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STUDIES ON THE PLANKTON AND SEDImENT DIATOmS IN XUANWU LAKE , NANJING, CHINA

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Chinese Journal of Oceanology and Limnology 1991年第3期9卷 277-289页

作者：王如平 dickman Yangzhou Education College Yangzhou 225001 Biol. Sci. Dept. Brock Univ. Ontario Canada Received Jan. 11 1990 M.D

The sediment diatom data based on a 16cm long sediment core removed from near the center of the lake indicated that nutrient pollution tolerant diatoms have replaced pollution intolerant taxa which were common near the base of the core (about 35 years before present ). These observations support the hypothesis that there is progressive eutrophication in Xuanwu Lake . This conclusion is corroborated by direct comparisons of the present day phytoplankton and zooplankton species composition within the lake and published accounts of its species composition during the mid 1970s.

关键词： removed nutrient eutrophication tolerant phytoplankton replaced conclusion biomass progressive dominated

SGT1 Is Induced by the Potato virus X TGBp3 and Enhances Virus Accumulation in Nicotiana benthamiana

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molecular Plant 2012年第5期5卷 1151-1153页

作者： Chang-ming Ye Vicky Kelly mark Payton martin B. dickman Jeanmarie Verchot Department of Entomology and Plant Pathology Oklahoma State UniversityStillwaterOK 74078USA Department of Statistics Oklahoma State University StillwaterOK 74078USA Institute for Plant Genomics and Biotechnology Department of Plant Pathology and MicrobiologyTexas A&M UniversityCollege StationTX 77843USA

Dear Editor, Host chaperone proteinsarecritical factors in plant virus infec- tion. One ofthe most commonly identified host factors involved in plant virus infection is Hsp70, which functions in ATP hydroly- sis, protein folding, assembly of protein complexes, and translo- cation between cellular compartments. A comparative study of plant virus infection, including Potato virus X （PVX）, reported that Hsp70 is up-regulated by virus infection and possibly con- tributes to pathogenesis in both Arabidopsis and N. benthami- ana plants （Aparicio et al., 2005）. Cytosolic Hsp70 interacts with the tombusvirus and tymovirus replication complexes （Wang et al., 2009）, the potyvirus coat protein （Hafren et al., 2010）, and closteroviruses encode an HSP70 homolog that functions to enable virus intercellular transport （Agranovsky et al., 1998）.

关键词： Accumulation Potato Nicotiana

Past changes in the abundance of diatoms as inferred from a sediment core from Hebe Haven, Saikung, Hong Kong

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Journal of Environmental Sciences 1999年第4期11卷 423-431,442页

作者： WONG, Y. Y.\+1, dickman, m.D.\+1, PAN Shao\|ming\+2 (1. Department of Ecology and Biodiversity, The University of Hong Kong, Pokfulam Road, Hong Kong 2. State Pilot Laboratory of Coast and Island Exploitation, Nanjing University, Nanjing 210093, China 香港大学香港南京大学海岸、滩涂与海岛开发国家试点实验室江苏南京

The purpose of this study was to infer changes in water quality from diatom stratigraphy of a sediment core taken from Hebe Haven, New Territories, Hong Kong, China. Diatoms and diatom fragments were counted in the top (0—5 cm) and bottom (20—25 cm) portions of the core. The core was age dated using 210 Pb and these results were used to calculate a mean sedimentation rate(0 69 cm/a). A significant difference in the total number of diatoms and their relative abundance between the top 0—5 cm and the bottom 20—25 cm was found ( p m species diversity and a more even diatom species composition occurred at 20—25 cm some 40—60 years ago. This difference was interpreted as a reflection of the water quality changes which have occurred over the last 40—60 years in Hebe Haven. Benthic diatoms once flushed in the clear waters of Hebe Haven as reported by individuals who swam and boated there immediately after WW II. Increased turbidity in recent years has apparently increased the relative abundance of planktonic diatoms at the expense of benthic diatoms which today are unable to receive sufficient light to grow on the bottom of the Hebe Haven Harbor (mean depth about 6 m). The observed increase in planktonic diatom abundance in the top 5 cm of the sediment core was attributed to increased nutrient loading to Hebe Haven over the last three decades.

关键词： paleoecology eutrophicaiton diatoms water quality sediments

Thermodynamic contributions of 5’- and 3’-single strand dangling-ends to the stability of short duplex DNAs

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Journal of Biophysical Chemistry 2012年第1期3卷 1-15页

作者： Rebekah dickman Fidelis manyanga Greg P. Brewood Daniel J. Fish Cameron A. Fish Charlie Summers m. Todd Horne Albert S. Benight Portland Bioscience Inc. Portland USA

