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Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： Hui-Hui LIU meng ZHANG Yuan-Lin GUO Cheng-Gang ZHU na-Qiong WU Ying GAO Rui-Xia XU Jie QIAN Ke-Fei DOU Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AmI).However,data regarding their prognostic value in the oldest old with AmI are ***,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVm)in the oldest old(≥80 years)with *** In this prospective study,a total of 933 consecutive old patients with AmI admitted to FuWai hospital(Beijing,China)were *** admission,ABG,SHR,and GG were assessed and all participants were classified according to their ***-meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVm within 30 days and long-term *** During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were ***-meier analyses showed the lowest CVm in quartile 1 of ABG and in quartile 2 of SHR and *** adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVm risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term ***,we observed similar associations of these acute glycemic parameters with 30-day *** Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVm among the oldest old with AmI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

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Dna methylation of SmPD3-based diagnostic biomarkers of naSH and mild fibrosis

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Genes & Diseases 2024年第1期11卷 99-102页

作者： na Wu mofan Feng Siran Yue Xinyu Shi nan Tang Yalan Xiong Jianying Wang Lei Zhang Hualing Song Yi Shi Guang He Guang Ji Baocheng Liu Shanghai Innovation Center of Traditional Chinese medicine Health Service School of Public HealthShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Institute for Advancing Translational medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China

Non-alcoholic fatty liver disease(naFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with naFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(naSH),accompanied by bridging *** advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over ***,even slight inflammation or fibrosis in naFLD can significantly increase the likelihood of progression compared to steatosis *** underscores the importance of revising the present methods of monitoring naFLD patients to ensure early detection and effective management of the disease.

关键词： naFLD inflammation naSH

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Synthesis of highly stable Ni nanoparticles via electrostatic self-assembly for enhanced hydrogen storage of mgH_(2)

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Rare metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan Liu Rui Shi Yun-Feng Zhu Ji-Guang Zhang Ya-na Liu Jun Wang Yao Zhang Xiao-Hui Hu Zhi-Bin Liu Li-Quan Li College of materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech UniversityNanjing 211816China School of materials Science and Engineering Southeast UniversityNanjing 211189China

magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed Ni-based catalyst(Ni/Al_(2)O_(3)/GN)was fabricated to promote the hydrogen storage performance of mgH_(2)via the electrostatic effect of NiAl-LDH/GN precursor with a co-calcination reduction ***_(2)-5wt%Ni/Al_(2)O_(3)/GN exhibits excellent hydrogen storage performance,releasing about 5.7 wt%hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt%in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·mol^(-1).Impressively,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in Ni/Al_(2)O_(3)/GN on the hydrogen storage performance of mgH_(2)was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of Ni/Al_(2)O_(3)/GN was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： magnesium hydride Ni/Al_(2)O_(3)/GN Hydrogen storage performance Catalytic mechanism

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A reference-grade genome of the xerophyte Ammopiptanthus mongolicus sheds light on its evolution history in legumes and droughttolerance mechanisms

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Plant Communications 2024年第7期5卷 157-177页

作者： Lei Feng Fei Teng na Li Jia-Cheng Zhang Bian-Jiang Zhang Sau-na Tsai Xiu-Le Yue Li-Fei Gu Guang-Hua meng Tian-Quan Deng Suk-Wah Tong Chun-ming Wang Yan Li Wei Shi Yong-Lun Zeng Yue-ming Jiang Weichang Yu Sai-ming Ngai Li-Zhe An Hon-ming Lam Jun-Xian He School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongSha TinNew TerritoriesHong KongChina Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China BGI-Shenzhen Tech Co. Ltd.Beishan Industrial ZoneYantian DistrictShenzhen 518083China School of Life Sciences and ministry of Education Key Laboratory of Cell Activities and Stress Adaptations Lanzhou UniversityLanzhou 730030China State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Applied Botany&Key Laboratory of South China Agricultural Plant molecular Analysis and Genetic Improvement South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China

