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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques

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Journal of Pharmaceutical Analysis 2019年第6期9卷 437-448页

作者： Kumar Padmapriya Ritu barthwal Department of Biotechnology Indian Institute of Technology Roorkee

Coralyne is an important alkaloid due to its anti-cancer and other medicinal *** targets DNA in cells and acts as human topoisomerase-I poison,telomerase inhibitor and nucleic acid *** has high tendency to undergo self-association,which is a matter of concern for therapeutic *** understanding of its interaction with DNA requires precise knowledge of chemical shifts in Nuclear magnetic Resonance(NmR)spectra besides *** present study is the first report of a complete assignment of all 1H/13C resonances in NmR spectra of coralyne in DmsO-d6 using one dimensional 1H/13C and two dimensional NmR *** chemical shift of all proton and several 13C resonances have also been obtained in D2O and *** same has been calculated using Density Functional Theory(DFT).NmR spectra of coralyne show upfield shift of 0.6e1.2 ppm in aromatic ring protons suggesting stacking *** from 11 intra molecular NOE cross peaks in 2D 1H e1H ROEsY spectra,3 short distance NOE correlations,H6e10OCH3,H5e10OCH3 and H12e16CH3,give direct independent evidence of the formation of a stacked *** absorbance,fluorescence,circular dichroism and fluorescence lifetime experiments conducted in the present investigations corroborate results obtained by NmR.

关键词： Coralyne alkaloid NmR spectra Chemical shift calculations Restrained molecular dynamics

Repulsive Polarons in One-Dimensional Fermi Gases

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Communications in Theoretical Physics 2019年第5期71卷 617-622页

作者： Ya-Dong song sachin barthwal state Key Laboratory of magnetic Resonance and Atomic and molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China school of Physical sciences University of Chinese Academy of SciencesBeijing 100049China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

Using the variational method, we study the properties of a spin-down impurity immersed in a onedimensional(1 D) spin-up Fermi sea. With repulsive interactions between them, the impurity is dressed up by surrounding particles in Fermi sea and forms a polaron. We clearly calculate the binding energy, effective mass, momentum distribution, Tan contact, and pair correlation. Even in strong repulsive regimes, the results can agree with the exact Bethe Ansatz results. The repulsive polaron energy E+ is below Fermi energy EF and no negative effective masses are found in whole interaction regimes, unequal masses polarons are also calculated. We show a clear momentum distribution and calculate the Tan contact from three different aspects. Furthermore, we explore the particle-hole excitation and find that the hole terms in Fermi sea have a great influence on the polaron energy and contact in repulsive regime. These results show that the variational method can still be used effectively in 1 D repulsive polaron system.

关键词： polaron variational method Tan contact cold atom

Heavy metal Accumulation in medicinal Plants Collected from Environmentally Different sites

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Biomedical and Environmental sciences 2008年第4期21卷 319-324页

作者： JYOTI barthwal smITHA NAIR POONAm KAKKAR Herbal Research section Industrial Toxicology Research Centre

Objective To estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. methods soil and plant samples of Abutilon indicum, Calotropis procera, Euphorbia hirta, Peristrophe bycaliculata, and Tinospora cordifolia were collected from 3 environmentally different sites of the city： heavy traffic area （HTA）, industrial area （IA）, and residential area （RA）. Pb by inductively coupled plasma emission spectrometry and compared Cd, Cr, and Ni were estimated in soil and plant samples Results The level of heavy metal was higher in soil than in plant parts studied. Accumulation of heavy metals varied from plant to plant. Pb was the highest in Calotropis procera root from HTA site and the lowest in Peristrophe bycaliculata whole plant from IA site. It was also lower in residential area than in heavy traffic area. Conclusion The level of heavy metal content differed in the same medicinal plant collected from environmentally different sites of the same city. Thus, it reiterates our belief that every medicinal plant sample should be tested for contaminant load before processing it further for medication.

关键词： Heavy metals medicinal plants Lead Cadmium Chromium Herbal raw material

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina silvera-simón manel m.santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Convergence of COVID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of Virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree V Dhotre Ajay m Gavkare sachin s mumbre Pradnya s Dhotre Department of microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COVID-19-positive patients compared to non-COVID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandemic.

关键词： Recurrent stroke COVID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

microRNA-99a: a potential double-edged sword targeting macrophage inflammation and metabolism

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Cellular & molecular Immunology 2021年第9期18卷 2290-2292页

作者： mohita maurya manoj Kumar barthwal Department of Pharmacology Counsil of Scientific and Industrial Research-Central Drug Research InstitutionLucknowIndia Academy of scientific and Innovative Research(AcsIR) GhaziabadIndia

In a recent study published in Cellular and molecular Immunology,Jaiswal et *** the importance of microRNA-99a(miR-99a)in adipose tissue inflammation and macrophage phenotype activation[1].In this study,miR-99a mimics inhibited the m1 macrophage phenotype and adipose tissue inflammation by targeting TNFα,which was accompanied by an improvement in diabetic dyslipidemia and insulin signaling[2].This study highlights the therapeutic importance of miR-99a in metabolic diseases in which inflammation is a key player.

关键词： inflammation metabolism macrophage

Integrated assessment of adventitious rhizogenesis in Eucalyptus : root quality index and rooting dynamics

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Journal of Forestry Research 2020年第6期31卷 2145-2161页

作者： Romeet saha Harish singh Ginwal Girish Chandra santan barthwal Division of Genetics and Tree Improvement Forest Research InstituteDehra DunUttarakhand 248195India statistics Division ICFREForest Research InstituteDehra DunUttarakhand 248006India

Clonal propagation of eucalypts has considerable importance due to the increasing demands for short rotation tree *** quality is important as it governs the soil exploitation capacity of the plant and the anchorage of trees which are susceptible to wind *** study assesses the quality of adventitious rooting by coppice cuttings of commercially important Eucalyptus clones using multiple attribute ranking of the diff erences in parameters of root *** eff ects of diff erent concentrations of indole-3-butyric acid(IBA)on root development were *** were treated with 500,1000,4000,6000 mg L−1 IBA and tannic acid for 10 s,2 h and 24 *** length of root systems,number of roots,shoot to root ratios,number of root segments,extent of forking,rooting percentage,average root diameters,and number of root tips were *** relational analysis was used to create a comparability sequence to rank *** the concentration of auxin(IBA)and increasing the length of exposure produced better quality roots in Eucalyptus camaldulensis and interspecifi c hybrids(reciprocal hybrids of *** and ***),while the opposite was observed with *** clones.A root quality index was proposed,based on the Dickson quality index for the assessment of root system characteristics and considered total mass,shoot:root ratios,total length of root systems,and average root *** has the advantage of implementation convenience.A positive correlation was obtained between grey relational analysis grades and root quality *** dynamics were studied by evaluating the total length of the root system at seven-day intervals and plotting daily current and medium increments using regression *** curves showed the variation in growth rates among the diff erent clones,and their intersection gave the optimal time of permanence(time at which further growth is restricted)which varied *** highest daily cu

关键词： IBA Eucalyptus Rooting dynamics Root quality Grey-relational analysis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting