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Efficacy of medium-chain fatty acid salts distilled from coconut oil against two enteric pathogen challenges in weanling piglets

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Journal of Animal Science and Biotechnology 2020年第1期11卷 251-267页

作者： Paola López-Colom Lorena Castillejos Agustina Rodríguez-Sorrento mónica Puyalto Juan Josémallo Susana maría martín-Orúe Animal nutrition and Welfare Service Animal and Food Science DepartmentFacultat de VeterinàriaUniversitat Autònoma de BarcelonaBellaterraSpain norel S.A MadridSpain.

Background:The search for alternatives to antibiotics in pig production has increased the interest in natural resources with antimicrobial properties,such as medium-chain fatty acids(mCFA)as in-feed *** study evaluated the potential of a novel blend of mCFA salts(DiC)from distilled coconut oil with a lauric acid content to reduce enteropathogens and control intestinal diseases around *** experimental disease models were implemented in early-weaned piglets,consisting of two oral challenges:Salmonella Typhimurium(1.2×10~8 CFU)or enterotoxigenic Escherichia coli(ETEC)F4(1.5×10~9 CFU).The parameters assessed were:animal performance,clinical signs,pathogen excretion,intestinal fermentation,immune-inflammatory response,and intestinal ***:The Salmonella challenge promoted an acute course of diarrhea,with most of the parameters responding to the challenge,whereas the ETEC F4 challenge promoted a mild clinical course.A consistent antipathogenic effect of DiC was observed in both trials in the hindgut,with reductions in Salmonella *** counts in the cecum(P=0.03)on d 8 post-inoculation(Pi)(Salmonella trial),and of enterobacteria and total coliform counts in the ileum and colon(Pn d 8 Pi(ETEC F4 trial).When analyzing the entire colonic microbiota(16 S rRnA gene sequencing),this additive tended(P=0.13)to reduce the Firmicutes/Bacteroidetes ratio and enriched Fibrobacteres after the Salmonella *** the ETEC F4 challenge,DiC prompted structural changes in the ecosystem with increases in Dialister,and a trend(P=0.14)to increase the Veillonellaceae *** parameters such as the intestinal fermentation products or serum pro-inflammatory mediators were not modified by DiC supplementation,nor were the histological *** the intraepithelial lymphocyte(iEL)counts were lowered by DiC in animals challenged with Salmonella(P=0.07).With ETEC F4,the iEL counts were higher with DiC on d 8 Pi(P=0.08).Conclusions:This study c

关键词： Enteric pathogen Gut microbiota intestinal immunity medium-chain fatty acids Weaning pig

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Enhancement of Second- and Third-Order nonlinear Optical Susceptibilities in magnetized Semiconductors

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Chinese Physics Letters 2008年第9期25卷 3276-3279页

作者： m. Singh P. Aghamkar S. Duhan Department of Applied Sciences P.D.M. College of Engineering Bahadurgarh-124507 India Department of Applied Physics G.J. University of Science and Technology Hisar-125001 India Department of Physics Chaudhary Devi Lal University Sirsa-125055 India

Using electromagnetic treatment, an expression of effective nonlinear optical susceptibility χe [= χe^（2）＋ χe^（3） E] is obtained for Ⅲ-Ⅴ semiconducting crystals in an applied transverse dc magnetic fiem under off-resonant transition regime. The origin of nonlinear interaction lies in nonlinear polarization arising from the crystal properties such as piezoelectricity and electrostriction. numerical estimates have been made by a representative n-inSb crystal at 77K duly irradiated by a pulsed 10.6-μm CO2 laser under off-resonant transition regime. Efforts are dedicated to optimizing doping level and externally applied dc magnetic field to achieve maximum χe^（2） and χ3^（3）. The results are found to be in good agreement with the available literature. The analysis shows that χe^（2） and χe^（3） can be significantly enhanced in doped Ⅲ-Ⅴ semiconductors by the proper selection of doping concentration and dc magnetic field, which confirms its potential as a candidate material for the fabrication of nonlinear optical devices.

关键词： the power-law exponents precipitation durative abrupt precipitation change

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使用英国国家健康体系数据提升国民健康水平

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中国医院院长 2017年第2期13卷 22-23页

作者： n m R Perrin 刘雨

健康档案所包含的信息对于提供医疗保健及推进医学研究有着巨大的潜力。但前提是公众及专业人士要对妥善管理的患者数据访问体系有信心。上周发表的两篇报告向这一目标迈出了重要的一步。

关键词：数据访问健康水平健康体系国民英国医学研究医疗保健健康档案

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Generalized quantum mechanical two-Coulomb-center problem (Demkov problem)

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Chinese Physics B 2013年第9期22卷 245-251页

作者： A.m.Puchkov A.V.Kozedub E.O.Bodnia Theoretical Department Institute of PhysicsSt. Petersburg State University Department of Computational Physics Faculty of PhysicsSt. Petersburg State University

We present a new exactly solvable quantum problem for which the Schrtidinger equation allows for separation of variables in oblate spheroidal coordinates. namely, this is the quantum mechanical two-Coulomb-center problem for the case of an imaginary intercenter parameter and complex conjugate charges are considered. Since the potential is defined by the two-sheeted mapping whose singularities are concentrated on a circle rather than at separate points, there arise additional possibilities in the choice of boundary conditions. A detailed classification of the various types of boundary-value problems is given. The quasi-radial equation leads to a new type of boundary value problem which has never been considered before. Results of the numerical calculations, which allow conclusions to be drawn about the structure of the energy spectrum, are shown. Possible physical applications are discussed.

关键词： two-Coulomb-center problem potential models

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Human myoblast genome therapy

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Journal of Geriatric Cardiology 2006年第3期3卷 135-151页

作者： Peter K Law Danlin m Law Eugene KW Sim Khawja H Haider margarita n Vakhromeeva ilia i Berishvili Leo A Bockeria Choong-Chin Liew Cell Transplants Asia Ltd. Canada national University medical institutes National University of Singapore Singapore Department of Pathology and Laboratory medicine University of Cincinnati Ohio USA Bakoulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences Russia Bingham and Women's Hospital The Cardiovascular Genome Unit Harvard Medical School USA

Human myoblast Genome Therapy (HmGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. injection injury activates regeneration of host myofibers that fuse with the engrafted myoblasts, sharing their nuclei in a common gene pool of the syncytium. Thus, through nuclear transfer and complementation, the normal human genome can be transferred into muscles of patients with genetic disorders to achieve phenotype repair or disease prevention. myoblasts are safe and efficient gene transfer vehicles endogenous to muscles that constitute 50% of body weight. Results of over 280 HmGT procedures on Duchenne muscular Dystrophy (DmD) subjects in the past 15 years demonstrated absolute safety. myoblast-injected DmD muscles showed improved histology. Strength increase at 18 months post-operatively averaged 123%. in another application of HmGT on ischemic cardiomyopathy, the first human myoblast transfer into porcine myocardium revealed that it was safe and effective. Clinical trials on approximately 220 severe cardiomyopathy patients in 15 countries showed a mortality. most subjects received autologous cells implanted on the epicardial surface during coronory artery bypass graft, or injected on the endomyocardial surface percutaneously through guiding catheters. Significant increases in left ventricular ejection fraction, wall thickness, and wall motion have been reported, with reduction in perfusion defective areas, angina, and shortness of breath. As a new modality of treatment for disease in the skeletal muscle or myocardium, HmGT emerged as safe and effective. Large randomized multi-center trials are under way to confirm these preliminary results. The future of HmGT is bright and exciting.

关键词： heart regeneration human genome therapy myoblasts

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CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells

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World Journal of Gastroenterology 2013年第17期19卷 2621-2628页

作者： János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter mátyus Evelin Horváth Gábor Speer istván Takács Zsolt nagy Henrik Horváth Péter Lakatos 1 st Department of internal medicine Semmelweis University Department of Organic Chemistry University of Szeged Department of Organic Chemistry Semmelweis University

Aim:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. mETHODS:We examined the expression of CYP24A1 mRnA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:in response to 1,25-D3, CYP24A1 mRnA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. COnCLUSiOn:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC.

关键词： Colorectal cancer CYP24A1 inhibition Vitamin D3 Tetralone derivatives Caco-2 cell culture

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巴西土壤调查中所用的分类系统

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土壤学进展 1990年第4期18卷 29-34,54页

作者： m.n.Camargo 杜国华

本文阐述了巴西土壤调查中所应用的土壤分类系统的诊断层、诊断特性,及它们与美国和联合国粮农组织有关系统的异同。并列出高级分类单元的检索。

关键词：土壤调查分类系统巴西

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南乌拉尔的上前寒武纪地层

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华北地质 1981年第2期 14-25页

作者： n.m.Chumakov 高坪仙

关于上前寒武系的进一步划分问题,南乌拉尔的剖面具有很重要的意义,因为它的许多地层单位具有普遍的地层意义(上里菲提穆里、库达什等)。穿过南乌拉尔上前寒武纪地层,或更确切地说是经过巴什基尔复背斜的剖面,许多代的地质学家都仔细研... 详细信息

关于上前寒武系的进一步划分问题,南乌拉尔的剖面具有很重要的意义,因为它的许多地层单位具有普遍的地层意义(上里菲提穆里、库达什等)。穿过南乌拉尔上前寒武纪地层,或更确切地说是经过巴什基尔复背斜的剖面,许多代的地质学家都仔细研究过,尽管它各个时期的某些构造还未最后确定。这种剖面尤其

关键词：砂岩层卢卡亚组加什细粒砂岩厚度辉绿岩体粉砂岩碎屑岩碎屑砂岩石英岩状砂岩前寒武纪地层

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用于勘探和开发的下一代可视化技术

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国外石油动态 2002年第6期 6-7页

作者： n．m．Zamel 谢力

浸入式可视化技术能够使多学科工作队讨论油田开发场景，如在付出昂贵的代价前设计虚拟升。然而，即使对先进的可视化系统来说，大量的数据仍构成了挑战。需要一个遥控协作模型来集中不同位置的和专家意见。

关键词：油气勘探开发可视化技术高分辨率油藏模拟地震-模拟技术一体化

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Substituent effect on spectral and antimicrobial activity of Schiff bases derived from aminobenzoic acids

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Advances in Biological Chemistry 2013年第5期3卷 475-479页

作者： Felicia n. Ejiah Tolulope m. Fasina Oluwole B. Familoni Folashade T. Ogunsola Department of Chemistry University of Lagos Lagos Nigeria Department of medical microbiology College of Medicine University of Lagos Lagos Nigeria

The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities. The absorption maxima in all three solvents exhibited dependence on the position of substituent with the absorption maxima undergoing a red shift as solvent polarity increased. The in vitro antibacterial activity of the compounds against some clinically important bacteria namely Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), Enterococcus feacalis (ATCC 29212) was determined in n,n”-dimethylformamide and 1,4-dioxane using the agar dilution method. The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent.

关键词： Schiff Base Aminobenzoic Acid Antibacterial Activity Salicyaldehyde Electronic Spectra

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