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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER mULLA YOUSEF KATIB ASIm m.ALmUGHAmSI DUAA S.ALKHAYAT mOHAmED mOSAAD SAmIR T.ALFOTIH RAWAN ALAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz medical City Madinah42311Saudi Arabia Prince mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNm staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

Thermoelectric Properties of Single molecule Junction in Presence of Dephasing and Different Coupling Geometries

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Communications in Theoretical Physics 2015年第9期64卷 361-366页

作者： Z.Golsanamlou m.bagheri Tagani H.Rahimpour Soleimani Department of Physics University of Guilan

The thermoelectric properties of a benzene molecule coupled to three-dimensional metallic electrodes are examined in the presence of dephasing processes using Green function formalism in the linear response regime. The three different kind of configurations(ortho, meta and para) are taken into account for the coupling between the molecule and electrodes. Results show that the thermoelectric properties of the single molecular junction are strongly dependent on the coupling geometry. Our results predict that the thermoelectric efficiency is increased in specific geometry as a consequence of interference effects. It is found that the dephasing effects result in the reduction of the thermoelectric efficiency.

关键词： nanostructures electrical conductivity thermal con

Documentation of the Sirjan Orocline in the southeast Sanandaj-Sirjan Zone, Iran

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Journal of mountain Science 2020年第3期17卷 528-541页

作者： Abdolreza PARTABIAN Sasan bagheri Fariba mORSHEDI Timothy mKUSKY Department of Geology College of SciencesUniversity of Sistan and BaluchestanZahedan 98167-45845Iran Center for Global Tectonics School of Earth SciencesChina University of GeosciencesWuhan 430074China

At the southeastern part of the SanandajSirjan Zone of Iran, a group of structural elements outline a large-scale arc curvature around a vertical axis. This curvature comprises several elongated structural elements and their dividing faults, axialfold traces, layering, and foliation. The most frequent lithological units include Paleozoic metamorphic rocks, mesozoic-Paleogene sedimentary rocks, and mesozoic magmatic-ophiolitic complex disposed in several anticlines and synclines, forming a horseshoeshaped structure with a 240-km arc length and a 90-km wavelength. We name this structure the Sirjan Orocline, and characterize this structure here through field observations and satellite image analyses. The Sirjan Orocline formed during the late EoceneOligocene related to the most significant deformation event after regional metamorphism. The final form of this structural arc is affected by a younger tectonic event that compressed and transected this structure.

关键词： Orocline The Sanandaj-Sirjan Zone Curvedstructures Central-EastIranian microcontinent

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Qualitative Land Suitability Evaluation for main Irrigated Crops in the Shahrekord Plain, Iran: A Geostatistical Approach Compared with Conventional method

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Pedosphere 2013年第6期23卷 767-778页

作者： Y.SAFARI I.ESFANDIARPOUR-BOROUJENI A.KAmALI m.H.SALEHI m.bagheri-BODAGHABADI College of Agriculture Vali-e-Asr University of Rafsanjan Department of Soil Science College of AgricultureVali-e-Asr University of Rafsanjan Department of Soil Science College of AgricultureShahrekord University

The purity of soil map units and their quality for various uses like land suitability evaluation are always *** main objective of this study was to compare the precision of qualitative land suitability classification based on geostatistical and conventional soil mapping methods for main irrigated crops in the Shahrekord Plain,Central Iran.A regular grid sampling method consisting 104sample points was designed and soil samples were *** kriged maps were achieved for all studied soil attributes after physico-chemical ***,to combine kriged maps and ecological requirements of the studied crops,a script was designed in ILWIS 3.4 software and consequently,kriged qualitative land suitability maps were *** qualitative land suitability was also mapped based on the representative pedon analysis in each soil map ***,comparison of the conventional and kriged maps was carried out using the statistical method,error *** results showed that the overall accuracies of wheat,sugar beet,potato and alfalfa maps were 39.8%,24.3%,18.7%and 18.6%at subclass category,respectively,whereas these values increased to80.9%,82.3%,23.7%and 82.3%at class level,***,it can be stated that thanks to the relative facility of conventional soil survey compared with geostatistical methods,this method can be expressed as a preferable way for handling a usual land suitability evaluation design;but using soil map units as land suitability delineations may lead to unsatisfactory results in estimation of quantity and type of existing limitations.

关键词： land use planning ordinary kriging representative pedon soil variability

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

PCL/HA静电纺丝纤维涂层对可降解mg/HA复合材料的表面改性:力学性能、腐蚀和生物相容性

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Transactions of Nonferrous metals Society of China 2024年第5期34卷 1470-1486页

作者： m.SHAmSI m.SEDIGHI A.bagheri School of mechanical Engineering Iran University of Science and TechnologyTehranIran

采用搅拌铸造和挤压法制备mg/HA复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/HA)纤维(2.5%和5%HA,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73mPa(纯镁)提高到151mPa,提高了107%... 详细信息

采用搅拌铸造和挤压法制备mg/HA复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/HA)纤维(2.5%和5%HA,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73mPa(纯镁)提高到151mPa,提高了107%。SEm、EDS和XRD分析表明,HA颗粒分布在多孔涂层中。极化曲线结果表明,涂层试样的耐腐蚀性能均优于未涂覆试样。PCL涂层使样品的腐蚀电流密度降低了两个数量级。通过极化和体外腐蚀试验证明了HA在涂层中的有效性。涂层和随后形成的Ca-P层阻碍了模拟体液与基体的接触和渗透,从而起到保护表面的作用。PCL/2.5%HA涂层样品的腐蚀速率最低,其平均值为0.98mm/a,与未涂层样品相比,在14天内减少了81%。根据3天mTT结果,使用PCL/2.5%HA涂层可使细胞活性从43%提高到121%。综上,涂覆PCL/2.5%HA纤维的mg/HA复合材料在生物可吸收植入物方面具有广阔的应用前景。

关键词：镁基复合材料复合涂层生物可降解羟基磷灰石聚己内酯纤维

Novel azo dyes derived from 8-methyl-4-hydroxyl-2-quinolone:Synthesis,UV-vis studies and biological activity

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Chinese Chemical Letters 2013年第5期24卷 425-428页

作者： E.O.moradi Rufchahi H.Pouramir m.R.Yazdanbakhsh H.Yousefi m.bagheri m.Rassa Department of Chemistry Faculty of ScienceLahijan BranchIslamic Azad University Department of Chemistry Faculty of SciencesUniversity of Guilan Department of Biology Faculty of SciencesUniversity of Guilan

In this study,N,N＇-di-（2-methylphenyl）malonamide was synthesized and reacted with polyphosphoric acid to afford *** novel azo disperse dyes were then synthesized by linking diazotized p-substituted aniline derivatives with *** solvatochromism of these azo dyes in various solvents was *** the compounds were then evaluated for their antibacterial activity against four bacteria,*** *** luteus, Salmonella enterica,and Pseudomonas *** results showed that some of these compounds have high levels of antibacterial activity.

关键词： Azo dyes Disperse dyes Hydroxyl quinolone Absorption spectrum Antibacterial studies