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The Effect of Curcumin on Patients with Chronic Fatigue Syndrome/myalgic Encephalomyelitis: An Open Label Study

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International Journal of Clinical medicine 2018年第5期9卷 356-366页

作者： C. (Linda) m. C. van Campen K. riepma Frans C. visser Stichting Cardiozorg Hoofddorp Netherlands Curesupport Valkenburg Netherlands

myalgic encephalomyelitis/chronic fatigue syndrome (mE/CFS), recently renamed as systemic exertion intolerance disease (SEID), is a chronic and often disabling disease. Although the exact pathophysiological mechanism of mE/CFS is unknown, immunological abnormalities may play an important role. Curcumin is a herb with powerful anti-oxidative, and anti-inflammatory properties. Therefore, we hypothesized that curcumin has favorable effects on symptomatology in mE/CFS patients. In total 52 patients participated, nine stopped the use of curcumin because of side effects. All remaining patients (n = 43) met the criteria for CFS;72% met the criteria for mE. Before and 8 weeks after the use of curcumin complexed with phosphatidyl choline, 500 mg bid, the CDC inventory for assessment of Chronic Fatigue Syndrome was filled in. The CDC questions (n = 19) were scored and divided into 2 parts: the first being specific for CFS complaints (n = 9), the second being scores of less specific symptoms (n = 10);denoted as CDC rest score. results showed that 8 weeks curcumin use significantly decreased the CFS related symptom scores, but not the CDC rest scores. Analyzing the data separately for mE and CFS patients, the same significance for the CFS symptom scores was present. Conclusion: in this open-labeled study, 8 weeks curcumin use in a phosphatidyl choline complex reduced mE/CFS symptomatology. Therefore, a randomized placebo controlled study is warranted to assess its efficacy in mE/CFS patients.

关键词： Curcumin Chronic Fatigue Syndrome myalgic Encephalomyelitis CDC CFS Symptom Inventory

Quantification of the Beneficial Effects of Compression Stockings on Symptoms of Exercise and Orthostatic Intolerance in Chronic Fatigue Syndrome/myalgic Encephalomyelitis Patients

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International Journal of Clinical medicine 2018年第5期9卷 367-376页

作者： C. (Linda) m. C. van Campen Freek W. A. Verheugt Frans C. visser Stichting Cardiozorg Hoofddorp Netherlands radboud UmC Department of Cardiology Nijmegen Netherlands

Chronic fatigue syndrome and myalgic encephalomyelitis (CFS/mE) are, amongst others, characterized by exercise intolerance, pain, post exertional malaise and orthostatic intolerance. It has been shown in venous disease and sport participation that compression stockings may improve exercise performance and reduce post exercise muscle soreness. moreover, its use is advocated in orthostatic hypotension. Therefore, it was hypothesized that compression stockings may reduce symptomatology in CFS/mE patients. methods: 100 patients used compression stockings class II for minimally 3 weeks and thereafter filled in a questionnaire, based on the rand 36 physical activity questions (n = 9), whether compression stockings changed perceived symptoms or not. moreover, 7 questions referring to prolonged standing and sitting, to recovery post exercise, muscle pain during or immediately post exercise, and to dizziness/light-headedness during or immediately post exercise, while standing and during prolonged sitting were added. Questions were scored as 1: able to perform activity much less while wearing the stockings, 2: perform activity somewhat less, 3: no perceived change in activity, 4: perform activity slightly better, 5: able to perform activity much better while wearing the stockings. results: In patients able to answer the question, all mean scores per activity were significantly higher than 3, being no perceived change in activity while wearing the stockings. Subgroup analysis showed that patients with orthostatic intolerance reported higher effects than patients without orthostatic intolerance. Conclusion: This pilot study suggests that compression stockings may be useful to reduce symptomatology of physical activities in CFS/mE patients, especially in patients with orthostatic intolerance. Larger prospective studies with hard endpoints are warranted.

关键词： Chronic Fatigue Syndrome myalgic Encephalomyelitis Compression Stockings Exercise Tolerance Orthostatic Intolerance

Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?

