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Helicobacter pylori and gastric cancer: current status of the Austrian-Czech-German gastric cancer prevention trial (PRISmA-Study)

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World Journal of Gastroenterology 2001年第2期7卷 243-247页

作者： S.miehlke C.Kirsch B.Dragosics m.Gschwantler G.Oberhuber D.Antos P.Dite J.Lauter J.Labenz A.Leodolter P.malfertheiner A.Neubauer G.Ehninger m.stolte E.Bayerdorffer medical Department I GastroenterologyHematologyOncologyPulmonology & Infectious DiseasesTechnical University Hospital Carl Gustav CarusDresdenGermany Gesundheitszentrum Süd ViennaAustria medical Department 4 Krankenanstalt RudolfstiftungViennaAustria Institute for Pathology General HospitalViennaAustria Surgical Department Ludwig-Maximilians-University Hospital GroβhadernMunichGermany Univerzitni nemocnice Jihlavska Brno-BohuniceCzech Republic Institute for medical Statistics Otto-von-Guericke-UniversityMagdeburgGermany Department of medicine Evang. Jung-Stilling HospitalSiegenGermany Department of Gastroenterology Otto-v.-Guericke University HospitalMagdeburgGermany Department for Hematology Oncology&ImmunologyUniversity Hospital MarburgGermany Institute of Pathology Klinikum BayreuthBayreuthGermany

AIm To test the hypothesis that Helicobacter pylori eradication alone can reduce the incidence of gastric cancer in a subgroup of individuals with an increased risk for this fatal *** It is a prospective, randomized,double-blind, placebo-controlled multinational multicenter trial. men between 55 and 65 years of age with a gastric cancer phenotype of Helicobacterpylori gastritis are randomized to receive a 7-day course of omeprazole 2 × 20 mg,clarithromycin 2 × 500 mg, and amoxicillin 2 ×lg for 7 days, or omeprazole2 × 20mg plusplacebo. Follow - up endoscopy is scheduled 3months after therapy, and thereafter in one-year intervals. Predefined study endpoints are gastric cancer, precancerous lesions (dysplasia, adenoma), other cancers, *** Since march 1998, 1524 target patients have been screened, 279 patients (18.3%) had a corpus-dominant type of *** gastritis, and 167 of those were randomized (58.8%). In the active treatment group (n -- 86), H. pylori infection infection was cured in 88.9% of patients. Currently, thecumulative follow-up time is 3046 months (253.8patient-years, median follow-up 16 months). So far, none of the patients developed gastric cancer or any precancerous lesion. Three(1.8%) patients reached study endpoints other than gastric *** Among men between 55 and 65years of age, the gastric cancer phenotype of *** gastritis appears to be more common than expected. Further follow- up and continuing recruitment are necessary to fulfil the main aim of the study.

关键词： Helicobacter pylori Helicobacter infections/complications Helicobacter infections/drug therapy stomach neoplasms /microbiology stomach neoplasms/drug therapy gastritis/microbiology gastritis/drug therapy

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Barrett食管诊断状况的探讨——经组织学诊断1000例分析

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德国医学 1998年第2期15卷 88-89页

作者： m.Grunewald m.Vieth H.Kreibich B.Bethke m.stolte 程斌 Institut für Pathologie Klinikum BayreuthPreuschwitzer Str.101D-95445 BayreuthGermany 同济医科大学附属同济医院

在世界上许多发达国家随着胃食管返流性疾病的逐步增加,Barrett食管与Barrett癌的发病率亦有增加。Barrett食管的内镜与组织学诊断、Barrett发育不良与Barrett早期癌变在将来亦显得越来越重要。人们期望做到,在返流性疾病中尽早发现Bar-... 详细信息

在世界上许多发达国家随着胃食管返流性疾病的逐步增加,Barrett食管与Barrett癌的发病率亦有增加。Barrett食管的内镜与组织学诊断、Barrett发育不良与Barrett早期癌变在将来亦显得越来越重要。人们期望做到,在返流性疾病中尽早发现Bar-rett食管的进展,并进行合理的内镜活检检查,以发现在Barrett粘膜上发展而来的新生物形成、发育不良与早期癌变。

关键词：食管疾病 Barrett食管诊断食管肿瘤

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Hydrological Responses and Flow Pathways in an Acrisol on a Forested Hillslope with a monsoonal Subtropical Climate

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Pedosphere 2017年第6期27卷 1037-1048页

作者： Lars-Erik SORBOTTEN Jannes stolte WANG Yanhui Jan mULDER Norconsult AS N-1338 Sandvika(Norway) Norwegian Institute of Bioeconomy Research(NIBIO) N-1430 Aas(Norway) Research Institute of Forest Ecology Environment and ProtectionChinese Academy of ForestryBeijing 100091(China) Department of Environmental Sciences Norwegian University of Life SciencesN-1432 Aas(Norway)