Plants that grow in extreme environments represent unique sources of stress-resistance genes and *** mongolicus(Leguminosae)is a xerophytic evergreen broadleaf shrub native to semi-arid and desert regions;however,its drought-tolerance mechanisms remain poorly ***,we report the assembly of a reference-grade genome for ***,describe its evolutionary history within the legume family,and examine its drought-tolerance *** assembled genome is 843.07 mb in length,with 98.7%of the sequences successfully anchored to the nine chromosomes of *** genome is predicted to contain 47611 protein-coding genes,and 70.71%of the genome is composed of repetitive sequences;these are dominated by transposable elements,particularly longterminal-repeat *** analyses revealed two whole-genome duplication(WGD)events at 130 and 58 million years ago(mya)that are shared by the genus Ammopiptanthus and other legumes,but no species-specific WGDs were found within this *** genome reconstruction revealed that the *** genome has undergone fewer rearrangements than other genomes in the legume family,confirming its status as a"relict plant".Transcriptomic analyses demonstrated that genes involved in cuticular wax biosynthesis and transport are highly expressed,both under normal conditions and in response to polyethylene glycol-induced *** induction of genes related to ethylene biosynthesis and signaling was also observed in leaves under dehydration stress,suggesting that enhanced ethylene response and formation of thick waxy cuticles are two major mechanisms of drought tolerance in *** expression of AmERF2,an ethylene response factor unique to ***,can markedly increase the drought tolerance of transgenic Arabidopsis thaliana plants,demonstrating the potential for application of *** genes in crop improvement.

关键词： Ammopiptanthus mongolicus genome sequencing genome evolution drought tolerance cuticular wax ethylene

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纵向通风作用下隧道内氢泄漏爆炸隐患分析

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西南交通大学学报 2024年第1期59卷 81-86页

作者：谢永亮吕娜西南交通大学机械工程学院四川成都610031

为研究纵向通风能否有效控制隧道中泄漏氢气的扩散以及降低可燃氢云的超压危害,本文以一长100 m的方形隧道为研究对象,利用FLUENT软件对隧道内氢气泄漏扩散现象进行数值模拟,基于可燃氢云爆炸超压对人和建筑物的危害分级,分析纵向通风... 详细信息

为研究纵向通风能否有效控制隧道中泄漏氢气的扩散以及降低可燃氢云的超压危害,本文以一长100 m的方形隧道为研究对象,利用FLUENT软件对隧道内氢气泄漏扩散现象进行数值模拟,基于可燃氢云爆炸超压对人和建筑物的危害分级,分析纵向通风降低隧道内氢气泄漏爆炸危害性的作用效果.研究结果表明:计算工况下,隧道内发生氢气射流火灾时的纵向风速范围为6.5~8.0 m/s;纵向通风能够有效控制隧道内氢气的泄漏和扩散,但不能完全消除隧道氢泄漏爆炸的可能性和危害性.

关键词：氢能隧道火灾爆炸数值模拟纵向通风临界风速

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甲基化转移酶WTAP调节转录激活因子4表达加剧缺氧/复氧诱导的心肌细胞损伤

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中华危重病急救医学 2024年第3期36卷 279-285页

作者：杨娜曹敏成都市第三人民医院麻醉科四川成都610000 成都市第三人民医院泌尿外科四川成都610000

目的观察甲基化转移酶Wilms肿瘤蛋白1相关蛋白(WTAP)在缺氧/复氧(H/R)诱导的心肌细胞损伤中的调节作用及其分子机制。方法①实验一:将H9C2心肌细胞分为空白对照组和H/R模型组。采用H/R诱导H9C2细胞建立心肌缺血/再灌注(I/R)损伤模型;空... 详细信息

