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Bio-fabrication of liver cancer stem cells and testing of gemcitabine

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Journal of Cancer metastasis and Treatment 2023年第1期9卷 497-505页

作者： Evrim.cevik Omer Erdogan Ozge cevik Department of machinery and metal Technologies Aydin Adnan Menderes UniversityKocarli Vocational High SchoolAydin 09970Turkey Department of medicinal Biochemistry Aydin Adnan Menderes UniversitySchool of MedicineAydin 09010Turkey

Aim:Cancer stem cells are cell populations that are essential in drug resistance and cancer *** liver cancer cells exhibit the characteristics of cancer stem cells,and it is crucial to study the activities and interactions of drugs in these ***7 is a human liver cancer cell with stem cell biomarkers and is used with induced pluripotent stem cells to form various cancer organoids through encapsulation *** to their ease of use without animal testing,bio-fabrication studies of cell-encapsulated models have gained importance in the pharmaceutical industry in recent *** study aimed to biofabricate Huh7 human liver cancer stem cells by alginate encapsulation and test gemcitabine’s ***:Huh7 cells were encapsulated with alginate(0.8%w/v)and fibronectin,and their viability was evaluated with 3.2μm gemcitabine on days 1,3,6,9,and ***,gene expressions of stem cell markers CD90 and AFP were evaluated in encapsulated Huh7 cells by *** addition,IL-6 secretion in the cell medium was measured by ELISA for the tumor ***:Encapsulation of Huh7 cells was found to maintain their viability and stem cell properties for up to 12 *** addition,alginate-encapsulated Huh7 cells were bio-fabricated to demonstrate long-term gemcitabine *** the effect of the gemcitabine was evaluated in alginate-encapsulated Huh7 cells,CD90 and AFP mRNA levels were significantly reduced in the cells and IL-6 secretion was decreased in the tumor ***:This study demonstrated that bio-fabrication of alginate-encapsulated Huh7 cells is a novel approach for long-term drug testing in liver cancer ***-fabricated alginate-encapsulated cancer stem cells may be a cheaper and faster method for the testing of many drugs.

关键词： Bio-fabrication cancer stem cells gemcitabine liver cancer alginate beads

Development of an Amperometric Hydrogen Peroxide Biosensor based on the Immobilization of Horseradish Peroxidase onto Nickel Ferrite Nanoparticle-Chitosan Composite

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Nano-micro Letters 2011年第2期3卷 91-98页

作者： Furkan Yalcner Emre cevik mehmet Senel Abdulhadi Baykal Department of Chemistry Faculty of Arts and SciencesFatih University

Nickel ferrite(NiFe_2O_4) nanoparticles have been dispersed in chitosan solution in order to fab ricate nanocomposite *** peroxidase(HRP) has been immobilized onto this chitosan NiFe_2O_4 nanocomposite film via physical *** size of the NiFe_2O_4 nanoparticles has been estimated us ing X ray diffraction pattern and scanning electron microscopy(SEm) to be 40±9 *** chitosan NiFe_2O_4 nanocomposite film and HRP/chitosan NiFe_2O_4 bioelectrode have been characterized using SEm *** HRP/chitosan NiFe_2O_4 nanocomposite bioelectrode has a response time of 4 s,linearity as 0.3 to 12 m m of H2O2,sensitivity as 22 n A/m *** effects of p H and the temperature of the immobilized HRP electrode have also been studied.

关键词： Biosensor NiFe_2O_4 Horseradish peroxidase Nanoparticle Chitosan

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糖尿病视网膜病变患者高密度脂蛋白-3和总抗氧化能力以及NO_x水平分析（英文）

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国际眼科杂志 2017年第12期17卷 2197-2202页

作者： Ustundag Yasemin Akdogan müberra Demirci Hakan Günay Leyla Huysal Kagan cevik Sadik Gorkem Barazi Ayse Yildirim Saglik Bilimleri大学布尔萨Yuksek Ihtisas教学研究医院临床化学土耳其布尔萨16330 Yildirim Saglik Bilimleri大学布尔萨Yuksek Ihtisas教学研究医院眼科土耳其布尔萨16330 Yildirim Saglik Bilimleri大学布尔萨Yuksek Ihtisas教学研究医院全科医学土耳其布尔萨16330

目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL_3)、NO_x和总抗氧化状态之间的关系。方法:前瞻性病例对照研究。106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人。患者均行血清高密度... 详细信息

