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Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study

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Infectious Diseases of Poverty 2021年第5期10卷 14-27页

作者： Violeta Ramos‑Sesma miriam Navarro Jara Llenas‑garcía Concepción gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑Jorgensen maría garcía‑López Concepción Amador‑Prous maría‑Paz Ventero‑martín Pedro guevara‑Hernández Ana garijo‑Saiz Ares Sanchez‑Sanchez Cristina Bernal‑Alcaraz Ana‑Isabel Pujades‑Tarraga Roser muñoz‑Perez maría Flores‑Chávez José‑manuel Ramos‑Rincón Internal medicine Service HLA Inmaculada HospitalGranadaSpain Public Health Science History and Gynecology DepartmentUniversidad Miguel Hernández de ElcheAlicanteSpain Epidemiology Unit Public Health Center of Elche AlicanteSpain Internal medicine Department Hospital Vega Baja de Orihuela(AlicanteSpain)-Foundation for the Promotion of Health and Biomedical Research of the Valencia Region(FISABIO)AlicanteSpain Clinical medicine Department University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal medicine Department Hospital Marina BaixaLa Vila Joiosa(AlicanteSpain)-FISABIOAlicanteSpain Internal medicine Department General University Hospital of Alicante–Biomedical and Health Research Institute of Alicante(ISABIAL)AlicanteSpain Parasitology Area University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal medicine Department University Hospital of Sant Joan(Sant Joan d’AlacantSpain)–FISABIOAlicanteSpain microbiology Service General University Hospital of Alicante–ISABIALAlicanteSpain Pediatric Department General University Hospital of Alicante–ISABIALAlicanteSpain Digestive Service General University Hospital of Alicante–ISABIALAlicanteSpain Reference and Research Laboratory in Parasitology National Center of Microbiology/Mundo Sano FoundationMadridSpain

Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration *** carriers may host the parasite for years,without knowing they are *** aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening ***:Three community-based campaigns were performed in Alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi *** completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and *** seroposi‑tive for *** underwent diagnostic confrmation by two diferent *** were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aORs),adjusting for age,sex,and time in ***:A total of 596 participants were included in the study;17%were aged under 18 *** in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among *** but one case were in *** was independently associated with having been born in Bolivia(aOR:102,95%CI:13–781)and a primary school-level education(aOR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received *** analysis showed that coming from Argentina(aOR:13,95%CI:1.61–1188)or Bolivia(aOR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aOR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the *** primary level studies(aOR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aOR:4.63,95%CI:2.52–847)were independently associated with a lower level of ***:Community-based interventions are a good strategy for diagnosi

关键词： Chagas disease Trypanosoma cruzi Knowledge Community-based intervention migrant Early diagnosis Screening

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Optimization of mycelial growth of Xylaria papulis Lloyd(Xylariaceae)in indigenous liquid culture conditions,science city of muñoz,Nueva Ecija,Philippines

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Studies in Fungi 2022年第1期7卷 176-182页

作者： mark Kevin S.Lopez Sofronio P.Kalaw Rich milton R.Dulay Angeles m.De Leon Renato g.Reyes Biology Department College of Arts and SciencesDon Mariano Marcos Memorial State University–North La Union Campus/SapilangBacnotanLa Union Philippines 2515 Center for Tropical mushroom Research and Development Department of Biological SciencesCollege of ScienceCentral Luzon State University/Science City of MuñozNueva EcijaPhilippines 3120

The search for potential and inexhaustible sources of bioactive compounds with great functional activities is imperative for potential drug leads in treating various human *** this regard,this study investigated the optimum liquid medium and physical culture conditions for the mycelial growth of *** Lloyd for nutraceutical *** greatest mycelial biomass was achieved in PSB liquid medium among the indigenous media evaluated,such as potato sucrose broth(PSB),corn meal broth(CmB),rice bran broth(RBB),and coconut water(CW).In terms of pH,*** Lloyd was observed to grow in a wide range of pH(5.0−8.5),but the best mycelial growth was observed at pH *** temperature of 28℃,lighted(137 lux),and static conditions were the other optimum physical culture conditions for mycelial growth of *** Lloyd.