目的观察甲基化转移酶Wilms肿瘤蛋白1相关蛋白(WTAP)在缺氧/复氧(H/R)诱导的心肌细胞损伤中的调节作用及其分子机制。方法①实验一:将H9C2心肌细胞分为空白对照组和H/R模型组。采用H/R诱导H9C2细胞建立心肌缺血/再灌注(I/R)损伤模型;空白对照组不进行处理。采用N6-甲基腺苷(m6A)Rna甲基化测定试剂盒检测m6A水平;分别采用实时荧光定量聚合酶链反应(RT-qPCR)和蛋白质免疫印迹试验(Western blotting)检测甲基化转移酶〔WTAP、甲基转移酶样蛋白(mETTL3、mETTL14)〕的基因和蛋白表达水平。②实验二:将H9C2心肌细胞分为空白对照组、H/R+sh-NC组、H/R+sh-WTAP组。H/R+sh-WTAP组转染sh-WTAP以敲降WTAP表达,其余各组制模方法同实验一。转染48 h后,采用流式细胞术检测细胞凋亡率;采用Western blotting检测WTAP、活化天冬氨酸特异性半胱氨酸蛋白酶3(caspase-3)、活化多聚二磷酸腺苷酸核糖聚合酶(PARP)、转录激活因子4(ATF4)、蛋白激酶Rna样内质网激酶(PERK)、磷酸化PERK(p-PERK)和CCAAT/增强子结合蛋白同源蛋白(CHOP)的蛋白表达水平;采用免疫荧光染色观察ATF4阳性表达情况。③实验三:将H9C2心肌细胞分为空白对照组、H/R+sh-NC组、H/R+sh-WTAP和H/R+sh-WTAP+ATF4组。H/R+sh-WTAP+ATF4组用过表达质粒ATF4转染H9C2心肌细胞,其余各组制模方法同实验二。采用流式细胞术检测细胞凋亡率;采用Western blotting检测ATF4、CHOP、活化caspase-3和活化PARP的蛋白表达水平。结果①实验一:H/R模型组m6A甲基化水平较空白对照组显著上调。RT-qPCR检测结果显示,H/R模型组mETTL3、mETTL14和WTAP基因表达水平均较空白对照组显著上调,以WTAP上调最显著;Western blotting检测结果呈相同趋势。提示甲基化转移酶WTAP的表达水平在H/R诱导的心肌细胞中显著上调。②实验二:H/R+sh-WTAP组细胞凋亡水平较H/R+sh-NC组明显减少〔(14.16±1.58)%比(24.51±2.38)%,P<0.05〕。Western blotting检测结果显示,H/R+sh-WTAP组WTAP、活化caspase-3、活化PARP、p-PERK、ATF4和CHOP的蛋白表达水平均较H/R+sh-NC组显著下调。荧光显微镜下显示,H/R+sh-WTAP组ATF4阳性信号较H/R+sh-NC组显著减弱〔(19.36±1.81)%比(32.83±2.69)%,P<0.01〕。提示敲降WTAP可抑制H/R诱导的心肌细胞凋亡和内质网应激。③实验三:H/R+sh-WTAP+ATF4组细胞凋亡水平较H/R+sh-WTAP组显著增加〔(26.61±2.76)%比(17.14±0.87)%,P<0.05〕。Western blotting检测结果显示,H/R+sh-WTAP+ATF4组ATF4、CHOP、活化caspase-3和活化PARP的蛋白表达水平较H/R+sh-WTAP组显著上调。提示过表达ATF4可逆转sh-WTAP对H/R诱导的心肌细胞中内质网应激和细胞凋亡的抑制作用。结论甲基化转移酶WTAP可调节ATF4表达,介导细胞凋亡和内质网应激,促进H/R诱导的心肌细胞损伤。

关键词：甲基转移酶 Wilms肿瘤蛋白1相关蛋白细胞凋亡内质网应激缺氧/复氧

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An Analysis of the Low moving Speed of Landfalling Typhoon In-Fa in 2021

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Journal of Tropical meteorology 2024年第1期30卷 51-60页

