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Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat

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Journal of Integrative Agriculture 2022年第4期21卷 917-932页

作者： marcus GRIFFITHS Jonathan A.ATKINSON Laura-Jayne GARDINER Ranjan SWARUP michael P.POUND michael H.WILSON malcolm J.BENNETT Darren m.WELLS School of Biosciences University of NottinghamSutton Bonington CampusLE125RDUK Future Food Beacon of Excellence University of NottinghamSutton Bonington CampusLE125RDUK Integrative Phenomics Group School of BiosciencesUniversity of NottinghamSutton Bonington CampusLE125RDUK IBm Research The Hartree CentreWarringtonWA44ADUK School of Computer Science University of NottinghamNottinghamNG81BBUK

The root system architecture(RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. However, little is known about the genetic basis of RSA and resource adaptive responses in wheat(Triticum aestivum L.). Here, a high-throughput germination paper-based plant phenotyping system was used to identify seedling traits in a wheat doubled haploid mapping population, Savannah×Rialto. Significant genotypic and nitrate-N treatment variation was found across the population for seedling traits with distinct trait grouping for root size-related traits and root distribution-related traits. Quantitative trait locus(QTL) analysis identified a total of 59 seedling trait QTLs. Across two nitrate treatments, 27 root QTLs were specific to the nitrate treatment. Transcriptomic analyses for one of the QTLs on chromosome 2 D, which was found under low nitrate conditions, revealed gene enrichment in N-related biological processes and 28 differentially expressed genes with possible involvement in a root angle response. Together, these findings provide genetic insight into root system architecture and plant adaptive responses to nitrate, as well as targets that could help improve N capture in wheat.

关键词： doubled-haploid population nitrate RNA-seq quantitative trait loci root system architecture Triticum aestivum L.(wheat)

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Two Dimensional Triptycene End-Capping and Its Influence on the Self-Assembly of Quinoxalinophenanthrophenazines

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Chinese Journal of Chemistry 2023年第10期41卷 1198-1208页

作者： Lisa Ro■ Julius Reitemeier Farhad Ghalami Wen-Shan Zhang Jurgen H.Gross Frank Rominger Sven m.Elbert Rasmus Schroder marcus Elstner michael mastalerz Institute of Organic Chemistry Heidelberg UniversityIm Neuenheimer Feld 270D-69120HeidelbergGermany Institute of Physical Chemistry and Theoretical Chemical Chemistry Karlsruhe Institute of TechnologyKaiserstrae 12D-76131KarlsruheGermany BioQuant University HeidelbergIm Neuenheimer Feld 267D-69120HeidelbergGermany

In this report we investigated two-dimensionally triptycene end-capped QPPs in terms of their solution and solid-state *** this purpose,a triphenylene based ortho-diamine decorated with two triptycenyl units as well as a phenylene diamine with two non-annulated triptycene units have been *** of condensation reactions with a pyrene-based tetraketone and ortho-diamines yielded a series of QPPs and UV/Vis investigations of the corresponding compounds led to the conclusion,that the QPPs form dimers in solution,which was further supported by ***-crystal X-ray analysis of the triply and quadruply triptycene end-capped QPPs furthermore showed shortπ-π-distances of 3.3-3.4?and a perfect shape match during the dimerization of the triply triptycenyl end-capped QPP making it possible synthon for crystal engineering.

关键词： Triptycene Quinoxalinophenanthrophenazine N-Heteropolycycles Polycyclic aromatic compounds Aggregation

Positive association between forest management, environmental change, and forest bird abundance

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Forest Ecosystems 2019年第1期6卷 26-37页

作者： Ernst Detlef Schulze Dylan Craven Andrew m.Durso Jiri Reif marcus Guderle Franz Kroiher Petra Hennig Anne Weiserbs Peter Schall Christian Ammer Nico Eisenhauer max Planck Institute for Biogeochemistry Biodiversity Macroecology and Biogeography Faculty of forest Science and Forest Ecology University G?ttingen Institute of Environmental Studies Faculty of ScienceCharles University Thünen-Institute for Forest Ecosystems Aves-Natagora Départment Etudes Silviculture and Forest Ecology of the temperate Zones University of G?ttingen German Centre for Integrative Biodiversity Research (iDiv) and Leipzig University Institute of Biology

