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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in murine model

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Chinese Journal of Integrative medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva maria galan-moya Jose Ramon munoz-Rodriguez miguel Angel de la Cruz-morcillo Francisco Javier Redondo-Calvo Ignacio gracia-Fernandez Peter m.Elias Jose manuel Perez-Ortiz mao-Qiang man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HmgCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,Pmoreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HmgCoA,SPT,filaggrin,loricrin and involucrin(Pgnificantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),Pmulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

用8—羟基喹啉铜氯仿溶液反萃取和配位基交换的分光光度法测定水中的硫化物

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环境科学与管理 1984年第2期 61-64页

作者： m.Román Ceba F.Vinagre Jara J.A.muňoz Leyva 杨建军

本文提出了一个用稀释的8—羟基喹啉铜氯仿溶液光度法测定硫化物的方法。该方法基于有色络合物的有机溶液与阴离子水溶液一起振荡时产生脱色作用。确定了几个可变因素（pH、振荡时间、体积比等）对脱色的影响。本法非常灵敏(410mm处表... 详细信息

本文提出了一个用稀释的8—羟基喹啉铜氯仿溶液光度法测定硫化物的方法。该方法基于有色络合物的有机溶液与阴离子水溶液一起振荡时产生脱色作用。确定了几个可变因素（pH、振荡时间、体积比等）对脱色的影响。本法非常灵敏(410mm处表观摩尔吸收系数为2.35×10～41mol-1cm-1)且可用于其它硫离子存在时硫化物的测定。对水中微量硫化物进行了光度法测定并将所得结果与亚、甲篮法所得结果进行了比较。在本工作中,8—羟基喹啉铜的氯仿溶液经硫化物水溶液反萃取后,常用于间接分光光度法测定硫化物。本方法简单,快速、灵敏且具选择性,它可用于其它硫离子存在时水中微克范围的硫化物分析。本方法与测定硫化物的经典分光光度法—亚甲篮法相比明显地优越。

关键词：硫化物硫离子硫代硫酸盐硫化合物阴离子分光光度法测定氯仿溶液溶剂萃取反萃取

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu miguel Santos-Santos Ignacio lllán-gala Victor montal Teresa Estellés Isabel Barroeta miren Altuna Javier Arranz Laia muñoz Olivia Belbin Isabel Sala maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles Rafael Blesa Jordi Clarimón maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea Sant Pau memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas(CIBERNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(gFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma gFAP(pgFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pgFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pgFAP was increased in FTD but lower than in AD(all Pmbination of both plasma markers improved the diagnostic performance to discriminate FTD from AD(area under the curve[AUC]:combination 0.78;pgFAP 0.7;pNfL 0.61,all PgFAP correlated with cognition,CSF and plasma NfL,and cortical thickness(all Pgher tertile of pgFAP was associated with greater change in mmSE score and poor cognitive outcome during follow-up both in FTD(1.40 points annually,hazard ratio[HR]3.82,PgFAP and pNfL levels differ in FTD and AD;and their combination is useful for distinguishing between the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

糖化血红蛋白与口服葡萄糖耐量试验在产后糖尿病筛查中的作用

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中国糖尿病杂志 2012年第12期20卷 921-921页

作者：吴红花 Picón mJ murri m muoz A 北京大学第一医院内分泌科 100034

妊娠期糖尿病（gDm）患病率不断提高，这些患者产后发生糖耐量异常、T2Dm风险明显提高，而且gDm史是心血管疾病预测因素。因此，重新评价其产后糖代谢状态非常重要。糖代谢状态筛查方式上，过去10年中ADA一直在不断更新。由于OgTT操作... 详细信息

妊娠期糖尿病（gDm）患病率不断提高，这些患者产后发生糖耐量异常、T2Dm风险明显提高，而且gDm史是心血管疾病预测因素。因此，重新评价其产后糖代谢状态非常重要。糖代谢状态筛查方式上，过去10年中ADA一直在不断更新。由于OgTT操作较为复杂，简便易行的空腹血糖更受推崇，但患者仍需禁食至少8h后方可进行检测。因此，无需空腹状态的HbA1c现在已成为最被推荐的方式。基于此，本研究旨在评价HbA1c（单独或联合空腹血糖）对判断有gDm病史的患者产后糖代谢状态的作用。

关键词：口服葡萄糖耐量试验糖化血红蛋白糖尿病筛查产后糖代谢状态 HbA1c 妊娠期糖尿病空腹血糖

世界家庭医生组织(WONCA)研究论文摘要汇编——基础医疗中无射血分数数据的心力衰竭患者预后及影响因素研究

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中国全科医学 2017年第17期20卷 2154-2154页

作者：本刊编辑部 mUoz m A munDET-TUDURI X REAL J

背景根据电子医疗记录,全科医生对心力衰竭患者诊断的正确率有较大差异。本文旨在探究:电子诊疗记录是否有射血分数数据对诊断为心力衰竭患者预后的影响,心力衰竭患者电子诊疗记录中无射血分数数据的原因。方法本研究为基于西班牙巴塞罗... 详细信息

