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Chinese Journal of mechanical Engineering 2021年第6期34卷 51-62页

作者： m.nuño J.Bühring m.N.Rao K.-U.Schröder Institute of Structural mechanics and Lightweight Design RWTH Aachen UniversityWüllnerstraβe 752072 AachenGermany

Sandwich structures possess a high bending stiffness compared to monolithic structures with a similar *** makes them very suitable for lightweight applications,where high stiffness to weight ratios are *** common m.nufacturing methods of sandwich structures involve adhesive bonding of the core material with the ***,adhesive bonding is prone to delamination,a failure mode that is often difficult to *** paper presents the results of delamination testing of fully additive m.nufactured(Am)AlSi10mg sandwich structures with pyramidal lattice truss core using Laser Powder Bed Fusion(LPBF).The faces and struts are 0.5 mm thick,while the core is 2 mm *** inclination of the struts is 45°.To characterise the bonding strength,climbing drum peel tests and out-of-plane tensile tests are *** formulas are derived to predict the expected failure loads and *** analytics and tests are supported by finite element(FE)*** the analytic approach,design guidelines to avoid delamination in Am sandwich structures are *** study presents a critical face sheet thickness to strut diameter ratio for which the structure can *** ratio is mainly influenced by the inclination of the *** peel tests resulted in face yielding,which can also be inferred from the analytics and *** out-of-plane tensile tests didn’t damage the structure.

关键词： Additive m.nufacturing Sandwich Structures Pyramidal Lattice Core

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Green hydrogen energy production:current status and potential

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Clean Energy 2024年第2期8卷 1-7页

作者： Ali o.m.maka mubbashar mehmood The Libyan Centre for Research and Development of Saharian Communities MurzuqLibya School of Engineering and Physical Sciences Heriot-Watt UniversityEdinburghEH144ASUK

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen ***,by implementing this technique,hydrogen will become a sustainable and clean energy source by lowering greenhouse gas emissions and reducing our reliance on fossil *** key benefit of producing green hydrogen by utilizing green energy is that no harmful pollutants or greenhouse gases are directly released throughout the ***,to guarantee all of the environmental advantages,it is crucial to consider the entire hydrogen supply chain,involving storage,transportation and end *** is a promising clean energy source and targets plan pathways towards decarbonization and net-zero emissions by *** paper has highlighted the techniques for generating green hydrogen that are needed for a clean environment and sustainable energy ***,it summarizes an overview,outlook and energy transient of green hydrogen ***,its perspective provides new insights and research directions in order to accelerate the development and identify the potential of green hydrogen production.

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen

AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension:A retrospective analysis

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Asian Pacific Journal of Tropical medicine 2024年第9期17卷 418-424页

作者： Hanzhong Yu Lei Li Shuyao Wei Qianqian Kong Wei nu Bo Dong Yuewu Zhao Li Wang Department of Clinical Laboratory the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221116China Department of Clinical Laboratory Xuzhou Tumor HospitalXuzhouJiangsu 221005China Department of Cardiovascular medicine the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221116China

objective:To investigate whether angiotensinⅡtype 1 receptor(AGTR1 A1166C)gene polymorphism was associated with the effectiveness of valsartan monotherapy in Chinese patients with essential ***:This retrospective analysis included 198 patients(≥18 years of age)who received valsartan monotherapy(80 mg/day)for newly developed essential hypertension at the authors’center between January 1,2020 and December 31,*** for AGTR1 A1166C gene polymorphism was done by polymerase chain reaction(PCR)-melting curve analysis of genomic DNA from peripheral blood samples.A dominant genetic model for AGTR1 A1166C(AA genotype versus AC+CC genotype)was *** regression analysis of baseline variables and AGTR1 polymorphism was conducted to identify predictors of target blood pressure attainment(mmHg)at the 4-week ***:The median age of the 198 patients was(53.7±13.5)years,and 58%were *** assays showed that 164 patients had the AA genotype,and 34 patients were of the AC/CC genotype,including 30 with the AC genotype and 4 with the CC *** distribution was consistent with Hardy Weinberg equilibrium.109 Patients(55.1%)attained the blood pressure *** analysis showed that smoking(versus no smoking,HR 0.314,95%CI 0.159-0.619,P=0.001)and AGTR1 A1166C AA genotype(versus AC/CC,HR 2.927,95%CI 1.296-6.611,P=0.023)were significant and independent predictors of target attainment.25 Patients(73.5%)with AGTR1 A1166C AC/CC genotype attained the target versus 51.2%(51/164)of patients with AGTR1 A1166C AA genotype(P=0.017).Patients with AGTR1 A1166C AC/CC genotype had a significantly greater reduction in systolic blood pressure[(33.1±10.8)mmHg versus(29.2±11.7)mmHg in AA carriers;(P=0.029)].Conclusions:Hypertensive patients carrying one or two C alleles of the AGTR1 A1166C gene were more responsive to valsartan treatment.

