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Surgery for Peyronie＇s disease

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Asian Journal of Andrology 2013年第1期15卷 27-34页

作者： Laurence A levine Stephen m Larsen Department of Urology Rush University Medical Center Chicago IL 60612 USA

Peymnie＇s disease （PD） is most simply referred to as a fibrotic wound-healing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing and shortening, which may compromise sexual function. Although a variety of non-surgical treatments have been suggested, none to date offer a reliable and effective correction of the penile deformity. As a result, surgery remains the gold standard treatment option, offering the most rapid and reliable treatment which will be the focus of this article. We review the preoperative evaluation, surgical algorithm, graft materials and postoperative management of PD. Outcomes for tunical shortening, tunical lengthening and penile prosthesis placement for penile straightening are reviewed. Tunica albuginea plication is the preferred method of straightening for men with adequate rigidity and less severe disease defined as curvature less than 70° without narrowing/hinging. men who have more severe, complex deformity, but maintain strong preoperative erectile function should be considered candidates for straightening with plaque incision or partial excision and grafting. Finally, for those men who have inadequate rigidity and PD, penile prosthesis placement with straightening is the best approach to address both problems.

关键词： penile prosthesis Peyronie's disease, penile reconstruction plaque excision and grafting plaque incision tunica albuginea plication

modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian Journal of Andrology 2020年第1期22卷 51-59页

作者： matthew J Ziegelmann m Ryan Farrell Laurence A levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

Surgical solutions to the problem of massive weight loss

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World Journal of Gastroenterology 2006年第41期12卷 6602-6607页

作者： Jason A Spector Steven m levine Nolan S Karp Division of Plastic Surgery Weill medicine College of Cornell University New YorkNY 10021United States Institute of Reconstructive and Plastic Surgery Division of Plastic SurgeryNew York University School of MedicineNew YorkNY 10016United States

In response to the global rise in obesity, bariatric surgery has become increasingly more popular and successful As a result, the demand for body contouring following massive weight loss is rapidly growing. Although bariatric procedures may produce impressive weight loss, people who achieve massive weight loss are often unhappy with the hanging folds of skin and subcutaneous tissue that remain. This review examines the nature of the post-bariatric deformity in each body region and briefly reviews common approaches to their treatment.

关键词： Weight loss Bariatric surgery Body contour surgery

Development of a building information model-guided post-earthquake building inspection framework using 3D synthetic environments

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 279-307页

作者： Nathaniel m.levine Yasutaka Narazaki Billie F.Spencer Department of Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Zhejiang University-University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining 314400China

Computer vision-based inspection methods show promise for automating post-earthquake building *** methods survey a building with unmanned aerial vehicles and automatically detect damage in the collected ***,assessing the damage′s impact on structural safety requires localizing damage to specific building components with known design and *** paper proposes a BIm-based automated inspection framework to provide context for visual surveys.A deep learning-based semantic segmentation algorithm is trained to automatically identify damage in *** BIm automatically associates any identified damage with specific building ***,components are classified into damage states consistent with component fragility models for integration with a structural *** demonstrate the framework,methods are developed to photorealistically simulate severe structural damage in a synthetic computer graphics environment.A graphics model of a real building in Urbana,Illinois,is generated to test the framework;the model is integrated with a structural analysis to apply earthquake damage in a physically realistic manner.A simulated UAV survey is flown of the graphics model and the framework is *** method achieves high accuracy in assigning damage states to visible structural *** assignment enables integration with a performance-based earthquake assessment to classify building safety.

关键词： computer vision earthquake engineering building information model physics-based graphics model synthetic environment

Phenotypic plasticity in prostate cancer： role of ntrinsically disordered proteins

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Asian Journal of Andrology 2016年第5期18卷 704-710页

作者： Steven m mooney mohit Kumar Jolly Herbert levine Prakash Kulkarni Department of Biology University of Waterloo Waterloo ON N2L 3G1 Canada Center for Theoretical Biological Physics Rice University Houston TX 77005 USA Department of Bioengineering Rice University Houston TX 77005 USA Department of Physics and Astronomy Rice University Houston TX 77005 USA institute for Bioscience and Biotechnology Research University of Maryland Rockville Maryland 20850 USA

A striking characteristic of cancer ceLls is their remarkable phenotypic plasticity, which is the ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic changes such as a partial or complete epithelial to mesenchymal transition （EmT） that play important roles in their survival and proliferation, and development of resistance to therapeutic treatments, are widely believed to arise due to somatic mutations in the genome. However, there is a growing concern that such a deterministic view is not entirely consistent with multiple lines of evidence, which indicate that stochasticity may also play an important role in driving phenotypic plasticity. Here, we discuss how stochasticity in protein interaction networks （PINs） may play a key role in determining phenotypic plasticity in prostate cancer （PCa）. Specifically, we point out that the key players driving transitions among different phenotypes （epithelial, mesenchymal, and hybrid epithelial/mesenchymal）, including ZEB1, SNAIl, OVOL1, and OVOL2, are intrinsically disordered proteins （IDPs） and discuss how plasticity at the molecular level may contribute to stochasticity in phenotypic switching by rewiring PINs. We conclude by suggesting that targeting iDPs implicated in EmT in PCa may be a new strategy to gain additional insights and develop novel treatments for this disease, which is the most common form of cancer in adult men.

关键词： epithelial to mesenchymal transition intrinsically disordered proteins prostate cancer state-switching

Bacterial biota in reflux esophagitis and Barrett's esophagus

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World Journal of Gastroenterology 2005年第46期11卷 7277-7283页

作者： Zhiheng Pei Liying Yang Richard m Peek Jr Steven m levine David T Pride martin J Blaser Departments of Pathology and medicine New York University School of Medicine New York NY 10016 the United States of America and Department of Veterans Affairs New York Harbor Health System New York NY 10010United States Department of Pathology New York University School of Medicine New York NY 10016 United States Jr Department of Medicine Vanderbilt University School of Medicine Nashville TN 37212United States Department of medicine New York University School of Medicine New York NY 10016 United States Departments of medicine and microbiology New York University School of Medicine New York NY 10016United States Departments of medicine and microbiology New York University School of Medicine New York NY 10016the United States of America and Department of Veterans AffairsNew York Harbor Health System New York NY 10010 United States

AIm： To identify the bacterial flora in conditions such as Barrett＇s esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora. mETHODS： Using broad-range 16S rDNA PCR, esophageal biopsies were examined from 24 patients [9 with normal esophageal mucosa, 12 with gastroesophageal reflux disease （GERD）, and 3 with Barrett＇s esophagus]. Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned. In one patient with Barrett＇s esophagus, 99 PCR clones were analyzed. RESULTS： Two separate clones were recovered from each patient （total = 48）, representing 24 different species, with 14 species homologous to known bacteria, 5 homologous to unidentified bacteria, and 5 were not homologous （〈97% identity） to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett＇s esophagus patients, and 10 in normal esophagus patients. Further analysis concentrating on a single biopsy from an individual with Barrett＇s esophagus revealed the presence of 21 distinct bacterial species. members of four phyla were represented, including Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria. microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory. CONCLUSION： These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations.

关键词： Bacterial biota Esophagus 16S rDNA PCR

Basic business statistics : 7th ed.

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Folate and vitamin B12 in idiopathic male infertility

1999年

作者： mark L. Berenson David m. levine.

来源：畅想之星图书光盘版（南... 评论

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Asian Journal of Andrology 2011年第6期13卷 856-861页

作者： Laurel E murphy James L mills Anne m molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J levine Division of Epidemiology Statistics and Prevention Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD 20892 USA School of medicine Trinity College Dublin Dublin Ireland Glotech Inc Rockville MD 20850 USA Department of Obstetrics and Gynecology Sk~ne University Hospital in Lund Lund University S-221 85 Lund Sweden Reproductive medicine Centre Skane University Hospital Maimo Lund University S-205 02 Malmo Sweden

Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites and genes. We investigated whether idiopathic male infertility is associated with variants in folate, vitamin B12 （B12） and total homocysteine （tHcy）-related genes and measured these metabolites in blood. We conducted a case-control study that included 153 men with idiopathic infertility and 184 fertile male controls recruited at the Fertility Center and Antenatal Care Center, University Hospital, malmo and Lund, Sweden. Serum folate, red cell folate （RCF）, serum B12, plasma tHcy and semen quality were measured. Subjects were genotyped for 20 common variants in 12 genes related to folate/B12/ homocysteine metabolism. metabolite concentrations and genotype distributions were compared between cases and controls using linear and logistic regression with adjustment for covariates. The phosphatidylethanolamine N-methyltransferase （PEmT） m 175V and TCblR rs173665 polymorphisms were significantly associated with infertility （P=0.01 and P=0.009, respectively）, but not with semen quality. Among non-users of supplements, infertile men had lower serum folate concentrations than fertile men （12.89 vs. 14.73 nmoll^- 1 P=0.02）, but there were no significant differences in RCF, B 12 or tHcy. Folate, B 12 and tHcy concentrations were not correlated with any semen parameters. This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility. Although additional data are needed to confirm these initial findings, our results suggest that PEmTand TCbIR, genes involved in choline and B12 metabolism, merit further investigation in idiopathic male infertility.

关键词： folate idiopathic male infertility semen quality vitamin B12

Business statistics / 4th ed.

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