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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.salgado Jose m.santiago samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAsT EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Quantum pseudodots under the influence of external vector and scalar fields

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Chinese Physics B 2018年第8期27卷 109-117页

作者： m Eshghi s m Ikhdairt Department of Physics Imam Hossein Comprehensive UniversityTehranIran Department of Physics Faculty of ScienceAn-Najah National UniversityNablusPalestine Department of Electrical Engineering Near East UniversityNicosiaNorthern CyprusMersin 10Turkey

We study the spherical quantum pseudodots in the schr6dinger equation by using the pseudo-harmonic plus harmonic oscillator potentials considering the effect of the external electric and magnetic fields. The finite energy levels and the wave functions are calculated. Furthermore, the behavior of the essential thermodynamic quantities such as, the free energy, the mean energy, the entropy, the specific heat, the magnetization, the magnetic susceptibility, and the persistent currents are also studied by using the characteristic function. Our analytical results are found to be in good agreement with the other works. The numerical results on the energy levels as well as the thermodynamic quantities have also been given.

关键词： schr6dinger equation harmonic oscillator pseudo-harmonic potential thermodynamic quantities quantum pseudo-dots characteristic function

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New ordered mAX phase mo_2 TiAlC_2: Elastic and electronic properties from first-principles

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Chinese Physics B 2016年第10期25卷 323-329页

作者： m A Hadi m s Ali Department of Physics University of Rajshahi Department of Physics Pabna University of Science and Technology

First-principles computation on the basis of density functional theory(DFT) is executed with the CAsTEP code to explore the structural, elastic, and electronic properties along with Debye temperature and theoretical Vickers’ hardness of newly discovered ordered mAX phase carbide mo2TiAlC2. The computed structural parameters are very reasonable compared with the experimental results. The mechanical stability is verified by using the computed elastic constants. The brittleness of the compound is indicated by both the Poisson’s and Pugh’s ratios. The new mAX phase is capable of resisting the pressure and tension and also has the clear directional bonding between atoms. The compound shows significant elastic anisotropy. The Debye temperature estimated from elastic moduli(B, G) is found to be 413.6 K. The electronic structure indicates that the bonding nature of mo2TiAlC2is a mixture of covalent and metallic with few ionic characters. The electron charge density map shows a strong directional mo–C–mo covalent bonding associated with a relatively weak Ti–C *** calculated Fermi surface is due to the low-dispersive mo 4d-like bands, which makes the compound a conductive *** hardness of the compound is also evaluated and a high value of 9.01 GPa is an indication of its strong covalent bonding.

关键词： new ordered mAX phase density functional theory calculations Debye temperature Vickers hardness

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Oblique collisional effects of dust acoustic waves in unmagnetized dusty plasma

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Chinese Physics B 2020年第6期29卷 304-313页

作者： m s Alam m R Talukder Department of mathematics Chittagong University of Engineering and TechnologyChittagong-4349Bangladesh Plasma science and Technology Laboratory Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi-6205Bangladesh

Effects of oblique collisions of the dust acoustic(DA)waves in dusty plasma are studied by considering unmagnetized fully ionized *** plasma consists of inertial warm negatively charged massive dusts,positively charged dusts,superthermal kappa distributed electrons,and isothermal *** extended Poincaré–Lighthill–Kuo(e PLK)method is employed for the drivation of two-sided Korteweg–de Vries(KdV)equations(KdVEs).The Kd V soliton solutions are derived by using the hyperbolic secant *** effects of superthermality index of electrons,temperature ratio of isothermal ion to electron,and the density ratio of isothermal ions to negatively charged massive dusts on nonlinear coefficients are *** effects of oblique collision on amplitude,phase shift,and potential profile of right traveling solitons of DA waves are also *** study reveals that the new nonlinear wave structures are produced in the colliding region due to head-on collision of the two counter propagating DA *** nonlinearity is found to decrease with the increasing density ratio of ion to negative dust in the critical *** phase shifts decrease(increase)with increasing the temperature ratio of ion to electron(κe).The hump(compressive,κeshaped(rarefactive,κe>κec)solitons are produced depending on the angle(θ)of oblique collision between the two waves.

