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metal-organic frameworks (mOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

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Science China Chemistry 2025年

作者： Bo Han erhai Hu Bei-er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum Anne Zulfia Syahrial Qingyu Yan SCARCE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of materials Science and Engineering Nanyang Technological University material Science and Engineering Research group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia metallurgical & materials Engineering Department Fakultas Teknik Universitas Indonesia

metal-organic frameworks (mOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,mOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that mOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which mOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of mOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of mOFs are comprehensively ***,we explore the distinct advantages of mOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of mOFs for advanced energy storage solutions.

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Action of ZDY101 on passive avoidance test and brain m-receptor density after intracranial co-injection of Aβ plus ibotenic acid

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Nuclear Science and Techniques 2001年第4期12卷 250-255页

作者： HUYa－er XIAZong－Qin 等 ResearchLaboratoryofCellRegulation ShanghaiSecondMedicalUniversityShanghai200025

The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from Chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total m-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain m-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of m-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of m-cholinergic receptor density was an important factor in improving the memory of such animal model.

关键词：放射医学 Alzeimer病动物模型

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:gastric cancer(gC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in gC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 gC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(gI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating gC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： gastric cancer(gC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cgAS–STINg axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: Her-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sequential occurrence of T790m mutation and small cell lung cancer transformation in EgFR-positive lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2836-2843页

作者： er Hong Xi-er Chen Jia mao Jing-Jing Zhou Ling Chen Jia-Yi Xu Wei Tao Department of Respiratory Ningbo Municipal Hospital of Traditional Chinese MedicineAffiliated to Zhejiang Chinese Medical UniversityNingbo 315000Zhejiang ProvinceChina Department of Radiology Ningbo Municipal Hospital of Traditional Chinese MedicineAffiliated to Zhejiang Chinese Medical UniversityNingbo 315000Zhejiang ProvinceChina

BACKgROUND The emergence of secondary drug resistance when treating epidermal growth factor receptor(EgFR)mutated non-small cell lung cancer(NSCLC)using EgFRtyrosine kinase inhibitors(EgFR-TKIs),seriously affects the therapeutic efficacy and survival of ***,we report a case of advanced NSCLC focusing on the application of multiple biopsy modalities to reveal the development of multiple resistance mechanisms during targeted *** SUmmARY A 54-year-old male patient presented with EgFR 19Del-mutated advanced lung adenocarcinoma,and exhibited the development of a T790m mutation during initial TKI *** 3 mo of Osimertinib treatment,a mixed response was *** biopsy of the progressive lesion showed transformation to small cell lung cancer(SCLC)harboring RB1 and TP53 mutations,with loss of the original T790m mutation.A standard chemotherapy regimen with Anlotinib for SCLC was *** biopsy revealed adenocarcinoma combined with SCLC after tumor *** patient’s overall survival was 24 *** multiple biopsy modalities can reveal the development of multiple resistance mechanisms which help with treatment *** treatment regimens according to the drug resistance mechanism significantly improved the prognosis of such patients.

关键词： Adenocarcinoma Epidermal growth factor receptor-tyrosine kinase inhibitor Epidermal growth factor receptor-T790m mutation Small cell lung cancer transformation Chemotherapy Case report

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death