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Accuracy of genomic selection in biparental populations of flax(Linum usitatissimum L.)

The Crop Journal 2016年第4期4卷 290-303页

作者： Frank m.you Helen m.Booker Scott D.Duguid Gaofeng Jia Sylvie Cloutier morden Research and Development Centre Agriculture and Agri-Food Canada Crop Development Centre Department of Plant Sciences University of Saskatchewan Ottawa Research and Development Centre Agriculture and Agri-Food Canada

Flax is an important economic crop for seed oil and stem fiber. Phenotyping of traits such as seed yield, seed quality, stem fiber yield, and quality characteristics is expensive and time consuming. Genomic selection(GS) refers to a breeding approach aimed at selecting preferred individuals based on genomic estimated breeding values predicted by a statistical model based on the relationship between phenotypes and genome-wide genetic markers. We evaluated the prediction accuracy of GS(rmP) and the efficiency of GS relative to phenotypic selection(RE) for three GS models: ridge regression best linear unbiased prediction(RR-BLUP),Bayesian LASSO(BL), and Bayesian ridge regression(BRR), for seed yield, oil content, iodine value, linoleic, and linolenic acid content with a full and a common set of genome-wide simple sequence repeat markers in each of three biparental populations. The three GS models generated similar rmPand RE, while BRR displayed a higher coefficient of determination(R^2)of the fitted models than did RR-BLUP or BL. The mean rmPand RE varied for traits with different heritabilities and was affected by the genetic variation of the traits in the *** for seed yield generated a mean RE of 1.52 across populations and marker sets, a value significantly superior to that for direct phenotypic selection. Our empirical results provide the first validation of GS in flax and demonstrate that GS could increase genetic gain per unit time for linseed breeding. Further studies for selection of training populations and markers are warranted.

关键词： Genomic selection SSR Flax Linseed Seed yield Fatty acid composition

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Inheritance of marsh spot disease resistance in cranberry common bean(Phaseolus vulgaris L.)

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The Crop Journal 2022年第2期10卷 456-467页

作者： Bosen Jia Robert L.Conner Nadeem Khan Anfu Hou Xuhua Xia Frank m.you Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawaOntario K1A 0C6Canada Department of Biology University of OttawaOttawaOntario K1N 6N5Canada morden Research and Development Centre Agriculture and Agri-Food CanadaMordenManitoba R6M 1Y5Canada

Common bean(Phaseolus vulgaris) is an annual legume crop that is grown worldwide for its edible dry seeds and tender pods. marsh spot(mS) of the seeds is a physio-genic stress disease affecting seed quality in beans. Studies have suggested that this disease involves a nutritional disorder caused by manganese deficiency, but the inheritance of resistance to this disease has not been reported. A biparental genetic population composed of 138 recombinant inbred lines(RILs) was developed from a cross between an mS resistant cultivar ‘Cran09’ and an mS susceptible cultivar ‘messina’. The 138 RILs and their two parents were evaluated for mS resistance during five consecutive years from 2015 to 2019 in sandy and heavy clay soils in morden, manitoba, Canada. The mS incidence(mSI) and the mS resistance index(mSRI) representing disease severity were shown to be both highly correlated heritable traits that had high broad-sense heritability values(H;) of 86.5% and 83.2%, respectively. No significant differences for mSI and mSRI were observed between the two soil types in all five-(mSI) or four-year(mSRI) data collection, but significant correlations among years were observed despite mS resistance was moderately affected by year. The mSIs and mSRIs displayed a right-skewed distribution, indicating a mixed genetic model involving a few major genes and polygenes. Using the joint segregation analysis method, the same four major genes with additive-epistasis effects showed the best fit for both traits, explaining 84.4% and85.3% of the phenotypic variance for mSI and mSRI, respectively. For both traits, the m1, m2, m3 and m4 acted as the favorable(resistant) alleles for the four genes where m and m represent two alleles of each gene. However, due to epistatic effects, only the individuals of the m1 m2 m3 m4 haplotype appeared to be highly resistant, whereas those of the m1 m2 m3 m4 haplotype were the most susceptible. The m4 allele significantly suppressed the additive effects of m1 m

关键词： Common bean Cranberry bean marsh spot Resistance Recombinant inbred line(RIL) Joint segregation analysis major gene Polygene

