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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal models and Experimental medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.munley Erick E.Pons Kolenkode b.Kannan Elizabeth m.Whitley Letitia E.bible Philip A.Efron Alicia m.mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(bm)erythroid progenitor(CFU-GEmm,bFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesma resulted in markedly more profound inhibition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(pmoglobin(pbody weight ratios(p=0.004).both LCHS and PT demonstrated suppression of CFU-E and bFU-E growth compared to naive(pma G-CSF was elevated in PT compared to both na?ve and LCHS(pmonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

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Function and dysfunction of GEmIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles H.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAm)has resulted in an increased interest in GEmIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEmIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEmIN5 within the context of NEDCAm,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAm,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEmIN5 neurodevelopmental disorder neurological disease SmN complex

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Air purifier or fresh air system?A comparison of energy consumption and cost in urban China residential buildings

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Science China(Technological Sciences) 2024年第9期67卷 2637-2647页

作者： GUO Yong SUN ZhiWei WESCHLER Louise b ZHANG YinPing Department of building Science Tsinghua UniversityBeijing 100084China beijing Key Laboratory of Indoor Air Quality Evaluation and Control Beijing 100084China Independent Researcher Colts Neck 07722NJUSA

Chinese urban residential buildings face serious indoor air quality *** purification systems(e.g.,air purifiers,fresh air systems)that supply fresh air or purify indoor air are widely used in residential buildings to improve indoor air *** the challenges of energy conservation and emission reduction,it is urgent to guide residents on choosing appropriate air purification *** key problem is how to identify the best air purification system with the lowest energy consumption or operating *** of air purification systems have rarely been conducted on the premise that they should deliver air such that the main indoor pollutant concentrations all meet air quality *** ignored in comparisons are the increased filtration resistance caused by dust accumulation on the filter and the cost of filter *** this study,we propose a method to compare residential air purification systems based on energy consumption and total cost,and we provide methods to select air purification systems in China's different climatic *** used a standard two-person bedroom as the example,and determined the most suitable(minimum cost or energy consumption)air purification systems for the capital cities of the provinces in Chinese mainland.

关键词： IAQ fresh air system air purifier energy consumption cost

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Enhanced quantum resources via two distant atom-cavity systems under the influence of atomic dissipation

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Communications in Theoretical Physics 2024年第2期76卷 62-73页

作者： m Setodeh Kheirabady m K Tavassoly m Rafeie E Ghasemian Laser and Optics Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran Department of Electrical Engineering Faculty of Intelligent Systems Engineering and Data SciencePersian Gulf UniversityBushehrIran

Quantum resources such as entanglement and coherence are the holy grail for modern quantum technologies. Although the unwanted environmental effects tackle quantum information processing tasks, suprisingly these key quantum resources may be protected and even enhanced by the implementation of some special hybrid open quantum systems. Here, we aim to show how a dissipative atom-cavity-system can be accomplished to generate enhanced quantum *** do so, we consider a couple of dissipative cavities, where each one contains two effective two-level atoms interacting with a single-mode cavity field. In practical applications, a classical laser field may be applied to drive each atomic subsystem. After driving the system, a bell-state measurement is performed on the output of the system to quantify the entanglement and coherence. The obtained results reveal that the remote entanglement and coherence between the atoms existing inside the two distant cavities are not only enhanced, but can be stabilized, even under the action of dissipation. In contrast, the local entanglement between two atoms inside each dissipative cavity attenuates due to the presence of unwanted environmental ***, the local coherence may show the same behavior as the remote ***, the system provides the steady state entanglement in various interaction regimes,particularly in the strong atom-cavity coupling and with relatively large detuning. more interestingly, our numerical analyses demonstrate that the system may show a memory effect due to the fact that the death and revival of the entanglement take place during the interaction. Our proposed model may find potential applications for the implementation of long distance quantum networks. In particular, it facilitates the distribution of quantum resources between the nodes of large-scale quantum networks for secure communication.

关键词： remote entanglement and coherence atomic dissipation steady state entanglement bell-statemeasurement

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Effects of multiple shapes for steady flow with transformer oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied mathematics and mechanics(English Edition) 2024年第2期45卷 373-388页

作者： m.RAHmAN m.TURKYILmAZOGLU Z.mUSHTAQ Department of mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c mATLAb *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,Re=2,m=1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil brinkman number skin friction coefficient double rotating disk Nusselt number Sherwood number

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Long-term outcomes of urethral balloon dilation for anterior urethral stricture: A prospective cohort study

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Asian Journal of Urology 2024年第3期11卷 480-485页

作者： Ahmed m.Abdel Gawad Abhijit Patil Abhishek Singh Arvind P.Ganpule Ravindra b.Sabnis mahesh R.Desai Department of Urology Muljibhai Patel Urological HospitalNadiadIndia Department of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(bD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to ***:This study included men who had urethral bD for significant anterior urethral stricture disease between January 2017 and march *** about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative ***,information about the self-calibration procedure was collected and where available,free flow(FF)measurements during the follow-up period were recorded and *** was defined as a lack of symptoms and acceptable FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 *** mean follow-up period was 37 *** long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our *** time to recurrence ranged from 91 days to 1635 days,with a mean of 670 *** stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(pbration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after bD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(pbut also improved the overall stricture-free survival and FF parameters.

