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Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative medicine 2024年第3期22卷 286-294页

作者： Jia-jia Liu Xue Zhang Bang-lan Cai man-man Qi Yong-bin Chi Bin Peng Deng-hai Zhang School of medicine Shanghai UniversityShanghai 200444China Shanghai Health Commission Key Lab of Artificial Intelligence-Based management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China School of Basic medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid molecular docking

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Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of m2 macrophages through the mmP23B pathway

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World Journal of Diabetes 2024年第9期15卷 1962-1978页

作者： man Lu Xiao-Wen Guo Fang-Fang Zhang Dan-Hong Wu Di Xie Feng-Qin Luo Department of Anesthesiology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina Department of Emergency Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Diabetes is often associated with gastrointestinal dysfunctions,which can lead to ***(DEX)is a commonly used sedative in perioperative diabetic patients and may affect gastrointestinal *** To investigate whether sedative doses of DEX alleviate diabetes-caused intestinal *** Sedation/anesthesia scores and vital signs of streptozotocin(STZ)-induced diabetic mice under DEX sedation were *** mice were divided into saline and DEX *** injecting sedatives intraperitoneally,tight junctions(TJs)and apoptotic levels were evaluated 24 hours later to assess the intestinal barrier *** role of DEX was validated using Villin-mmP23B flox/flox mice with intestinal epithelial *** vitro,high glucose and hyperosmolarity were used to culture Caco-2 monolayer cells with STZ *** techniques were used to monitor the barrier and mitochondrial *** mmP23B protein levels in the intestinal tissue of STZ-induced diabetic mice were significantly higher than those in the intestinal tissue of control mice,with the DEX group displaying decreased mmP23B ***-mediated TJ disruption,increased intestinal mucosal permeability,and systemic inflammation in wild-type mice might be reversed by *** Caco-2 cells,mmP23B was associated with increased reactive oxygen species accumulation,mitochondrial membrane potential depolarization,and TJ *** DEX reduces mmP23B,which may potentially contribute to STZ-induced intestinal barrier dysfunction,affecting TJ modification through mitochondrial dysfunction.

关键词： Diabetes Dexmedetomidine Intestinal barrier Piezo1 Tight junctions

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V0405 Dra:A New Deep and Low mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

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Research in Astronomy and Astrophysics 2024年第6期24卷 287-293页

作者： Chao-Yue Li Lin-Qiao Jiang Jie Zheng Yi-man Liu Xiao-Yu Long min Sun Han-Lu Zhang Xiao-man Tian School of Science Leshan Normal UniversityLeshan 614000China Center for Applied Optics Research Leshan Normal UniversityLeshan 614000China Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan Leshan 614000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Aeronautics Shandong Jiaotong UniversityJinan 250000China

V0405 Dra is a W Uma-type binary *** on the TESS data,we have conducted an orbital period study and performed a light curve analysis for the *** orbital period study reveals that the O-C curve for V0405 Dra exhibits secular decrease at an extremely high rate of d P/dt=-2.71×10^(-6)day year^(-1),along with periodic variations characterized by an amplitude of A_(3)=0.0032 day and a period of P_(3)=1.413 *** orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system,for which we estimate a minimum mass of m_(3)=0.77m_(⊙).By employing the 2013 version of the Wilson-Devinney(W-D)method to synthesize a light curve,we derived photometric solutions indicating that V0405 Dra is a new deep(f=68.7%)and low-mass ratio(q=0.175)contact *** fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star,or due to angular momentum *** further mass transfer and loss of angular momentum,the binary will gradually evolve into a tighter contact configuration,eventually leading to a merger into a single star,following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

关键词： (stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:individual(V0405 Dra)

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Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： Hang PAN Jian-Ping TANG Liang CHENG man-Chun LI Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of mesoscale Severe Weather/ministry of Education Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern *** to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern ***,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River *** study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(SWAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the *** temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen *** increases in streamflow are observed in April,August,September,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme *** projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and *** spread among the results of CmIP6 models is greater than that of CmIP5 models,with lower signal-to-noise ratio(SNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty SWAT mongolian Plateau

