-regulated kinase 1/2(ERK1/2)signaling pathway or the p38 mitogen-activated protein kinase pathway attenuated TGF-β1-induced expression of subsets of these *** of keloid keratinocytes,previously shown to be increased compared with normal keratinocytes,was significantly reduced by inhibition of TGF-β1 or E

关键词： Keloid Keratinocyte Epithelial-mesenchymal transition Wound healing Scar Fibrosis

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标称应力法中构件S-N疲劳曲线的预测

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工程设计学报 1999年第1期6卷 14-20页

作者： H.mERTENS m.hahn 缪炳祺陈巍柏林工业大学机械设计研究所浙江工业大学机电工程学院杭州汽轮动力集团有限公司研究所情报室戴姆勒-奔驰公司

局部法只需利用材料特性参数就可预测构件受交变载荷时的寿命。尽管如此，采用试验Ｓ－Ｎ疲劳曲线的标称应力法由于其更加可靠而仍是强度计算的主要方法。本文对局部法作了一些改进，例如引进了由局部多轴应力状态引起的流变障碍及应力... 详细信息

局部法只需利用材料特性参数就可预测构件受交变载荷时的寿命。尽管如此，采用试验Ｓ－Ｎ疲劳曲线的标称应力法由于其更加可靠而仍是强度计算的主要方法。本文对局部法作了一些改进，例如引进了由局部多轴应力状态引起的流变障碍及应力梯度的影响。文中采用所改进的方法，对构件的Ｓ—Ｎ疲劳曲线进引了预测，并将其与试验结果进行了比较。

关键词： S-N 疲劳曲线标称应力法构件

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Pirfenidone inhibits epithelial–mesenchymal transition in keloid keratinocytes

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Burns & Trauma 2020年第1期8卷 441-451页

作者： Latha Satish Alexander Evdokiou Eleni Geletu Jennifer m.hahn Dorothy m.Supp Research Department Shriners Hospitals for Children—CincinnatiCincinnatiOH 45229 USA Department of Pathology&Laboratory medicine University of CincinnatiCincinnatiOH 45229USA Department of Surgery University of CincinnatiCincinnatiOH 45229USA

Background:Keloids are benign fibroproliferative skin lesions that are difficult to treat and become a lifetime predicament for *** treatment modalities have been put forth,but as yet no satisfactory approach to the prevention or treatment of keloids has been *** process of epithelial-to-mesenchymal transition(EmT)has been implicated in keloid scarring,as keloid keratinocytes display an EmT-like *** study investigated the potential of pirfenidone,an antifibrotic agent,to counteract EmT-like alterations in keloid keratinocytes,including gene expression,cell migratory and proliferative ***:Normal and keloid keratinocytes were isolated from discarded normal skin tissues and from resected keloid tissues,*** were quiesced for 24 h without epidermal growth factor DS-Qi1mCDigital and were exposed to transforming growth factor-beta1(TGF-β1;10 ng/mL),with or without pirfenidone(400μg/mL),for an additional 24 *** effects of pirfenidone on cytotoxicity,cell migration,cell proliferation,and on expression of genes and proteins involved in EmT were *** significance was determined by two-way ANOVA using Sigma ***:We found that pirfenidone did not elicit any cytotoxic effect at concentrations up to 1000μg/mL.A statistically significant dose-dependent decrease in basal cell proliferation rate was noted in both normal and keloid keratinocytes when exposed to pirfenidone at concentrations ranging from 200 to 1000μg/*** significantly decreased basal cell migration in both normal and keloid keratinocytes,but a significant decrease in TGF-β1-induced cell migration was seen only in keloid *** inhibition of the expression of TGF-β1-induced core EmT genes,namely hyaluronan synthase 2,vimentin,cadherin-11,and wingless-type mmTV integration site family,member 5A along with fibronectin-1,was observed in both normal and keloid keratinocytes treated with *** addi

关键词： Keloids EmT genes Cell migration Proliferation Pirfenidone Fibronectin

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Solvation Effects on the Dielectric Constant of 1 m LiPF6 in Ethylene Carbonate:Ethyl methyl Carbonate 3:7