Differential scanning calorimetry (DSC) melting analysis was performed on 27 short double stranded DNA duplexes containing 15 to 25 base pairs. Experimental duplexes were divided into two categories containing either two 5’ dangling-ends or one 5’ and one 3’ dangling-end. Duplex regions were incrementally reduced from 25 to 15 base pairs with a concurrent increase in length of dangling-ends from 1 to 10 bases. Blunt-ended duplexes from 15 to 25 base pairs served as controls. An additional set of molecules containing 21 base pair duplexes and a single four base dangling-end were also examined. DSC melting curves were measured in varying concentrations of sodium ion (Na+). From these measurements, thermodynamic parameters for 5’ and 3’ dangling-ends were evaluated as a function of dangling end length. 5’ ends were found to be slightly stabilizing but essentially constant while the 3’ ends were destabilizing with increasing length of the dangling-end. 3’ ends also display a stronger dependence on Na+ concentration. In lower Na+ environment, the 3’ ends were more destabilizing than in higher salt environment suggesting a more significant electrostatic component of the destabilizing interactions. Analysis of thermodynamic parameters of dangling ended duplexes as a function of Na+ concentration indicated the 3' dangling ends behave differently than 5' dangling ended and blunt-ended duplexes. molecules with one 5' and one 3' dangling end showed variation in excess specific heat capacity (ΔCp) when compared to the blunt-ended molecule, while the molecules with two 5’ ends had ΔCp values that were essentially the same as blunt-ended duplexes. These observations suggested differences exist in duplexes with 3’ and 5’ dangling ends, which are interpreted in terms of composite differences in interactions with Na+, solvent, and terminal base pairs of the duplex.

关键词： DNA Thermodynamics Dangling-Ends DNA Stability

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将老年患者的药物不良反应降到最低

中国实用乡村医生杂志 2008年第10期15卷 37-39页

作者： Cung B.Pham Robert L.dickman 周泓旭 Tufts University Family medicine Residency MaldenMassachusetts M.D. Tufts University School of medicine BostonMassachusetts M.D 中国医科大学

老年患者承受着不可预见的药物副作用。失落、抑郁、精神错乱以及皮疹都会导致药物不良反应的发生。大约1／3使用5种以上药物的老年患者每年都会发生药物间的不良反应，这些患者中，约2／3需要医疗关注。而实际上，这些反应中，约95％... 详细信息

老年患者承受着不可预见的药物副作用。失落、抑郁、精神错乱以及皮疹都会导致药物不良反应的发生。大约1／3使用5种以上药物的老年患者每年都会发生药物间的不良反应，这些患者中，约2／3需要医疗关注。而实际上，这些反应中，约95％可以被预料到，28％可以被预防。

关键词：不良反应老年干预措施

补充燕麦AVA和耐力训练对恢复期心梗大鼠的影响

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补充燕麦AVA和耐力训练对恢复期心梗大鼠的影响

FtsH4 protease controls biogenesis of the PSII complex by dual regulation of high light-inducible proteins

2015年中国生理学会运动生理学专业委员会会议暨“运动与心血管保护”学术研讨会

作者：高晓娟 Jonathan R.dickman 廖鹏吉立力郑州大学体育系威斯康辛大学天津体育学院明尼苏达大学

目的:减少炎症和促进心功能恢复对心梗(mI)患者非常重要。耐力训练可增加心肌抗氧化酶活性,降低脂质过氧化水平。燕麦蒽酰胺(AVA)具有抗氧化和消炎作用,推测补充AVA对mI大鼠有保护作用。本文探究AVA补充和耐力训练对mI大鼠心脏功能恢复... 详细信息

目的:减少炎症和促进心功能恢复对心梗(mI)患者非常重要。耐力训练可增加心肌抗氧化酶活性,降低脂质过氧化水平。燕麦蒽酰胺(AVA)具有抗氧化和消炎作用,推测补充AVA对mI大鼠有保护作用。本文探究AVA补充和耐力训练对mI大鼠心脏功能恢复和降低炎症产生作用。方法:雌性SD大鼠(8周龄,n=64)随机分为对照组(C)、假手术组(Sham)和mI手术组。mI组采取冠状动脉左前降支结扎。mI手术组和假手术组随机分为AVA组和训练组。所有手术组大鼠饲料添加AVA,饲料燕麦粉所占重量比为50%,AVA含量为152 mg/kg(AVA组)和10.4mg/kg(对照组)。训练过程中每周称量饲料2次。大鼠术后1周进行跑台耐力训练,跑台速度27m/min,坡度15°,60min/d,5d/wk。二氯荧光氧化法(DCF)测定心肌活性氧(ROS)生成速率。ELISA检测肿瘤坏死因子-α(TNF-α)蛋白表达。高效液相色谱法检测谷胱甘肽GSH。氧电极法测定心肌线粒体呼吸比率(RCR:态3/态4最大比率)。Western Blot检测p-IκB、p-AmPK和核蛋白PGC-1α蛋白,β-actin为内参。结果:mI后左心室ROS生成增多(PmI手术后,p-AmPK蛋白表达表达增加,AVA可以抑制p-AmPK的增加,但耐力训练作用不明显。RCR在mI后降低,原因是mI后线粒体氧化呼吸偶联中态3下降而态4升高。单纯耐力训练抑制RCR降低,但AVA补给对此无明显作用。结论:mI增加ROS产生、降低线粒体氧化呼吸作用。耐力训练促进线粒体氧化呼吸偶联,增加PGC-1α蛋白表达。AVA补给降低ROS产生,抑制炎症通路p-AmPK等蛋白表达。