Background: The global decrease in wildlife populations, especially birds, is mainly due to land use change and increasing intensity of land use(Parmesan and Yohe 2003). However, impacts of management tools to mitigate biodiversity loss at regional and global scales are less apparent in forest regions that have a constant forest area,and which did not suffer from habitat degradation, and where forests are sustainably managed, such as in Central Europe or the northeastern USA. A biodiversity assessment for Germany suggested, for example, that bird populations were constant(Bundesamt für Naturschutz 2015).Results: This study shows that changes in the environment and in forest management over the past 45 years have had a significant, positive effect on the abundance of non-migratory forest bird species in Central Europe. Economy(timber prices and GDP), forest management(timber harvest and mixed forest area), and environmental factors(atmospheric CO_2 concentration and nitrogen deposition) were investigated together with changes in abundances of migratory and non-migratory forest birds using partial least squares path modeling. Climate change, resulting in longer seasons and milder winters, and forest management, promoting tree diversity, were significantly positively related to the abundance of non-migratory forest birds and explained 92% of the variation in their abundance in Europe. Regionally-migrating forest birds had stable populations with large variation, while birds migrating across continents declined in recent decades, suggesting significant, contrasting changes in bird populations in Europe. In northeastern North America we also found evidence that non-migratory forests have experienced long-term increases in abundance, and this increase was related to management. The increase of populations of nonmigratory forest birds in Europe and North America is associated with an increase in structural diversity and disturbances at the landscape ***: Our

关键词： Climate change Birds Biodiversity Timber harvest Econo my Forest management

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Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis

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World Journal of Gastroenterology 2009年第44期15卷 5558-5562页

作者： Erwin Gbele marcus mhlbauer Hartwig Paulo monika Johann Christin meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand Department of Internal medicine University Medical Center RegensburgD-93042 RegensburgGermany Department of Psychiatry University Medical Center RegensburgD-93042 RegensburgGermany

AIm:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (mCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).mETHODS:mCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ***:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 mCP-1 genotype AA is a risk factor for the development of SBP.

关键词： monocyte chemotactic protein-1 Chemokines Spontaneous bacterial peritonitis Polymorphism Livercirrhosis

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated

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Genes & Diseases 2014年第1期1卷 64-74页

作者： Wei Zhou Jun Zhang Adam I.marcus Department of Hematology and medical Oncology The Winship Cancer InstituteEmory University School of MedicineAtlantaGeorgia

LKB1 is commonly thought of as a tumor suppressor gene because its hereditary mutation is responsible for a cancer syndrome,and somatic inactivation of LKB1 is found in nonsmall cell lung cancer,melanoma,and cervical ***,unlike other tumor suppressors whose main function is to either suppress cell proliferation or promote cell death,one of the functions of LKB1-regulated AmPK signaling is to suppress cell proliferation in order to promote cell survival under energetic stress *** unique,pro-survival function of LKB1 has led to the discovery of reagents,such as phenformin,that specifically exploit the vulnerability of LKB1-null cells in their defect in sensing energetic *** targeted agents represent a novel treatment strategy because they induce cell killing when LKB1 is *** review article summarizes various vulnerabilities of LKB1-mutant cells that have been reported in the literature and discusses the potential of using existing or developing novel reagents to target cancer cells with defective LKB1.

关键词： metabolic stress Targeted therapy Tumor Suppressor Tumor vulnerability

Green-light fundus autofluorescence in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 75-80页

作者： Lukas Reznicek Simeon Dabov Christos Haritoglou Anselm Kampik marcus Kernt Aljoscha S Neubauer Department of Ophthalmology Ludwig Maximilians University

AIm:To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema(DmE). mETHODS:A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 diabetic eyes had DmE and were compared to 41 diabetic eyes without DmE. In all subjects, green-light FAF images were obtained, quantified and classified into various FAF patterns. Cross-sectional optical coherence tomography (OCT) scans were obtained for evaluation of Inner/Outer segment (IS/OS) layer integrity, measurements of central RPE-IS/OS layer thickness as well as classification of DmE into various subtypes. ·RESULTS:meancentralgreen-lightFAFintensityofeyes with DmE (1.289 ±0.140)log did not significantly differ from diabetic patients without DmE (1.317 ±0.137)log. most classifiable FAF patterns were seen in patients with cystoid DmE. mean central retinal thickness (CRT) of all study eyes with DmE was (501.9±112.4)μm compared to (328.2±27.0)μm in diabetic patients without DmE. Patients with DmE had significantly more disrupted photoreceptor IS/OS layers than diabetic patients without DmE (28/51 vs 5/41, P mean RPE-IS/OS thickness of patients with DmE (60.7±14.1)μm was significantly (PmE (73.5 ±9.4)μm. Correlation analysis revealed non-significant correlations of green-light FAF intensity and OCT parameters in all subtypes of DmE. ·CONCLUSION:Our results indicate a poor correlation of central green-light FAF intensity with CRT, IS/OS layer integrity or RPE-IS/OS layer thickness in diabetic patients with or without DmE and its various subtypes. Thus, central green-light FAF is not suitable for detection of retinal thickening in DmE.

关键词： diabetic macular edema fundus autofluorescence optical coherence tomography

CLINICAL PHARmACOLOGY IN THE UNITED STATES

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中国临床药理学杂志 1986年第4期 205-209页

作者： marcus m.Reidenberg Professor of Clinical Pharmacology Cornell University medical College New York. m.D.

