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Journal of magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.J.Li J.H.Chu m.m.Li D.N.Zou L.B.tong School of metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEp)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEp/FG composite coating is 2131 times lower than that of bare mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of mg alloys.

关键词： mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer

Analytical evaluation of steady-state solute distribution in through- diffusion and membrane behavior test under non-perfectly flushing boundary conditions

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Journal of Rock mechanics and Geotechnical Engineering 2024年第1期16卷 258-267页

作者： Guannian Chen Yuchao Li Kristin mSample-Lord Shan tong School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China mOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Ningbo ZCONE High-tech Company Limited Ningbo315000China Department of Civil and Environmental Engineering Villanova UniversityVillanovaPAUSA

The through-diffusion and membrane behavior testing procedure using a closed-system apparatus has been widely used for concurrent measurement of diffusion and membrane efficiency coefficients of low-permeability clay-based barrier ***,the common assumption of perfectly flushing conditions at the specimen boundaries could induce errors in analyses of the diffusion coefficients and membrane *** this study,an innovative pseudo three-dimensional(3D)analytical method was proposed to evaluate solute distribution along the boundary surfaces of the soil-porous disks system,considering the non-perfectly flushing *** results were consistent with numerical models under two scenarios considering different inflow/outflow *** proposed model has been demonstrated to be an accurate and reliable method to estimate solute distributions along the *** calculated membrane efficiency coefficient and diffusion coefficient based on the proposed analytical method are more accurate,resulting in up to 50%less relative error than the traditional approach that adopts the arithmetic mean value of the influent and effluent *** retar-dation factor of the clay specimen also can be calculated with a revised cumulative mass ***,the simulated transient solute transport matched with experimental data from a multi-stage through-diffusion and membrane behavior test,validating the accuracy of the proposed method.

关键词： Diffusion testing membrane behavior Coupled transport Clay barrier Transport modeling

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of pKm supports antitumor immunity

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Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand p.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin p.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and pathogenesis program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA present address:University of Colorado Boulder BoulderCO 80309USA present address:Dana Farber Cancer Institute BostonMA 02215USA present address:massachusetts Institute of Technology BostonMA 02139USA present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of pKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,pKm alternative splicing occurred independently of CD28-driven pI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 pKm2

Advancements in Humanoid Robots: A Comprehensive Review and Future prospects

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 301-328页

作者： Yuchuang tong Haotian Liu Zhengtao Zhang IEEE CAS Engineering Laboratory for Intelligent Industrial Vision Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.

关键词： Future trends and challenges humanoid robots human-robot interaction key technologies potential applications

Functional predictability of universal gene circuits in diverse microbial hosts

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Quantitative Biology 2024年第2期12卷 129-140页

作者： Chenrui Qin tong Xu Xuejin Zhao Yeqing Zong Haoqian m.Zhang Chunbo Lou Qi Ouyang Long Qian peking-Tsinghua Joint Center for Life Sciences Peking UniversityBeijingChina CAS Key Laboratory of microbial physiological and metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijingChina Bluepha Co. LtdBeijingChina Center for Cell and Gene Circuit Design CAS Key Laboratory of Quantitative Engineering BiologyGuangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina

Although the principles of synthetic biology were initially established in model bacteria,microbial producers,extremophiles and gut microbes have now emerged as valuable prokaryotic chassis for biological *** the host range in which designed circuits can function reliably and predictably presents a major challenge for the concept of synthetic biology to *** this work,we systematically characterized the cross-species universality of two transcriptional regulatory modules—the T7 RNA polymerase activator module and the repressors module—in three non-model *** found striking linear relationships in circuit activities among different organisms for both *** model fitting revealed host non-specific parameters defining the universality of both ***,a genetic NOT gate and a band-pass filter circuit were constructed from these modules and tested in non-model *** models employing host non-specific parameters were successful in quantitatively predicting circuit behaviors,underscoring the potential of universal biological parts and predictive modeling in synthetic bioengineering.

关键词： circuit predictability host-independent genetic circuits host-nonspecific parameters parts characterization transcriptional regulatory modules

Influence of ecological function protection zone on the water conservation in Gansu-Qinghai Contiguous Region of the upper Yellow River

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Journal of mountain Science 2024年第4期21卷 1345-1357页

作者： tong Huali CHEN Qingbo ZHANG Xuan College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Gansu province Land Use and Comprehensive Improvement Engineering Research Center Lanzhou 730070China

The implementation of Ecological Function protection Zone(EFpZ)policy is significant for the ecological restoration and conservation of soil and water in the territory *** manuscript analyzed and quantified the impact of EFpZ on the regional water conservation function,based on land use data from 2005,2008,2010,2015 and 2020,by conducting a counterfactual simulation along with the GeoSOS-FLUS model and the InVEST *** results demonstrate that the delineation of EFpZ can significantly influence the water conservation.(1)From 2010 to 2020,as the EFpZ was implemented,the water conservation in the study area was increasing year by year,with a growth rate of 0.03×10^(8) m^(3)∙a^(-1).On the other hand,the simulated water conservation capacity without the implementation of EFpZ decreased year by year,with a decrease rate of 0.01×10^(8) m^(3)∙a^(-1).(2)The EFpZ accounts for only 23%of the total area,but the contribution rate of water conservation reaches 80%.The actual values of water conservation and average water yield per unit pixel in the EFpZ show an increasing trend both internally and externally,while the counterfactual simulation values exhibit a decreasing trend.(3)The water conservation is much higher within the EFpZ than without *** implementation of EFpZ has a significant effect on the improvement of the water conservation capacity in maqu EFpZ and Yellow River Source *** protection effectiveness should be enhanced in Qilian mountain EFpZ and afforestation activities need to be carefully considered in Loess plateau EFpZ.