关键词：燕麦蒽酰胺(AVA) 耐力训练心肌梗塞线粒体抗氧化

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Plant Communications 2023年第1期4卷 272-286页

作者： Vendula Krynická Petra Skotnicová Philip J.Jackson Samuel Barnett Jianfeng Yu Anna Wysocka Radek Kaña mark J.dickman Peter J.Nixon C.Neil Hunter Josef Komenda The Czech Academy of Sciences Institute of MicrobiologyCentre AlgatechNovohradská 23737901 TreboñCzech Republic Plants Photosynthesis and SoilSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK Department of Chemical and Biological Engineering University of SheffieldSheffield S13JDUK Sir Ernst Chain Building-Wolfson Laboratories Department of Life SciencesSouth Kensington CampusImperial College LondonLondon SW72AZUK Faculty of Science University of South Bohemia37005 Ceské BudějoviceCzech Republic

FtsH proteases are membrane-embedded proteolytic complexes important for protein quality control and regulation of various physiological processes in bacteria,mitochondria,and *** most cyanobacteria,the model species Synechocystis *** 6803 contains four FtsH homologs,FtsH1–***1–FtsH3 form two hetero-oligomeric complexes,FtsH1/3 and FtsH2/3,which play a pivotal role in acclimation to nutrient deficiency and photosystem Ⅱ quality control,***4 differs from the other three homologs by the formation of a homo-oligomeric complex,and together with Arabidopsis thaliana AtFtsH7/9 orthologs,it has been assigned to another phylogenetic group of unknown *** results exclude the possibility that Synechocystis FtsH4 structurally or functionally substitutes for the missing or non-functional FtsH2 subunit in the FtsH2/3 ***,we demonstrate that FtsH4 is involved in the biogenesis of photosystem Ⅱ by dual regulation of high light-inducible proteins(Hlips).FtsH4 positively regulates expression of Hlips shortly after high light exposure but is also responsible for Hlip removal under conditions when their elevated levels are no longer *** provide experimental support for Hlips as proteolytic substrates of *** labeling of FtsH4 enabled us to assess its localization using advanced microscopic *** show that FtsH4 complexes are concentrated in well-defined membrane regions at the inner and outer periphery of the thylakoid *** on the identification of proteins that co-purified with the tagged FtsH4,we speculate that FtsH4 concentrates in special compartments in which the biogenesis of photosynthetic complexes takes place.

关键词： thylakoid photosystemⅡbiogenesis FtsH4 high light-inducible protein proteolysis

肺移植患者术后淋巴增生性疾病与胃肠道相关性:1例病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 18-19页

作者： Shitrit D. Shitrit A. B. -G. dickman R. m.R. Kramer. 张欣(译) 史敏(校) 不详 Pulmonary Institute Rabin Medical Center Beilinson Campus Petah Tikva 49100 Israel

PURPOSE: Lymphoproliferative disorder is a well-recognized complication of lung transplantation. Risk factors include Epstein-Barr virus infection and immuno-suppression. The gastrointestinal manifestations of posttransplant lymphoproliferative disorder in lung transplant recipients have not been fully characterized. mETHODS: Case presentation and 16 previously reported cases of posttransplant lymphoproliferative disorder with gastrointestinal involvement are reviewed. RESULTS: Patient ages ranged from 25 to 65 (median, 52) years. median time fromlung transplantation to onset of posttransplant lymphoproliferative disorder was 36 (range, 1-109) months; 35 percent of cases (6/17) occurred within 18 months; Eighty-eight percent of patients (15/17) had positive Epstein-Barr virus serology before transplantation. In five patients (29 percent), the posttransplant lymphoproliferative disorder also involved sites other than the gastrointestinal tract. The most common gastrointestinal site of posttransplant lymphoproliferative disorder was the colon, followed by the small intestine and stomach. Clinical features included abdominal pain, nausea, and bloody diarrhea. Diagnosis was based on typical pathologic changes on gastrointestinal tract biopsy obtained mainly by colonoscopy. Treatment included a reduction in the immunosuppressive regimen in 15 of 17 cases (88 percent) and surgical resection in 10 (59 percent). One patient was untreated. Seven of 16 patients (44 percent) responded to treatment and 9 patients died. median time from onset of posttransplant lymphoproliferative disorder to death was 70 (range,10-85) days. CONCLUSIONS: Posttransplant lymphoproliferative disorder with gastrointestinal involvement is a unique entity that should be considered in all Epstein-Barr-Virus-positive lung transplant recipients who present with abdominal symptoms. Although immunosuppressive modulation and resection can lead to remission, the risk of death is 50 percent.

关键词：移植后淋巴增生性疾病疾病患者病例报道胃肠道肺移植术后 EB病毒感染血清学指标阳性淋巴增生性病变免疫抑制剂