关键词： culture liquid optimum

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四价人乳头瘤病毒疫苗的效力和效果:10年真实世界研究的系统综述

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中国病毒病杂志 2018年第4期8卷 329-335,346页

作者： Suzanne m.garland Susanne K.Kjaer Nubia muoz Stan L.Block Darron R.Brown mark J.DiNubile Brianna R.Lindsay Barbara J.Kuter gonzalo Perez geraldine Dominiak-Felden Alfred J.Saah Rosybel Drury Rituparna Das Christine Velicer 王华庆中国疾病预防控制中心免疫规划中心

预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索Pubmed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病... 详细信息

预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索Pubmed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病变的效力或效果的观察性研究的报道。十年来,真实世界环境中HPV疫苗效果越来越明显,尤其在疫苗接种率较高国家中那些在HPV暴露发生之前接种的女孩。据报道,疫苗可使HPV6、11、16、18感染最多减少约90%,生殖器疣减少约90%,低度宫颈细胞学异常减少约45%,经组织学证实的高度宫颈异常减少约85%。但HPV疫苗接种计划的公共卫生潜力尚未完全实现,HPV相关疾病仍具有较高的发病率和死亡率,因此仍需要提高HPV疫苗接种计划的人群覆盖率。

关键词： HPV疫苗接种宫颈癌宫颈癌癌前病变生殖器疣佳达修

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胆固醇介导的星形胶质细胞活化与淀粉样前体蛋白表达升高和进展相关

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神经损伤与功能重建 2015年第6期10卷 525-525页

作者： Evangelina Avila-mu?oz Clorinda Arias 王晶 Departamento De medicina genómica Y Toxicología Ambiental Instituto De Investigaciones BiomédicasUniversidad Nacional Autónoma De México

胆固醇对于保持脂筏的完整性起必要作用,其被认为是阿尔茨海默病(AD)中淀粉样蛋白生成的关键调节因子。大多数关于淀粉样前体蛋白(APP)代谢和β淀粉样蛋白(Aβ)生成的研究都聚焦于神经元。虽然在大多数AD患者和AD转基因模型脑内发现活... 详细信息

胆固醇对于保持脂筏的完整性起必要作用,其被认为是阿尔茨海默病(AD)中淀粉样蛋白生成的关键调节因子。大多数关于淀粉样前体蛋白(APP)代谢和β淀粉样蛋白(Aβ)生成的研究都聚焦于神经元。虽然在大多数AD患者和AD转基因模型脑内发现活化的星形胶质细胞,但星形胶质细胞在AD中的作用尚未得到充分探索。在神经元Aβ生成中胆固醇的作用已得到充分研究,并归因于APP代谢中脂筏的参与。因此,本研究分析星形胶质细胞中胆固醇的作用,以及APP的表达和进展。本研究发现,胆固醇的表达导致星形胶质细胞活化,提高APP水平,增强APP和BACE-1的交互作用。这些作用与星形胶质细胞细胞膜的神经节苷脂gm1-胆固醇斑块和增高的ROS相关。

关键词： APP代谢 ROS 培养的星形胶质细胞脂筏

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石英-长石熔体中的相关系及其组成与水溶解度的关系

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地质地球化学 1995年第2期23卷 7-15页

作者： m.Pichavant 朱永峰北京大学地质系

本文给出了Qz－Ab和Qz－Or体系在水饱和及水不饱和状态下2×108Pa和5×108Pa时的液相线关系。这些资料可以说明，（1）等压条件下熔体中水含量的变化和（2）水饱和状态下压力的变化对体系相平衡的影响。二者产生的影响不同，并且取决于... 详细信息

本文给出了Qz－Ab和Qz－Or体系在水饱和及水不饱和状态下2×108Pa和5×108Pa时的液相线关系。这些资料可以说明，（1）等压条件下熔体中水含量的变化和（2）水饱和状态下压力的变化对体系相平衡的影响。二者产生的影响不同，并且取决于所研究的体系。2×108Pa压力下，熔体中水含量增高导致Qz－Ab体系的液相线温度及共结温度降低的程度比oz-Or体系的高，而共结成分保持不变。相反，P（＝PH2O）由2×108Pa升至5×108Pa的影响主要是使Qz－Ab体系的共结成分向富Ab方向变化，但在Qz－Or体系中观察不到共结组分的改变。等压条件下熔体因其中水含量的变化对两体系影响的差异可能是由于水在含钠熔体中的溶解度比在含钾熔体中高的缘故。不同压力（＝PH2O）下体系的液相线相关系是压力和熔体中水含量影响的综合反映。本研究中，熔体中水含量的变化范围预示着所观察到的相关系的变化涉及到分子水的作用。对铝硅酸盐玻璃及熔体中水溶解机理的光谱资料及现行模式进行了检验，认为不同的铝硅酸盐熔体具有不同的水溶解度是分子水差异结合所致。