关键词： ion acoustic wave dusty plasma kappa distribution ePLK method hyperbolic secant method

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Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： Carlos m Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez Department of Basic sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including Pubmed/mEDLINE,Web of science,Embase,scopus,and sciELO,as well as examining gray literature sources on Google scholar.A comprehensive electronic database search was conducted from the databases’inception until may 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;Ps in three clinical trials were 75,and there were 24 graft rejections in two *** All clinical trials reported significant proportions of antimicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals solid organ transplant recipients Infections microorganisms Cytomegalovirus

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Petrology, geochemistry, radioactivity, and m–W type rare earth element tetrads of El sela altered granites, south eastern desert,Egypt

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Acta Geochimica 2019年第1期38卷 95-119页

作者： A.m.El mezayen m.A.Heikal m.G.El-Feky H.A.shahin I.K.Abu Zeid s.R.Lasheen Geology Department Faculty of Science Al Azhar University Nuclear material Authority

The southern part of the Eastern Desert of Egypt—about 30 km southwest of Abu-Ramad city—is mainly covered by ophiolitic rocks(sul Hamed), island arc assemblage, younger granites(muscovite granites of Qash Amer and two mica granites of El sela), and various acidic and basic dikes. Field, petrological, and geochemical studies indicate that the El sela shear zone has been subject to hydrothermal and supergene alteration such as kaolinization, albitization, sericitization, and hematitization. It is invaded by quartz ENE–WsW veins associated with hydrothermal alteration accompanied by radioactive mineralization. The investigated younger granitic rocks had very low contents of compatible elements, such as Cr, Ni,and Co; and high contents of incompatible elements, such as Zr, and large ion lithophiles, such as sr, especially in the El sela shear zone. major oxide and trace element analyses revealed calc-alkaline affinity and peraluminous *** highly differentiated granitic rocks' lower Zr/Hf and higher Y/Ho than the normal ratio are consistent with hydrothermal alteration. most samples had rare earth element(REE)-patterns with an m-type tetrad effect in the first and fourth segments and a W-type tetrad in the third segment. The average ∑REE in the studied granites was lower than the world granite average; the ratio of light to heavy REEs greater. The main radioactive, uranium-bearing, and uraniferous Fe and mn minerals are uranothorite,autunite, uranophane and autunite as compounds, kasolite,columbite, xenotime, uranophane-bearing zircon and jarosite, silver-bearing pyrite, hematite, and autunite-bearing pyrolusite.

关键词： Geochemistry REE-tetrad effect Radioactive minerals Radiometric measurements Qash Amer El sela

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Daily variation of radon gas and its short-lived progeny concentration near ground level and estimation of aerosol residence time

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Chinese Physics B 2016年第5期25卷 111-118页

作者： m mohery A m Abdallah A Ali s s Baz Physics Department Faculty of Science University of Jeddah Physics Department Faculty of Science Sohag University Astronomy Department Faculty of Science King Abdulaziz University Astronomy Department Faculty of Science Cairo University Physics Department Girls Faculty of Science King Abdulaziz University

Atmospheric concentrations of radon（^（222）Rn） gas and its short-lived progenies^（218）Po,^（214）Pb, and^（214）Po were continuously monitored every four hours at the ground level in Jeddah city, Kingdom of saudi Arabia. The measurements were performed three times every week, starting from November 2014 to October 2015. A method of electrostatic precipitation of positively charged^（218）Po and ^（214）Po by a positive voltage was applied for determining^（222）Rn gas concentration. The short-lived^（222）Rn progeny concentration was determined by using a filter holder connected with the alpha-spectrometric technique. The meteorological parameters（relative air humidity, air temperature, and wind speed） were determined during the measurements of^（222）Rn and its progeny concentrations.^（222）Rn gas as well as its short-lived progeny concentration display a daily and seasonal variation with high values in the night and early morning hours as compared to low values at noon and in the afternoon. The observed monthly atmospheric concentrations showed a seasonal trend with the highest values in the autumn/winter season and the lowest values in the spring/summer season. moreover, and in parallel with alphaspectrometric measurements, a single filter-holder was used to collect air samples. The deposited activities of^（214）Pb and the long-lived^（222）Rn daughter ^（210）Pb on the filter were measured with the gamma spectrometric technique. The measured activity concentrations of^（214）Pb by both techniques were found to be relatively equal largely. The highest mean seasonally activity concentrations of ^（210）Pb were observed in the autumn/winter season while the lowest mean were observed in the spring/summer season. The mean residence time（mRT） of aerosol particles in the atmospheric air could be estimated from the activity ratios of ^（210）Pb/^（214）Pb.

