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Animal Diseases 2024年第3期4卷 224-230页

作者： Claire A.vázquez‑manzanilla maría F.Cárdenas‑marrufo Eduardo Gutiérrez‑Blanco matilde Jiménez‑Coello Nelly R.Pech‑Sosa Antonio Ortega‑Pacheco Departamento de Salud Animal y medicina Preventiva Facultad de Medicina Veterinaria y ZootecniaCampus de Ciencias Biológicas y AgropecuariasUniversidad Autónoma de YucatánMéridaYucatán 97100México Unidad Interinstitucional de Investigación Clínica y Epidemiológica Facultad de MedicinaUniversidad Autónoma de YucatánMéridaYucatán 97000México

Chronic kidney disease is commonly diagnosed in dogs,and clinical signs may be aggravated when infected agents are *** this case report,33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp.,Ehrlichia canis,and Anaplasma *** seroprevalence for Leptospira *** 39.4%.The most frequent serovars found were Pyrogenes,Canicola,Bratislava and Australis,with serological titers between 1:100 to 1:*** signs included fever,depression,decreased body condition,vomiting and hema‑*** laboratory fndings were anemia,leukocytosis,thrombocytopenia,increased liver enzymes,urea and creatinine,hyperbilirubinemia and *** leptospira seronegative dogs were positive for one or both monitored homoparasites(i.e.,*** and ***);only three leptospira seropositive dogs were positive for one or both *** also suggest that endemic hemoparasites of dogs should be moni‑tored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.

关键词： Anaplasma Chronic kidney disease Dog Ehrlichia Leptospira

Interindividual Age-Independent Differences in Human CX43 Impact ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-mendívil maría Pérez-Zabalza Antoni Oliver-Gelabert Josémaría vallejo-Gil Javier Fañanás-mastral manuel vázquez-Sancho Javier AndréBellido-morales Alexánder Sebastián vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental medicine and Biology of Cuyo(ImBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Geochemistry and mineralogy of beach sediments in the northern Gulf of mexico,Tamaulipas state,mexico:implication for provenance

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Journal of Palaeogeography 2024年第3期13卷 375-400页

作者： mayank Shukla Sanjeet K.verma mayla A.Ramos-vázquez John S.Armstrong-Altrin Karla R.Hernández-martínez Sumit mishra vivek P.malviya Héctor Hernández-mendoza Posgrado de la Division de Geociencias Aplicadas Instituto Potosino de Investigacion Científica y Tecnologica(IPICYT)Camino a la Presa San José2055San Luis Potosí78216Mexico Division de Geociencias Aplicadas Instituto Potosino de Investigación Científica y Tecnologica(IPICYT)Camino a la Presa San Jose 2055San Luis Potosí78216Mexico Universidad Nacional Autonoma de méxico Instituto de Ciencias del Mar y LimnologíaUnidad de ProcesosOceanicos y CosterosCiudad UniversitariaCiudad de México 04510Mexico Department of marine Sciences Bharathidasan UniversityTiruchirappalli620024Tamil NaduIndia Instituto de Geociencias Universidad Nacional Autonoma de MéxicoBoulevard Juriquilla 300176230JuriquillaQueretaroMexico Department of Applied Geology Dr.Harisingh Gour Central UniversitySagar470002Madhya PradeshIndia Instituto de Investigacion de Zonas Desérticas Universidad Autònoma de San Luis PotosíAltair 200CP 78377San LuisS.L.P.Mexico Universidad del Centro de mexico Capitán Caldera 75CP 78250San LuisS.L.P.Mexico

Geochemical and mineralogical studies were performed in the La Pesca(LP)and Tesoro Altamira(TA)beach sediments,located in the Tamaulipas state,northern Gulf of *** main aim of this study is to infer the weathering history and provenance and to discriminate the tectonic environment of the beach *** sediments are composed of quartz with small amounts of accessory minerals such as plagioclase,calcite,orthoclase,microcline,and *** beach sediments are classified as fine-grained and very well sorted,however LP has coarse skewed and leptokurtic sediments,whereas TA has fine-skewed and very leptokurtic *** chemical index of weathering(CIW’)indicates intense weathering in the source *** quartz grain microtextures in the LP and TA are classified into mechanical,chemical,and mechanical/chemical *** features such as fractures,pits,percussion marks,abrasion fatigue,and v-shaped marks favor high-energy littoral,fluvial,subaqueous-marine,and aeolian *** chemical features indicate solution pits and crystalline overgrowth,which suggests a silica saturated marine *** mechanical/chemical features display adhering particles and elongated depressions suggest formation in a sub-aqueous nearshore marine *** and trace elements-based provenance discrimination diagrams indicate a felsic source derived from the mesa Central(mC),Sierra madre Oriental(SmOr)and Oaxaquia *** major and trace element concentrations imply a passive margin setting for the northern Gulf of mexico,which is consistent with the general geology.