关键词：石英熔体长石熔体相关系水溶解度

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在前交叉韧带撕裂病人的mR成像中对骨损伤诊断的短期临床重要性

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国际医学放射学杂志 2012年第5期 488-488页

作者： R.Kijowski m.L.Sanogo K.S.Lee A.muoz del Río T.A.mcguine g.S.Baer 刘丽 Department of Radiology University of Wisconsin School of Medicine and Public Health600 Highland AveClinical Science Center-E3/311MadisonWI 53792-3252

摘要目的检测在早期前交叉韧带撕裂(ACL)病人中骨损伤与短期临床预后之间的联系。材料与方法此回顾性研究取得评审机构的同意,无需获得知情同意书。该研究包括114例ACL撕裂的病人(男57例,女57例,平均年龄分别为26.1及25.1岁),均行mRI检... 详细信息

摘要目的检测在早期前交叉韧带撕裂(ACL)病人中骨损伤与短期临床预后之间的联系。材料与方法此回顾性研究取得评审机构的同意,无需获得知情同意书。该研究包括114例ACL撕裂的病人(男57例,女57例,平均年龄分别为26.1及25.1岁),均行mRI检查及ACL重建手术,并且在手术前和术后1年填写国际膝关节文献委员会(IKDC)的膝关节评估问卷。所有的mR影像均由2名放射科医师单独审阅来决定每一个膝关节表面的压缩性骨折。

关键词：病人 ACL 前交叉韧带关节韧带 mR 骨损伤骨髓水肿

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Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome

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World Journal of Diabetes 2013年第3期4卷 64-69页

作者： Carley A gomez-meade Adriana Carrillo gabriela Lopez-mitnik Sarah E messiah Kristopher L Arheart Nestor de la Cruz-muoz Division of Pediatric Endocrinology Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFL 33130United States Division of Pediatric Clinical Research Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFL 33130United States Department of Epidemiology and Public Health Sciences Division of BiostatisticsUniversity of Miami Miller School of MedicineMiamiFL 33130United States Department of Surgery University of Miami Miller School of MedicineMiamiFL 33130United States

AIm:To examine the effect of gastric bypass surgery on cardiometabolic health among women with polycystic ovarian syndrome(PCOS).mETHODS:Retrospective medical chart review identified women(n = 389) with PCOS who underwent Roux-en-Y gastric bypass surgery from 2001-2009 in one surgical *** repeated measures linear mixed models were fit using the mIXED procedureto assess mean change in cardiometabolic disease risk factors from before to 1-year after surgery and were evaluated by ethnicity [Hispanic,non-Hispanic black(NHB) and white(NHW)].RESULTS:The majority of the sample was Hispanic(66%,25% NHB,9% NHW).mean body mass index significantly improved 1 year post-surgery for all ethnic groups(45.5 to 35.5 kg/m2 for Hispanics,46.8 to 37.7 kg/m2 for NHB and 45.7 to 36.7 kg/m2 for NHW,P mong Hispanic women mean total cholesterol(198.1 to 160.2 mg/dL),low-density lipoproteins(LDL) cholesterol(120.9 to 91.0 mg/dL),triglycerides(148.6 to 104.8 mg/dL),hemoglobin A1c(6.2% to 5.6%),alanine aminotransferase(28.1 to 23.0 U/L) and aspartate aminotransferase(23.5 to 21.6 U/L) decreased significantly(P mong NHB,mean total cholesterol(184.5 to 154.7 mg/dL),LDL cholesterol(111.7 to 88.9 mg/dL) and triglycerides(99.7 to 70.0 mg/dL) decreased significantly(P mong NHW,mean total cholesterol(200.9 to 172.8 mg/dL) and LDL cholesterol(124.2 to 96.6 mg/dL),decreased significantly(P group comparisons of all cardiometabolic outcomes adjusted for age and type of surgery before and 1 year after surgery showed no statistical difference between the three groups for any ***:Cardiometabolic disease risk improvements vary by ethnicity and obesity may impact glucose tolerance and liver function changes more in Hispanic women with PCOS vs non-Hispanic women.