The nature of subsurface flow depends largely on hydraulic conductivity of the vadoze zone, permeability of the underlying bedrock, existence of soil layers differing in hydraulic properties and macropore content, soil depth, and slope *** of flow pathways on forested hillslopes is essential to understand hydrological dynamics and solute transport ***, with their argic Bt horizons, are challenging in this *** further elucidate flow pathways of water and short-term variability of soil moisture patterns in Acrisols, a field study was conducted on a forested hillslope in a sub-catchment of the Tie Shan Ping(TSP)watershed, 25 km northeast of Chongqing City, *** catchment is covered by a mixed secondary forest dominated by masson pine(Pinus massoniana).Soil saturated hydraulic conductivity(K sat) was significantly reduced at the interface between the AB and Bt horizons(2.6 × 10^(-5) vs.1.2 × 10^(-6) m s^(-1)), which led to that the flow volume generated in the Bt horizon was of little quantitative importance compared to that in the AB *** was a marked decrease in porosity between the OA and AB horizons, with a further decrease deeper in the mineral ***, the content of soil pores > 300 μm was higher in the AB horizon(14.3%)than in the Bt horizon(6.5%).This explained the difference in soil K sat *** study showed that Bt horizon had limited water transport capability, forcing part of the infiltrated rainwater as interflow through the OA and AB ***, the topsoil responded quickly to rainfall events, causing frequent cycles of saturation and aeration of soil pores.

关键词： dye tracer hillslope hydrology hydraulic conductivity preferential flow soil pores subsurface lateral flow

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溃疡性结肠炎的肠道散发性腺瘤:内镜下切除是一种有效的治疗手段

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 43-44页

作者： Vieth m. Behrens H. stolte m. 王铮 Institut für Pathologie Klinikum Bayreuth GmbHPreuschwitzer Str 101D-95445 BayreuthGermany Prof.

Background and aims:In studies with small numbers of cases,it has been shown that endoscopic resection of adenomas in ulcerative colitis represents adequate *** a larger study cohort with more prolonged follow up,we assessed the reliability of this ***:Between 1988 and 2002,148 consecutive patients,mainly from private gastroenterologists’ practices,with ulcerative colitis were diagnosed as having an *** 60 patients,histological diagnosis was established in biopsies and in 87 patients in polypectomy specimens;one patient underwent proctocolectomy following *** outcome of these patients was analysed after a mean follow up period of 6.0(3.63) ***:Among 60 patients,surprisingly without endoscopic treatment,48.3% developed ulcerative colitis associated neoplasia in the same colon segment(23.3% low grade intraepithelial neoplasia;8.3% high grade intraepithelial neoplasia;16.7% carcinoma) .Among 87 patients undergoing polypectomy of the adenoma,follow up revealed colitis associated neoplasia in other segments of colon in 4.6% of ***:Development of adenocarcinomas in a total of 6.7% of the overall patient group,and in 2.3% of those undergoing polypectomy,indicates that biopsy based diagnosis of an adenoma in ulcerative colitis must be considered to mandate endoscopic resection of the lesion;40% of affected patients did not receive any form of endoscopic removal of the *** shows that the most recent guidelines are not followed in a considerable number of patients with ulcerative colitis in private practice in *** polypectomy of the adenoma represents adequate therapy,further regular follow up examinations are nevertheless necessary.

关键词：溃疡性结肠炎性腺瘤镜下切除结肠直肠切除术上皮内瘤腺瘤切除内镜检查肿瘤形成胃肠病组织

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评估高清晰放大内镜诊断Barrett食管肠化生及异常增生的敏感性、观察者间及观察者自身判定结果的差异性

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 60-61页

作者： mayinger B. Oezturk Y. stolte m. 张欣 Department medicine II Krankenhaus München-PasingSteinerweg 5DE-81241 MunichGermany Dr.

*** endoscopy with acetic acid or dye for diagnosis of Barrett’s esophagus is presently undergoing clinical *** studies report good accuracy in predicting specialized intestinal *** date,however,there is no definitive information on the inter-and intra-observer variability of these methods applied to the diagnosis of normal and dysplastic Barrett’s *** and *** patients with endoscopically suspected Barrett’s esophagus were investigated prospectively with the zoom endoscope after contrast enhancement of the mucosa with 1.5%acetic *** hundred and twenty-three enlarged and histologically investigated areas of gastric,cardiac,normal and dysplastic Barrett’s mucosa were photodocumented and in randomized sequence presented to 4 endoscopists in a blinded manner(2 with and 2 without experience of zoom endoscopy for evaluation).The reference for the first evaluation(A1)was standard endoscopic photographs of the respective,histologically confirmed mucosal *** a second evaluation(A2),the pictures were again interpreted by the same blinded investigators,but this time a modified pit-pattern classification as proposed by Sharma et *** employed as the evaluation *** diagnostic sensitivity for specialized intestinal metaplasia and dysplasia in Barrett’s esophagus calculated for the A1 evaluation ranged-investigator dependently-from 54.9%to 80.7%and for A2 from 42.2%to 81.5%.The inter-and intra-observer variability for the evaluation procedure A1 and A2 was high(all kappa values monstrated high intra-observer variability and low sensitivity in comparison with the experienced *** diagnosis of Barrett’s mucosa using enhanced magnification endoscopy after acetic acid instillation is associated with a high level of interobserver *** reason is a frequent mismatch between cardiac mucosa and non-dyspl

关键词： Barrett食管诊断特异性诊断敏感性异常增生内镜诊断肠化生评估自身

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