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A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon Lim Peter A.Zoss Terry L.Powley Hyowon Lee matthew P.ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable Devices Purdue UniversityWest LafayetteINUSA Department of Psychological Sciences Purdue UniversityWest LafayetteINUSA Purdue Institute of Integrative Neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the *** better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication *** several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel *** microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µ*** thick design can potentially harm the delicate tissue structures,including the nerve *** this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a *** demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve ***,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

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Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna m. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk ward michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren ming-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda College of Veterinary medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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Bayesian modeling of dynamic behavioral change during an epidemic

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Infectious Disease modelling 2023年第4期8卷 947-963页

作者： Caitlin ward Rob Deardon Alexandra m.Schmidt Division of Biostatistics University of MinnesotaMinneapolisMNUSA Faculty of Veterinary medicine University of CalgaryCalgaryABCanada Department of mathematics and Statistics University of CalgaryCalgaryABCanada Department of Epidemiology Biostatisticsand Occupational HealthMontrealQCCanada

For many infectious disease outbreaks,the at-risk population changes their behavior in response to the outbreak severity,causing the transmission dynamics to change in *** change is often ignored in epidemic modeling efforts,making these models less useful than they could *** address this by introducing a novel class of datadriven epidemic models which characterize and accurately estimate behavioral *** proposed model allows time-varying transmission to be captured by the level of“alarm”in the population,with alarm specified as a function of the past epidemic *** investigate the estimability of the population alarm across a wide range of scenarios,applying both parametric functions and non-parametric functions using splines and Gaussian *** model is set in the data-augmented Bayesian framework to allow estimation on partially observed epidemic *** benefit and utility of the proposed approach is illustrated through applications to data from real epidemics.

关键词： Bayesian inference Compartmental model SIR SEIR Transmission modeling

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强直性脊柱炎放射影像受累类型769例大样本公认方法的再分析

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国际医学放射学杂志 2011年第2期 172-172页

作者： J.H.Jang m.m.ward A.N.Rucker J.D.Reveille J.C.Davis Jr m.H.Weisman 王鹤 Department of Rheumatology Cedars-Sinai Medical Center

目的重新审视放射诊断学对强直性脊柱炎(AS)的诊断模式。材料与方法本前瞻性研究已得到机构审查委员会批准,获得书面知情同意书。共769例AS病人(男性

关键词：强直性脊柱炎脊椎炎脊柱融合

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Optimization Ensemble Weights model for Wind Forecasting System

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Computers, materials & Continua 2022年第11期73卷 2619-2635页

作者： Amel Ali Alhussan El-Sayed m.El-kenawy Hussah Nasser AlEisa m.El-SAID Sayed A.ward Doaa Sami Khafaga Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Electrical Engineering Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Delta Higher Institute of Engineering and Technology(DHIET) Mansoura35111Egypt Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairo11629Egypt Faculty of Engineering Delta University for Science and TechnologyGamasaMansoura11152Egypt

Effective technology for wind direction forecasting can be realized using the recent advances in machine ***,the stability and safety of power systems are expected to be significantly ***,the unstable and unpredictable qualities of the wind predict the wind direction a challenging *** paper proposes a practical forecasting approach based on the weighted ensemble of machine learning *** weighted ensemble is optimized using a whale optimization algorithm guided by particle swarm optimization(PSO-Guided WOA).The proposed optimized weighted ensemble predicts the wind direction given a set of input *** conducted experiments employed the wind power forecasting dataset,freely available on Kaggle and developed to predict the regular power generation at seven wind farms over forty-eight *** recorded results of the conducted experiments emphasize the effectiveness of the proposed ensemble in achieving accurate predictions of the wind *** addition,a comparison is established between the proposed optimized ensemble and other competing optimized ensembles to prove its ***,statistical analysis using one-way analysis of variance(ANOVA)and Wilcoxon’s rank-sum are provided based on the recorded results to confirm the excellent accuracy achieved by the proposed optimized weighted ensemble.

关键词： Guided Whale Optimization Algorithm(Guided WOA) forecasting machine learning weighted ensemble model wind direction

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Angling of hybrid sunfish from a hatchery pond with potential implications for community fisheries

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Aquaculture and Fisheries 2023年第1期8卷 91-95页

作者： Brian G.Blackwell matthew J.ward Todd m.Kaufman South Dakota Department of Game Fish and Parks603 East 8th AvenueWebsterSD57274USA South Dakota Department of Game Fish and Parks44437139A StreetWaubaySD57273USA

Hatcheries are frequently called upon to produce catchable-sized fish for stocking community fishing *** attributes of fish selected for stocking into community ponds are that they are easy to produce in a hatchery system to sizes anglers are interested in catching and they provide anglers with high catch rates once *** sunfish[male Bluegill(Lepomis macrochirus)×female Green Sunfish(***)]have attributes that potentially make them attractive for use in community fishing *** assessed initial angler catch rates of 100 stocked hybrid sunfish in a 0.12-ha hatchery pond and after being subjected to angling(four,1-hr catch-and-release fishing events with five anglers).We also investigated whether catch rates would change following a supplemental stocking of an additional 100 hybrid sunfish(four,1-hr catch-and-release fishing events with five anglers).The anal fin of each fish in the second stocking was hole punched to differentiate them from those of the first stocking and fish caught by anglers were hole punched in the caudal fin each time they were caught before being released back into the *** catch rates were highest during initial fishing events that followed stocking(9.2 fish/angler hr and 18.0 fish/angler hr)and substantially declined in subsequent events(≤3.4 fish/angler hr).Catches of the newly stocked fish and previously stocked fish contributed to the high catch following the supplemental ***(80%)of the fish were caught in the first 30 min of each event and 45%were caught during the first 10 *** were able to catch 88%of the fish from the first stocking and 67%from the second stocking at least *** mortality occurred during the study as all fish were recovered when the pond was *** results suggest that hybrid sunfish will potentially provide high initial catch rates following stocking into community ponds,but managers should expect reduced catch rates following initial fishing even without h

关键词： Hybrid sunfish Angling Community fishing ponds

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Exploring the Spatial Control of Topotactic Phase Transitions Using Vertically Oriented Epitaxial Interfaces

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Nano-micro Letters 2022年第1期14卷 47-58页

作者： Wenrui Zhang Jie Zhang Shaobo Cheng Christopher m.Rouleau Kim Kisslinger Lihua Zhang Yimei Zhu Thomas Z.ward Gyula Eres materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Ningbo Institute of materials Technology and Engineering Chinese Academy of SciencesNingboZhejiang 315201P.R.China Condensed matter Physics and materials Science Brookhaven National LaboratoryUptonNY 11973USA Center for Nanophase materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA

Engineering oxygen vacancy formation and distribution is a powerful route for controlling the oxygen sublattice evolution that affects diverse functional *** controlling of the oxygen vacancy formation process is particularly important for inducing topotactic phase transitions that occur by transformation of the oxygen *** we demonstrate an epitaxial nanocomposite approach for exploring the spatial control of topotactic phase transition from a pristine perovskite phase to an oxygen vacancy-ordered brownmillerite(Bm)phase in a model oxide La_(0.7)Sr_(0.3)mnO_(3)(LSmO).Incorporating a minority phase NiO in LSmO films creates ultrahigh density of vertically aligned epitaxial interfaces that strongly influence the oxygen vacancy formation and distribution in *** structural characterizations reveal strong interactions between NiO and LSmO across the epitaxial interfaces leading to a topotactic phase transition in LSmO accompanied by significant morphology evolution in *** the NiO nominal ratio as a single control parameter,we obtain intermediate topotactic nanostructures with distinct distribution of the transformed LSmO-Bm phase,which enables systematic tuning of magnetic and electrical transport *** use of self-assembled heterostructure interfaces by the epitaxial nanocomposite platform enables more versatile design of topotactic phase structures and correlated functionalities that are sensitive to oxygen vacancies.

关键词： Epitaxial interface Nanocomposite Functional oxides Oxygen vacancy Topotactic phase transition

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magnetic field induction and magnetic force distribution profiles in plasma focus discharge device

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Plasma Science and Technology 2021年第7期23卷 110-120页

作者： A A LASHIN T m ALLAm H A EL-SAYED Kamal m AHmED S A ward H m SOLImANand m A ABOUELATTA Plasma and Nuclear Fusion Department Nuclear Research CentreEgyptian Atomic Energy AuthorityInshas 13759Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 11152Egypt Electrical Engineering Department Faculty of Engineering at ShoubraBenha UniversityCairo 11629Egypt

We report a simple-to-perform technique to investigate the distribution of the azimuthal magnetic field induction,Bθ,and the induced magnetic force acting on the plasma current sheath(PCS)in a plasma focus(PF)*** in situ measurement technique can undoubtedly be beneficial when other fast-imaging techniques are not *** are not *** work was conducted in the low-energy mather-type EAEA-PF1 device operated in *** axial distribution(Bθ)z along the coaxial electrodes system was measured with a four magnetic-probe set technique at different radial distances(r=2.625×10^(−2) to 4.125×10^(−2) m)within the annular space between the coaxial electrodes during the 1st and 2nd half cycles of the discharge current waveform,where inner electrode of coaxial electrode system has a+ve polarity and−ve polarity,***,radial and total magnetic force distribution profiles were estimated from Bθ*** of PCS shape in terms of its inclination(curvature)angle,θ,along the axial rundown phase and the correlation between the magnetic forces per unit volume acting on the PCS,the inclination angleθof the PCS,and the formation of a powerful PF action during the 1st and 2nd half cycles is carried *** of inclination angle,θ,on total magnetic force per unit volume acting on PCS axial motion was studied,separately,during the 1st and 2nd half cycles.

关键词： plasma focus azimuthal magnetic field magnetic force inclination angle plasma current sheath

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair Lydia m.Hite Jennifer Cloward Robert E.ward Carter Kruse Herman A.van Wietmarchsen Nick van Eekeren Scott L.Kronberg Frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,Pmals,the muscle of pen-finished animals displayed elevated glucose metabolites(~1.6-fold),triglycerides(~2-fold),markers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished animals displayed improved mitochondrial(~1.3-fold higher levels of various Krebs cycle metabolites)and carnitine metabolism(~3-fold higher levels of long-chain acyl carnitines)(all Pmeat,while having lower levels of a common advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all Pmins B5,B6,and C,gamma/beta-tocopherol,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all Pme concentrate feeding,or grazing plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

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