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Propranolol hydrochloride degradation using La@TiO_(2) functionalized with CmCD

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Journal of Rare Earths 2022年第4期40卷 579-585,I0003页

作者： Gustavo Lopes Colpani Vitor Follmann Santos Rubieli Carla Frezza Zeferino micheli Zanetti Josiane maria muneron de mello Luciano Luiz Silva Natan Padoin Regina de Fatima Peralta muniz moreira márcio Antônio Fiori Cíntia Soaresc Post-Graduate Program in Technology and Innovation management Community University of ChapecóRegionChapecó89809-900Brazil department of Chemical Engineering Community University of ChapecóRegionChapecó89809-900Brazil Laboratory of materials and Scientific Computing(LabmAC) Department of Chemical and Food EngineeringFederal University of Santa CatarinaFlorianópolis88040-900Brazil

Propranolol hydrochloride can be considered a persistent and bioaccumulative pharmaceutical in the *** drug and its by-products are potentially toxic and have adverse effects,since these compounds have been associated with endocrine-disrupting effects,reproductive deficiencies,embryo abnormalities and pericardial ***_(2)–La 0.05%–carboxymethyl-β-cyclodextrin(CmCD)nanoparticles were successfully prepared by a simple two-step method,which consists of sonification and *** characterization analyses reveal that lanthanum is dispersed on the semiconductor surface,probably forming Ti–O–La bonds,which can induce oxygen vacancies and surface defects that effectively restrain the recombination of photogenerated electron/holes *** efficiency of TiO_(2)–La 0.05%–CmCD samples in degradation of propranolol under UV-light irradiation is higher than that of pristine TiO_(2) within 20 min reaction,probably due to complex formation between theβ-blocker and the oligosaccharide,which allows us to propose a photocatalytic mechanism based on the formation of intermediates and competition of these compounds to the radicals and CmCD cavities.

关键词： TiO_(2) Lanthanum CmCD Propranolol Photocatalysis Functionalization

Inhibition of Ptychopetalum olacoides on Acetylcholinesterase Isoforms in Brain of mice

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Chinese Herbal medicines 2012年第3期4卷 189-194页

作者： FIGUEIRó micheli POCHmANN Daniela PORCIúNCULA Lisiane Oliveira NUNES Domingos Sávio ELISABESTKY Elaine Laboratório de Etnofarmacologia Departamento de Farmacologia Instituto de Ciências Básicas da Saúde Universidade Federal do Rio Grande do Sul Rua Sarmento Leite 500 Porto Alegre Brazil Laboratório de Estudos sobre o Sistema Purinérgico PPG-Bioquímica Instituto de Ciências Básicas da Saúde Universidade Federal do Rio Grande do Sul Rua Sarmento Leite 500 Porto Alegre Brazil departamento de Química Universidade Estadual de Ponta Grossa Campus Uvaranas Bloco M Ponta Grossa Brazil

Objective To further characterize the acetylcholinesterase inhibitors (AChE-Is) pattern of Ptychopetalum olacoides ethanol extract (POEE) on the cytosolic globular monomer (G1) and membrane bound globular tetramer (G4) AChE isoforms in brain areas relevant for cognition. methods The G1 and G4 AChE isoforms were prepared according to the reported methods and the determination of AChE activity used was adapted from colorimetric method. Results POEE mostly inhibited G1 in hippocampus (75%), and G4 in frontal cortex (58%) and striatum (75%) (P mpus was of a competitive nature for G1 but uncompetitive for G4. Conclusion Considering the high density of cholinergic projection to the cortex and striatum, and the usefulness of conserving cytosolic acetylcholine to replenish synaptic vesicles in a highly active cognition site such as hippocampus, we argue that this could be a desirable profile for a clinically relevant AChE-I.