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Energy & Environmental materials 2024年第1期7卷 253-256页

作者： Julian Self Nathan T.hahn Kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 m LiPF_(6)in EC:EmC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EmC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EmC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 m LiPF_(6)in EC:EmC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

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A multi-photon(7×7)-focus 3D laser printer based on a 3D-printed diffractive optical element and a 3D-printed multi-lens array

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Light(Advanced manufacturing) 2024年第1期5卷 26-39页

作者： Pascal Kiefer Vincent hahn Sebastian Kalt Qing Sun Yolita m.Eggeler martin Wegener Dmm2O-Cluster of Excellence Karlsruhe Institute of Technology(KIT)and Heidelberg University76128 KarlsruheGermany Institute of Applied Physics(APH) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Nanotechnology(INT) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Laboratory for Electron microscopy(LEm) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany

One of the challenges in the field of multi-photon 3D laser printing lies in further increasing the print speed in terms of voxels/***,we present a setup based on a 7×7 focus array(rather than 3×3 in our previous work)and using a focus velocity of about 1 m/s(rather than 0.5 m/s in our previous work)at the diffraction limit(40×/NA1.4 microscope objective lens).Combined,this advance leads to a ten times increased print speed of about 108 voxels/*** demonstrate polymer printing of a chiral metamaterial containing more than 1.7×10^(12) voxels as well as millions of printed microparticles for potential pharmaceutical *** critical high-quality micro-optical components of the setup,namely a diffractive optical element generating the 7×7 beamlets and a 7×7 lens array,are manufactured by using a commercial two-photon grayscale 3D laser printer.

关键词： 3D laser printing Direct laser writing multi-photon absorption multi-focus optics Diffractive optical element Lens array

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Enhanced activity and durability of FeCoCrmoCBY nanoglass in acidic hydrogen evolution reaction

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Journal of materials Science & Technology 2024年第3期170卷 212-220页

作者： mengyang Yan Shuangqin Chen Shangshu Wu Xuechun Zhou Shu Fu Di Wang Christian Kübel Horst hahn Si Lan Tao Feng Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of Nanotechnology Karlsruhe Institute of TechnologyKarlsruhe 76021Germany

In the present work,a multi-element nanoglass(m-NG)of FeCoCrmoCBY is obtained first time by the laser ablation combined with inert gas condensation(laser-IGC)*** with the conventional rapid-quenched metallic glass(mG)with identical composition,the Fe-based m-NG demonstrates a superior performance as a self-supported electrocatalyst for hydrogen evolution reaction(HER)in acidic *** enhanced HER activity of m-NG is proposed to be closely related to its high en-ergy states,which is originated from the unique inhomogeneous nanostructures with a high density of low-coordinated ***,the Fe-based m-NG exhibits an outstanding comprehensive catalytic performance even beyond the commercial Pt/C catalyst in long-term test due to its self-optimization *** work not only opens the way to the preparation of m-NGs by the novel laser-IGC technique,but also makes a great contribution to developing low-cost,high-efficient,and super-durable HER electrocat-alysts in acidic environment.

关键词： Nanoglass Inert gas condensations High energy states Hydrogen evolution reactions

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计算超导螺线管磁体中电磁应力的解析方法

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Acta mechanica Sinica 2024年第4期40卷 4-20页

作者： Jeonghwan Park Kibum Choi Yufan Yan Jaemin Kim Seungyong hahn Department of Electrical and Computer Engineering Seoul National UniversitySeoul08826Republic of Korea Applied Superconductivity Center and Electric Power Institute Seoul National UniversitySeoul08826Republic of Korea

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来... 详细信息

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来的自保护行为至关重要.根据关键磁体设计参数(如目标中心场、背景磁场、内外绕组直径和外部径向堆叠),我们给出了可以从解析上确定高场超导磁体具有压缩径向应力的电磁-力学条件.本文提出的方法可以识别干绕线圈中径向匝间接触行为的3种不同模式:(1)完全分离;(2)完全接触;以及(3)混合模式(即部分分离和接触).文章随后提出一种使用完全压缩径向应力电磁-力学条件来计算干绕线圈中应力分布的解析方法.并通过有限元分析示例验证了解析方法与数值方法的良好一致性.文章结果可以帮助磁体工程师在早期设计阶段更好地概览高场超导磁体的电磁-力学行为.

