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影像引导下肾上腺经皮冷冻消融的方法与技术研究

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国际医学放射学杂志 2011年第2期 176-176页

作者： B.T.Welch T.D.Atwell D.A.Nichols C.T.Wass m.r.callstrom B.C.Leibovich 唐光健 mayo medical School

目的评价肾上腺冷冻消融治疗相关的安全性、技术成功率、并发症与血流动力学变化。材料与方法学院委员会批准了此项回顾性研究,无需病人知情同意,符合HIPAA

关键词：肾上腺病人内分泌腺冷冻消融治疗高血压危象

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使用超声辐射力所诱导的剪切波评估肝黏弹性

国际医学放射学杂志 2013年第3期 272-272页

作者： S.Chen W.Sanchez m.r.callstrom B.Gorman J.T.Lewis S.O.Sanderson 田凤娟 Department of Biomedical Engineering Mayo Clinic

目的旨在研究超声弹性成像在肝纤维化分期中的黏度价值,同时确定使用一种肝黏弹性模型评价肝弹性是否可以提高肝纤维化分期的精确性。材料与方法本项研究自2010年2月起至2011年3月止,符合HIPAA并经机构审查委员会批准,同时获得所有受试... 详细信息

目的旨在研究超声弹性成像在肝纤维化分期中的黏度价值,同时确定使用一种肝黏弹性模型评价肝弹性是否可以提高肝纤维化分期的精确性。材料与方法本项研究自2010年2月起至2011年3月止,符合HIPAA并经机构审查委员会批准,同时获得所有受试者的知情同意书。10名健康志愿者(8名女性和2名男性,年龄27～55岁)和35例肝病病人(女17例,男18例,年龄19～74岁)接受肝脏(肝组织活检6个月内)超声弹性检测。超声数据经剪切波分散超声振动(SDUV)方法以及时间达到峰值(TTP)方法进行分析,其中前一种方法中弹性和黏度的测量通过评估剪切波传播速度的分散所获得,后一种方法中组织黏度可忽略而只有弹性得到有效剪切波速的评估。肝纤维化分期通过使用mETAVIr评分系统进行组织学评估。弹性和黏度的相关性用Pearson相关系数评估。SDUV和TTP结果经受试者操作特征(rOC)曲线分析进行评估。结果研究者发现SDUV所检测的弹性与黏度具有显著的相关性(r=0.80),SDUV与TTP检测的弹性也具有显著的相关性(r=0.94)。区分F0-F1级纤维化和F2-F4级纤维化rOC曲线下的面积:SDUV测量的弹性为0.98,SDUV测量的黏度为0.86,TTP测量的弹性为0.95。结论结果表明对于肝纤维化分期,在95～380Hz之间用SDUV测量的弹性与黏度,以及用SDUV与TTP测量的弹性均具有相关性,尽管SDUV测量的弹性在rOC曲线下的面积更大。

关键词：剪切波相关性黏弹性肝纤维化肝疾病

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHArI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Charaeterizability of the Group ~2D_p(3) by its Order Components,Where p≥5 is a Prime Number Not of the Form 2~m+1

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Acta mathematica Sinica,English Series 2008年第7期24卷 1117-1126页

作者： m.r.DArAFSHEH School of mathematics College of ScienceUniversity of TehranTehranIran

The author will prove that the group ^2Dp（3） can be uniquely determined by its order components, where p ≠ 2^m ＋ 1 is a prime number, p ≥ 5. more precisely, if OC（G） denotes the set of order components of G, we will prove OC（G） = OC（^2Dp（3）） if and only if G is isomorphic to ^2Dp（3）. A main consequence of our result is the validity of Thompson＇s conjecture for the groups under consideration.

关键词： prime graph order component linear group

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural regeneration research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural regeneration research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImrAN T.ASGHAr Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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