关键词： acetylcholinesterase Alzheimer’s disease kinetic analysis molecular isoforms Ptychopetalum olacoides

Psychopharmacological Profile of Hydroalcoholic Extract and P-Hydroxybenzoic Acid Obtained from <i>Bourreria huanita</i>(Boraginaceae) in mice

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Pharmacology & Pharmacy 2014年第11期5卷 983-995页

作者： Iandra Holzmann Daiane Cattani micheli Corso Daiane Perondi Sabrina Zanella Cristiani Burger Luiz Carlos Klein Júnior Valdir Cechinel Filho Sully m. Cruz miguel F. Torres Armando Cáceres márcia maria de Souza Programa de Pós-Graduação em Ciências Farmacêuticas Universidade do Vale do Itajaí Itajaí Brazil Núcleo de Investigações Químico Farmacêuticas Universidade do Vale do Itajaí Itajaí Brazil Facultad de CCQQ y Farmacia Universidad de San Carlos Guatemala City Guatemala

Bourreria huanita (Lex.) Hemsl. (Boraginaceae) is a very rare and highly appreciated tree in mesoamerica for its medicinal properties and beauty. It grows in a region extending from central mexico to Costa Rica. Ethnobotanical surveys have shown that the infusion of dried flowers is popularly used as a tranquilizer to cure several diseases. In the present study we report the isolation of p-hydroxybenzoic acid (pHBZ) obtained from the hydroalcoholic extract (HE) of B. huanita, and the effect of both, the extract and the compound on the central nervous system in mice. HE of B. huanita (100, 150, 300 mg/kg) and pHBZ (10 mg/kg) were orally administered to mice and 1 h later, behavioral tests were performed. The effects of HE and pHBZ were tested by pentylenetetrazole (PTZ) and strychnine (STR) induced seizures, pentobarbital-induced hypnosis, the forced swimming test and the tail suspension test, the elevated plus maze, apomorphine-induced stereotypy and the climbing test, the inhibitory avoidance test and the open-field test. B. huanita extract produced hypnotic, anxiolytic and antidepressant effects in animals, with no change in motor performance. On the other hand, the extract did not reduce PTZ and STR-induced convulsions, apomorphine-induced stereotypy or climbing. moreover, no changes were observed in the animals’ memory. The compound pHBZ was effective only in the depression tests. The results obtained in the present study suggest that B. huanita exhibited sedative, antidepressant and hypnotic activities in mice, and that the antidepressant activity may be mediated by an isolated compound identified as pHBZ.

关键词： Bourreria huanita Antidepressant Sedative and Hypnotic Activities P-Hydroxybenzoic Acid

High-elevation hypoxia impacts perinatal physiology and performance in a potential montane colonizer

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Integrative Zoology 2020年第6期15卷 544-557页

作者： Jérémie SOUCHET Eric J.GANGLOFF Gaëlle micheli Coralie BOSSU Audrey TROCHET Romain BERTRAND Jean CLOBERT Olivier CALVEZ Albert mARTINEZ-SILVESTRE Elodie DARNET Hugo LE CHEVALIER Olivier GUILLAUmE marc mOSSOLL-TORRES Laurent BARTHE Gilles POTTIER HervéPHILIPPE Fabien AUBRET Station d’Ecologie Théorique et Expérimentale du Centre National de la Recherche Scientifique MoulisFrance department of Zoology Ohio Wesleyan UniversityDelawareOhioUSA Catalonia Reptile and Amphibian Rescue Center(CRARC) MasquefaBarcelonaSpain Bomosa Pl.Parc de la MolaLes EscaldesAndorra Pirenalia EncampAndorra Nature En Occitanie ToulouseFrance Département de Biochimie Centre Robert-CedergrenUniversitéde MontréalMontréalCanada

Climate change is generating range shifts in many organisms,notably along the elevational gradient in mountainous ***,moving up in elevation exposes organisms to lower oxygen availability,which may reduce the successful reproduction and development of oviparous *** test this possibility in an upwardcolonizing species,we artificially incubated developing embryos of the viperine snake(Natrix maura)using a split-clutch design,in conditions of extreme high elevation(hypoxia at 2877 m above sea level;72%sea-level equivalent O2 availability)or low elevation(control group;*** at 436 m above sea level).Hatching success did not differ between the two *** developing at extreme high elevation had higher heart rates and hatched earlier,resulting in hatchlings that were smaller in body size and slower swimmers compared to their siblings incubated at lower ***,post-hatching reciprocal transplant of juveniles showed that snakes which developed at extreme high elevation,when transferred back to low elevation,did not recover full performance compared to their siblings from the low elevation incubation *** results suggest that incubation at extreme high elevation,including the effects of hypoxia,will not prevent oviparous ectotherms from producing viable young,but may pose significant physiological challenges on developing offspring in *** early-life performance limitations imposed by extreme high elevation could have negative consequences on adult phenotypes,including on fitness-related traits.

关键词： developmental plasticity embryonic metabolism high-elevation hypoxia locomotor performance Natrix maura

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白色迷宫

现代装饰（家居） 2011年第5期 24-31页

作者： Simone micheli Juergen Eheim 夏明媚 Simone micheli Architectural Hero

项目地址意大利奥德尔佐项目面积300m^2这套住宅改建自一个宽敞的阁楼,其设计采用了非传统的形式,设计师将其描绘成"非常规的纯粹"。简单的空间布局和家具饰品都是为着这种"纯粹"而设计。

关键词：项目地址项目面积洗台空间布局整面墙拼花地板有彩色中密度纤维板床头架推拉门

Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2006年第8期12卷 1219-1224页

作者： Catherine m Pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe morel Jean-Louis Frossard Laboratoire de Physiopathologie Hépatique et Imagerie moléculaire H■pitaux Universitaires de GenèveB■timent CRoom 6-79524 Rue Micheli-du-Crest1205 GenevaSwitzerland Division of Gastroentérologie et Hépatologie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département APSI H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département de Chirurgie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland

AIm： To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis. mETHODS： Nice had cerulein administration to induce acute pancreatitis and were pretreated with either anti-mouse neutrophil serum or gadolinium chloride （GdCh） to prevent Kupffer cell activation, or both treatments. Injury was assessed in pancreas and lungs. myeloperoxidases （mPO） assessed neutrophil infiltration. Interleukin-6 （IL-6） and IL-10 were measured in serum, pancreas, lungs and liver. RESULTS： In mice with acute pancreatitis, neutrophil depletion reduced the severity of pancreatitis and pancreatitis-associated lung injury. Kupffer cell inactivation by GdCh had less protective effect, although IL-6 and IL-10 concentrations were significantly decreased. The protective treatment brought by neutrophil depletion was not enhanced by Kupffer cell inactivation and both treatments did not combine their protective effects. CONCLUSION： Our results confirm the role of activated neutrophils in aggravating organ injury in acute pancreatitis while the role of Kupffer cell activation is less obvious.

关键词： Acute pancreatitis Cytokines Neutrophils Kupffer cells Pulmonary injury

青少年运动缺乏症(EDD)研究的10大问题

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北京体育大学学报 2015年第11期38卷 50-58页

作者： Avery D. Faigenbam Thomas m. Best James macDonald Gregory D. myer Andrea Stracciolini 新泽西州立大学 EwingNJ 08628USA 俄亥俄州立大学 ColumbusOH 43210USA 美国全国儿童医院 ColumbusOH 43025USA 辛辛那提儿童医院医学中心 CincinnatiOH 45229USA 辛辛那提大学 CincinnatiOH 45221USA 运动损伤预防micheli中心 WalthamMA 02453USA 波士顿儿童医院 BostonMA 02115USA 哈佛医学院 BostonMA 02138USA

运动缺乏症(EDD)是一种儿科疾病,特点是中高强度体力活动(mVPA)下降,低于目前的推荐量,也与积极的健康结果不一致。目前,大多数儿童和青少年符合EDD的诊断标准,因为他们没有达到日常mVPA的最低要求。本文的目的是强调10个与青少年EDD有... 详细信息

运动缺乏症(EDD)是一种儿科疾病,特点是中高强度体力活动(mVPA)下降,低于目前的推荐量,也与积极的健康结果不一致。目前,大多数儿童和青少年符合EDD的诊断标准,因为他们没有达到日常mVPA的最低要求。本文的目的是强调10个与青少年EDD有关的重要研究问题。需要进行重要的研究来更好地定义EDD的临床表现,包括评估体力活动行为以确定开始出现EDD的年龄或发育阶段;包括运动技巧和体能的运动起源(kinesiogenesis)的检测;以及对影响青少年mVPA的生活方式因素的评估。关于治疗EDD的干预措施和政策的研究问题,包括评估对卫生保健从业者进行运动医学重要性的教育和训练;确定在临床上识别和治疗EDD青少年的方法的有效性;开发敏感的、特效的、经济的方法以诊断青少年EDD;以及定制方法以促进本病诊疗的医疗保险赔付。如果未来研究不能优化EDD青少年的识别、治疗和管理方案,具有重大影响的生物医学、心理、经济和政治的新的卫生保健问题将会不断出现。