关键词： Beach sediments Geochemistry mineralogy Provenance Tamaulipas Tectonic setting

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Solar-assisted photocatalytic water splitting using defective UiO-66 solids from modulated synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia m.Rueda-Navarro maría Cabrero-Antonino Paula Escamilla valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer Ignacio vayá Guillaume maurin Herme G.Baldoví Sergio Navalón Departamento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia molecular(ICmOL) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPv-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

metal-organic frameworks(mOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from *** paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic modulators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) was the most active photocatalyst,followed by UiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-NH_(2) solid was more active than the parent mOF in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous *** on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(Uv-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photoluminescence and photoelectrochemical measurements together with density functional theory(DFT)*** results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker UiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(mOFs) UiO-66 materials carboxylic acid modulators water splitting solar light

vegetation Response To Soil And morphological Properties In An Arid Region Alluvial Fan Landscape. Pre-Andes Of San Juan， Argentina

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Journal of Earth Science 2024年

作者： FLORES Daniel Germán OCA?A Raúl Emmanuel mELIáN Edgardo ORTEG Andrés ESPER ANGILLIERI maría Yanina PITTALUGA maría Alejandra CIGEOBIO (CONICET-UNSJ) Av.José I.de la Roza y meglioli Gabinete de Geología Ambiental， INGEO， Universidad Nacional de San Juan， Av.José I.de la Roza y meglioli

The monte Desert is characterized by a great diversity of landforms created with fluvial， alluvial which the vegetation patterns are related to. The present work has the following objectives: 1: determine whether topographical attributes， surface characteristics， soil properties and vegetation patterns vary between alluvial landforms， and 2: define whether morphometric， soil and surface properties influence vegetation patterns along alluvial landscape. morphometric data were obtained by processing a 5 m digital elevation model. The coverage of rock fragments， fine sediments and mulch was quantified. Observations and descriptions of the soil profiles were restricted to the uppermost 50 cm. vegetation properties were calculated using a Point Quadrat method. The relationship between variables was evaluated through multivariate statistical analysis. The main results show the presence of 45 plant species distributed in 19 families， where shrubs are dominant. The wind effect， topographic wetness and dissection of the landscape are limiting factors of diversity. The coverage of superficial rock fragments influence vegetation coverage through the distribution and availability of rainwater. Furthermore， the different soil textures reveal that the silt content favors an increase in vegetation coverage. The presence of v horizon could condition the installation and development of vegetation in the early stages of growth.

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Pharmacodynamic Study of Parallel Groups Comparing the Effect of Rivaroxaban 20 mg (Laboratorios Leti, S.A.v.) vs Rivaroxaban 20 mg (Bayer Laboratories) on Prothrombin Time

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International Journal of Clinical medicine 2024年第3期15卷 123-133页

作者： Elsy Rodriguez de Roa maría Gonzalez Yibirin David Rincón matute Carolina Aguilera Centro médico Uslar Distrito Capital Caracas Venezuela Investigación Clínica Grupo Leti Guarenas Venezuela

