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Anthracene removal and mineral N Dynamics in a Surfactant-Amended Soil

Pedosphere 2014年第6期24卷 783-790页

作者： m.r.crdenas-aquino G.SALOmóN-HErNNDEZ .AGUILAr-cHVEZ m.L.LUNA-GUIDO r.m.r.cH L.DENDOOVEN Laboratory of Soil Ecology Department of Biotechnology and BioengineeringCinvestavMexico D.F.C.P.07360 (Mexico)

Surfactants, such as non-ionic Surfynol 485 （ethoxylated 2,4,7,9-tetramethyl-5-decyne-4,7-diol）, have been applied to accelerate removal of polycyclic aromatic hydrocarbons from soil. This study investigated the dissipation of anthracene, and carbon （c） and nitrogen （N） mineralization in soil amended with non-ionic Surfynol 485 at different rates. Soil samples of a Typic Fragiudept taken from Otumba, mexico were spiked with anthracene at a final concentration of 520 mg kg^-1 dry soil using acetone as solvent, amended with 0.0, 24.9, 49.8 or 124.4 g kg^-1 soil of the surfactant and incubated in the laboratory. The soil not amended with anthracene, acetone and the surfactant was used as a control. Dynamics of c and N and the concentration of anthracene were monitored for 56 d. After 56 d of incubation, 38% of the anthracene was removed from the unamended soil, and 47%, 55% and 66% of the anthracene were removed when 24.9, 49.8 and 124.4 g kg^-1 of the surfactant were applied, respectively. Application of acetone, anthracene or surfactant increased the emission of cO2, but decreased the mineral N compared to the unamended control. Applying the surfactant to the acetone or anthracene-amended soil reduced emission of cO2, but increased the mineral N at the lower application rates of the surfactant. It was found that the application of the non-ionic surfactant increased the bioavailability of anthracene and thus its removal from soil, increased c mineralization, but decreased N miaeralization. consequently, the application of non-ionic surfactant could be easily used to accelerate the removal of pollutants from hydrocarbon-contaminated soils, but mineral N in the soil would decrease, which might inhibit plant growth.

关键词： acetone anthracene bioavailability c mineralization cO2 emission non-ionic surfactant Surfynol 485 polycyclic aromatic hydrocarbons

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOcELL 2022年第8期46卷 1867-1873页

作者： ANA m.cÁrdenas I.GALLO FErNANDO D.mArENGO centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： cortical actin Neuroendocrine cell chromaffin cell Exocytosis Endocytosis

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X-ray diffraction analysis by rietveld refinement of FeAl alloys doped with terbium and its correlation with magnetostriction

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Journal of rare Earths 2023年第8期41卷 1217-1224,I0004页

作者： J.S.Uribe-chavira G.Herrera-Pérez c.r.Santillán-rodríguez r.J.Sáenz-Hernández J.A.matutes-aquino m.c.Grijalva-castillo materials Physics Department Centro de Investigación en Materiales AvanzadosS.C.Miguel de Cervantes 120Chihuahua31136ChihMexico cONAcYT–centro de Investigación en materiales Avanzados S.C.Miguel de Cervantes 120Chihuahua31136ChihMexico

Fe_(81)Al_(19) polycrystalline alloys doped with Tb(0-0.25 at%) were obtained by arc *** introduction of Tb favors the formation of columnar grains in the micro structure of the alloys,which develops a texture in the [100]crystal *** examination shows that the alloys are composed in great proportion by the disordered body-centered cubic(bcc),A2 phase and by a small proportion of the ordered bcc,B2 *** a consequence of doping with Tb,the lattice parameter increases,so the calculated apparent crystallite size increases,indicating a decrease in dislocation density and therefore in *** change in the magnetostriction with the magnetic field,dλ_(T)/dH,is directly related to strain anisotropy that can favor the iron easy magnetization axis on the [100] *** increase in total magnetostriction is found in the doped alloys with a maximum of 90 × 10^(-6) at 300 K for the alloy containing 0.027 at% *** enhancement is a threefold value of the undoped alloy,which is attributed to the smaller maximum strain value and the preferential orientation formation by the columnar grains.

关键词： FeAl alloy magnetostriction rietveld refinement microstrains Preferred orientation rare earths

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural regeneration research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KcD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(Gc)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in Gc progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KcD *** and SNU-5 Gc cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KcD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(Ic_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KcD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KcD kinases for treating Gc and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(Gc) Dual inhibition JAK2 PI3KcD SBL-JP-0004 molecular docking molecular dynamics simulation

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural regeneration research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo centro de Biología molecular Severo Ochoa(cBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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A new global raster water mask at 250 m resolution

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International Journal of Digital Earth 2009年第4期2卷 291-308页

作者： m.L.carroll J.r.Townshend c.m.Dimiceli P.Noojipady r.A.Sohlberg Department of Geography University of MarylandCollege Park MDUSA

Accurate depiction of the land and water is critical for the production of land surface parameters from remote sensing data *** parameters,including the land surface temperature,active fires and surface reflectance,can be processed differently when the underlying surface is water as compared with *** errors in the underlying water mask can then pervade into these products and any products created from *** many global databases have been created to depict global surface *** databases still fall short of the current needs of the terrestrial remote sensing community working at 250 m spatial *** most recent attempt to address the problem uses the Shuttle radar Topography mission(SrTm)data set to create the SrTm Water Body Data set(SWBD 2005).The SWBD represents a good first step but still requires additional work to expand the spatial coverage to include the whole globe and to address some erroneous discontinuities in major river *** address this issue a new water mask product has been created using the SWBD in combination with mODIS 250 m data to create a complete global map of surface water at 250 m spatial *** effort is automated and intended to produce a dataset for use in processing of raster data(mODIS and future instruments)and for masking out water in final terrestrial raster data *** new global dataset is produced from remotely sensed data and provided to the public in digital format,free of *** data set can be found on the Global Land cover Facility(GLcF)website at http://*** dataset is expected to be a base set of information to describe the surface of Earth as either land or water which is a fundamental distinction upon which other descriptions can be made.

关键词： digital earth land cover remote sensing mODIS water

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Brain-penetrating neurotrophic factor mimetics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

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Neural regeneration research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Guava extract (Psidium guajava) alters the labelling of blood constituents with technetium-99m

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 429-435页

作者： ABrEU P.r.c. ALmEIDA m.c. BErNArDO r.m. BErNArDO L.c. BrITO L.c. GArcIA E.A.c. FONSEcA A.S. BErNArDO-FILHO m. Department of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil Department of Physiology Biological Sciences and Health Center Federal University of Sergipe So Cristóvo Sergipe 49100000 Brazil Department of Pharmacology and Psychobiology Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil

Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory dis-turbances and is used as anti-inflammatory medicine. In nuclear medicine, blood constituents (Bc) are labelled with techne-tium-99m (99mTc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of Bc with 99mTc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of Bc with 99mTc. Blood samples of Wistar rats were incubated with different concentrations of guava extract and labelled with 99mTc after the percentage of incorporated radioactivity (%ATI) in Bc was determined. The results suggest that aqueous guava extract could present antioxidant action and/or alters the membrane structures involved in ion transport into cells, thus decreasing the radiolabelling of Bc with 99mTc. The data showed significant (Pration of ATI in Bc from blood incubated with guava extract.

关键词： Antioxidant Blood constituents Psidium guajava Technetium-99m

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