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Selective butyric acid production from CO_(2)and its upgrade to butanol in microbial electrosynthesis cells

Environmental Science and Ecotechnology 2024年第1期17卷 119-127页

作者： meritxell Romans-Casas Laura Feliu-Paradeda michele Tedesco Hubertus V.m.Hamelers Lluis Bañeras m.d.lors balaguer SebastiàPuig Paolo dessì Institute of the Environment University of Girona.Campus MontiliviCarrer Maria Aurélia Capmany 69E-17003GironaSpain molecular microbial Ecology Group Institute of Aquatic EcologyUniversity of GironaMaria Aurelia Capmany 4017003GironaSpain Wetsus European Centre of Excellence for Sustainable Water TechnologyOostergoweg 98911MALeeuwardenthe Netherlands

microbial electrosynthesis(mES)is a promising carbon utilization technology,but the low-value products(i.e.,acetate or methane)and the high electric power demand hinder its industrial *** this study,electrically efficient mES cells with a low ohmic resistance of 15.7 mU m^(2)were operated galvanostatically in fed-batch mode,alternating periods of high CO_(2)and H2 *** promoted acetic acid and ethanol production,ultimately triggering selective(78%on a carbon basis)butyric acid production via chain *** average production rate of 14.5 g m^(-2)d^(-1)was obtained at an applied current of 1.0 or 1.5 mA cm^(-2),being megasphaera *** key chain elongating *** a second cell with the catholyte containing the enriched community resulted in butyric acid production at the same rate as the previous cell,but the lag phase was reduced by 82%.Furthermore,interrupting the CO_(2)feeding and setting a constant pH2 of 1.7e1.8 atm in the cathode compartment triggered solventogenic butanol production at a pH below *** efficient cell design resulted in average cell voltages of 2.6e2.8 V and a remarkably low electric energy requirement of 34.6 kWhel kg1 of butyric acid produced,despite coulombic efficiencies being restricted to 45%due to the cross-over of O_(2)and H2 through the *** conclusion,this study revealed the optimal operating conditions to achieve energy-efficient butyric acid production from CO_(2)and suggested a strategy to further upgrade it to valuable butanol.

关键词： Biocathode Bioelectrochemical system Chain elongation Hydrogen partial pressure megasphaera

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New genes emerging for colorectal cancer predisposition

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World Journal of Gastroenterology 2014年第8期20卷 1961-1971页

作者： Clara Esteban-Jurado Pilar Garre maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer muoz Francesc balaguer Teresa Ocaa Antoni Castells Josep m Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel department of Gastroenterology Hospital ClínicCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD)Institut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)University of Barcelona08036 BarcelonaCataloniaSpain molecular Oncology Laboratory Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Bioinformatics platform Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain Centre Nacional d’Anàlisi Genòmica (CNAG) Parc Científic de Barcelona08028 BarcelonaSpain department of Gastroenterology Hospital del Mar-IMIM (Hospital del Mar Medical Research Centre)Pompeu Fabra University08003 BarcelonaSpain Galician Public Foundation of Genomic medicine (FPGmX) Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)Genomics Medicine GroupHospital ClínicoSantiago de CompostelaUniversity of Santiago de Compostela15706 GaliciaSpain Center of Excellence in Genomic medicine Research King Abdulaziz University21589 JeddahKingdom of Saudi Arabia Gastroenterology department Hospital DonostiaNetworked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD)Basque Country University20080 San SebastiánSpain

Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed *** cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic *** syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common *** hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic *** can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate *** far,30 common,low-penetrance susceptibility variants have been identified for ***,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease *** using whole-genome sequencing,germline mutations in the POLE and POLd1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis.

