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multidimensional modeling of the stenosed carotid artery: A novel CAD approach accompanied by an extensive lumped model

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Acta mechanica Sinica 2014年第2期30卷 259-273页

作者： A.Kashefi m.mahdinia B.Firoozabadi m.Amirkhosravi G.Ahmadi m.S.Saidi Department of mechanical Engineering Sharif University of Technology Department of mechanical Engineering University of California Berkeley Faculty of Engineering Department of Mechanical EngineeringSharif University of Technology Faculty of Engineering Department of Mechanical and Aeronautical EngineeringClarkson University

This study describes a multidimensional 3D/lumped parameter（LP） model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. A new extensive LP model of the entire arterial network（48 arteries） was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. A computer aided-design（CAD） algorithm was proposed to effciently handle the coupling of two or more 3D models with the LP model, and substantially lessen the coupling processing time. Realistic boundary conditions and Navier-Stokes equations in healthy and stenosed models of carotid artery bifurcation（CAB） were used to investigate the unsteady Newtonian blood flow velocity distribution in the internal carotid artery（ICA）. The present simulation results agree well with previous experimental and numerical studies. The outcomes of a pure LP model and those of the coupled 3D healthy model were found to be nearly the same in both cases. Concerning the various analyzed 3D zones, the stenosis growth in the ICA was not found as a crucial factor in determining the absorbing boundary *** paper demonstrates the advantages of coupling local and systemic models to comprehend physiological diseases of the cardiovascular system.

关键词： Hemodynamic 3D/LP coupling CAD Realis-tic boundary conditions Carotid artery bifurcation Stenosis

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