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World Journal of Nephrology 2016年第5期5卷 448-454页

作者： Elizabeth Oei Klara Paudel Annemarie visser Hazel Finney Stanley L Fan Department of renal medicine and Transplantation Barts Health NHS Trust Department of Nutrition and Dietetics Barts Health NHS Trust Department of Clinical Biochemistry Barts Health NHS Trust

AImTo study the relationship between overhydration （OH） in peritoneal dialysis （PD） patients and cardiac ***, as measured by body composition monitor （BCm）, is associated with increased mortality in dialysis pa-tients. BCm has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mor-tality, and if there was a correlation between OH and cardiac troponin-T （cTnT） levels. Finally, we wished to determine if improving OH values would lead to a decrement in cTnT. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCm and cTnT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH （〉＋2L）.The Fresenius Body Composition monitor was used to obtain hydration parameters. cTnT levels were done as part of routine clinical care. Data was analysed using SPSS version *** were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage （10.3 mo vs 37.0 mo, P 〈 0.0001） and were significantly more overhydrated by BCm measurement （2.95 L vs 1.35 L, P 〈 0.05）. The mean （standard error of the means） hydration status of the 336 patients was ＋1.15 （0.12） L and the median [interquartile range （IQr）] cTnT level was 43.5 （20-90） ng/L. The cTnT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log （cTnT） with the OH value （Spearman r value 0.425, P 〈 0.0001）. We identifed a sub-group of patients that were severely overhydrated; m

关键词： Bioimpedance Fluid status Peritoneal dialysis mortality Overhydration Cardiac troponin

利用GBSSI和SBD作为“锚”将荧光素酶定位到淀粉粒中效果的比较

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自然科学进展 2006年第6期16卷 679-683页

作者：季勤 Jean-Paul Vincken Krit raemakers Luc C.J.m.Suurs richard G.F.visser 淮阴师范学院生物系淮安223300 Laboratory of Plant Breeding Department of Plant SciencesWageningen UniversityWageningenThe Netherlands

利用马铃薯淀粉粒结合型淀粉合成酶Ⅰ(GBSSI)作为“锚”,在马铃薯淀粉粒形成时将荧光素酶(LUC)定位到淀粉粒中．并对GBSSI／LUC重组蛋白质在转基因淀粉粒中的定位与积累、重组蛋白质中GBSSI与淀粉粒的亲和性以及荧光素酶的活性等进行了... 详细信息

利用马铃薯淀粉粒结合型淀粉合成酶Ⅰ(GBSSI)作为“锚”,在马铃薯淀粉粒形成时将荧光素酶(LUC)定位到淀粉粒中．并对GBSSI／LUC重组蛋白质在转基因淀粉粒中的定位与积累、重组蛋白质中GBSSI与淀粉粒的亲和性以及荧光素酶的活性等进行了分析．结果表明,GBSSI／ LUC重组蛋白质在马铃薯淀粉粒中获得了特异性表达,但与以微生物的淀粉粒结合结构域(SBD) 作为“锚”的SBD／LUC重组蛋白质相比较,它与淀粉粒的亲和性以及荧光素酶的活性均下降．由此认为,在淀粉粒形成过程中,利用SBD作为“锚”将荧光素酶蛋白质定位到淀粉粒中的效果要优于GBSSI．

关键词：荧光素酶 GBSSI SBD amf马铃著

长时程深部脑刺激外侧苍白球对转基因Huntington病大鼠认知和运动的影响(英文)

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神经解剖学杂志 2006年第3期22卷 275-280页

作者：曹春燕 Yasin Temel Arjan Blokland Veerle visser-Vandewalle Harry W.m. Steinbusch 陈生弟刘振国上海交通大学医学院附属瑞金医院神经病学研究所上海200025 马斯特里赫特大学心理学系马斯特里赫特大学医院神经外科马斯特里赫特大学欧洲神经科学研究院上海交通大学医学院附属新华医院神经内科上海200092

我们研究了深部脑刺激(deep brain stimulation, DBS)对转基因Huntington病大鼠认知能力和运动功能的影响。实验结果表明:电极植入手术能改善Huntington病大鼠的认知能力,例如:在选择反应时间实验(choice reaction time task,CrT task)... 详细信息

我们研究了深部脑刺激(deep brain stimulation, DBS)对转基因Huntington病大鼠认知能力和运动功能的影响。实验结果表明:电极植入手术能改善Huntington病大鼠的认知能力,例如:在选择反应时间实验(choice reaction time task,CrT task)中,反应准确率增加,偏倚率减少。但对不同基因型大鼠,改善程度相同。在对大鼠外侧苍白球部(GPe)进行长时间深部脑刺激后,反应准确率增加,不同基因型大鼠的增加幅度有所不同。另外,深部脑刺激后, CrT实验中的运动时间和反应时间并没有变化。但是纯合子大鼠的舞蹈样运动明显改善。本研究结果表明深部脑刺激转基因Huntington病大鼠的GPe能明显改善其认知能力和运动功能,这预示着DBS在Huntington病的治疗中将有很大的应用前景。