目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL_3)、NO_x和总抗氧化状态之间的关系。方法:前瞻性病例对照研究。106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人。患者均行血清高密度脂蛋白-3的浓度检测和血清NO_x水平测定。用铁还原法(FRAP)测量血浆总抗氧化能力。结果:糖尿病患者(Dm)空腹血糖、糖化血红蛋白、甘油三酯显著高于对照组。正常人中HDL_3水平为14.4(12.0)mg/dL,糖尿病视网膜病变患者为18.1(12.6)mg/dL,糖尿病无视网膜病变患者为14.0(12.5)mg/dL,组间差异无统计学意义(P=0.262)。糖尿病患者FRAP水平低于对照组(P=0.003),但糖尿病视网膜病变组与非糖尿病视网膜病变组之间其差异无统计学意义。结论:研究发现:2型糖尿病视网膜病变患者、糖尿病无视网膜病变患者以及对照组间HDL和HDL_3水平无明显不同。HDL_3可能无法预测糖尿病视网膜病变患者的患病风险。糖尿病患者中血清NO_x水平较高,FRAP水平较低。

关键词：高密度脂蛋白糖尿病视网膜病变一氧化氮总抗氧化

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干眼症和前睑缘炎及季节性过敏性结膜炎中三种检测方法结果的比较(英文)

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国际眼科杂志 2013年第11期13卷 2163-2168页

作者： mutlu Acar Volkan Yaylali Ahmet cevik Tufan Cem Ylldmm 安卡拉Diskapi耶尔德勒姆贝亚培训和研究医院卫生系眼科土耳其安卡拉06110 棉花堡大学医学院眼科系土耳其德尼兹利20070 棉花堡大学医学院组织胚胎学系土耳其德尼兹利20070

目的:比较三组临床患者和对照组患者的泪液功能测试,眼表染色以及结膜印象细胞学检测的结果。方法:这是一个单中心,前瞻性,双盲,随机对照试验。研究包括泪液分泌分数小于10mm和泪膜破裂时间(TBUT)小于10s的20例干眼症患者,有干燥和结痂... 详细信息

目的:比较三组临床患者和对照组患者的泪液功能测试,眼表染色以及结膜印象细胞学检测的结果。方法:这是一个单中心,前瞻性,双盲,随机对照试验。研究包括泪液分泌分数小于10mm和泪膜破裂时间(TBUT)小于10s的20例干眼症患者,有干燥和结痂睫毛的20例前睑缘炎患者,上眼睑睑板结膜乳头肥大的20例季节性过敏性结膜炎患者和20例对照组患者。比较泪液分泌的分数,泪膜破裂时间,眼表染色(牛津分级方案),杯状细胞密度(尼尔森分级方案评估所有患者的印象细胞学和化生分数)。结果:三组患者和对照组患者在泪液功能测试结果,眼表染色评分,杯状细胞密度和化生分数上有显著差异(P<0.001)。结论:结果证明这三种疾病的炎症反应造成严重眼表损害,并在局部产生炎症。这种损伤产生非常严重的影响,尤其是对结膜杯状细胞密度和化生。杯状细胞损伤程度与临床研究结果有关联。

关键词：前睑缘炎结膜印象细胞学干眼症眼球表面染色季节性过敏性结膜炎

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A Double-Sided View to Adult Vaccination:The Opinions and Attitudes of Patients and Health Workers

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Health 2018年第12期10卷 1697-1713页

作者： Raziye Sule Gümüstakim Pinar Bilgili murat cevik Duygu Ayhan Baser Adem Doganer Selda Handan Karahan Saper Zuhal Kanevetci Ergül Ozcelebi medical Faculty Sutcu Imam UniversityKahramanmarasTurkey Department of Family medicine Medical SchoolHacettepe UniversityAnkaraTurkey

Objective: Although there are adult vaccination schemes in our country, there are serious deficiencies in the way that doctors direct the patients to this vaccination, but also patients have to make and demand these vaccinations. The aim of our study is to identify the shortcomings in this area and draw a roadmap for what arrangements should be made in terms of physicians and patients in order to increase adult immunization rates in primary care. method: We conducted a two-phase, multicentered, descriptive clinical trial between October and December 2017. The first phase of the trial was carried out with patients from 3 Family Health Centers in Antalya, Istanbul and Osmaniye. Patients to be interviewed were selected voluntarily among Family Health Center’s applicants. The second phase of the trial was carried out with health workers, who were participated to trial from 26 different provinces of Turkey. In the process, a questionnaire of 19 questions was applied to primary health care workers by the internet. Results: 490 patients were included in the study. There was a significant difference between gender, age, education level and guideline follow-up and vaccination status of patients [p Conclusion: As a result of the studies including our study about adult vaccination, only 10% - 20% of the targeted groups in adults can be vaccinated. However, just like in childhood during adulthood, vaccinations protect individuals from diseases and provide economic benefits. Firstly, the knowledge level of physicians on adult immunization should be updated with in-service trainings, they should first be convinced to vaccinate because they are in risk group and then they should be recommended vaccination to patient to increase the vaccination rates.

关键词： Adult Vaccination Health Workers Patients

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center münchen Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy