检索结果-南通市图书馆

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés mercedes Lachén-montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.naffaa Department of Psychology and neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Improvement of microstructure and mechanical Behavior of Gas Tungsten Arc Weldments of Alloy C-276 by Current Pulsing

在线全文

学校读者我要写书评

暂无评论

Acta metallurgica Sinica(English Letters) 2015年第2期28卷 208-215页

作者： m.manikandan n.Arivazhagan m.nageswara rao G.madhusudhan Reddy School of mechanical and Building Sciences VIT University Defence metallurgical and Research Laboratory

Superalloy C-276 is known to be prone to hot cracking during fusion welding by Gas Tungsten Arc method. microsegregation occurring during cooling of fusion zone with consequent appearance of topologically close-packed phases P and IX has been held responsible for the observed hot cracking. The present work investigated the possibility of suppressing the microsegregation in weldments by resorting to current pulse. Weldments were made by continuous current gas tungsten arc welding and pulsed current gas tungsten arc welding using ERniCrmo-4 filler wire. The weld joints were studied with respect to microstructure, microsegregation, and mechanical properties. Optical microscopy and scanning electron microscopy were employed to study the microstructure. Energy-Dispersive X-ray Spectroscopy was carried out to evaluate the extent of microsegregation. Tensile testing was carried out to determine the strength and ductility. The results show that the joints fabricated with pulsed current gave rise to narrower welds with practically no heat affected zone, a refined microstructure in the fusion zone, reduced microsegregation, and superior combination of mechanical properties.

关键词： Alloy C-276 Pulsed current gas tungsten arc welding microsegregation

mitochondria–cGAS–STInG axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

An improved analytical model of 4H-SiC mESFET incorporating bulk and interface trapping effects

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2015年第1期36卷 64-75页

作者： m.Hema Lata rao n.V.L.narasimha murty School of Electrical Sciences IIT BhubaneswarBhubaneswar 751013India

An improved analytical model for the current–voltage（I–V） characteristics of the 4H-SiC metal semiconductor field effect transistor（mESFET） on a high purity semi-insulating（HPSI） substrate with trapping and thermal effects is presented. The 4H-SiC mESFET structure includes a stack of HPSI substrates and a uniformly doped channel layer. The trapping effects include both the effect of multiple deep-level traps in the substrate and surface traps between the gate to source/drain. The self-heating effects are also incorporated to obtain the accurate and realistic nature of the analytical model. The importance of the proposed model is emphasised through the inclusion of the recent and exact nature of the traps in the 4H-SiC HPSI substrate responsible for substrate *** analytical model is used to exhibit DC I–V characteristics of the device with and without trapping and thermal effects. From the results, the current degradation is observed due to the surface and substrate trapping effects and the negative conductance introduced by the self-heating effect at a high drain voltage. The calculated results are compared with reported experimental and two-dimensional simulations（Silvaco -TCAD）. The proposed model also illustrates the effectiveness of the gate–source distance scaling effect compared to the gate–drain scaling effect in optimizing 4H-SiC mESFET performance. Results demonstrate that the proposed I–V model of 4H-SiC mESFET is suitable for realizing SiC based monolithic circuits（mmICs） on HPSI substrates.

关键词： SiC mESFET HPSI substrate deep-level traps mmICs

Artificial neural network approach for prediction of stress–strain curve of near b titanium alloy

在线全文

学校读者我要写书评

暂无评论

Rare metals 2014年第3期33卷 249-257页

作者： Srinivasu Gangi Setti R.n.rao mechanical Engineering National Institute of Technology

In the present study, artificial neural network（Ann） approach was used to predict the stress-strain curve of near beta titanium alloy as a function of volume fractions of a and b. This approach is to develop the best possible combination or neural network（nn） to predict the stress-strain curve. In order to achieve this, three different nn architectures（feed-forward back-propagation network,cascade-forward back-propagation network, and layer recurrent network）, three different transfer functions（purelin, Log-Sigmoid, and Tan-Sigmoid）, number of hidden layers（1 and 2）, number of neurons in the hidden layer（s）,and different training algorithms were employed. Ann training modules, the load in terms of strain, and volume fraction of a are the inputs and the stress as an *** system was trained using the prepared training set（a,16 % a, 40 % a, and b stress-strain curves）. After training process, test data were used to check system accuracy. It is observed that feed-forward back-propagation network is the fastest, and Log-Sigmoid transfer function is giving the best results. Finally, layer recurrent nn with a single hidden layer consists of 11 neurons, and Log-Sigmoid transfer function using trainlm as training algorithm is giving good result, and average relative error is1.27 ± 1.45 %. In two hidden layers, layer recurrent nn consists of 7 neurons in each hidden layer with trainrp as the training algorithm having the transfer function of LogSigmoid which gives better results. As a result, the nn is founded successful for the prediction of stress-strain curve of near b titanium alloy.

关键词： Artificial neural network (Ann) Stressstrain curve Titanium alloys

Separation of metallic and Semiconducting Single-Walled Carbon nanotubes Through Fluorous Chemistry

在线全文

学校读者我要写书评

暂无评论

nano Research 2009年第3期2卷 183-191页

作者： Sandeep Ghosh n.R.rao Chemistry and Physics of materials Unit DST unit on Nanoscience and CSIR Centre of Excellence in ChemistryJawaharlal Nehru Centre for Advanced Scientifi c ResearchJakkur P.O.Bangalore-560064India Solid State and Structural Chemistry Unit Indian Institute of ScienceBangalore-560012India

Separation of metallic from semiconducting single-walled carbon nanotubes has been a major challenge for some time and some previous efforts have resulted in partial success. We have accomplished the separation effectively by employing fl uorous chemistry wherein the diazonium salt of 4-heptadecafl uorooc tylaniline selectively reacts with the metallic nanotubes present in the mixture of nanotubes. The resulting fl uoroderivative was extracted in perfl uorohexane leaving the semiconducting nanotubes in the aqueous layer. The products have been characterized by both Raman and electronic absorption spectroscopy. The method avoids the cumbersome centrifugation step required by some other procedures.

关键词： Carbon nanotubes metallic semiconducting fl uorous separation