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自身免疫性胰腺炎:病程演变、分期、疗效评估及可预测对类固醇激素治疗疗效的CT特征

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国际医学放射学杂志 2009年第2期32卷 178-178页

作者： D.V.sahani N.I.sainani V.Deshpande m.s.shaikh D.L.Frinkelberg C.F.Castillo 范丽 Department of Radiology Massachusetts General Hospital-Harvard Medical School

目的通过CT评价自身免疫性胰腺炎（AIP）形态学特征的演变，确定可预测类固醇激素治疗（CsT）效果的影像学特征。方法此符合HIPAA法案的回顾性研究经审查委员会批准。在一组63例AIP病人中，将治疗前进行CT检查的15例（男性12例，女... 详细信息

目的通过CT评价自身免疫性胰腺炎（AIP）形态学特征的演变，确定可预测类固醇激素治疗（CsT）效果的影像学特征。方法此符合HIPAA法案的回顾性研究经审查委员会批准。在一组63例AIP病人中，将治疗前进行CT检查的15例（男性12例，女性3例；平均年龄64．7岁，范围30～84岁）病人纳入研究，通过分析胰腺、胰周和胰管的变化来评价病程演变。

关键词：自身免疫性胰腺炎类固醇激素病程演变 CT特征治疗疗效疗效评估预测形态学特征

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Wavelet Decomposition Impacts on Traditional Forecasting Time series models

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Computer modeling in Engineering & sciences 2022年第3期130卷 1517-1532页

作者： W.A.shaikh s.F.shah s.m.Pandhiani m.A.solangi Department of mathematics and statistics Quaid-e-Awam University of EngineeringScience&TechnologyNawabshahSindhPakistan Department of Basic sciences&Related studies Mehran University of Engineering&TechnologyJamshoroSindhPakistan Department of General studies Jubail University CollegeAl JubailSaudi Arabia

This investigative study is focused on the impact of wavelet on traditional forecasting time-series models,which significantly shows the usage of wavelet *** Decomposition(WD)algorithm has been combined with various traditional forecasting time-series models,such as Least square support Vector machine(LssVm),Artificial Neural Network(ANN)and multivariate Adaptive Regression splines(mARs)and their effects are examined in terms of the statistical *** WD has been used as a mathematical application in traditional forecast modelling to collect periodically measured parameters,which has yielded tremendous constructive ***,it is observed that the wavelet combined models are classy compared to the various time series models in terms of performance ***,combining wavelet forecasting models has yielded much better results.

关键词： Impact wavelet decomposition combined traditional forecasting models statistical analysis

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina silvera-simón manel m.santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Experimental studies and artificial neural network modeling of surface tension of aqueous sodium L-prolinate solutions and piperazine blends

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1904-1911页

作者： muhammad shuaib shaikh A.m.shariff m.A.Bustam sahil Garg Khadija Qureshi Pervez Hameed shaikh Inamullah Bhatti Department of Chemical Engineering Mehran University of Engineering&Technology JamshoroSindh 76062Pakistan CO2 Research Centre(CO2REs) Universiti Teknologi PETRONASBandar Seri Iskandar 32610PerakMalaysia school of Chemical Engineering The University of QueenslandSt Lucia 4072Australia Office of Research Innovation and Commercialization(ORIC) Mehran University of Engineering&Technology JamshoroSindh 76062Pakistan

The surface tension study is very crucial for the design of CO2 gas absorption contacting equipment. The significance of the surface tension has been increasing due to its consideration in various technological fields. This property influences the mass transfer and hydrodynamics of gas absorption systems, mainly multiphase systems, in which the interface between gas and liquid exists. Therefore, in this study, surface tension of aqueous solutions of sodium L-prolinate(sP) and piperazine(PZ) blends were measured at ten different temperatures from(298.15 to 343.15) K. The sP mass fractions were 0.10, 0.20, and 0.30;while the mass fractions of PZ were 0.02 and 0.05. The experimental results showed that the surface tension increase with increasing the mass fractions of sP and PZ in aqueous blends, and decrease linearly with rising temperature. The experimental data of surface tension were correlated by two empirical correlations as a function of temperature and mass fractions for estimating the predicted data using the optimized correlation coefficients. moreover, the modeling of surface tension data was carried out using Artificial Neural Network(ANN) approach. The results obtianed from ANN modeling were compared with applied empirical correlation. It was found that the ANN approach outperformed the empirical correlation used in this study. Besides, a quantitative analysis of variation(ANOVA) was performed in order to determine the significance of data. The surface tension of aqueous sP and sP + PZ was also compared with various conventional solvents.

关键词： surface tension L-Prolinate Piperazine Correlation Prediction Neural network

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.s.Almutairi Jie ma Aisling stewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-sJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

Impact of long term uplift on stream networks in tectonically active Northern Hill Range, Kachchh palaeo-rift basin, western India

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Journal of mountain science 2021年第6期18卷 1609-1629页

作者： Akash PADmALAL Deepak m mAURYA Naimisha P VANIK mohamedharoon A shaikh Prabhuti TIWARI Laxman s CHAmYAL Department of Geology The Maharaja Sayajirao University of BarodaVadodara 390002GujaratIndia

The study deals with stream response to sustained tectonic during the Cenozoic and development of two parallel scarps in the western Kachchh. The study encompasses fluvial networks developed over the Jara and Jumara domes, which are a part of the laterally extensive belt of flexures bounded by the Kachchh mainland Fault(KmF) to their north and called as Northern Hill Range(NHR). Parameters such as longitudinal profile, Hack profile, stream length gradient index(sL), hypsometric curve, hypsometric integral(HI), valley floor width to height ratio(Vf), elongation ratio(Re) and escarpment sinuosity(Es) were analysed. Hack profiles of the major rivers draining through the area show similar convex up nature suggesting primary influence of the tectonics in controlling and shaping the landscape of the region. Elongation ratio sion indicated by the low values of hypsometric integral suggest the tendency of river systems to increase the basin area longitudinally rather than laterally. The study suggests that higher net uplift in the eastern half(Jumara dome) caused the rivers to overcome the structural control and to carve out generally straight north oriented channels. The rivers of western part(Jara dome) show more prominent structural control of cuesta girdles formed in compact lithologies and attributed to the domal structure. The ~10 km long Jaramara scarp believed to the remnant of older KmF scarp, is a product of headward erosion of the fluvial channels through different hard and soft litho-units of the area. The similar orientation of Jaramara scarp and morphology of the Ukra intrusive body suggests that the Ukra intrusive played a significant role in controlling the formation and morphology of the Jaramara scarp.

关键词： Fluvial geomorphology Landscape evolution Kachchh paleo-rift basin Kachchh mainland Fault Tectonic uplift scarp evolution

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission