检索结果-南通市图书馆

Grass-Root Coaches Knowledge, Understanding, Attitude And Confidence to Deliver Injury Prevention Training in Youth Soccer: a Comparison of Coaches in Three EU Countries

引用

Journal of Science in Sport and Exercise 2020年第4期2卷 367-374页

作者： mark De Ste Croix F.Ayala S.Hernandez Sanchez m.lehnert J.Hughes School of Sport and Exercise University of GloucestershireCheltenham GL502RHUK Department of Sport Sciences Sport Research CentreMiguel Hernandez University of ElcheElche 03202Spain Department of Pathology and Surgery Physiotherapy Area Miguel Hernandez University of ElcheElche 03202Spain Department of Sport and Physical Culture Palacky UniversityOlomouc 77200Czech Republic

Purpose It is well recognised that injury prevention training can reduce injury incidence,however current coach education pathways do not provide grass-root coaches with the knowledge and confidence to deliver such training to youth *** aim of this study was to explore differences in knowledge,understanding,attitude and confidence to deliver such injury prevention training in three European *** A total of 269 grass-root soccer coaches from 3 European countries(Czech Republic,UK,Spain)were recruited for this study.A validated questionnaire exploring knowledge,understanding,attitude towards and confidence to deliver youth injury prevention training was completed prior to a 2 h workshop on injury prevention *** between countries was examined using Bayesian factors to quantify the evidence for and against the hypothesis of independence(H0)by assuming a Poisson sampling scheme(as there was no a priori restriction on any cell count,nor on the grand total)(BF10 Poisson).Results Current knowledge,attitude and confidence to deliver injury prevention training to youth players was poor across all three European *** few coaches were currently using injury prevention training in their coaching sessions(23%).There were some country specific differences for attitude towards injury prevention training and confidence to deliver injury training,with Spanish coaches reporting a more positive attitude and confidence to deliver such *** fewer coaches in the UK were using injury prevention training compared to coaches in Spain and the Czech *** As coaches identified a need for coach education and few were delivering injury prevention training,there is a clear need to embed and implement this programme into the grassroots coaching framework of sports governing bodies to improve adoption,implementation and maintenance.

关键词： Youth Injury prevention training Coach education movement competency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of inoculum size and antibiotics on bacterial traveling bands in a thin microchannel defined by optical adhesive

引用

microsystems & Nanoengineering 2021年第5期7卷 41-59页

作者： Yang Liu Thomas lehnert martin A.m.Gijs Laboratory of microsystems Ecole Polytechnique Federale de LausanneCH-1015 LausanneSwitzerland

Phenotypic diversity in bacterial flagella-induced motility leads to complex collective swimming patterns,appearing as traveling bands with transient locally enhanced cell *** bands are known to be a bacterial chemotactic response to self-generated nutrient gradients during growth in resource-limited *** this work,we studied different parameters of Escherichia coli(***)collective migration,in particular the quantity of bacteria introduced initially in a microfluidic chip(inoculum size)and their exposure to antibiotics(ampicillin,ciprofloxacin,and gentamicin).We developed a hybrid polymer-glass chip with an intermediate optical adhesive layer featuring the microfluidic channel,enabling high-content imaging of the migration dynamics in a single bacterial layer,*** bacteria are confined in a quasi-2D space that is fully observable with a high-magnification microscope ***-chip bacterial motility and traveling band analysis was performed based on individual bacterial trajectories by means of custom-developed *** of swimming speed,tumble bias and effective diffusion properties allowed the assessment of phenotypic heterogeneity,resulting in variations in transient cell density distributions and swimming *** found that incubation of isogeneic£coli with different inoculum sizes eventually generated different swimming phenotype ***,incubation with antimicrobials promoted bacterial chemotaxis in specific cases,despite growth ***,*** filamentation in the presence of antibiotics was assessed,and the impact on motility was *** propose that the observation of traveling bands can be explored as an alternative for fast antimicrobial susceptibility testing.

关键词： traveling collective transient

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

引用

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Search for microglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the Doctrinal and Institutional Organization of a Buddhist Commentarial Project Commissioned by ming Taizu

引用

Fudan Journal of the Humanities and Social Sciences 2014年第2期7卷 147-170页

作者： martin lehnert Department of Asian Studies Ludwig Maximilian University of Munich Japan CenterOettingenstr.67 80538 Munich Germany

A commentarial project commissioned by emperor ming Taizu （r.1368-1398） in 1377, which was dedicated to the Prajnaparamita-hrdaya-sutra, theVajracchedika-prajfiaparamita-sutra, and the Lankavatara-sutra, defined coherent standards of Buddhist learning by reference to early Chinese translations and Indian commentarial literature. In order to provide a clear-cut basis for the education of the clergy, its selective and reductive approach aimed at a standardization of doctrine and homogenization of terminology. Production and purport of the commentarial project are documented in a series of paratexts, prefaces, colophons, production notes and memoranda. They indicate a strong consciousness for the institutional, ideological and political aspects of the production procedure and its benefits for controlling the formation of Buddhist authority. Such decidedly functional under- standing of the institutional aspects of the production of exegesis leads to the conclusion that besides the normativity of doctrinal knowledge the main objective was to establish a basis for institutional integration of those who are in the privileged position to select whom they allow to assume authority, and to define the selection standards as well.

关键词： ming Taizu Buddhist exegesis Institutionalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

引用

Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

引用

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Corporate managers,price noise and the investment factor

引用

Financial Innovation 2022年第1期8卷 1782-1799页

作者： Thorsten lehnert Department of Finance University of Luxembourg6Rue Richard Coudenhove-Kalergi1359 LuxembourgLuxembourg

This study investigates the impact of flows between bond and equity funds on investment factors over the period 1984–*** determines contemporaneous mispricing effects and a statistical reversal relation between these flows and both legs of the investment *** statistical reversal relationship between previous flows and the investment factor is economically significant.A one-standard-deviation shock to flows causes a 0.29%decrease in investment factor returns,which are reversed within 5 months.A trading strategy based on signals from past flows and the investment factor outperforms the market by 0.68%in the months following positive flows and produces significant alphas after accounting for well-known equity risk *** findings are interpreted as evidence in favor of a behavioral explanation,in which sentiment influences actual managerial *** retail investors and managers are swept up in market euphoria,retail investors shift their holdings from bond to equity mutual funds,and high-investment firms invest more ***-level euphoria has a different impact on high-and low-investment firms,and thus the investment factor can be ***,the mispricing occurs during these periods,and the reversal relationship is especially pronounced for a high-investment portfolio versus a low-investment *** a result,during the months following periods of positive flows,the investment factor outperforms the market ***,this study’s measure of flows,which serves as a proxy for market-level euphoria,outperforms other measures of investor sentiment.

关键词： Corporate investment Investment factor mutual funds Fund flows Net exchanges Price noise market stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：