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Formation and Surface Structural Features of Crystalline Ceramic Nanocomposite Coatings on Aluminium Using Lithium Sulphate with Silicate Additive

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Acta metallurgica Sinica(English Letters) 2014年第2期27卷 185-197页

作者： m.mubarak ali V.Raj Department of Chemistry Chikkaiah Naicker College Advanced materials Research Laboratory Department of ChemistryPeriyar University

We have synthesized a series of the ceramic coatings by anodization of aluminium using lithium sulphate and sodium silicate additive. Our experiments show that the present coatings are nanocomposites in nature, consisting of a mixture of nanocrystalline alumina, silica, aluminium silicate and mullite; the formation of alumina was similar to conventional anodizing technology, while the formation of mullite was attributed to an addition of sodium silicate. The microhardness of the coatings progressively increased with the increasing current density up to 0.2 A/cm2, which could mainly be attributed to the decrease of porosity in the interfacial region of the oxides up to the range. From the performance of the coatings against corrosion （Tafel/Nyquist plots）, it was inferred that the coatings fabricated by lithium sulphatesodium silicate bath have enhanced corrosion resistance （Rp = 3.12 kΩ）, as well as better microhardness value than that of the lithium sulphate bath alone （Rp = 660.96 Ω） which confirm the perception that the silica particles included in the anodized alumina matrices randomly. Presence of Al, Si and O indicated that the electrolyte components had been intensively incorporated into the coatings.

关键词： Anodization Nanocomposite Ceramic Lithium sulphate

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali mohamed margherita Piccolella mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

High-dose-rate intraluminal brachytherapy during preoperative chemoradiation for locally advanced rectal cancers

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World Journal of Gastroenterology 2010年第35期16卷 4436-4442页

作者： mutahir ali Tunio mansoor Rafi Altaf Hashmi Rehan mohsin Abdul Qayyum mujahid Hasan Amjad Sattar muhammad mubarak Department of Radiation Oncology Sindh Institute of Urology and Transplantation Department of Surgical Oncology Sindh Institute of Urology and Transplantation Department of medical Oncology Sindh Institute of Urology and Transplantation Department of Gastroenterology Sindh Institute of Urology and Transplantation Department of Radiology Sindh Institute of Urology and Transplantation Department of Pathology Sindh Institute of Urology and Transplantation

AIm:To determine the feasibility and safety of high dose rate intraluminal brachytherapy(HDR-ILBT) boost during preoperative chemoradiation for rectal ***:Between 2008 and 2009,thirty-six patients with locally advanced rectal cancer(≥ T3 or N+),were treated initially with concurrent capecitabine(825 mg/m2 oral twice daily) and pelvic external beam radiotherapy(EBRT)(45 Gy in 25 fractions),then were randomized to group A;HDR-ILBT group(n = 17) to receive 5.5-7 Gy×2 to gross tumor volume(GTV) and group B;EBRT group(n = 19) to receive 5.4 Gy×3 fractions to GTV with *** patients underwent total mesorectal ***:Grade 3 acute toxicities were registered in 12 patients(70.6%) in group A and in 8(42.1%) in group *** pathologic response of T stage(ypT0) in group A was registered in 10 patients(58.8%) and in group B,3 patients(15.8%) had ypT0(P median follow up of 18 mo,late grade 1 and 2 sequelae were registered in 3 patients(17.6%) and 4 patients(21.1%) in the groups A and B,***:HDR-ILBT was found to be effective dose escalation technique in preoperative chemoradiation for rectal cancers,with higher response rates,downstaging and with manageable acute toxicities.

关键词： High dose rate Intraluminal brachytherapy boost Locally advanced rectal cancer Preoperative chemoradiation

Revolution in the diagnosis and management of hepatitis C virus infection in current era

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World Journal of Hepatology 2022年第4期14卷 647-669页

作者： Farina m Hanif Zain majid Nasir Hassan Luck Abbas ali Tasneem Syed muddasir Laeeq muhammed mubarak Department of Hepatogastroenterology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Histopathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

Chronic hepatitis C virus(HCV)infection is a major global public health problem,particularly in developing part of the *** advances have been made in the early diagnosis and treatment of the *** management has been particularly revolutionized during the past two *** this review,we summarize the major advances in the diagnostic and management armamentarium for chronic HCV *** focus of the present review is on the newer directly acting anti-viral agents,which have revolutionized the management of chronic HCV *** of uncomplicated chronic HCV infection and of specific complications and special at-risk populations of patients will be covered in *** the advent and approval of highly effective and well tolerable oral agents,still many challenges remain,particularly the affordability,the equitable distribution and access to later *** World Health Organization aims to eliminate viral hepatitis including HCV by 2030 since its poses a major public health *** is an urgent need to ensure uniform and early access to diagnostic and therapeutic facilities throughout the world if the later goal has to be realized.

关键词： Hepatitis C virus Interferons Diagnosis management Directly acting antiviral agents

New ordered mAX phase mo_2 TiAlC_2: Elastic and electronic properties from first-principles

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Chinese Physics B 2016年第10期25卷 323-329页

作者： m A Hadi m S ali Department of Physics University of Rajshahi Department of Physics Pabna University of Science and Technology

First-principles computation on the basis of density functional theory(DFT) is executed with the CASTEP code to explore the structural, elastic, and electronic properties along with Debye temperature and theoretical Vickers’ hardness of newly discovered ordered mAX phase carbide mo2TiAlC2. The computed structural parameters are very reasonable compared with the experimental results. The mechanical stability is verified by using the computed elastic constants. The brittleness of the compound is indicated by both the Poisson’s and Pugh’s ratios. The new mAX phase is capable of resisting the pressure and tension and also has the clear directional bonding between atoms. The compound shows significant elastic anisotropy. The Debye temperature estimated from elastic moduli(B, G) is found to be 413.6 K. The electronic structure indicates that the bonding nature of mo2TiAlC2is a mixture of covalent and metallic with few ionic characters. The electron charge density map shows a strong directional mo–C–mo covalent bonding associated with a relatively weak Ti–C *** calculated Fermi surface is due to the low-dispersive mo 4d-like bands, which makes the compound a conductive *** hardness of the compound is also evaluated and a high value of 9.01 GPa is an indication of its strong covalent bonding.

关键词： new ordered mAX phase density functional theory calculations Debye temperature Vickers hardness

Robust stability analysis of Takagi-Sugeno uncertain stochastic fuzzy recurrent neural networks with mixed time-varying delays

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Chinese Physics B 2011年第8期20卷 1-15页

作者： m.Syed ali Department of mathematics Thiruvalluvar UniversityVellore-632 106TamilnaduIndia

In this paper, the global stability of Takagi-Sugeno （TS） uncertain stochastic fuzzy recurrent neural networks with discrete and distributed time-varying delays （TSUSFRNNs） is considered. A novel LmI-based stability criterion is obtained by using Lyapunov functional theory to guarantee the asymptotic stability of TSUSFRNNs. The proposed stability conditions are demonstrated through numerical examples. Furthermore, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is removed. Comparison results are demonstrated to show that the proposed method is more able to guarantee the widest stability region than the other methods available in the existing literature.

关键词： recurrent neural networks linear matrix inequality Lyapunov stability time-varyingdelays TS fuzzy model

Novel delay-dependent stability analysis of Takagi-Sugeno fuzzy uncertain neural networks with time varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： m. Syed ali Department of mathematics Thiruvalluvar University

This paper presents the stability analysis for a class of neural networks with time varying delays that are represented by the Takagi^ugeno IT-S） model. The main results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear matrix inequality-based designs are proposed that outperform the previous results found in the literature. Numerical examples are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear matrix inequality Lyapunov stability time varying delays

Stability analysis of markovian jumping stochastic Cohen Grossberg neural networks with discrete and distributed time varying delays

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Chinese Physics B 2014年第6期23卷 131-137页

作者： m.Syed ali Department of mathematics Thiruvalluvar University

In this paper, the global asymptotic stability problem of markovian jumping stochastic Cohen-Grossberg neural networks with discrete and distributed time-varying delays （mJSCGNNs） is considered. A novel LmI-based stability criterion is obtained by constructing a new Lyapunov functional to guarantee the asymptotic stability of mJSCGNNs. Our results can be easily verified and they are also less restrictive than previously known criteria and can be applied to Cohen-Grossberg neural networks, recurrent neural networks, and cellular neural networks. Finally, the proposed stability conditions are demonstrated with numerical examples.

关键词： Cohen-Grossberg neural networks global asymptotic stability linear matrix inequality Lyapunovfunctional time-varying delays