关键词： Essential hypertension AngiotensinⅡtype 1 receptor antagonist Valsartan AGTR1 A1166C Gene polymorphism

A native herbaceous community exerts a strong allelopathic effect on the woody range-expander Betula fruticosa

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Journal of Plant Ecology 2024年第4期17卷 131-140页

作者： Lichao Wang Ayub m.o.oduor Yanjie Liu State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China University of Chinese Academy of Sciences Beijing 100049China Department of Applied Biology Technical University of KenyaNairobiKenya

Biological invasions by alien and range-expanding native plant species can suppress native plants through ***,the homeland security hypothesis suggests that some native plants can resist invasion by producing allelopathic compounds that inhibit the growth of invasive *** research has focused on allelopathic interactions between individual native and invasive plant species,with less emphasis on how allelopathy helps entire native communities resist ***,limited knowledge exists about allelopathic interactions between range-expanding native species and recipient native communities,and their influence on invasion *** bridge this knowledge gap,we conducted two greenhouse competition experiments to test reciprocal allelopathic effects between a native woody range-expanding species,Betula fruticosa,and a community of four native herbaceous species(Sanguisorba officinalis,Gentiana manshurica,Sium suave and Deyeuxia angustifolia)in *** assessed whether *** and the native community differed in their competitive effects and responses,and whether these were influenced by activated carbon,which neutralizes allelochemicals in the *** carbon reduced the suppressive effects of the native community on the above-ground biomass of ***,which indicates that the native community exerted a strong allelopathic effect on *** contrast,activated carbon only marginally enhanced the suppressive effects of *** on the native community,which indicates that allelopathy is not the primary mechanism by which *** exerts its ***,these findings support the homeland security hypothesis and suggest that biotic resistance from the native herbaceous community may limit the invasion success of the woody range-expander ***.

关键词： allelochemicals competition encroachment global change non-native shrub

Fast prediction of rain erosion in wind turbine blades using a data-based computational tool

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Journal of Hydrodynamics 2024年第3期36卷 504-518页

作者： Juan m.Gimenez Sergio R.Idelsohn Eugenio oñate Centre Internacional de mètodes numèrics en Enginyeria(CImNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)face a high risk of failure due to environmental factors like erosion,particularly in high-precipitation areas and offshore *** this paper we introduce a novel computational tool for the fast prediction of rain erosion damage on WT blades that is useful in operation and maintenance decision making *** approach is as follows:Pseudo-Direct numerical Simulation(P-DNS)simulations of the droplet-laden flow around the blade section profile are employed to build a high-fidelity data set of impact statistics for potential operating *** this database as training data,a machine learning-based surrogate model provides the feature of the impact pattern over the 2-D section for given wind and rain *** this information,a fatigue-based model estimates the remaining lifetime and erosion damage for both homogeneous and coating-substrate blade *** prediction is done by quantifying the accumulated droplet impact energy and evaluating operative conditions over time periods for which the weather at the installation site is *** this work,we describe the modules that compose the prediction method,namely the database creation,the training of the surrogate model and their coupling to build the prediction ***,the method is applied to predict the remaining lifetime and erosion damage to the blade sections of a reference *** evaluate the reliability of the tool,several site locations(offshore,coastal,and inland),the coating material and the coating thickness of the blade are *** few m.nutes we are able to estimate erosion after many years of *** results are in good agreement with field observations,showing the promise of the new rain erosion prediction approach.

关键词： Wind turbine blades leading edge erosion fatigue Pseudo-Direct numerical Simulation(P-DNS) machine learning eblader

Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative medicine 2024年第3期22卷 235-244页

作者： miguel Faria mónica Teixeira maria João Pinto Paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal REQUImTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SoERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:Six electronic databases(Pubmed,EBSCo,Cochrane Library,Scielo,b-on and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using meSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(SmD)with 95%confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(SmD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SmD=–1.10,95%CI[–1.59,–0.61])or usual care(SmD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain meta-analysis Systematic review

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Use of DREAm to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 91-104页

作者： Daniela m.Pampanin Daniel Schlenk matteo Vitale Pierre Liboureau magne o Sydnes Department of Chemistry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Department of Environmental Sciences University of California RiversideRiversideCA 92521USA

Concerns related to environmental risks associated with pharmaceuticals and personal care products(PPCPs)have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic *** and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPCPs is ***,the suitability of a dose-related risk and effect assessment model,which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined,in combination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a PPCP *** of the most utilized PPCPs in Norway were measured in influent and effluent samples and used to parameterize the fate *** than 90%removal was attained for 12 out of 22 detected *** was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 *** simulations provided valuable information regarding the discharge plume distribution over time,which can aid planning of future environmental monitoring ***(using fish liver cells,PLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-o-deethylase(ERoD)*** present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPCP contamination into consideration when establishing environmental regulations.

