检索结果-南通市图书馆

1.5 T多模态内源性对比mrI评价化学诱导的大鼠乳腺癌的纤维化特征

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2018年第3期 372-372页

作者： N.P.Jerome J.K.r.Boult m.r.orton J.A.d 'Arcy A.Nerurkar m.O.Leach 李建慧 Cr-UK Cancer Imaging Centre Division of Radiotherapy and Imaging The Institute of Cancer Research

摘要目的探讨多参数、内源性对比mrI检测和量化化学诱导的乳腺癌大鼠模型的纤维化能力。方法选择给予N-甲基-N-亚硝基脲诱导的乳腺癌雌性SD大鼠(n=18),使

关键词：

替代扩散衰减模型的扩散加权mr成像对VEGF抑制剂诱导转移性腹盆腔肿瘤的早期变化是敏感的

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2016年第4期 452-452页

作者： m.r.orton C.messiou D.Collins V.A.morgan J.Tessier H.Young 方壮念 CrUK and EPSrC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust

摘要目的评价扩散加权成像对监测VEGF抑制剂早期治疗效果的作用。方法纳入29例腹盆腔转移瘤的病人,并行DW-mrI检查。病人治疗前进行2次检查,在用西地尼布治疗后的7 d、28 d再分别进行1次检查。采用单指数、双指数和拉伸指数模型对肿瘤... 详细信息

摘要目的评价扩散加权成像对监测VEGF抑制剂早期治疗效果的作用。方法纳入29例腹盆腔转移瘤的病人,并行DW-mrI检查。病人治疗前进行2次检查,在用西地尼布治疗后的7 d、28 d再分别进行1次检查。采用单指数、双指数和拉伸指数模型对肿瘤进行测量计算,并分别评价治疗

关键词：双指数模型腹盆腔 mr 抑制剂浮选药剂 VEGF

神经内分泌肿瘤肝转移:利用动态对比增强mr成像监测和预测放射性示踪奥曲肽的治疗反应

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2012年第3期 281-281页

作者： K.miyazaki m.r.orton r.L.Davidson J.A.d'Arcy V.Lewington T.S.Koh 刘学焕 Institute of Cancer research Cancer Research UK and EPSRC Cancer Imaging CentreSuttonSurrey SM2 5NGEngland

目的评估动态对比增强mr(DCEmr)成像监测及评价神经内分泌肝转移瘤病人对钇90(90Y)标记的奥曲肽(90Y-DOTATOC)的治疗反应。材料与方法本项研究获当地研究和伦理委员会批准,病人均签署知情同意书。20例神经内分泌肿瘤肝转移病人在静脉注... 详细信息

目的评估动态对比增强mr(DCEmr)成像监测及评价神经内分泌肝转移瘤病人对钇90(90Y)标记的奥曲肽(90Y-DOTATOC)的治疗反应。材料与方法本项研究获当地研究和伦理委员会批准,病人均签署知情同意书。20例神经内分泌肿瘤肝转移病人在静脉注射90Y-DOTATOC前及治疗

关键词：肿瘤肝神经内分泌动态对比增强治疗反应 mr 奥曲肽

Heterogeneity of mature oligodendrocytes in the central nervous system

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

维普期刊数据库

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

在线全文

学校读者我要写书评

暂无评论

World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

machine Learning Techniques in Predicting Hot Deformation Behavior of metallic materials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,machine Learning(mL)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected mL techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** mL-based regression methods of Artificial Neural Networks(ANNs),Support Vector machine(SVm),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied mL techniques provide such precise results of the solved regression analysis.

关键词： machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHArI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词：

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EmBL Partnership for molecular medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

维普期刊数据库