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橡胶参考资料 1996年第2期26卷 20-27页

作者： S.Norzalia B.Surani m.y.ahmad fuad 樊玉燕

前言韧性往往是许多工程应用方面材料选择中的决定因素。塑料在工程和其它方面的用量不断增加,在小的程度上是由于过去三十年间既新又韧的塑料材料的开发。

关键词：聚丙烯橡胶增韧改性抗冲击性共混胶

Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach

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Animal models and Experimental medicine 2024年第1期7卷 36-47页

作者： Roa'a H.S.yosief Iqbal m.Lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks fuad A.Iraqi Department of Clinical microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael School of molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:We studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:Significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and Stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-Seq *** candidate genes from our study will be further assessed with a human cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-Seq

Arrhythmia Prediction on Optimal Features Obtained from the ECG as Images

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Computer Systems Science & Engineering 2023年第1期44卷 129-142页

作者： fuad A.m.Al-yarimi Department of Computer Science King Khalid UniversityAbhaKingdom of Saudi Arabia

A critical component of dealing with heart disease is real-time identifi-cation,which triggers rapid *** main challenge of real-time identification is illustrated here by the rare occurrence of cardiac *** contribu-tions to cardiac arrhythmia prediction using supervised learning approaches gen-erally involve the use of demographic features(electronic health records),signal features(electrocardiogram features as signals),and temporal *** the signal of the electrical activity of the heartbeat is very sensitive to differences between high and low heartbeats,it is possible to detect some of the irregularities in the early stages of *** paper describes the training of supervised learning using features obtained from electrocardiogram(ECG)image to correct the limitations of arrhythmia prediction by using demographic and electrocardio-graphic signal *** experimental study demonstrates the usefulness of the proposed Arrhythmia Prediction by Supervised Learning(APSL)method,whose features are obtained from the image formats of the electrocardiograms used as input.

关键词： ECG records electrocardiogram morphological features(mF) empirical mode decomposition algorithm HOS

Comparative Evaluation of Data mining Algorithms in Breast Cancer

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Computers, materials & Continua 2023年第10期77卷 633-645页

作者： fuad A.m.Al-yarimi Department of Computer Science King Khalid UniversityMuhayel AseerSaudi Arabia

Unchecked breast cell growth is one of the leading causes of death in women globally and is the cause of breast *** only method to avoid breast cancer-related deaths is through early detection and *** proper classification of malignancies is one of the most significant challenges in the medical *** to their high precision and accuracy,machine learning techniques are extensively employed for identifying and classifying various forms of *** data mining algorithms were studied and implemented by the author of this review and compared them to the present parameters and accuracy of various algorithms for breast cancer diagnosis such that clinicians might use them to accurately detect cancer cells early *** article introduces several techniques,including support vector machine(SVm),K star(K∗)classifier,Additive Regression(AR),Back Propagation Neural Network(BP),and *** algorithms are trained using a set of data that contains tumor parameters from breast cancer *** the results,the author found that Support Vector machine and Bagging had the highest precision and accuracy,***,assess the number of studies that provide machine learning techniques for breast cancer detection.

关键词： many-core multi-core N-conjugate shuffle multi-port content addressable memory interconnection network

Optimal Load Balancing in Cloud Environment of Virtual machines

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Computer Systems Science & Engineering 2022年第6期41卷 919-932页

作者： fuad A.m.Al-yarimi Sami Althahabi majdy mohammed Eltayeb Department of Computer Science King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia Department of Information System King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia

Cloud resource scheduling is gaining prominence with the increasingtrends of reliance on cloud infrastructure solutions. Numerous sets of cloudresource scheduling models were evident in the literature. Cloud resource scheduling refers to the distinct set of algorithms or programs the service providersengage to maintain the service level allocation for various resources over a virtualenvironment. The model proposed in this manuscript schedules resources of virtual machines under potential volatility aspects, which can be applied for anypriority metric chosen by the server administrators. Also, the model can be flexible for any time frame-based analysis of the load factor. The model discussed inthis manuscript relies on the Bollinger Bands tool for understanding the potentialvolatility aspects of a Virtual machine. The experimental study of the model compared to the contemporary load balancing model called STLB (Starvation Threshold-based Load Balancing) refers to a simple and potential model that can bemore pragmatic for sustainable ways of load balancing.

关键词： Cloud computing service level agreements virtual machines load balancing scheduling

Hydromagnetic peristaltic transport of copper-water nanofluid with temperature-dependent effective viscosity

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Particuology 2016年第4期14卷 133-140页

作者： Fahad m. Abbasi Tasawar Hayat Sabir A. Shehzad fuad Alsaadi Naif Altoaibi Department of mathematics COMSATS Institute of lnformation Technology Islamabad 44000 Pakistan Department of mathematics Quaid-l-Azam University 45320 Islamabad 44000 Pakistan Department of Electrical and Computer Engineering Faculty of Engineering King Abdulaziz University Jeddah Saudi Arabia Department of mathematics COMSATS Institute of Information Technology Sahiwal Pakistan

The unique chemical mechanical, and thermodynamic properties of nanofluids make them a subject of great interest for scientists from all domains. Such fluids are of particular significance in biomedical engineering owing to their vast and novel applications in modern drug delivery systems; for example, mixed convective peristaltic flow of water-based nanofluids under the influence of an externally applied magnetic field is of particular significance. Hence, a lot of research has focused on peristalsis in the presence of velocity and thermal slip effects. An empirical relation for the effective viscosity of the nanofluid is proposed here for the first time. The viscosity of the nanofluid varies with temperature and nanoparticle volume fraction. Numerical simulation of the resulting nonlinear system of equations is presented for different quantities of interest. The results indicate that the maximum velocity and temperature of the copper-water nanofluid increase for larger variable viscosity parameter. The pressure gradient in the wider part of the channel is also found to increase as a function of the variable viscosity parameter. The variable viscosity parameter also influences the size of the trapped bolus. An increase in the nanoparticle volume fraction reduces the reflux phenomenon in a peristaltic flow.

关键词： Temperature dependent effective viscosity Copper-water nanofluid Peristalsis Slip effect magnetohydrodynamics

Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

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Cancer Pathogenesis and Therapy 2024年第4期2卷 231-245页

作者： md.Liakot Ali Amdad Hossain Roky S.m.Asadul Karim Azad Abdul Halim Shaikat Jannatul Naima meem Emtiajul Hoque Abu mohammed fuad Ahasan mohammed murshedul Islam md.Saifur Rahaman Arif md.Saqline mostaq md.Zihad mahmud mohammad Nurul Amin mdAshiq mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyasha Health Biomedical Research Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh School of Basic Pharmaceutical and Toxicological Sciences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hospital Dhaka 1229Bangladesh

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing ***,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental *** duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic *** systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin *** outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin *** comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin *** of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in ***,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal ***,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关键词： Autophagy Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds

Ding w-Flat modules and Dimensions

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Algebra Colloquium 2018年第2期25卷 203-216页

作者： fuad Ali Ahmed Almahdi mohammed Tamekkante Department of mathematics Faculty of Sciences King Khalid University P. O. Box. 9004 Abha Saudi Arabia Laboratory mACS Faculty of Sciences University Moulay Ismail 5000 P.B. 11201 Zitoune Meknes Morocco

The introduction of w-operation in the class of flat modules has been successful. Let R be a ring. An R-module m is called a w-fiat module if Tor1r（m, N） is GV-torsion for all R-modules N. In this paper, we introduce the w-operation in Gorenstein homological algebra. An R-module m is called Ding w-flat if there exists an exact sequence of projective R-modules ... → P1 → P0 → p0 → p1 → ... such that m Im（P0 → p0） and such that the functor HomR （-,F） leaves the sequence exact whenever F is w-flat. Several well- known classes of rings are characterized in terms of Ding w-flat modules. Some examples are given to show that Ding w-flat modules lie strictly between projective modules and Gorenstein projective modules. The Ding w-flat dimension （of modules and rings） and the existence of Ding w-flat precovers are also studied.

关键词： w-fiat module and dimension Gorenstein projective module and dimension,strongly Gorenstein flat module

Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model,cellular platform,and clinical human data

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Animal models and Experimental medicine 2023年第6期6卷 537-558页

作者： Osayd Zohud Iqbal m.Lone Aysar Nashef fuad A.Iraqi Department of Clinical microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael Department of Oral and maxillofacial Surgery Baruch Padeh Medical CenterPoriyaIsrael Azrieli Faculty of medicine Bar-Ilan UniversityRamat GanIsrael

Head and neck squamous cell cancer(HNSCC)is a leading global *** year,more than 830000 people are diagnosed with HNSCC globally,with more than 430000 *** is a deadly diverse malignancy with many tumor locations and biological *** originates from the squamous epithelium of the oral cavity,oropharynx,nasopharynx,larynx,and *** most frequently impacted regions are the tongue and *** investigations have demonstrated the critical role of host genetic susceptibility in the progression of *** the advances in our knowledge,the improved survival rate of HNSCC patients over the last 40 years has been *** to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic *** results indicate a need to identify more genetic factors underlying this complex disease,which can be better used in early detection and prevention *** lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC *** this report,we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes(*** 4 and P53 genes)to identify genetic factors affecting the development of this complex disease using genome-wide association studies,epigenetics,micro RNA,long noncoding RNA,lnc RNA,histone modifications,methylation,phosphorylation,and proteomics.

关键词： animal models Collaborative Cross mice genomics head and neck squamous cell cancinoma host genetic susceptibility

management of nonalcoholic fatty liver disease in the middle East

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World Journal of Gastroenterology 2020年第25期26卷 3528-3541页

作者： Faisal m Sanai Faisal Abaalkhail fuad Hasan muhammad Hamed Farooqi Nawal Al Nahdi Zobair m younossi Gastroenterology Unit Department of MedicineKing Abdulaziz Medical CityJeddah 21423Saudi Arabia Department of medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Liver Transplant King Fahad Specialist HospitalDammam 32253Saudi Arabia Department of Internal medicine Faculty of MedicineKuwait UniversitySafat 13110Kuwait Dubai Diabetes Center Dubai Health AuthorityDubai 00000United Arab Emirates Department of Gastroenterology and Hepatology Dubai Health AuthorityRashid hospitalDubai 00000United Arab Emirates Department of medicine Inova Fairfax Medical CampusFalls ChurchVA 22042United States

The prevalence of nonalcoholic fatty liver disease(NAFLD)in the middle East is increasing in parallel to an increase in the prevalence of associated risk factors such as obesity,metabolic syndrome,and type 2 diabetes *** 20%to 30%of the patients progress to develop nonalcoholic steatohepatitis(NASH),a histological subtype of NAFLD,with features of hepatocyte injury such as hepatocyte *** can progress to fibrosis,cirrhosis,and even hepatocellular *** thus causes a substantial burden on healthcare systems and it is imperative that appropriate strategies are discussed at a regional level to facilitate effective management tailored to the needs of the *** fulfil this unmet need,expert gastroenterologists,hepatologists,and endocrinologists from the region came together in three advisory board meetings that were conducted in Saudi Arabia,United Arab Emirates,and Kuwait,to discuss current local challenges in NAFLD screening and diagnosis,and the different available management *** experts discussed the disease burden of NAFLD/NASH in the middle East;screening,diagnosis,and referral patterns in NAFLD;and available treatment options for NAFLD and *** paper summarizes the discussions and opinion of the expert panel on the management of NAFLD/NASH and also presents an extensive literature review on the topic.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis middle East Expert opinion