关键词： daily variation radon progeny concentration meteorological variables

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Assessment of lnc RNA GAs5, lnc RNA HEIH, lnc RNA BIsPR and its m RNA BsT2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4

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World Journal of Gastroenterology 2020年第2期26卷 168-183页

作者： Nourhan m El samaloty marwa I shabayek Ramy s Ghait shohda A El-maraghy sherine m Rizk maha m El-sawalhi Biochemistry section PharmacologyToxicology and Biochemistry DepartmentFaculty of Pharmaceutical Sciences and Pharmaceutical IndustriesFuture UniversityCairo 11795Egypt Internal medicine Gastroenterology and Hepatology DepartmentFaculty of MedicineAin Shams UniversityCairo 11566Egypt Biochemistry Department Faculty of PharmacyCairo UniversityCairo 11562Egypt

BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in *** evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral *** To investigate the expression profiles of circulating lncRNAGAs5,lncRNAHEIH,lncRNABIsPR and mRNABsT2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV *** One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this *** lncRNAs and mRNABsT2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).REsULTs Our results indicated that serum lncRNAGAs5 and LncRNABIsPR were upregulated,whereas mRNA BsT2 and LncRNA HEIH were downregulated in naïve *** contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAs5 and lncRNABIsPR with higher mRNABsT2 compared to naïve ***,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABsT2 compared to treated ***5 and lncRNABIsPR were positively correlated with viral load and ALT at Ps mRNABsT2 was negatively correlated with viral load at Psignificant positive correlation between lncRNA HEIH and AFP was observed at Pssion of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV.

关键词： lncRNA GAs5 lncRNA BIsPR mRNA BsT2 lncRNA HEIH Hepatitis C Biomarkers

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Effect of Colouring Process on Pitting susceptibility of Austenitic stainless steel

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Journal of materials science & Technology 2008年第3期24卷 400-406页

作者： s.s.mahmoud m.m.Ahmed Chemistry Department University College of Girls for ArtsScience and EducationAin Shams University

Colouring of the austenitic stainless steel alloy （20.45% Cr, 8.57% Ni） was carried out in NaNO3-KNO3 eutectic melt without and with additions of Na2O2, NaCl and their mixtures at different temperatures ranging from 400-600℃, under open-circuit and galvanostatic anodic polarization conditions. The produced colours greatly depend on the thickness of oxide films, which in turn depends on the composition of the molten bath and its temperature. The more attractive, bright, adherent and uniform coloured oxide films can be obtained at 400, 450 and 500℃ in molten nitrate bath containing NaCl and Na2O2 mixtures. The pitting corrosion susceptibility of the coloured oxide films was tested in FeCl3 and NaCl as corrosive media. The obtained results indicate that the pitting corrosion susceptibility of the coloured oxide films greatly depends on the previous operating conditions of the colouring process of the stainless steel specimens such as the composition of molten bath, temperature and technique of colouring process.

关键词： stainless steel alloy Pitting corrosion Colouring processes

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Cost-effective integrated strategy for the fabrication of hard-magnet barium hexaferrite powders from low-grade barite ore

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International Journal of minerals,metallurgy and materials 2016年第9期23卷 991-1000页

作者： m.m.s.sanad m.m.Rashad Central metallurgical R & D Institute

Ultrafine barium hexaferrite（BaFe12O19） powders were synthesized from the metallurgical extracts of low-grade Egyptian barite ore via a co-precipitation route. Hydrometallurgical treatment of barite ore was systematically studied to achieve the maximum dissolution efficiency of Fe（～99.7%） under the optimum conditions. The hexaferrite precursors were obtained by the co-precipitation of Bas produced by the reduction of barite ore with carbon at 1273 K and then dissolved in diluted HCl and FeCl3 solution at pH 10 using NaOH as a base; the product was then annealed at 1273 K in an open atmosphere. The effect of Fe^3＋/Ba^2＋ molar ratio and the addition of hydrogen peroxide（H2O2） on the phase structure, crystallite size, morphology, and magnetic properties were investigated by X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry. single-phase BaFe（12）O（19） powder was obtained at an Fe^3＋/Ba^2＋ molar ratio of 8.00. The formed powders exhibited a hexagonal platelet-like structure. Good maximum magnetization（48.3 A×m^2×kg^–1） was achieved in the material prepared at an Fe^3＋/Ba^2＋ molar ratio of 8.0 in the presence of 5% H2O2 as an oxidizer and at 1273 K because of the formation of a uniform, hexagonal-shaped structure.

关键词： chemical process barite ore treatment characterization magnetic properties ferrites

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