关键词：深部脑刺激选择反应实验转基因Huntington病大鼠外侧苍白球

用氧化裂解和四极质谱检测法测定地面水中有机悬浮物的元素组成

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环境科学与管理 1981年第12期 113-117页

作者： H.F.r.reijnders D.Onderdelinden m.G.visser B.Griepink 乔志清

本研究采用燃烧后四极质谱(QmS)检测装置测定地面水中有机悬浮物的元素组成。用离心法收集几种类型水中的固体物质。结果表明,本方法可用于水特性鉴定等方面。包括予处理和元素分析约需30分钟。无论水污染研究还是废物和天然有机物代谢... 详细信息

本研究采用燃烧后四极质谱(QmS)检测装置测定地面水中有机悬浮物的元素组成。用离心法收集几种类型水中的固体物质。结果表明,本方法可用于水特性鉴定等方面。包括予处理和元素分析约需30分钟。无论水污染研究还是废物和天然有机物代谢机理的探讨,都越来越对地面水中不溶物内的有机质部分的元素组成感兴趣。有机质的组成极为复杂,因为它可能含有多种工业组分及脂肪、蛋白质和碳水化合物的代谢物。所以,进行全面的结梅分析以确定化合物的种类及其含量是不实际的而且几乎是不可能的。然而,元素分析可以给出化合物种类的有用信息,如脂肪或蛋白质的存在。最近Baumeister(1978)进行了地面水中悬浮物的CHN分析(即碳氢氮分析,译注)。他发现,各种不同试样的颗粒中C/N比率颇为一致。这可说明均来源于生物。

关键词：悬浮物悬浮体地面水四极质谱元素组成

父母卒中后孩子的情绪、行为障碍以及健康状况的临床病程与预测

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 55-56页

作者： visser-meily A. Post m. meijer A.m. 高艳琼 rehabilitation Center 'De Hoogstraat' Rembrandtkade 10 3583 TM Utrecht Netherlands

Background and Purpose -The purpose of this research was to describe the clinical course of children’s functioning (depression, behavioral problems, and health status) during the first year after parental stroke and to determine which patient-, spouse-, or child-related factors at the start of inpatient rehabilitation can predict children’s functioning after parental stroke at 1-year poststroke. methods -Interviews with 82 children (4 to 18 years of age) and their parents (n=55) shortly after admission to a rehabilitation center, 2 months after discharge from inpatient rehabilitation, and 1 year after stroke. Depression was assessed using the Children Depression Inventory, behavioral problems with the Child Behavior Check List, and health status with the Functional Status II. Potential predictors were gender and age (child), activities of daily living disability and communication ability (patient), and spouse’s depression and perception of the marital relationship. results - At the start of the stroke patient’s rehabilitation, 54%of the children had ≥1 subclinical or clinical problems, which improved to 29%1 year after stroke. Children’s functioning 1 year after stroke could best be predicted by their functioning at the start of rehabilitation. Spouse depression and perception of marital relationship were also significant predictors. A total of 28%to 58%of the variance in children’s functioning could be explained. Conclusions -Children’ s functioning after parental stroke improved during the first year after stroke. Identifying children at risk for problems 1 year after stroke requires assessment of children’s functioning and the healthy spouse’s depressive symptoms and perception of the marital relationship at the start of rehabilitation. This demonstrates the need for a family-centered approach in stroke rehabilitation.

关键词：行为障碍临床病程机能状态儿童行为康复中心抑郁情况夫妻关系检查表入院患者抑郁状况

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适用于工业真空系统的通用低温泵

真空 1980年第2期 73-78+85页

作者： J.visser.B.Symersky ,A.J.m.Geraerts ,任家生

25－羟维生素D和甲状旁腺激素与高血压的相关性

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中华高血压杂志 2014年第6期22卷 587-588页

作者： van Ballegooijen AJ Kestenbaum B Sachs mC de Boer IH Siscovick DS Hoofnagle AN Ix JH visser m Brouwer IA 练桂丽叶鹏机构不详

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高... 详细信息

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。

关键词： 25-羟维生素D 甲状旁腺激素高血压相关性维生素D缺乏肾素血管紧张素系统血管炎性反应 25(OH)D