背景根据电子医疗记录,全科医生对心力衰竭患者诊断的正确率有较大差异。本文旨在探究:电子诊疗记录是否有射血分数数据对诊断为心力衰竭患者预后的影响,心力衰竭患者电子诊疗记录中无射血分数数据的原因。方法本研究为基于西班牙巴塞罗那52个社区卫生服务中心的回顾性队列研究,对年龄>40岁且随访5年的8378例心力衰竭患者资料进行了分析。结果仅有8.5%的患者电子病历中有射血分数数据。2009-2012年,患者的累积住院率和病死率共为37.6%。射血分数数据未记录在病历中的患者累积住院率和病死率高于射血分数记录在病历中的患者[HR=1.84,95%CI(1.68,1.95)];有住院史[HR=1.81,95%CI(1.68,1.95)]、需家庭护理[HR=1.58,95%CI(1.46,1.71)]的患者均具有较高的不良结局风险。高龄、社会经济地位差、肥胖、需家庭护理、使用髓袢利尿剂的患者更易出现电子病历未记录射血分数。结论基层医疗中,心力衰竭患者电子病历中无射血分数数据较为普遍,多发生在高龄、社会经济地位差、身体虚弱的患者中,预后较差。

关键词：射血分数 WONCA 电子病历电子医疗记录诊疗记录家庭护理家庭医生基础医疗住院率社会经济地位

Subclinical hearing loss associated with aging

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Journal of Otology 2023年第3期18卷 111-117页

作者： Cristian Aedo-Sanchez Jose Oliveros Constanza Aranguiz Camila munoz Claudia Lazo-maturana Enzo Aguilar-Vidal Departamento de Tecnología médica Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología médica Facultad de MedicinaUniversidad de ChileChile

Objective:Contribute to clarifying the existence of subclinical hearing deficits associated with ***:In this work,we study and compare the auditory perceptual and electrophysiological performance of normal-hearing young and adult subjects(tonal audiometry,high-frequency tone threshold,a triplet of digits in noise,and click-evoked auditory brainstem response).Study sample:45 normal hearing volunteers were evaluated and divided into two groups according to age.27 subjects were included in the“young group”(mean 22.1 years),and 18 subjects(mean 42.22 years)were included in the“adult group.”Results:In the perceptual tests,the adult group presented significantly worse tonal thresholds in the high frequencies(12 and 16 kHz)and worse performance in the digit triplet tests in *** the electrophysiological test using the auditory brainstem response technique,the adult group presented significantly lower I and V wave amplitudes and higher V wave latencies at the supra-threshold *** the threshold level,we observed a significantly higher latency in wave V in the adult *** addition,in the partial correlation analysis,controlling for the hearing level,we observed a relationship(negative)between age and speech in noise performance and high-frequency *** significant association was observed between age and the auditory brainstem ***:The results are compatible with subclinical hearing loss associated with aging.

关键词： Age-related hearing loss Cochlear synaptopathy Auditory electrophysiology Speech perception Aging

Detection of <i>Para</i>-Chloroaniline Resulting from the Interaction between Sodium Hypochlorite and Chlorhexidine Analyzed by mass Spectrometry

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American Journal of Analytical Chemistry 2019年第12期10卷 629-640页

作者： miriam muñ oz Arratia marí a de Lourdes Lanzagorta Rebollo Francisco Javier Pé rez Flores Rodolfo garcí a Contreras José Luis molinari Soriano Ana marí a Ferná ndez Presas

5.1% of sodium hypochlorite (NaOCl) mixed with 2% of chlorhexidine (CHX) forms a brown precipitate that corresponds to para-chloroaniline (PCA), whether PCA is formed after the combination of NaOCl, CHX, and ethylenediaminetetraacetic acid (EDTA) by means of electron impact (high resolution and interlaced scanning) and ionization by fast atom bombardment (FAB), was analyzed. The brown precipitate, showed signals 127 and 153 Da, corresponding to p-chloroaniline and p-chlorophenyl isocyanate, respectively. These results were analyzed and compared with signals from the interlaced scanning program and confirmed with high resolution mass spectrometry analysis and compared with the NIST database. The mass spectra of this precipitated after different days confirmed the evolution of byproducts with the presence of a peak m/z = 127, due to the decrease of the fragment m/z = 153, which disappeared after 180 days. A blue and a white precipitate were observed by the addition of CHX (2%) with or without polyethylene glycol, respectively, EDTA (17%) and NaOCl (5.1%) precipitates contain chlorhexidine (m/z = 505), but no PCA was detected. We confirmed that PCA is not formed directly as a byproduct of CHX oxidation, but through the formation of the para-chlorophenyl isocyanate intermediate, which degrades slowly to PCA.

关键词： Chlorhexidine Para-Chloroaniline Para-Chlorophenyl Isocyanate EDTA Sodium Hypochlorite

Final Results of a Phase II Study of Bevacizumab, Cisplatin and Pemetrexed as First-Line Therapy for Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2016年第7期7卷 455-463页

作者： guillermo López Vivanco Eider Azkona Sergio Carrera Aintzane Sancho Itziar Rubio Juan manuel mañé Begoña Calvo Unai Aresti Aitziber Buque Inés marrodán Alberto muñoz Servicio de Oncología médica Hospital de Cruces Bilbao Spain

Background: Efficacy and safety data for cisplatin and pemetrexed plus bevacizumabinnon squamousnon non-small cell lung cancer (NSCLC) are still limited. Nevertheless, either bevacizumab plus platinum doublet or pemetrexed plus platinum is approved options for first line therapy. Predictive factors for bevacizumab are needed. KRAS is one of the most common oncogenic drivers in lung cancer. Its prognostic and predictive value in NSCLC is under investigation. Patients and methods: This trial evaluates the addition of bevacizumab 7.5 mg/kg to cisplatin 75 mg/m2 plus pemetrexed 500 mg/m2 as first line treatment in stage IV non-squamous NSCLC patients. maintenance bevacizumab was received as monotherapy until progressive disease, unacceptable toxicityor consent with drawal. The primary objective was progression free survival (PFS). Secondary objectives included overall survival (OS), safety, global objective responses and the determination of KRAS mutation at baseline. Results: From march 2009 to march 2012, 31 patients were enrolled. mean age was 59.19 (standard deviation (SD) 8.53). From all the patients included in this trial, 67.70% were men. KRAS was wild type in 19 patients (58.06%);in 7 (22.58%) was mutated and was unknown in 6 patients (19.35%). median PFS for KRAS mutated patients was 4 months, whereas for the KRAS wild type it was 7.9 months (P = 0.0031). median OS was 4 months for the KRAS population, and 16.1 months for the KRAS wild type (P = 0.0032). Twenty four patients (77.42%) experienced at least a grade 3 - 4 adverse event. The most common grade 3 - 4 toxicity was asthenia. Conclusions: Both PFS and OS were statistically longer for the KRAS wild type patients compared with the KRAS mutated population (P = 0.0031). median OS was shorter than the reported in previous trials with bevacizumab. Nevertheless, focussing on the OS for KRAS wild type patients, this achieves a result or 16.1 months. Therefore, this would be a consistent dat

关键词： Non-Small-Cell Lung Cancer Bevacizumab Pemetrexed Predictive Biomarker KRAS

mixed-Species Allometric Equations to Quantify Stem Volume and Tree Biomass in Dry Afromontane Forest of Ethiopia

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Open Journal of Forestry 2022年第3期12卷 263-296页

作者： mindaye Teshome Carlos moreira miquelino Eleto Torres gudeta Weldesemayat Sileshi Patricia Povoa de mattos Evaldo muñoz Braz Hailemariam Temesgen Samuel José Silva Soares da Rocha mehari Alebachew Departamento de Engenharia Florestal Universidade Federal de Vi&#231 osa (UFV) Vi&#231 osa MG Brazil Central Ethiopia Environment and Forest Research Centre Addis Ababa Ethiopia University of Kwazulu-Natal Pietermaritzburg South Africa Embrapa Florestas Colombo PR Brazil Department of Forest Engineering Resources and Management College of Forestry Oregon State University Corvallis USA Departamento de Ciências Florestais Universidade Federal de Lavras (UFLA) Lavras MG Brazil

Volume and biomass equations are essential tools to determine forest productivity and enable forest managers to make informed decisions. However, volume and biomass estimation equations are scarce for Afromontane forests in Africa in general and Ethiopia in particular. This limits our knowledge of the standing volume of wood, biomass, and carbon stock of the forests therein. In this study, we developed a new mixed-species volume and biomass equations for Afromontane forests and compared them with generic pantropical and local models. A total of 193 sampled trees from seven dominant tree species were used to develop the equations. Various volume and biomass equations were fitted using robust linear and nonlinear regression. model comparison indicated that the best model to estimate stem volume was ln(v)=-9.909+ 0.954*ln(d2h), whereas the best model to estimate biomass was ln(b)=-2.983+ 0.949*ln(ρd2h) . These equations explained over 85% of the variations in the stem volume and biomass measurements. The mean density and basal area of trees in the forest with d ≥ 2 cm was 631.5 stems·ha-1 and 24.4 m2·ha-1. Based on the newly developed equations, the forest has on average 303.0 m3·ha-1 standing volume of wood and 283.8 mg·ha-1 biomass stock. The newly developed allometric equations derived from this study can be used to accurately determine the stem volume, biomass, and carbon storage in the Afromontane forests in Ethiopia and elsewhere with similar stand characteristics and ecological conditions. By contrast, the generic pan-tropical and other local models appear to provide biased estimates and are not suitable for dry Afromontane forests in Ethiopia. The estimated stem biomass and carbon stock in the Chilimo forest are comparable with the estimates from various tropical forests and woodlands elsewhere in Africa, indicating the importance of dry Afromontane fores

关键词： Carbon Stock Site-Specific model Robust Regression Natural Forest