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Grain refinement of mg-Ca alloys by native mgO particles

Journal of magnesium and Alloys 2024年第3期12卷 980-996页

作者： Shihao Wang Yun Wang quentin m.Ramasse Zhongyun Fan Super STEm Laboratory SciTech Daresbury CampusDaresbury WA44ADUK School of Chemical and Process Engineering University of LeedsLeeds LS29JTUK BCAST Brunel University LondonUxbridgeMiddlesex UB83PHUK

In mg-Ca alloys the grain refining mechanism,in particular regarding the role of nucleant substrates,remains the object of *** native mgO is being recognised as a nucleating substrate accounting for grain refinement of mg alloys,the possible interactions of mgO with alloying elements that may alter the nucleation potency have not been elucidated ***,we design casting experiments of mg-xCa alloys varied qualitatively in number density of native mgO,which are then comprehensively studied by advanced electron *** results show that grain refinement is enhanced as the particle number density of mgO *** native mgO particles are modified by interfacial layers due to the co-segregation of Ca and N solute atoms at the mgO/mg *** aberration-corrected scanning transmission electron microscopy and electron energy loss spectroscopy,we reveal the nature of these Ca/N interfacial layers at the atomic *** of the crystallographic termination of mgO,Ca and N co-segregate at the mgO/mg interface and occupy mg and O sites,respectively,forming an interfacial structure of a few atomic *** interfacial structure is slightly expanded,less ordered and defective compared to the mgO matrix due to compositional deviations,whereby the mgO substrate is altered as a poorer template to nucleate mg *** solidification in a TP-1 mould,the impotent mgO particles account for the grain refining mechanism,where they are suggested to participate into nucleation and grain initiation processes in an explosive *** work not only reveals the atomic engineering of a substrate through interfacial segregation but also demonstrates the effectiveness of a strategy whereby native mgO particles can be harnessed for grain refinement in mg-Ca alloys.

关键词： mg-Ca alloy Grain refinement mgO Interfacial segregation STEm/EELS Solidification.

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丁溴东莨菪碱能显著降低前列腺mp-mRI的运动伪影并显示前列腺解剖结构

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国际医学放射学杂志 2018年第2期 234-235页

作者： T.Ullrich m.quentin A.K.Schmaltz C.Arsov C.Rubbert D.Blondin R.Rabenalt 孙成凤 Department of Diagnostic and Interventional Radiology University Dusseldorf Medical Faculty

摘要目的前瞻性研究使用丁溴东莨菪碱(HBB)提高3.0 T前列腺mRI(mp-mRI)解剖细节显示及降低运动相关伪影价值。方法 103例病人[(65±10)岁]被纳入本项研究,肌

关键词：运动伪影 mp-mRI 前列腺东莨菪碱解剖结构

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以mRI引导下活检为参照的前列腺ESUR评分的一致性研究

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国际医学放射学杂志 2014年第1期 91-92页

作者： L.Schimmǒller m.quentin C.Arsov R.S.Lanzman A.Hiester R.Rabenalt 戚思 medical Faculty Department of Diagnostic and Interventional Radiology University Dusseldorf Moorenstr.540225 Dusseldorf Germany

目的最近欧洲泌尿生殖放射学会(ESUR)制定了前列腺mRI多参数成像(mp-mRI)评估和报告指南,包括前列腺影像报告与数据系统(PI-RADS)。本研究目的是观察阅

关键词：前列腺癌前列腺mRI PI-RADS ESUR 评分 mRI引导穿刺活检

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mRI介导下前列腺靶向活检:每个mRI病灶需要2个活检核心吗?

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国际医学放射学杂志 2017年第1期 101-102页

作者： L.Schimmller m.quentin D.Blondin F.Dietzel A.Hiester C.Schleich 谢双双 medical Faculty Department of Diagnostic and Interventional Radiology University Dusseldorf

摘要目的评估进行mR介导下前列腺靶向活检时每个mRI病灶选择少于2个活检核心的可行性。材料与方法回顾性分析290例病人[(66±7.8)岁,中位前列腺特异性抗原

关键词：靶向活检病灶前列腺男生殖器介导 mRI

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多参数mRI可以排除主动监测病人的前列腺癌进展：一项回顾性队列研究

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国际医学放射学杂志 2021年第1期44卷 117-117页

作者： T.Ullrich C.Arsov m.quentin F.mones A.C.Westphalen D.mally 程悦

摘要目的评价前列腺多参数mRI（mp-mRI）在主动监测（AS）病人中排除前列腺癌（PCa）进展的能力。方法最初纳入了147例在3 T mR设备上行mp-mRI(T2WI、DWI、

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用于前列腺癌诊断的mR序列:基于PI-RADS评分系统和mR靶向引导穿刺活检的验证

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国际医学放射学杂志 2014年第6期 610-610页

作者： L.Schimmller m.quentin C.Arsov A.Hiester C.Buchbender R.Rabenalt 刘代洪 Department of Diagnostic and Interventional Radiology University DusseldorfMedical FacultyMoorenstr.540255 DusseldorfGermany