关键词： Colorectal neoplasm, genetic predisposition to disease Next generation sequencing Genotype-phenotype correlation Genetic variant Single nucleotide polymorphism

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Colorectal cancer prognosis twenty years later

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World Journal of Gastroenterology 2010年第7期16卷 862-867页

作者： Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José m Enríquez-Navascués Rodrigo Jover Francesc balaguer Xavier Llor Xavier Bessa montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association department of Gastroenterology Donostia HospitalUniversity of Basque CountryCentro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas(CIBEREHD)20014 San SebastiánSpain department of Epidemiology Donostia HospitalCIBERESP20014 San SebastiánSpain department of Surgery Donostia Hospital20014 San SebastiánSpain department of Gastroenterology General Hospital department of Gastroenterology Clinic HospitalCIBEREHDIDIBAPS08036 BarcelonaSpain digestive diseases and Nutrition Secion University of IllinoisChicagoIL 60607United States department of Gastroenterology Del Mar Hospital08003 BarcelonaSpain department of Gastroenterology General Hospital 03010 AlicanteSpain

AIm:To evaluate changes in colorectal cancer(CRC) survival over the last 20 ***:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and ***Ⅱincluded 871 patients diagnosed in ***:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,Pd the difference was significant for all tumor *** surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(Pd chemotherapy compared with 50% of GroupⅡpatients(Pdoubled over the past 20 *** increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.

关键词： Colon cancer Prognosis Survival Chemotherapy Surgery

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Rare germline copy number variants in colorectal cancer predisposition characterized by exome sequencing analysis

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Journal of Genetics and Genomics 2018年第1期45卷 41-45页

作者： Sebastia Franch-Exposito Clara Esteban-Jurado Pilar Garre Isabel Quintanilla Saray duran-Sanchon marcos diaz-Gay Laia Bonjoch miriam Cuatrecasas Esther Samper Jenifer munoz Teresa Ocana Sabela Carballal maria Lopez-Ceron Antoni Castells maria Vila-Casadesus Sophia derdak Steven Laurie Sergi Beltran Jaime carvajal Luis Bujanda Clara Ruiz-Ponte Jordi Camps meritxell Gironella Juan Jose Lozano Francesc balaguer Joaquin Cubiella Trinidad Caldes Sergi Castellvi-Bel Gastroenterology department Hospital Clinic de Barcelona August Pi i Sunyer Biomedical Research Institute CIBER of Hepatic and Digestive Diseases University of Barcelona Barcelona 08036 Spain molecular Oncology Laboratory Hospital Clinico San Carlos Health Research Institute of the Hospital Clinico San Carlos Madrid 28040 Spain department of Pathology Hospital Clinic de Barcelona Barcelona 08036 Spain EPICOLON consortium Bioinformatics Platform CIBER of Hepatic and Digestive Diseases Barcelona 08036 Spain National Center of Genomic Analysis Science Park of Barcelona Barcelona 08028 Spain Andalusian developmental Biology Institute CSIC-Pablo de Olavide University-Andalusian Regional Government SeviUa 41013 Spain Gastroenterology department Hospital Donostia-Biodonostia Institute CIBER of Hepatic and Digestive Diseases University of the Basque Country (UPV/EHU) San Sebastian 20080 Spain Galician Public Foundation of Genomic medicine (FPGmX) CIBER of Rare Diseases Genomics Medicine Group Hospital Clinico Universitario University of Santiago de Compostela Santiago de Cornpostela 15706 Spain Castroenterology department Complexo Hospitalario Universitario de Ourense Ourense Biomedical Research Institute Ourense 32005 Spain

Colorectal cancer （CRC） is one of the most common neoplasms and an important cause of mortality worldwide （http：//globocan. ***]）. Approximately 35% of the variation in CRC susceptibility is likely due to heritable factors （Lichtenstein et al., 2000}. Genetic variations in the human genome include single nucleotide variants （SNVs）, short insertions and deletions, and larger structural variants resulting in gain or loss of genomic dNA larger than 1 kb, such as copy number variants （CNVs）. Leaving aside the importance of CNVs in sporadic tumor development, these variants can also be present in the germline dNA of healthy individuals from the general population and be considered polymorphic.

关键词： WHOLE-EXOmE GENE

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