国际著名临床药理学家雷登伯格教授（Professor marcus Rei-denberg）是美国康奈尔大学临床药理科主任、药理学与内科学教授、美国临床药理学会主席、国际药理联合会临床药理学会副主席、临床药理与治疗学（CPT）杂志主编。专长肾脏和... 详细信息

国际著名临床药理学家雷登伯格教授（Professor marcus Rei-denberg）是美国康奈尔大学临床药理科主任、药理学与内科学教授、美国临床药理学会主席、国际药理联合会临床药理学会副主席、临床药理与治疗学（CPT）杂志主编。专长肾脏和药物代谢、药代动力学、药效学之间关系的研究以及影响药物代谢因素的研究。在国际临床药理学术界享有很高的威望。曾担任第二届世界临床药理学与治疗学会议主席,对国际临床药理学科的发展作出了重要的贡献。雷登伯格教授对我国的临床药理学进展表示关注,特为本刊撰写了“美国的临床药理学情况”一文,现将全文发表。本期同时发表了雷登伯格教授于今年访华时在北京医科大学所作的学术报告“Renal drug elimination reevaluated”,以飧读者。

关键词：临床药理学治疗学临床医学 CLINICAL PHARmACOLOGY IN THE UNITED STATES 药物代谢 oral

Regulation of the New Arabidopsis Imprinted Gene AtBmIIC Requires the Interplay of Different Epigenetic mechanisms

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molecular Plant 2012年第1期5卷 260-269页

作者： Fabian Bratzel ChaoYang Alexandra Angelova Gema Lopez-Torrejon marcus Koch Juan Carlos del Pozo myriam Calonje Centre for Organismal Studies Heidelberg Department of Biodiversity and Plant Systernatics University of Heidelberg Im Neuenheirner Feld 345 69120 Heidelberg Germany Centro de Biotecnologia y Genomica de Plantas （UPm-INIA） Campus de Montegancedo s/n Boadilla del Monte 28660 Madrid Spain

Recently, it has been shown that plants contain homologs to the animal Polycomb repressive complex I （PRC1） components Bm11 and RINGIA/B. In Arabidopsis, there are three BmIl-like genes, two of which, AtBmIIA and B, are required during post-embryonic plant growth to repress embryonic traits and allow cell differentiation. However, little is known about the third BmIl-like gene, AtBmIIC. In this work, we show that AtBmIIC is only expressed during endosperm and stamen development. AtBmIIC is an imprinted gene expressed from the maternal allele in the endosperm but bialleli- cally expressed in stamen. We found that the characteristic expression pattern of AtBmIIC is the result of a complex epigenetic regulation that involves CG DNA methylation, RNA-directed non-CG DNA methylation （RdDm）, and PcG activity. Our results show the orchestrated interplay of different epigenetic mechanisms in regulating gene expression throughout development, shedding light on the current hypotheses for the origin and mechanism of imprinting in plant endosperm.

关键词： Epigenetics gene silencing development Polycomb Group proteins.

三种生物黄酮类化合物及其与棉酚相互作用抑制豚鼠肾脏11β-羟甾脱氢酶(英文)

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Acta Pharmacologica Sinica 2002年第1期23卷 94-98页

作者：王茂山,史红,王恪申,marcus m REIDENBERG 浙江省医学科学院计划生育研究所生化药理研究室浙江省医学科学院计划生育研究所生化药理研究室浙江省医学科学院计划生育研究所生化药理研究室 Now in Department of Pharmacology and medicine.Comell University medical College.1300 York Ave New York NY 10021 USA 杭州中国 310013 杭州中国 310013 杭州中国 310013

目的:探讨三种生物黄酮类化合物在棉酚诱发低血钾中的作用.方法:从豚鼠肾脏制备11β-羟甾脱氢酶,NAD为辅酶,加入待测化合物,37℃反应一小时后提取甾体,反相高压液相测定酶活性,热辐射图像法分析药物相互作用.结果:所试生物黄酮类化合物... 详细信息

目的:探讨三种生物黄酮类化合物在棉酚诱发低血钾中的作用.方法:从豚鼠肾脏制备11β-羟甾脱氢酶,NAD为辅酶,加入待测化合物,37℃反应一小时后提取甾体,反相高压液相测定酶活性,热辐射图像法分析药物相互作用.结果:所试生物黄酮类化合物均能抑制11β-羟甾脱氢酶,其IC50（95％可信限）分别为:槲皮素164（7-341）μmol/L,桑色素 913（385-2173）μmol/L,柑桔素2193 （1114-4315）μmol/L.当11β-羟甾脱氢酶分别用槲皮素,红桔素,桑色素,柑桔素加上棉酚处理时,其C1值分别为:0.92、0.85、0.98和1.01,结论:三种生物黄酮类化合物与棉酚在抑制11β-羟甾脱氢酶中具有协同或相加作用.

关键词：药物相互作用黄酮类棉酚羟甾类脱氢酶类低钾血症