摘要目的基于欧洲泌尿生殖放射学会(ESUR)评分系统(即前列腺影像报告和数据系统,PI-RADS),本研究采用mR引导穿刺前列腺活检作为参考标准,评估3 T mR T2加权

关键词：前列腺癌曲线下面积外周带 PI-RADS mR 穿刺活检评分系统靶向序列

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以高b值扩散加权影像上信号强度增高作为检出前列腺恶性病变的预测标志

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国际医学放射学杂志 2014年第2期 190-190页

作者： m.quentin L.Schimmller G.Antoch R.Rabenalt G.Antoch P.Albers D.Blondin 余晓 Department of Diagnostic and Interventional Radiology University Dusseldorf Medical Faculty Moorenstr5 40225 DusseldorfGermany

目的评估前列腺mRI中高b值扩散加权影像上高信号灶作为提示恶性病灶标志的价值。方法回顾性研究连续103例行前列腺mR检查及mR引导下穿刺活检的病

关键词：前列腺癌 mRI 扩散加权成像高b值 PI-RADS

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Clarifying predictions for COVID-19 from testing data: The example of New York State

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Infectious Disease modelling 2021年第1期6卷 273-283页

作者： quentin Griette Pierre magal Univ.Bordeaux IMBUMR 5251F-33400TalenceFrance CNRS IMBUMR 5251F-33400TalenceFrance

With the spread of COVID-19 across the world,a large amount of data on reported cases has become *** are studying here a potential bias induced by the daily number of tests which may be insufficient or vary over ***,tests are hard to produce at the early stage of the epidemic and can therefore be a limiting factor in the detection of *** a limitation may have a strong impact on the reported cases ***,some cases may be missing from the official count because the number of tests was not sufficient on a given *** this work,we propose a new differential equation epidemic model which uses the daily number of tests as an *** obtain a good agreement between the model simulations and the reported cases data coming from the state of New *** also explore the relationship between the dynamic of the number of tests and the dynamics of the *** obtain a good match between the data and the outcome of the ***,by multiplying the number of tests by 2,5,10,and 100 we explore the consequences for the number of reported cases.

关键词： Corona virus Testing data Reported and unreported cases Isolation Quarantine Public closings Epidemic mathematical model

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Role of monocytes and macrophages in experimental and human acute liver failure

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World Journal of Gastroenterology 2010年第15期16卷 1811-1819页

作者： Lucia A Possamai Charalambos Gustav Antoniades quentin m Anstee Alberto Quaglia Diego Vergani mark Thursz Julia Wendon Antiviral Centre 10th Floor QEQM building St Mary’s Hospital Imperial College London Institute of Liver Studies King’s College Hospital

Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the pathogenesis of ALF is activation of the immune system with mobilisation of cellular effectors and massive production of cytokines. As key components of the innate immune system, monocytes and macrophages are postulated to play a central role in the initiation, progression and resolution of ALF. ALF in humans follows a rapidly progressive clinical course that poses inherent difficulties in delineating the role of these pivotal immune cells. Therefore, a number of experimental models have been used to study the pathogenesis of ALF. Here we consider the evidence from experimental and human studies of ALF on the role of monocytes and macrophages in acute hepatic injury and the ensuing extrahepatic manifestations, including functional monocyte deactivation and multiple organ failure.

关键词： monocyte macrophage Acute liver failure Inflammation monocyte chemoattractant protein-1/ chemokine (C-C motif) receptor-2 Cytokine

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A Cross-sectional Real-life Study of the Prevalence,Severity,and Determinants of metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1377-1386页

作者： quentin Binet Audrey Loumaye michel P Hermans Nicolas Lanthier Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium Service d’Endocrinologie et Nutrition Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium

Background and Aims:most data on liver assessment in type 2 diabetes mellitus(T2Dm)patients are from retrospective cohorts with selection *** aimed at appraising the feasibility,results,and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease(mAFLD)severity and determinants in T2Dm ***:We conducted a 50-week crosssectional study enrolling adult T2Dm outpatients from a diabetes *** algorithm based on guidelines was applied using simple bioclinical scores and,if applicable,ultrasound and/or ***:Two hundred and thirteen patients were *** age and body mass index were 62 years and 31 kg/m^(2) and 29% of patients had abnormal transaminase *** acceptance rate of additional liver examinations was 92%.The prevalence of mAFLD,advanced fibrosis and cirrhosis was 87%,11%,and 4%,*** than half of the cases of advanced fibrosis had not been suspected and were detected by this *** was associated with poor glycemic control,elevated transaminases,low HDL-C and the absence of peripheral arterial *** fibrosis was linked to high waist circumference and excessive alcohol consumption,which should be interpreted with caution owing to the small number of patients reporting excessive ***:Simple bioclinical tools allowed routine triage of T2Dm patients for mAFLD severity,with high adherence of high-risk patients to subsequent noninvasive exams.

关键词： Noninvasive tests mAFLD Outpatient Steatosis Fibrosis

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