关键词： Pharmaceuticals Wastewater effluent Ciprofloxacin metoprolol Amitriptyline Carbamazepine modelling Risk assessment monitoring

Elucidating the Degradation Pathways of Human Insulin in the Solid State

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Journal of Analysis and Testing 2024年第3期8卷 288-299页

作者： Andrew Fagan Lorraine m.Bateman Joseph P.o'Shea Abina m.Crean SSPC the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of Pharmacy University College Cork Analytical and Biological Chemistry Research Facility (ABCRF) University College Cork School of Chemistry University College Cork

While there have been significant advances in the development of peptide oral dosage forms in recent years, highlighted by the clinical and commercial success of approved peptides such as Rybelsus?, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. one such barrier includes the poor physical and chemical stability inherent to their structures, which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution state. Using insulin as a model peptide, this work sought to contribute to the development of analytical techniques for investigating common insulin degradation pathways. Chemically denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy, reverse phase HPLC and size exclusion chromatography methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule respectively. Solid state degraded samples were prepared by heating insulin powder at 60 °C and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and compared with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. Reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Biopharmaceutical analysis Covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

Energy and blast performance of beryllium in a model thermobaric composition in comparison with alum.num and magnesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thomas m.Klapotke Stanisław Cudziło Waldemar A.Trzcinski Jozef Paszula Energetic materials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany military University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct comparison is made between the effectiveness of Al,mg,and Be powders as additional fuels in model thermobaric compositions containing 20%fuel,20%ammonium perchlorate,and 60%RDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determined calorimetric measurements of the heat of detonation,along with the overpressure histories in an explosion chamber filled with nitrogen,were used to determine the quasi-static pressure(QSP)under anaerobic *** measurements were also performed in a semi-closed bunker,and all blast wave parameters generated after the detonation of 500 g charges of the tested explosives were *** calorimetry results,QSP values,and blast wave parameters(pressure amplitude,specific and total impulses)clearly indicate that Be is much more effective as an additional fuel than either Al or mg in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the RDXwax/AP/Be explosive mixture is over 40%and 50%higher than that of the mixture containing alum.num and magnesium instead of beryllium,***,the TNT equivalent of the Be-containing composition due to the overpressure in the nitrogen-filled explosion chamber is 1.66,while the equivalent calculated using an air shock wave-specific impulse at a distance of 2.5 m is equal to *** high values of these parameters confirm the high reactivity of beryllium in both the anaerobic and aerobic stages of the thermobaric explosion.

关键词： Thermobaric explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave parameters

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Europium recovery process by means of polymeric nanoparticles functionalized with acrylic acid,curcumin and fumaramide

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Journal of Rare Earths 2024年第10期42卷 1950-1959页

作者： P.A.martínez-montoya J.m.del Río A.de J.morales-Ramirez m.Corea Escuela Superior de Ingeniería Química e Industrias Extractivas ESIQIE-IPNDepartamento de Ingeniería Metalúrgica UPALM S/N Col.Lindavista Escuela Superior de Ingenieria Química e Industrias Extractivas ESIQIE-IPNLaboratorio de Investigación en Polímeros y NanomaterialesUPALM S/N Col.Lindavista Centra de Investigación e Innovación Tecnológica CIITEC-IPNCda.de CECATIs/n

Polymeric nanoparticles of poly(methyl methacrylate) were obtained by emulsion polymerization techniques in a proce ss of two *** particles were functionalized with acrylic acid,curcumin,and fumaramide and three series of polymeric particles were *** incorporation of functional groups was confirmed by Fourier transform-infrared spectrosocopy(FT-IR) and ultraviolet-visible(UV-Vis) *** spherical morphology of particles with an average diameter of 100 nm was observed by scartning electron microscopy(SEm).The polymeric materials were used for recovery of [Eu]from synthetic *** nanoparticles show excellent chelation capacity to trap rare-earth ions,because they recover more than 85% of [Eu] at pH of *** images of SEm after extraction process show arrays between particles with larger average particle sizes to 1.5 *** addition,the particles have a good stripping capacity,exceeding 50% of it,maintaining their homogeneity in morphology and good stability in dispersion for the recovery and stripping processes.A pseudo-second model order is obtained for the extraction and stripping processes while the best results of stripping process are obtained at pH of6.

关键词： Chelating effect Emulsion polymerization Extraction process Rare earths Stripping process [Eu]recovery