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A universal cooperative assembly-oriented strategy for VS_(4) nanorod decoration on carbon nanostructures with enhanced magnesium storage properties

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Science China Chemistry 2024年第9期67卷 3153-3161页

作者： Yuehua man An Li Haowei Tang Jianlu Sun Yating Fei Yichen Du Xiaosi Zhou School of Chemistry and materials Science Nanjing Normal UniversityNanjing 210023China

VS_(4) has a unique layered atomic chain structure and has the potential to become a high-performance cathode material of magnesium-ion batteries with a high capacity and long cycle ***,low conductivity and sluggish mg^(2+)diffusivity during cycling limit its practical application in large-scale energy ***,a cooperative assembly-directed strategy is adopted to synthesize VS_(4) nanorods grown in situ on carbon nanotubes(CNTs/VS_(4)).VS_(4) nanorods are tightly anchored to CNTs through V-O-C interface covalent bonds,and CNTs can enhance the electronic conductivity of the *** addition,the ion insertion reaction using mg^(2+)and mg Cl^(+)as carriers reduces the polar barrier for divalent mg^(2+)ion *** rationally designed architecture promotes ion diffusion and electron transfer,thus facilitating reaction *** cooperative assembly-oriented strategy can endow CNTs/VS_(4) with excellent magnesium storage properties,including a high reversible capacity of 223.2 m Ah g^(-1)at a current density of 50 m A g^(-1),a remarkable discharge capacity of 91.8 m Ah g^(-1)even at 2,000 m A g^(-1),and an impressive capacity retention of 85.2% after 1,000 cycles at 500 m A g^(-1).moreover,this strategy can serve as a general synthetic method for the complexation of VS_(4) with other carbon nanostructures.

关键词： transition metal sulfides carbon nanostructure interfacial covalent bond magnesium-ion batteries cathode

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Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research International 2024年第6期31卷 1344-1354页

作者： Peng-bo Liu Shu-sen Cheng Yu-qing Xue Xiao-man Cheng Zhao Liu University of Science and Technology Beijing Beijing 100083China ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

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Effect of neodymium doping on structure,magnetic properties and microwave absorption performance of SrmnO_(3)

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Journal of Rare Earths 2024年第2期42卷 354-363,I0005页

作者： Jixiang Yue Lichun Cheng Jilei Xiong Qingrong Yao man Wang Yucheng Chen Qianxin Long Xiaojian Guo School of materials Science and Engineering Guilin University of Electronic TechnologyGuilin541004China Guangxi Key Laboratoryof Information materials Guilin University of Electronic Technology Guilin541004China Anhui Jihua New materials Co. Ltd.Anqing246300China

A simple composite Sr_(1-x)Nd_(x)mnO_(3)(x=0,0.05,0.1,0.15,0.2) nano powders were successfully prepared by the sol-gel method as a light-weight broadband electromagnetic wave *** effect of Nd^(3+)doping on the structure,microstructure and properties of SrmnO_(3) was *** is found that with the doping of Nd^(3+),the space group of the SrmnO_(3) changes from p63/mmc to pm3m,and the crystalline shape starts to change from hexagonal to cubic *** electron microscopy(SEm) and Brunauer-Emmett-Teller(BET) tests confirm that the particle sizes of the sample decrease and the specific surface area increases,which are attributed to the inhibition of grain growth after Nd^(3+)is doped.X-ray photoelectron spectroscopy(XPS) shows that after Nd^(3+)doping,the content of oxygen vacancy increases,and mn^(4+) converts to mn^(3+).Due to the defects of the materials,the polarization effect is enhanced,thus,the dielectric and magnetic properties of the doped samples are *** maximum reflection loss of the Sr_(0.85)Nd_(0.15)mnO_(3) is-33.41 dB at 7.84 GHz for a thickness of 2.4 mm,while Sr_(0.9)Nd_(0.1)mnO_(3) has the best bandwidth performance at 2.32 GHz with a reflection loss below-10dB.

关键词： Sr_(1-x)mn_xO_(3) Crystal structure microwave absorption magnetic properties Nano powder Rare earths

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Coupling Sb_(2)WO_(6)microflowers and conductive polypyrrole for efficient potassium storage by enhanced conductivity and K^(+) diffusivity

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Journal of Energy Chemistry 2024年第2期89卷 250-258,I0007页

作者： Ruiqi Tian Hehe Zhang Zeyu Yuan Yuehua man Jianlu Sun Jianchun Bao ming-Sheng Wang Xiaosi Zhou School of Chemistry and materials Science Nanjing Normal UniversityNanjing 210023JiangsuChina State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005FujianChina

Although metal oxide compounds are considered as desirable anode materials for potassium-ion batteries(PIBs)due to their high theoretical capacity,the large volume variation remains a key issue in realizing metal oxide anodes with long cycle life and excellent rate *** this study,polypyrroleencapsulated Sb_(2)WO_(6)(denoted Sb_(2)WO_(6)@PPy)microflowers are synthesized by a one-step hydrothermal method followed by in-situ polymerization and coating by *** the nanosheet-stacked Sb_(2)WO_(6)microflower structure,the improved electronic conductivity,and the architectural protection offered by the PPy coating,Sb_(2)WO_(6)@PPy exhibits boosted potassium storage properties,thereby demonstrating an outstanding rate property of 110.3 m A h g^(-1)at 5 A g^(-1)and delivering a long-period cycling stability with a reversible capacity of 197.2 m A h g^(-1)after 500 cycles at 1 A g^(-1).In addition,the conversion and alloying processes of Sb_(2)WO_(6)@PPy in PIBs with the generation of intermediates,K_(2)WO_(4)and K_(3)Sb,is determined by X-ray photoelectron spectroscopy,transmission electron microscopy,and exsitu X-ray diffraction during potassiation/*** functional theory calculations demonstrate that the robust coupling between PPy and Sb_(2)WO_(6)endues it with a much stronger total density of states and a built-in electric field,thereby increasing the electronic conductivity,and thus effectively reduces the K^(+)diffusion barrier.

关键词： Sb_(2)WO_(6) Polypyrrole coating Anode Potassium-ion battery In-situ TEm observation

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mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian man Fulin Zhu Yaqi Huang Yuhao Piao Yan Su Shengyuan Deng Ying Wan School of mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing

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molecular template derived ultrathin N-doped carbon layer on cobalt selenide nanobelts for durable and rapid sodium storage

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Nano Research 2024年第9期17卷 8145-8154页

作者： Chuanliang Wei Baojuan Xi Kangdong Tian Xinlu Zhang Quanyan man Keyan Bao Wutao mao Jinkui Feng Shenglin Xiong Key Laboratory of the Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringSchool of Materials Science and EngineeringShandong UniversityJinan 250100China Resource Environment and Clean Energy Laboratory School of Chemical and Environmental EngineeringJiangsu University of TechnologyChangzhou 213001China

Sodium-ion batteries(SIBs)are an attractive battery system because of similar characteristics to lithium-ion batteries(LIBs)and large Na element ***,exploring stable,high-capacity and high-rate anode materials for SIBs is still challenging ***,diethylenetriamine(DETA)molecular template derived ultrathin N-doped carbon(NC)layer decorated CoSe_(2)nanobelts(CoSe_(2)/NC)are prepared by solvothermal reaction followed by calcination *** CoSe_(2)/NC exhibits large potential as an anode for *** and theoretical calculations reveal that the in situ formed conductive ultrathin NC layer can not only relieve the volume change of CoSe_(2)but also accelerate electron and ion *** addition,the nanobelt structure of CoSe_(2)/NC with abundant exposed active sites can obviously accelerate the electrochemical *** the synergistic effect of special nanobelt structure and NC layer,the rate as well as cycling performances of CoSe_(2)/NC are obviously improved.A superior capacity retention of 94.8%is achieved at 2 A·g^(-1)after 2000 *** using Na3V2(PO4)3 cathodes,the pouch full batteries can work steadily at 0.5 C,verifying the application ***_(2)/NC anodes also exhibit impressive performances in LIBs and potassium-ion batteries(PIBs).

关键词： CoSe2 nanobelts ultrathin N-doped carbon layer sodium-ion batteries anode high rate

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