关键词： Water conservation function Ecological Function protection Zone Counterfactual simulation Geo SOS-FLUS model InVEST model

From traditional Chinese medicine formulations to effective anticancer agents:Insights from Calculus bovis

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World Journal of Gastroenterology 2024年第35期30卷 4011-4013页

作者： He-tong Zhao Department of Traditional Chinese medicine Navy No.905 HospitalShanghai 200050China

This editorial examines the therapeutic potential of traditional Chinese medicine(TCm)for aggressive cancers,particularly liver *** highlights the study by Huang et al,which shows how Calculus bovis,a component of the TCm pien Tze Huang,suppresses liver cancer by inhibiting m2 macrophage polarization via the Wnt/β-catenin *** research emphasizes the importance of transitioning from effective TCm formulations to isolating active components and understanding their *** the study provides valuable insights,it primarily focuses on the Wnt/β-catenin pathway and does not delve deeply into the mechanisms of individual *** research should aim to comprehensively study these components,explore their interactions,and validate findings through clinical *** approach will integrate traditional wisdom with modern scientific validation,advancing the development of innovative cancer treatments based on TCm formulations.

关键词： Calculus bovis Traditional Chinese medicine Liver cancer Tumor microenvironment m2 tumor-associated macrophages Wnt/β-catenin pathway

Concentration-dependent effects of reductive pulmonary inhalants on ultrafine particle-induced oxidative stress:Insights for health risk assessment

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Environmental Science and Ecotechnology 2024年第3期19卷 118-124页

作者： Ya-qi Yu tong Zhu BIC-ESAT and SKL-ESpC College of Environmental Sciences and EngineeringPeking UniversityBeijing100871PR China School of Environmental Science and Engineering Qingdao UniversityQingdao266071PR China

The impact of reductive pulmonary inhalants on ultrafine particles(UFps)-induced pulmonary oxidative stress remains a crucial consideration,yet the concentration-dependent effects of these inhalants have remained *** we synthesized composite UFps simulating atmospheric UFps,primarily composed of metals and *** subjected these UFps to varying concentrations(0e7000 mm)of two reductive pulmonary inhalants,N-acetylcysteine and salbutamol,to assess their influence on oxidative potential,measured through the dithiothreitol assay(Op^(DTT)).Simultaneously,we analysed the soluble metal content of UFps to uncover potential relationships between oxidative potential and metal *** results unveil a dual role played by these inhalants in shaping the OpDTT of composite ***,Op^(DTT) generally increased as inhalant concentrations rose from 0 to 300 ***,an intriguing reversal occurred when concentrations exceeded 500 mm,resulting in a decline in *** to untreated UFps,these inhalants induced promotion and inhibition effects within concentration ranges of 100e500 and>1000 mm,*** no significant correlation emerged between Op^(DTT) and soluble metal content as inhalant concentrations ranged from 0 to 7000 mm,noteworthy positive correlations emerged at lower inhalant concentrations(e.g.,N-acetylcysteine at 0 e300 mm).These findings provide insights into the potential influence of reductive pulmonary inhalants on health risks associated with UFp exposure,further underscoring the need for continued research in this critical area.

关键词： Concentration-dependent effects Oxidative potential Reductive pulmonary inhalants Soluble metals Simulated atmospheric ultrafine particles

Boundary points,minimal L^(2)Integrals and Concavity propertyⅢ—Linearity on Riemann Surfaces and Fibrations over Open Riemann Surfaces

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Acta mathematica Sinica,English Series 2024年第9期40卷 2091-2152页

作者： Qi An GUAN Zhi tong mI Zheng YUAN School of mathematical Sciences Peking UniversityBeijing 100871P.R.China School of mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044P.R.China Institute of mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China

In this article,we consider a modified version of minimal L^(2) integrals on sublevel sets of plurisubharmonic functions related to modules at boundary points,and obtain a concavity property of the modified *** applications,we give characterizations for the concavity degenerating to linearity on open Riemann surfaces and on fibrations over open Riemann surfaces.

关键词： minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex Kähler manifold

machine learning in metal-ion battery research: Advancing material prediction, characterization, and status evaluation

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Journal of Energy Chemistry 2024年第3期90卷 191-204,I0006页

作者： tong Yu Chunyang Wang Huicong Yang Feng Li Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Department of physics and Astronomy University of California IrvineIrvineCA92697USA

metal-ion batteries(mIBs),including alkali metal-ion(Li^(+),Na^(+),and K^(3)),multi-valent metal-ion(Zn^(2+),mg^(2+),and Al^(3+)),metal-air,and metal-sulfur batteries,play an indispensable role in electrochemical energy ***,the performance of mIBs is significantly influenced by numerous variables,resulting in multi-dimensional and long-term challenges in the field of battery research and performance *** learning(mL),with its capability to solve intricate tasks and perform robust data processing,is now catalyzing a revolutionary transformation in the development of mIB materials and *** this review,we summarize the utilization of mL algorithms that have expedited research on mIBs over the past five *** present an extensive overview of existing algorithms,elucidating their details,advantages,and limitations in various applications,which encompass electrode screening,material property prediction,electrolyte formulation design,electrode material characterization,manufacturing parameter optimization,and real-time battery status ***,we propose potential solutions and future directions for the application of mL in advancing mIB development.

关键词： metal-ion battery machine learning Electrode materials Characterization Status evaluation