作者：郑丽娜吕新刚李瑞 Jinan meteorological Bureau of Shandong Province Jinan 250102 China

The movement speed of Typhoon In-Fa(2021)was notably slow,at 10 km h-1or less,for over 20 hours following its landfall in Zhejiang,China,in contrast to other typhoons that have made *** study examines the factors contributing to the slow movement of Typhoon In-Fa,including the steering flow,diabatic heating,vertical wind shear(VWS),and surface synoptic situation,by comparing it with Typhoons Yagi(2018)and Rumbia(2018)which followed similar *** findings reveal that the movement speed of Typhoons Yagi and Rumbia is most closely associated with their respective 500 h Pa environmental winds,with a steering flow of 10^(-12)m s^(-1).In contrast,Typhoon InFa’s movement speed is most strongly correlated with the 850 h Pa environmental wind field,with a steering flow speed of only 2 m s^(-1).Furthermore,as Typhoon In-Fa moves northwest after landfall,its intensity is slightly greater than that of Typhoons Yagi and Rumbia,and the pressure gradient in front of Typhoon In-Fa is notably smaller,leading to its slow ***,the precipitation distribution of Typhoon In-Fa differs from that of the other two typhoons,resulting in a weak asymmetry of wavenumber-1 diabatic heating,which indirectly affects its movement *** analysis indicates that VWS can alter the typhoon’s structure,weaken its intensity,and ultimately impact its movement.

关键词： landfalling typhoon steering flow diabatic heating VWS

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Effects of Dietary Changes on the Gut microbiota of Cynops orientalis

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG Yuning XIE Siyu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi SHI Yingying SHI Zhirong HE Chunna ZHANG Yixin JIANG na ZHAO Jiaqi LI Supen WANG College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully *** this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order ***,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRna amplicon sequencing ***,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive ***,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various ***,we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of *** in a large-scale spatiotemporal *** study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16S rRna Caudata core microbiota diet gut microbiota

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The Uptake and Distribution Evidence of nano-and microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： HONG Tao SUN Wei DENG Yuan LYU Jian Da JIN Cui Hong BAI Ying Long na Jun ZHANG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(Pm group,the FI only increased in the lung at 2 h(Pm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(Pnano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of mPs could penetrate the organs.

关键词： microplastics nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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女性生殖道畸形的诊治和生育新观念

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中华妇产科杂志 2024年第5期59卷 343-345页

作者：朱兰陈娜中国医学科学院北京协和医院妇产科、国家妇产疾病临床医学研究中心、疑难重症及罕见病全国重点实验室北京100730

本文简要介绍两类罕少见的女性生殖道畸形疾病近年来的诊治和生育进展。强调对不合并功能性子宫内膜的mayer-Rokitansky-Küster-Hauser综合征(mRKH综合征)患者,非手术治疗(顶压法)为一线治疗,国内医师应更新治疗观念;少数合并功能性子... 详细信息

本文简要介绍两类罕少见的女性生殖道畸形疾病近年来的诊治和生育进展。强调对不合并功能性子宫内膜的mayer-Rokitansky-Küster-Hauser综合征(mRKH综合征)患者,非手术治疗(顶压法)为一线治疗,国内医师应更新治疗观念;少数合并功能性子宫内膜的mRKH综合征患者,明确诊断后应及时行腹腔镜双侧始基子宫切除术,是否同时行阴道重建术需与患方充分沟通后决策。目前,代孕和子宫移植技术均可实现mRKH综合征患者的生育需求,在法律允许的前提下,代孕对患者的创伤和经济成本等方面优于子宫移植。目前,先天性子宫颈发育异常患者保留生育功能的子宫颈管通道重建术式有贯通术和吻合术两类。对于有足够子宫颈组织的患者,可考虑行贯通术。吻合或贯通术后保持生殖道的通畅性是治疗成功的关键。保留生育功能的重建手术后患者可获得生育的希望,但总体妊娠率仍较低,需妇科、产科和生殖医学专家全程通力合作以改善该类患者的生育结局。

关键词：保留生育功能 mRKH综合征子宫颈管代孕子宫移植通畅性生育结局顶压法

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