关键词：小儿运动(pediatricexercise) 体力活动公共卫生改革

小波变换用于缺血性心脏病患者室性心律失常前心率变异性的分析

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 37-38页

作者： Burri H. Chevalier P. Arzi m. 孙凯 Cardiology Service University Hospital23 Micheli-du-Crest1211 GenevaSwitzerland

Introduction: Studies evaluating changes in HRV preceding the onset of ventric ular arrhythmias using conventional techniques have shown inconsistent results. Time-frequ-ency analysis of HRV is traditionally performed using short-term F ourier transform(STFT). Wavelet transform(WT) may however be better suited for a nalyzing non-stationary signals such as heart rate recordings. methods and resu lts: We studied patients with a history of myocardial infarction implanted with a defibrillator with an extended memory. The RR intervals during the 51 min prec eding ventricular events requiring electrical therapy were retrieved, and HRV st udied by WT and STFT. 111 episodes of ventricular arrhythmia were retrieved from 41 patients(38 males, age 64±8 years). Heart rate increased significantly befo re arrhythmia. There was no significant variation in low frequency/high frequenc y components(LF/HF) observed for the group as a whole, probably due to a great d egree of heterogeneity amongst individuals. A subset of 30 patients also had hea rt rate recordings performed during normal ICD follow-up. WT did not show any d ifference in HRV before arrhythmia onset and during control conditions. Conclusi on: Variations in HRV before onset of ventricular arrhythmias were not apparent in this large dataset, despite use of optimal tools for studying time-frequency analysis.

关键词：室性心律失常心率变异性小波变换心脏病患者缺血性傅立叶变换时频分析心肌梗死

急性幽门痉挛和胃蠕动不足:心房纤颤经皮射频消融治疗的心外不良反应

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 55-56页

作者： Shah D. Dumonceau J.-m. Burri H. 徐永城 Service de Cardiologie Hopital Cantonal Universitaire de Geneve Rue Micheli-du-Crest 24 CH-1211 Geneva Switzerland

OBJECTIVES: This study sought to describe a new adverse effect of percutaneous radiofrequency(RF) ablation for atrial fibrillation(AF). BACKGROUND: Extension of the RF lesion beyond atrial myocardium may affect mediastinal structures other than the esophagus. mETHODS: Circular mapping-guided isolation of the pulmonary veins was performed in two different electrophysiology laboratories, either individually and supplemented by ostial and posterior left atrial(LA) ablation or two by two with a series of ostial and posterior LA lesions. The RF energy was delivered point by point through a 5-mm open-tip irrigated catheter(40W maximum) or an 8-mm-tip catheter(45W maximum). RESULTS: In four(two in each electrophysiology laboratory) of 367 patients undergoing catheter ablation for AF, abdominal pain and distension developed within 48 h after the procedure. Investigation showed acute pyloric spasm and gastric hypomotility, probably the result of LA endocardially delivered RF affecting the periesophageal vagi. Complete spontaneous recovery occurred in two patients, but laparoscopic esophagojejunal anastomosis and endoscopic intra-pyloric Botulinum toxin injection, respectively, were performed to remedy delayed gastric emptying in two patients. CONCLUSIONS: Thermal injury during endocardial LA RF energy delivery may extend into the mediastinum and rarely may involve the periesophageal nerves, resulting in a syndrome of acute delayed gastric emptying. marked anatomic variability of periesophageal vagi renders it difficult to reliably avoid the area overlying this plexus, therefore, we advocate a reduction in maximum RF power and application duration on all of the posterior LA to try to avoid this complication.

关键词：心房纤颤经皮射频消融幽门痉挛不良反应电极导管电生理学导管消融标测左心房胃排空延迟