Background: The prevalence of both atrial fibrillation (FA) and diabetes mellitus (Dm) is increasing and they often occur together and constitute a high risk of thrombosis. Rivaroxaban is a Factor Xa inhibitor with a rapid onset and disappearance of action after oral administration;it acts by inhibiting the active form of the coagulation factor. In order to reflect the effect of the action of Rivaroxaban, we used the prothrombin time (PT);however, it′s not the most accurate, but it is the one available in our community. methods: This was a prospective, randomized, analyst-blinded, parallel group clinical study to verify the efficacy of Rivaroxaban Leti 20 mg (RL) (12 volunteers vs Rivaroxaban Bayer 20 mg (RB) (13 volunteers). The variables were determination of PT and Partial Thromboplastin Time (aPTT) at baseline and at 24, 48 and 72 hours after administering a daily dose of 20 mg for three days. The determination was carried out with the IDG method (Integrated Diagnostics Group Sanzay Corporation) with an International Sensitivity Index (ISI) of 1.17 PT and aPTT were taken before the first dose, and then, every day during the next 3 days, three hours after the ingestion of their daily dose at 7 am. Results: The 25 healthy volunteers were similar in age, BmI, and SBP/DBP level with a greater number of men in the Bayer group. The efficacy of rivaroxaban was similar in both groups with prolongation of PTT to the 2nd day of treatment with PT, and percentage changes from baseline (14.46 ± 0.97 for RB vs 14.17 ± 0.94 RL p: 0.45), PTT results and percentage changes from the base (RB: 34 ± 4.53 RL: 33.46 ± 2.82). The safety of rivaroxaban was good in both groups with no serious adverse events. The equivalence in the logarithmically transformed PT result (ln) on day two, mean and CI (90%) 99.2 (94.4-104) and 100 (99.5-100.8);neither the means nor the 90% confidence intervals of the PT variable transformed logarithmically to ensure its normality, were far from the 80%-125%

关键词： Pharmacodynamic Study Rivaroxaban Clinical Trial PT aPTT

Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate

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Journal of Integrative Agriculture 2015年第1期14卷 131-139页

作者： Abdelfattah Z m Salem German Buendía-Rodríguez mona m m Elghandour maría A mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C v Chagoyán maría A Cerrillo miguel A Rodríguez Faculty of veterinary medicine and Animal Science Autonomous University of the State of Mexico National Center of Disciplinary Research in Animal Physiology and Improvement INIFAP Ajuchitlán Institute of Agricultural Sciences Autonomous University of HidalgoEx-Hda. of Aquetzalpa Faculty of veterinary medicine and Animal Science Juárez University of the Durango State

An in vitro gas production （GP） technique was used to investigate the effects of combining different doses of Salix babylonica extract （SB） with exogenous fibrolytic enzymes （EZ） based on xylanase （X） and cellulase （C）, or their mixture （XC; 1：1 v/v） on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture （50：50, w/w） as substrate. Four levels of SB （0, 0.6, 1.2 and 1.8 mL g-1 dry matter （Dm）） and four supplemental styles of EZ （1 μL g-1 Dm; control （no enzymes）, X, C and XC （1：1, v/v） were used in a 4×4 factorial arrangement. In vitro GP （mL g-1 Dm） were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant pH was determined, and then filtered to determine dry matter degradability （DmD）. Fermentation parameters, such as the 24 h gas yield （GY24）, in vitro organic matter digestibility （OmD）, metabolizable energy （mE）, short chain fatty acid concentrations （SCFA）, and microbial crude protein production （mCP） were also estimated. Results indicated that there was a SBxEZ interaction （P〈0.0001） for the asymptotic gas production （b）, the rate of gas production （c）, GP from 6 to 72 h, GP2 （P=0.0095）, and GP4 （P=0.02）. The SB and different combination of enzymes supplementation influenced （P〈0.001） in vitro GP parameters after 12 h of incubation; the highest doses of SB （i.e., 1.8 mL g-1 Dm）, in the absence of any EZ, quadratically increased （P〈0.05） the initial delay before GP begins （L） and GP at different incubation times, with lowering b （quadratic effect, P〈0.0001 ） and c （quadratic effect, P〈0.0001 ; linear effect, P=0.0018）. The GP was the lowest （P〈0.05） when the highest SB level was combined with cellulose. There were SBxEZ interactions （P〈0.001） for OmD, mE, the partitioning factor at 72 h of incubation （PF72）, GY24, SCFA, mCP （P=0.0143）, and pH （P=0.0008）. The OmD, mE, GY24 and SCFA with supplementation of SB extract at 1.8 mL g-1 Dm were h

关键词： cellulase degradability gas production Salix babylonica xylanase

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Geochemical Characterization of Soils in the Playa Lake Environment of Laguna de Encinillas, Chihuahua, mexico