关键词：高温超导背景磁场径向应力力学条件拉伸应力匝间接触行为混合模式

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结直肠肿瘤的分子生物学及其临床意义

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德国医学 1999年第5期16卷 259-261页

作者： m.hahn O.N.Koufaki H.K.Schackert 陈义发 Abteilung Chirurgische Forschung Universittsklinikum Carl Gustav CarusTechnische Universitat DresdenFetscherstrasse 74D-01307 DresdenGermany 同济医科大学附属同济医院

越来越多的证据表明结直肠癌的发生与环境和遗传因素有关。癌症发生的最关键的遗传因素是参与细胞调控、增生和分化的癌基因、肿瘤抑制基因和看家基因,了解这些基因的改变对于结直肠肿瘤的诊断和处理有重要的意义。

关键词：大肠肿瘤肿瘤发生分子生物学结直肠肿瘤

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Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 359-363页

作者： Costantine Albany Noah m.hahn Indiana University Health Melvin and Bern Simon Cancer Center Indianapolis IN USA.

Defects within apoptotic pathways have been implicated in prostate cancer （PCa） tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins （HSPs） and the human androgen receptor （AR）, the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.

关键词： apatorsen apoptosis bcl-2 homologous antagonist-killer protein clusterin custirsen ganetespib heat-shock proteins prostatic neoplasms

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Colorectal mucosal histamine release by mucosa oxygenation in comparison with other established clinical tests in patients with gastrointestinally mediated allergy

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World Journal of Gastroenterology 2006年第29期12卷 4699-4705页

作者： m Raithel m Weidenhiller R Abel HW Baenkler EG hahn Functional Tissue Diagnostics Gastroenterology Department of Medicine ⅠUniversity Erlangen-NurembergGermany medicine Clinics Ⅲ Klinikum Augsburg Germany Clinical Immunology and Allergology Department of medicine Ⅲ University Erlangen-NurembergGermany

AIm： This study evaluated colorectal mucosal histamine release in response to blinded food challenge-positive and-negative food antigens as a new diagnostic procedure. mETHODS： 19 patients suffering from gastrointestinally mediated allergy confirmed by blinded oral provocation were investigated on grounds of their case history, skin prick tests, serum IgE detection and colorectal mucosal histamine release by ex vivo mucosa oxygenation. Intact tissue particles were incubated/stimulated in an oxygenated culture with different food antigens for 30 min. Specimens challenged with anti-human immunoglobulin E and without any stimulus served as positive and negative controls, respectively. mucosal histamine release （% of total biopsy histamine content） was considered successful （positive）, when the rate of histamine release from biopsies in response to antigens reached more than twice that of the spontaneous release. Histamine measurement was performed by radioimmunoassay. RESULTS： The median （range） of spontaneous histamine release from colorectal mucosa was found to be 3.2 （0.1%-25.8%） of the total biopsy histamine content. Food antigens tolerated by oral provocation did not elicit mast cell degranulation 3.4 （0.4%-20.7%, P=0.4）, while anti-IgE and causative food allergens induced a significant histamine release of 5.4 （1.1%-25.6%, P = 0.04） and 8.1 （1.5%-57.9%, P = 0.008）, respectively. 12 of 19 patients （63.1%） showed positive colorectal mucosal histamine release in accordance with the blinded oral challenge responding to the same antigen （s）, while the specificity of the functional histamine release to accurately recognise tolerated foodstuffs was found to be 78.6%. In comparison with the outcome of blinded food challenge tests, sensitivity and specificity of history （30.8% and 57.1%）, skin tests （47.4% and 78.6%） or antigen-specific serum IgE determinations （57.9% and 50%） were found to be of lower diagnostic accuracy in gastrointestinally mediated allergy. CONCLU

关键词： Gut Histamine release mucosa oxygenation Food allergy diagnostics Gastrointestinally mediatedallergy

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