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钆对比剂的速发型过敏反应:系统性综述和meta分析

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国际医学放射学杂志 2018年第2期 225-225页

作者： A.H.Behzadi Y.Zhao Z.Farooq m.r.prince 卜玮艺 Department of radiology Weill Cornell Medical Center

摘要目的通过系统性综述和meta分析,判定不同种类钆对比剂(GBCA)引起速发型过敏反应的概率有无差异。材料与方法于Pub med和Google学术数据库检索报道GB-

关键词：系统性综述对比剂速发型过敏反应

639例活检证实的肾源性系统性纤维化病人的系统评价

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国际医学放射学杂志 2019年第5期 616-616页

作者： H.Attari Y.Cao T.r.Elmholdt Y.Zhao m.r.prince 王姗 Department of radiology Weill Cornell Medical College&New York Presbyterian Hospital

摘要钆对比剂(GBCA)在mrI中的应用受肾源性系统纤维化(NSF)影响,但NSF发病率低且对其知之甚少。目的对NSF进行系统性回顾分析。材料与方法在Pubmed中检

关键词：肾源性系统性纤维化对比剂系统评价

对比剂由钆喷酸葡胺改用为钆布醇后,齿状核信号在T1WI上减低

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国际医学放射学杂志 2018年第4期 479-479页

作者： A.H.Behzadi Z.Farooq Y.Zhao G.Shih m.r.prince 朱静 Department of radiology Columbia College of Physicians and Surgeon

目的探究在使用6次以上线性钆对比剂（GBCA）(钆喷酸葡胺)后,更换大环类对比剂GBCA是否会使齿状核信号强度增加。材料与方法该研究回顾性纳入13例注射了至少6次（范围为6～18）钆喷酸葡胺后齿状核信号强度增加的病人,随访时间超过12个月... 详细信息

目的探究在使用6次以上线性钆对比剂（GBCA）(钆喷酸葡胺)后,更换大环类对比剂GBCA是否会使齿状核信号强度增加。材料与方法该研究回顾性纳入13例注射了至少6次（范围为6～18）钆喷酸葡胺后齿状核信号强度增加的病人,随访时间超过12个月,期间进行多次（范围为3～29）钆布醇增强mrI检查。2名放射科医师采用盲法评价齿状核-脑桥和齿状核-小脑脚的信号强度比值。采用配对t检验和线性回归分析其变化。结果在注射钆喷酸葡胺增强时,齿状核-脑桥和齿状核-小脑脚平均信号强度比值分别从0.98±0.03增加到1.10±0.03（Pr2=0.58,Pr2=0.61,PmrI检查齿状核信号强度增加。而当使用大环类GBCA（钆布醇）替换线性（钆喷酸葡胺）对比剂时,齿状核信号强度降低。

关键词：钆布醇信号强度齿状核 T1WI 对比剂

注射线性钆基对比剂超过35次后脑部mrIT1加权影像高信号程度的研究

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国际医学放射学杂志 2017年第2期 222-222页

作者： Y.Zhang Y.Cao G.L.Shih E.m.Hecht m.r.prince 吴兰蒋宇 Department of radiology Weill Cornell Medical College and Columbia College of Physicians and Surgeons

摘要目的对接受35次以上的线性钆基对比剂(GBCA)注射后的病人进行研究,探讨随着注射GBCA剂量的增加,大脑T1W mrI高信号的程度。材料与方法该回顾性研究

关键词：高信号背侧丘脑 mrIT1 对比剂程度

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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An Imbalanced Dataset and Class Overlapping Classification model for Big Data

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Computer Systems Science & Engineering 2023年第2期44卷 1009-1024页

作者： mini prince P.m.Joe Prathap Department of Information Technology St.Peter’s College of Engineering and TechnologyChennai600054TamilnaduIndia Department of Information Technology R.M.D Engineering CollegeChennai601206TamilnaduIndia

most modern technologies,such as social media,smart cities,and the internet of things(IoT),rely on big *** big data is used in the real-world applications,two data challenges such as class overlap and class imbalance *** dealing with large datasets,most traditional classiﬁers are stuck in the local optimum *** a result,it’s necessary to look into new methods for dealing with large data *** solutions have been proposed for overcoming this *** rapid growth of the available data threatens to limit the usefulness of many traditional *** such as oversampling and undersampling have shown great promises in addressing the issues of class *** all of these techniques,Synthetic minority Oversampling TechniquE(SmOTE)has produced the best results by generating synthetic samples for the minority class in creating a balanced *** issue is that their practical applicability is restricted to problems involving tens of thousands or lower instances of *** this paper,we have proposed a parallel mode method using SmOTE and mapreduce strategy,this distributes the operation of the algorithm among a group of computational nodes for addressing the aforementioned *** proposed solution has been divided into three ***ﬁrst stage involves the process of splitting the data into different blocks using a mapping function,followed by a pre-processing step for each mapping block that employs a hybrid SmOTE algo-rithm for solving the class imbalanced *** each map block,a decision tree model would be ***,the decision tree blocks would be com-bined for creating a classiﬁcation *** have used numerous datasets with up to 4 million instances in our experiments for testing the proposed scheme’s *** a result,the Hybrid SmOTE appears to have good scalability within the framework proposed,and it also cuts down the processing time.

关键词： Imbalanced dataset class overlapping SmOTE mapreduce parallel programming oversampling

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Generation scenarios of anodic structures and experimental realization of turbulence in unmagnetized plasma

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Plasma Science and Technology 2020年第8期22卷 90-98页

作者： prince ALEX Suraj Kumar SINHA Departimento di Fisica G.Occhialini Universita degli studi di MilanoBicoccaI-20126Italy Department of Physics Pondicherry UniversityKalapetPuducherry 605014India

In the present work,we report development of a DC glow discharge plasma(GDP)set-up to study controlled evolution of anodic structures having distinctive geometry,size and layers,generated in front of a positively biased electrode,submerged in unmagnetized *** such an anodic structure,we have also investigated the condition under which the turbulence is *** of these structures,generated in front of a positively biased electrode,depends on multiple parameters such as the ratio of anode to cathode size,electrode separation,gas pressure,biasing configuration such as anode bias,cathode bias and grounding *** attempted to classify different anodic structures observed experimentally,as anode glow,fireball,anode spot,double layer and multiple double layers(mDLs)based on its physical *** these structures the present investigation is focused on *** number of layers,observed in mDLs varied from as high as six to as low as zero,by controlling the operating discharge parameters,*** were carried out using Langmuir *** analysis of floating potential fluctuations corresponds to a multiple anodic structure showed emergence of turbulence,at its critical stage,satisfying condition for self-organized criticality(SOC).This was identified with three slopes observed in the power spectrum,resembling the sand-pile ***,the GDP is completely different from that of the magnetically confined plasma,the nature of turbulence observed with SOC,is very similar to that observed in the scrape of layer of fusion ***,the present investigation could provide new approach to study turbulence of similar nature,under an experimental condition that is free from the complexities of complicated field geometries used in confinement devices.

关键词： glow discharge plasma anode structure multiple anodic double layer turbulence unmagnetized plasma fireball

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A Novel Approach to Design Distribution Preserving Framework for Big Data

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Intelligent Automation & Soft Computing 2023年第3期35卷 2789-2803页

In several fields like financial dealing,industry,business,medicine,et cetera,Big Data(BD)has been utilized extensively,which is nothing but a collection of a huge amount of ***,it is highly complicated along with time-consuming to process a massive amount of ***,to design the Distribution Preserving Framework for BD,a novel methodology has been proposed utilizing manhattan Distance(mD)-centered Partition Around medoid(mD–PAm)along with Conjugate Gradient Artificial Neural Network(CG-ANN),which undergoes various steps to reduce the complications of ***,the data are processed in the pre-processing phase by mitigating the data repetition utilizing the map-reduce function;subsequently,the missing data are handled by substituting or by ignoring the missed *** that,the data are transmuted into a normalized ***,to enhance the classification performance,the data’s dimensionalities are minimized by employing Gaussian Kernel(GK)-Fisher Discriminant Analysis(GK-FDA).Afterwards,the processed data is submitted to the partitioning phase after transmuting it into a structured *** the partition phase,by utilizing the mD-PAm,the data are partitioned along with grouped into a ***,by employing CG-ANN,the data are classified in the classification phase so that the needed data can be effortlessly retrieved by the *** analogize the outcomes of the CG-ANN with the prevailing methodologies,the NSL-KDD openly accessible datasets are *** experiential outcomes displayed that an efficient result along with a reduced computation cost was shown by the proposed *** proposed work outperforms well in terms of accuracy,sensitivity and specificity than the existing systems.

关键词： Big data artiﬁcial neural network ﬁsher discriminant analysis distribution preserving framework manhattan distance