关键词： Bariatric surgery Polycystic ovary syndrome Cardiometabolic outcomes Weight outcomes morbid obesity

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-gómez Joana Vitallé Carmen gasca-Capote Alicia gutierrez-Valencia maría Trujillo-Rodriguez Ana Serna-gallego Esperanza muñoz-muela maría de los Reyes Jiménez-Leon mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-gonzález Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-mateos Josémiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-martínez Carmen Infante-Domínguez marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo márquez Josémanuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes manuela Aguilar-guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero maría Dolores Avilés maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba máximo Bernabeu-Wittel Candela Caballero-Eraso macarena Cabrera Enrique Calderón Jesús Carbajal-guerrero manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa michelle Espinoza Carmen Ferrándiz-millón marta Ferrer Teresa Ferrer Ignacio gallego-Texeira Rosa gámez-mancera Emilio garcía Horacio garcía-Delgado manuel garcía-gutiérrez maría Luisa gascón-Castillo Aurora gonzález-Estrada Demetrio gonzález Carmen gómez-gonzález Rocío gonzález-León Carmen grande-Cabrerizo Sonia gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-melero marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-márquez Daniel macías-garcía guillermo martín-gutiérrez Luis martín-Villén Josémolina Aurora morillo maría Dolores Navarro-Amuedo Dolores Nieto-martín Francisco Ortega maría Paniagua-garcía Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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应用改良颅眶颧入路处理复杂性颅底病变

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中华神经外科杂志 2003年第2期19卷 112-114页

作者：冯东侠 Joseph m.Zabramski 东南大学医学院附属江阴医院神经外科江苏省江阴市214400 美国凤凰城Barrow神经外科研究所脑血管颅底外科

目的　介绍应用改良颅眶颧入路处理复杂性颅底病变的手术方法及经验。方法　该入路采用“双瓣”技术 ,即首先行翼点开颅 ,取下额颞骨瓣。然后采用“六次切割”法 ,用气动锯分别割断颧弓根部、颧突、外侧眶缘和外侧眶壁、眶上缘和眶顶 ,... 详细信息

目的　介绍应用改良颅眶颧入路处理复杂性颅底病变的手术方法及经验。方法　该入路采用“双瓣”技术 ,即首先行翼点开颅 ,取下额颞骨瓣。然后采用“六次切割”法 ,用气动锯分别割断颧弓根部、颧突、外侧眶缘和外侧眶壁、眶上缘和眶顶 ,取下眶颧骨瓣 ,接下来进行硬脑膜内的显微操作。结果　本组 2 3例全部采用改良颅眶颧入路 ,术中发现该入路可缩短手术操作距离 ,对深部病变的观察角度明显扩大 ,降低了颅底病变的手术的难度。术后CT复查未见明显的脑牵拉性损伤 ,未发生额肌麻痹、眼球内陷、视力损害等并发症。结论　改良颅眶颧入路手术中没有骨质丢失 ,不需行眶顶重建 ,避免了术后的眼球内陷。另外。

关键词：复杂性颅底病变眶颧入路外科手术术式疗效

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脑组织疝入硬脑膜静脉窦及颅板的mRI表现、可能的原因及临床意义

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国际医学放射学杂志 2016年第4期 457-457页

作者： B.Battal S.Hamcan V.Akgun S.Sari O.oz m.Tasar 宋玉坤 Department of Radiology Gulhane Military Medical School

摘要目的确定mRI检查中脑实质疝入硬脑膜静脉窦（DVS）和/或颅板内的发病率、影像特点及临床意义。方法纳入6 160份头部mRI检查,每项检查包括至少一项高分辨率T;/T;加权成像序列,进行回顾性评价以确定偶发性脑实质疝入DVS和/或颅板,通... 详细信息

摘要目的确定mRI检查中脑实质疝入硬脑膜静脉窦（DVS）和/或颅板内的发病率、影像特点及临床意义。方法纳入6 160份头部mRI检查,每项检查包括至少一项高分辨率T;/T;加权成像序列,进行回顾性评价以确定偶发性脑实质疝入DVS和/或颅板,通过其显示脑疝的能力评估mRI序列,

关键词： mRI 脑实质 DVS 加权成像硬脑膜静脉窦临床意义

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