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Estimation of genetic parameters and their sampling variances for quantitative traits in the type 2 modified augmented design

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The Crop Journal 2016年第2期4卷 107-118页

作者： Frank m.you Qijian Song Gaofeng Jia Yanzhao Cheng Scott Duguid Helen Booker Sylvie Cloutier morden Research and Development Centre Agriculture and Agri-Food Canada Soybean Genomics and Improvement Laboratory USDA-ARS Crop Development Centre University of Saskatchewan Ottawa Research and Development Centre Agriculture and Agri-Food Canada

The type 2 modified augmented design(mAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical methods and data adjustment for soil heterogeneity have been previously described for this design. In the absence of replicated test genotypes in mAD2, their total variance cannot be partitioned into genetic and error components as required to estimate heritability and genetic correlation of quantitative traits, the two conventional genetic parameters used for breeding selection. We propose a method of estimating the error variance of unreplicated genotypes that uses replicated controls, and then of estimating the genetic parameters. Using the Delta method, we also derived formulas for estimating the sampling variances of the genetic *** simulations indicated that the proposed method for estimating genetic parameters and their sampling variances was feasible and the reliability of the estimates was positively associated with the level of heritability of the trait. A case study of estimating the genetic parameters of three quantitative traits, iodine value, oil content, and linolenic acid content, in a biparental recombinant inbred line population of flax with 243 individuals, was conducted using our statistical models. A joint analysis of data over multiple years and sites was suggested for genetic parameter estimation. A pipeline module using SAS and Perl was developed to facilitate data analysis and appended to the previously developed mAD data analysis pipeline(http://***/bioinformatics_ tools/mADPipeline/***).

关键词： Broad-sense heritability Genetic correlation Sampling variance modified augmented design

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The cloning of Rht23 revealed a point mutation in 5Dq leading to plant dwarfness and compact spike in common wheat

The cloning of Rht23 revealed a point mutation in 5Dq leadin...

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2017中国长三角遗传学大会

作者： Kaijun Zhao Jin Xiao Yu Liu Shulin Chen Chunxia Yuan Aizhong Cao Frank m.you Donglei Yang An Shengmin Haiyan Wang Xiue Wang State Key Laboratory of Crop Genetics and Germplasm Enhancement Cytogenetics InstituteNanjing Agricultural University/JCIC-MCP morden Research and Development Centre Agriculture and Agri-Food Canada

The domesticated Q gene on wheat chromosome 5 A(5 AQ) encode an AP2 transcription factor,conferring characters of free-threshing and subcompact *** B and D homeoalleles of hexaploid bread wheat are thought to be either a pseudogene or expressed at a low level,*** function of the low expressed allele on chromosome 5 D(5 Dq) was still *** identified a compact spike and dwarf mutant of Sumai 3,NAUH164,by EmS mutagenesis,and the mutant gene was designated as ***23 was mapped to a physical interval of 8.5 mb on chromosome 5 DL,in which the 5 Dq was *** present study,the 5 Dq/q’ were cloned from wild type Sumai 3 and its *** comparison showed that there occurred a SNP substitution(G3147 A) in the 5 Dq ORF-region,which has been proved as the binding site of *** SNP resulted in an Ala416 Thr mutation and changed the structure of 5 Dq *** expression change was observed for 5 AQ in the wild type and the *** the 5 Dq expression was significantly up-regulated in leaves,stems and spikes of NAUH164 than those in Sumai *** in the wild type Sumai 3,the Ta-miR172 expression was down regulated in leaf,stem and spike of the *** may due to the induced mismatch to *** further study the relationship of 5 Dq’ with Rht23,a SNP-based co-dominant marker,was *** analysis using a(NAUH164×Alondra’s) RIL population showed that the marker allele was co-segregated with the Rht23 mutant *** results suggest that Rht23 was a 5 Dq point mutation,which led to plant dwarf and compact spike *** results provided the evidence that the Q homolog on chromosome 5 D also has pleiotropic effect in regulation of plant architecture.

关键词： Common wheat Q gene Rht23 mutagenesis Single nucleotide polymorphism(SNP)

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基于对比增强CT检查及深度学习检测胰腺实性和囊性肿瘤

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国际医学放射学杂志 2023年第2期 228-229页

作者： H.J.Park K.Shin m.you S.Kyung S.Y.Kim S.H.Park 惠情情

摘要深度学习（DL）可以提高在影像中各种胰腺病变的诊断。目的开发和验证一种基于DL的方法以用于在腹部CT上自动识别患有各种实体和囊性胰腺肿瘤的病人，并将

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Enhanced Hoek-Brown(H-B)criterion for rocks exposed to chemical corrosion

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International Journal of mining Science and Technology 2024年第5期34卷 609-630页

作者： Hao Li Leo Pel Zhenjiang you David Smeulders Department of mechanical Engineering Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Center for Sustainable Energy and Resources School of EngineeringEdith Cowan UniversityJoondalupWA 6027Australia School of Chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia Gas and Energy Transition Research Centre The University of QueenslandBrisbaneQLD 4072Australia

Underground constructions often encounter water environments,where water–rock interaction can increase porosity,thereby weakening engineering ***,the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such *** study enhances the applicability of the Hoek-Brown(H-B)criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi(KPIm).A multiscale experimental investigation,including nuclear magnetic resonance(NmR),X-ray diffraction(XRD),scanning electron microscopy(SEm),pH and ion chromatography analysis,and triaxial compression tests,is employed to quantify pore structural changes and their linkage with the strength responses of limestone under coupled chemical-mechanical(C-m)*** employing ion chromatography and NmR analysis,along with incorporating the principles of free-face dissolution theory accounting for both congruent and incongruent dissolution,a kinetic chemical corrosion model is *** model aims to calculate the kinetic porosity alterations within rocks exposed to varying H+concentrations and ***,utilizing the generalized mixture rule(GmR),the kinetic porositydependent mi is *** of the KPIm-enhanced H-B criterion using compression test data from 5 types of rocks demonstrated a high level of consistency between the criterion and the experimental results,with a coefficient of determination greater than 0.96,a mean absolute percentage error less than 4.84%,and a root-mean-square deviation less than 5.95 ***,the physical significance of the porosity-dependent instantaneous mi is clarified:it serves as an indicator of a rock’s capacity to leverage the confining pressure effect.

关键词： Hoek-Brown(H-B)criterion Instantaneous mi Kinetic porosity-dependency Chemical corrosion Compressive strength

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Accelerated Primal-Dual Projection Neurodynamic Approach With Time Scaling for Linear and Set Constrained Convex Optimization Problems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1485-1498页

作者： you Zhao Xing He mingliang Zhou Tingwen Huang Chongqing Key Laboratory of Nonlinear Circuits and Intelligent Information Processing College of Electronic and Information EngineeringSouthwest UniversityChongqing 400715China School of Computer Science Chongqing UniversityChongqing 400044China Department of mathematics Texas A&M University at QatarDoha 23874Qatar IEEE

The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence *** previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization *** this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual *** satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence *** only requires assuming convexity of the objective *** validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments.

关键词： Accelerated projection neurodynamic approach lin-ear and set constraints projection operators smooth and nonsmooth convex optimization time scaling.

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A Quick Calculation method for Radiation Pattern of Submillimeter Telescope with Deformation and Displacement

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Research in Astronomy and Astrophysics 2024年第3期24卷 249-265页

作者： Jia you Yi-Wei Yao Zheng Wang School of Automation Southeast UniversityNanjing 210096China

Radiation pattern captures the electromagnetic performance of reflector antennas,which is significantly affected by the deformation of the primary reflector due to gravity and the displacement of the secondary *** the design process of large reflector antennas,a substantial amount of time is often dedicated to iteratively adjusting structural parameters and validating electromagnetic *** improve the efficiency of the design process,we first propose an approximate calculation method of optical path difference(OPD)for the deformation of the primary reflector under gravity and the displacement of the secondary *** an OPD fitting function based on the modified Zernike polynomials is proposed to capture the phase difference of radiation over the aperture plane,based on which the radiation pattern will be obtained quickly by the aperture field integration *** experiments demonstrate the effectiveness of the proposed quick calculation method for analyzing the radiation pattern of a 10.4 m submillimeter telescope antenna at its highest operating frequency of 856 *** comparison with the numerical simulation method based on GRASP(which is an antenna electromagnetic analysis tool combining physical optics(PO)and physical theory of diffraction(PTD)),the quick calculation method reduces the time for radiation pattern analysis from more than one hour to less than two ***,the quick calculation method exhibits excellent accuracy for the figure of merit(FOm)of the radiation ***,the proposed quick calculation method can obtain the radiation pattern with high speed and *** to the time-consuming numerical simulation method(PO and PTD),it can be employed for quick analysis of the radiation pattern for the lateral displacement of the secondary reflector and the deformation of the primary reflector under gravity in the design process of a reflector antenna.

关键词： instrumentation high angular resolution-methods data analysis-methods analytical

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High-Efficiency Dynamic Terahertz Deflector Utilizing a mechanically Tunable metasurface

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Research 2024年第3期2023卷 585-594页

作者： Zhenci Sun Chao Liang Chen Chen Xiayu Wang Enze Zhou Xiaomeng Bian Yuanmu Yang Rui you Xiaoguang Zhao Jiahao Zhao Zheng you Department of Precision Instrument Tsinghua UniversityBeijing 100084China State Key Laboratory of Precision measurement Technology and Instruments Tsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Integrated Circuits Beijing 100084China School of Instrument Science and Opto-Electronic Engineering Beijing Information Science and Technology UniversityBeijing 100016China.

Terahertz (THz) wave manipulation, especially the beam deflection, plays an essential role in various applications, such as next-generation communication, space exploration, and high-resolution imaging. Current THz optical components and devices are hampered by their large bulk sizes and passive responses, limiting the development of high-performance, miniaturized THz microsystems. Tunable metasurfaces offer a powerful dynamic optical platform for controlling the propagation of electromagnetic waves. In this article, we presented a mechanically tunable metasurface (mTm), which can achieve terahertz beam deflection and vary the intensity of the anomalous reflected terahertz wave by changing the air gap between the metallic resonator (mR) array with phase discontinuities and Au ground plane. The absence of lossy spacer materials substantially enhances deflection efficiency. The device was fabricated by a combination of the surface and bulk-micromachining processes. The THz beam steering capability was characterized using terahertz time domain spectroscopy. When the air gap is 50 μm, the maximum deflection coefficient reaches 0.60 at 0.61 THz with a deflection angle of ~44.5°, consistent with theoretical predictions. We further established an electrically tunable miniaturized THz device for dynamic beam steering by introducing a micro voice coil motor to control the air gap continuously. It is shown that our designed mTm demonstrates a high modulation depth of deflection coefficient (~ 62.5%) in the target steered angle at the operating frequency. Our results showcase the potential of the proposed mTm as a platform for high-efficiency THz beam manipulation.

关键词： tunable Efficiency resonator

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Copper-Free Resin-Based Braking materials:A New Approach for Substituting Copper with Fly-Ash Cenospheres in Composites

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Chinese Journal of mechanical Engineering 2024年第2期37卷 401-412页

作者： Kaikui Zheng youxi Lin Shanmin you Zhiying Ren Jianmeng Huang School of mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China National United Engineering Laboratory for Advanced Bearing Tribology Henan University of Science and TechnologyLuoyang 471023China

Copper particles emitted from braking have become a significant source of environmental ***,copper plays a crucial role in resin-based braking *** high-performance braking materials without copper has become a significant *** this paper,the resin-based braking materials were filled with flyash cenospheres to develop copper-free braking *** effects of fly-ash cenospheres on the physical properties,mechanical and friction and wear properties of braking materials were ***,the wear mechanism of copper-free resin-based braking materials filled with fly-ash cenospheres was *** results indicate that the inclusion of fly-ash cenospheres in the braking materials improved their thermal stability,hardness and impact strength,reduced their density,effectively increased the friction coefficient at medium and high temperatures,and enhanced the heat-fade resistance of the braking *** inclusion of fly-ash cenospheres contributed to the formation of surface friction film during the friction process of the braking materials,and facilitated the transition of form from abrasive wear to adhesive *** 100-350℃,the friction coefficient of the optimal formulation is in the range of 0.57-0.61,and the wear rate is in the range(0.29-0.65)×10^(-7) cm^(3)·N^(-1)·m^(-1),demonstrating excellent resistance to heat-fade and stability in friction *** research proposes the use of fly-ash cenospheres as a substitute for environmentally harmful and expensive copper in brake materials,which not only improves the performance of braking materials but also reduces their costs.

关键词： Fly-ash cenospheres Braking materials Friction and wear Heat-fade resistance Wear form

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