关键词： balloon dilation Internal urethrotomy Recurrence Self-calibration Urethral stricture

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Storylines of family medicine Ⅶ: family medicine across the lifespan

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Family medicine and Community Health 2024年第S3期12卷 61-69页

作者： William b Ventres Leslie A Stone Katharine C barnard Sara G Shields mark J Nelson maria Verónica Svetaz Clara m Keegan Joel J Heidelbaugh Paige b beck Lucille marchand Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA John Peter Smith Hospital Family medicine Residency Fort WorthTexasUSA Family and Community medicine Hennepin HealthcareMinneapolisMinnesotaUSA Family medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA Family medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅶ:family medicine across the lifespan’,authors address the following themes:‘Family medicine maternity care’,‘Seeing children as patients brings joy to work’,‘Family medicine and the care of adolescents’,‘Reproductive healthcare across the lifespan’,‘men’s health’,‘Care of older adults’,and‘being with dying’.may readers appreciate the range of family medicine in these essays.

关键词： life illustration family

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Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.D.Hossain m.S.Sikder m.N.I.Khan m.R.Rahman Physics Discipline Khulna UniversityKhulna9208Bangladesh Department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh Department ofComputer Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material Science Division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEm),energy dispersive X-ray(EDX),vibrating sample magnetometer(VSm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRD patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EDX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EDX Resistivity

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Tumor necrosis factor-alpha, transforming growth factor-beta, degree of lower urinary tract symptoms as predictors of erectile dysfunction in benign prostatic hyperplasia patients

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Asian Journal of Urology 2024年第2期11卷 280-285页

作者： Gede W.K.Duarsa Yeremia G.Kusumah Ronald Sugianto Pande m.W.Tirtayasa Tjokorda G.b.mahadewa Department of Urology Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Department of General Surgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia medical Doctor Study Program Faculty of MedicineUniversitas UdayanaBaliIndonesia Department of Urology Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Department of Neurosurgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (bPH) ***: Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in bali, Indonesia, including medical records and other administrative data. The sample was bPH patients with several history ***: Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in bPH patients (pme is not significant with ED (p=0.947).Conclusion: TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in bPH, while prostatic volume was not significant.

关键词： Prostate enlargement biomarker Erectiledysfunction Riskfactor

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Tracking the Ti^(4+)substitution in phlogopite by spectroscopic imaging:A tool for unravelling the growth of micas at HP-HT conditions

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Geoscience Frontiers 2024年第3期15卷 1-13页

作者： G.Della Ventura N.El moutaouakkil b.boukili S.bernardini A.Sodo L.Pronti m.Cestelli-Guidi F.Holtz F.Lucci Dipartimento di Scienze UniversitàRoma TreRomaItaly INFN-LNF via Fermi 200040 FrascatiRomaItaly INGV Via di Vigna Murata 60500143 RomaItaly Laboratory of Géosciences Water and Environment.Department of Earth Sciences.Faculty of SciencesUniversity Mohammed VRabatMorocco Leibnitz Universität Hannover Institute of MineralogyCallinstr 330167 HannoverGermany Dipartimento di Scienze della Terra e Geoambientali Universitàdi Bari“Aldo Moro”BariItaly

Phlogopite solid-solutions have a wide pressure-temperature(P-T)stability field and are ubiquitous in a wide variety of geological settings,from deep lithosphere magmatic environments to upper crust metamorphic *** composition represents therefore a valuable physical-chemical archive and may provide important information regarding its crystallization and the petrogenesis of the *** this paper we examine the phlogopite phenocrysts from the well-known Fort Regent mica-bearing lamprophyre minette from ***(Island of Jersey,UK).Phlogopite phenocrystals from lamprophyres generally show normal-step and continuous compositional zoning,however those from the Fort Regent minette show a peculiar texture characterized by dark brown high-Ti(average TiO_(2)≈8.5 wt.%)cores enveloped by euhedral low-to mid-amplitude zonation due to oscillatory contents in Ti,Fe and ***-barometry modelling based on biotite-only composition yields relatively high P-T estimates(T≈970±54℃at P≈0.73±0.13 GPa)for cores whereas lower values(T≈790±54℃at P≈0.29±0.13 GPa)are obtained for the outer *** temperatures(T≈1075±54℃)but extremely high and anomalous pressure values(P≈1.82±0.13 GPa)are obtained for the yellowish inner *** combination of electron micro probe(EmP)analysis and single-crystal infra-red(FTIR)imaging in the OH-stretching region shows that the exceptional and oscillatory Ti contents are due to the Ti-vacancy substitution,typical of crystallization and growth processes of HP/HT *** imaging provides additional insight for this process,confirming the dominant dioctahedral nature for the Ti-Fe-rich cores and outer *** of thermobaric estimates obtained from the phlogopite compositiononly model,based on the fine-scale compositional evolution,shows that pressure-temperature values from low-Ti high-mg domains should be carefully evaluated because the substitution mechanisms during the dark mica growth are not univocal

关键词： Ti-phlogopite Jersey minette(UK) Ti-substitution FTIR imaging Raman imaging Thermobarometric modelling

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