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Open Journal of Geology 2024年第9期14卷 900-918页

作者： maría Fernanda Ponce-González Alejandro villalobos-Aragón vanessa verónica Espejel-García Daphne Espejel-García Facultad de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

Laguna de Encinillas, located in Chihuahua, mexico, is an ephemeral lake situated within a playa lake sedimentary depositional environment. This region plays a significant role in the aquifer supplying water to Chihuahua City. A surficial soil sampling campaign was conducted in 2017, 2018, and 2021 to assess the potential impact of surface soil composition on groundwater quality. The collected soil samples were analyzed using inductively coupled plasma mass spectrometry (ICP-mS) following microwave-assisted digestion. The analytical results were employed to generate spatial distribution maps of elemental concentrations using QGIS, applying interpolation methods such as inverse distance weighting (IDW) and Kriging. The analysis revealed elevated concentrations of beryllium (Be), calcium (Ca), cadmium (Cd), chromium (Cr), magnesium (mg), and strontium (Sr) in the eastern part of the study area. In contrast, arsenic (As) and iron (Fe) were more prevalent in the western sector. Notably, high levels of barium (Ba), silver (Ag), cobalt (Co), potassium (K), and scandium (Sc) were identified in the northeastern region. At the same time, nickel (Ni), titanium (Ti), and vanadium (v) were concentrated in the northern portion. manganese (mn) was particularly prominent in the southern area. The geogenic source of these elements is likely linked to the volcanic rocks from the surrounding mountain ranges.

关键词： Groundwater Quality Soils El Sauz-Encinillas Aquifer Chihuahua GIS

Promotion of structural plasticity in area v2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato mariam masmudi-martín manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinforiano Posadas maría E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area v2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORm),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area v2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORm in young animals and prevent ORm deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORm *** findings suggest that BDNF-mediated neuronal structural plasticity in area v2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area v2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Suitable conditions for natural regeneration in variable retention harvesting of southern Patagonian Nothofagus pumilio forests

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Ecological Processes 2019年第1期8卷 240-251页

作者： mónica D.R.Toro manríquez Juan m.Cellini maría v.Lencinas Pablo L.Peri Karen A.Peña Rojas Guillermo J.martínez Pastur Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Laboratorio de Investigaciones en maderas(LImAD) Universidad Nacional de la Plata(UNLP)Diagonal 113 n°469(1904)La PlataBuenos AiresArgentina Instituto Nacional de Tecnología Agropecuaria(INTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)cc 332(9400)Río GallegosSanta CruzArgentina Departamento de Silvicultura y Conservación de la Naturaleza Facultad de Ciencias Forestales y de Conservación de la NaturalezaUniversidad de Chilecc 9206SantiagoChile.

Background:variable retention(aggregated and dispersed retention)harvesting proposed for Nothofagus pumilio was designed for timber purposes and biodiversity *** by opening canopy generates different microenvironments and creates contrasting conditions for seedling establishment,growth,and eco-physiology performance due to synergies(positives or negatives)with biotic and abiotic *** study evaluated the regeneration in different microenvironment conditions within managed stands during 5 years after *** forest structure after harvesting and different microenvironments were characterized in managed stands,where 105 regeneration plots were measured(3 stands×7 microenvironments×5 replicas).We characterized the seedling bank,as well as growth and ecophysiology performance of the *** and multivariate analyses were conducted for the ***:microenvironments offered different environmental conditions for natural regeneration(soil moisture and light availability).Seedling under debris and dicot plants showed better eco-physiological performance,establishment,and growth than plants growing under monocots or located in the dispersed retention without the protection of other understory *** most unfavorable microenvironment conditions were high canopy cover of remnant trees(inside the aggregates or close to trees in the dispersed retention)and heavily impacted areas(skidder extraction roads).Conclusions:Favorable microenvironments in the harvested areas will improve the natural recruitment,growth,and eco-physiology performance of the natural regeneration after *** is necessary to develop new silvicultural practices that decrease the unfavorable microenvironments(e.g.,road density or excessive woody accumulation),to assure the success of the proposed silvicultural method.

关键词： Aggregated retention Dispersed retention microenvironments Environmental variables Biometric values Biomass allocation Eco-physiology