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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & diseases 2024年第1期11卷 189-204页

作者： Ebrahim h.maleki Ahmad Reza Bahrami maryam m.matin department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(dTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zhu S.m.Weng P.Li X.F.Li h.Ai h.R.Pan Z.m.Sheng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of China Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of high Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(Thz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or Thz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or Thz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and Thz spectral ranges.

关键词： laser ultrashort photon

Assessment of plant diversity of endemic species of the Saharo-Arabian region in Egypt

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Journal of Arid Land 2024年第7期16卷 1000-1021,I0002-I0044页

作者： Asmaa S ABO hATAB Yassin m AL-SOdANY Kamal h ShALTOUT Soliman A hAROUN mohamed m EL-KhALAFY Botany and microbiology department Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33511Egypt Botany department Faculty of ScienceTanta UniversityTanta 31527Egypt

Savanna, semi-deserts, and hot deserts characterize the Saharo-Arabian region, which includes morocco, mauretania, Algeria, Tunisia, Libya, Egypt, Palestine, Kuwait, Saudi Arabia, Qatar, Bahrain, the United Arab Emirates, Oman, Yemen, southern Jordan, Syria, Iraq, Iran, Afghanistan, Pakistan, and northern India. Its neighboring regions, the Sudano-Zambezian region belonging to the Paleotropical Kingdom and the mediterranean and Irano-Turanian regions included in the holarctic Kingdom, share a large portion of their flora with the Saharo-Arabian region. despite the widespread acknowledgment of the region's global importance for plant diversity, an up to date list of the Saharo-Arabian endemics is still unavailable. The available data are frequently insufficient or out of date at both the whole global and the national scales. Therefore, the present study aims at screening and verifying the Saharo-Arabian endemic plants and determining the phytogeographical distribution of these taxa in the Egyptian flora. hence, a preliminary list of 429 Saharo-Arabian endemic plants in Egypt was compiled from the available literature. Indeed, by excluding the species that were recorded in any countries or regions outside the Saharo-Arabian region based on different literature, database reviews, and websites, the present study has reduced this number to 126 taxa belonging to 87 genera and 37 families. Regarding the national geographic distribution, South Sinai is the richest region with 83 endemic species compared with other eight phytogeographic regions in Egypt, followed by the Isthmic desert(the middle of Sinai Peninsula, 53 taxa). Sahara regional subzone(SS1) distributes all the 126 endemic species, Arabian regional subzone(SS2) owns 79 taxa, and Nubo-Sindian subzone(SS3) distributes only 14 endemics. Seven groups were recognized at the fourth level of classification as a result of the application of the two-way indicator species analysis(TWINSPAN) to the Saharo-Arabian endemic sp

关键词： endemism phytogeographical regions Saharo-Arabian floristic region Egyptian flora plant diversity two-way indicator species analysis(TWINSPAN)

Atomistic Investigation of Shock-Induced Amorphization within micro-shear Bands in hexagonal Close-Packed Titanium

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Acta metallurgica Sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： Z.C.meng K.G.Wang T.Ali d.Li C.G.Bai d.S.Xu S.J.Li A.h.Feng G.J.Cao J.h.Yao Q.B.Fan h.Wang R.Yang Institute of metal Research Chinese Academy of SciencesShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary Centre for Additive manufacturing(ICAm) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China School of materials Science and Engineering Tongji UniversityShanghai 201804China Key Laboratory for Light-Weight materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of Science and Technology on materials Under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(SFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming SFs and dislocations,there was a gradual increase in the density of dislocations and SFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： Shock compression Amorphization Shear band Titanium molecular dynamics

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le h.Nguyen-Xuan department of mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECh Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SImOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

Energy design and Optimization of Greenhouse by Natural Convection

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Fluid dynamics & materials Processing 2024年第8期20卷 1903-1913页

作者： h.Benzzine h.Labrim Aouatif Saad Y.Achour d.Zejli R.El Bouayadi Advanced Systems Engineering Laboratory(ASELab) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

This study addresses the pressing need for energy-efficient greenhouse management by focusing on the innovative application of natural *** primary objective of this study is to evaluate various ventilation strategies to enhance energy efficiency and optimize crop production in agricultural *** advanced numerical simulation tools,the study conducts a comprehensive assessment of natural ventilation’s effectiveness under real-world *** results underscore the crucial role of the stack effect and strategic window positioning in greenhouse cooling,providing valuable insights for greenhouse *** findings shed light on the significant benefits of optimized ventilation and also offer practical implications for improving greenhouse design,ensuring sustainable and efficient agricultural *** study demonstrated energy savings in cooling from November to April,with a maximum saving of 680 kWh in march,indicating the effectiveness of strategically positioning windows to leverage the stack *** approach enhances plant growth and reduces the need for costly cooling systems,thereby improving overall energy efficiency and lowering operational expenses.

关键词： Energy greenhouse cooling natural ventilation simulation temperature

A statistical approach to enhance the productivity of Streptomyces baarensis mh-133 for bioactive compounds

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Synthetic and Systems Biotechnology 2024年第2期9卷 196-208页

作者： mohamed h.Kalaba Gamal m.El-Sherbiny Osama m.darwesh Saad A.moghannem Botany and microbiology department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt Agricultural microbiology department National Research CentreDokkiCairoEgypt

The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that Streptomyces baarensis mh-133 could make more active *** trials were used to screen for critical variables influencing productivity using the Placket-Burman design *** mh-133 is significantly influenced by elicitation,yeast extract,inoculum size,and incubation period in terms of antibacterial activity.A total of 27 experimental trials with various combinations of these factors were used to carry out the response surface technique using the Box-Behnken *** analyses revealed that the model was highly significant(ph a lack-of-fit of 0.212 and a coefficient determination(R2)of ***,the model predicted that the response as inhibition zone diameter would reach a value of 27 *** optimal conditions,*** mh-133 produced 18.0 g of crude extract to each 35L and was purified with column *** active fraction exhibiting antibacterial activity was characterized using spectroscopic *** mIC and mBC values varied between 37.5 and 300μg/ml and 75 and 300μg/ml,*** conclusion,the biostatistical optimization of the active fraction critical variables,including environmental and nutritional conditions,enhances the production of bioactive molecules by Streptomyces species.

关键词： S.baarensis mh-133 Placket-Burman designBox-Behnken design ESKAPE Antibacterial activity

magnesium oxide(mgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： h.C.S.Perera V.Gurunanthanan Anoop Singh m.m.m.G.P.G.mantilaka G.das Sandeep Arya department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka department of humanities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(mgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of mgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of mgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of mgO nanoparticles,such as temperature,ph,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of mgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for mgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of mgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to mgO ***,there is a need to investigate the use of mgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： mgO nanoparticles Nanoadsorbent Wastewater treatment heavy metals dye separation Adsorption Synthesis methods

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid h.A.L-hashem Salah O.Bashir Amal F.dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed d.morsy department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone