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lymphangiogenesis: A new player in the heart’s adaptive response to exercise

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Journal of Sport and Health Science 2022年第4期11卷 421-423页

作者： Sanela Dozic Johannes V.Janssens Kate l.Weeks Central Clinical School Monash UniversityMelbourneVIC 3004Australia Department of Anatomy&Physiology The University of MelbourneParkvilleVIC 3010Australia Baker Department of Cardiometabolic Health The University of MelbourneParkvilleVIC 3010Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia

The heart’s lymphatic network is essential for maintaining fluid and immune cell *** vessels return interstitial fluid to the bloodstream,transport macromolecules such as proteins and lipids,and clear the heart of inflammatory cells.1 Several studies have demonstrated the importance of cardiac lymphatics and lymphangiogenesis(the formation of new lymphatic vessels from pre-existing vessels)in settings of cardiac pathology.2-6 Blocking endogenous lymphangiogenesis during myocardial infarction exacerbates myocardial edema and cardiac inflammation and fibrosis,while enhancing lymphangiogenesis attenuates ischemia-induced heart failure and pressure overload-induced cardiac dysfunction.3-5 Collectively,these studies identify stimulation of lymphangiogenesis as a potential therapeutic strategy for the treatment of cardiovascular diseases and heart failure.

关键词： cardiac stimulation endogenous

The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： Kimberley l.Way Angela S.lee Stephen m.Twigg Nathan A.Johnson Faculty of medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia Charles Perkins Centre University of SydneyCamperdownNSW 2006Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(mICE)in adults with diabetes;and(ii)compare the effects of HIIE and mICE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)mICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the mICE or CON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and mICE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of

关键词： Augmentation index Central systolic blood pressure Diabetes High-intensity interval exercise

Evaluation of multiplicative Weight of Covariance matrix on Hybrid Data Assimilation Schemes

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Atmospheric and Climate Sciences 2023年第2期13卷 255-281页

作者： Pedro m. González-Jardines maibys Sierra-lorenzo Adrián l. Ferrer-Hernández Center for Atmospheric Physics Institute of Meteorology Havana Cuba

This research develops a comparative study between different multiplicative weights that are assigned to the covariance matrix that represents the background error in two hybrid assimilation schemes: 3DEnVAR and 4DEnVAR. These weights are distributed between the static and time-invariant matrix and the matrix generated from the perturbations of a previous ensemble. The assigned values are 25%, 50%, and 75%, always having as a reference the ensemble matrix. The experiments are applied to the short-range Prediction System (SisPI) that works operationally at the Institute of meteorology. The impact of Tropical Storm Eta on November 7 and 8, 2020 was selected as a study case. The results suggest that by giving the main weight to the ensemble matrix more realistic solutions are achieved because it shows a better representation of the synoptic flow. On the other hand, it is observed that 3DEnVAR method is more sensitive to multiplicative weight change of the first guess. more realistic results are obtained with 50% and 75% relations with 4DEnVAR method, whereas with 3DEnVAR a weight of 75% for the ensemble matrix is required.

关键词： SisPI WRFDA Hybrid-methods Covariance Weights

Effect of complexing agent concentration on properties of CdZnS thin films in ammonia-thiourea system

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Optoelectronics letters 2023年第4期19卷 222-226页

作者： lü Chaoqun XUE Yuming DAI Hongli WANG luoxin WANG Yifan XIE Xin Institute of New Energy Intelligence Equipment School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China

In this paper,the effects of different concentrations of complexing agent(ammonia)on the surface morphology,composition,structure and photoelectric properties of Cd Zn S films were *** results of X-ray diffraction(XRD),scanning electron microscopy(SEm)and UV-visible spectrum showed that the surface morphology of the films became worse and the content of zinc decreased significantly with the increase of ammonia *** crystalline phase of Cd Zn S films was not influenced by the ammonia *** the film has good absorbance,transmittance greater than 70%and band gap width between 3.5 eV and 3.07 eV,it is suitable to be used as a buffer layer for solar *** S,Zn O and Zn(OH)_(2) were found in the precipitates at the bottom of the solution,and the formation of these precipitates affected the properties of the Cd Zn S films.

关键词： ammonia agent properties

耕地恢复实施路径调查与思考——以广东省耕地恢复示范点为例

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自然资源情报 2024年第1期 25-30页

作者：朱君玉谭春婵孙伟杰熊侣英广东精地规划科技有限公司广东广州510000 广东省土地调查规划院广东广州510000

本文在实地调研基础上,系统总结了广东省佛山市、东莞市和东源县等三个耕地恢复示范地区开展耕地恢复工作的经验做法和特色创新;针对试点中遇到的耕地破碎化、缺乏资金支持、缺乏统筹联动、后期管护难、配套政策不完善等问题,提出划定... 详细信息

本文在实地调研基础上,系统总结了广东省佛山市、东莞市和东源县等三个耕地恢复示范地区开展耕地恢复工作的经验做法和特色创新;针对试点中遇到的耕地破碎化、缺乏资金支持、缺乏统筹联动、后期管护难、配套政策不完善等问题,提出划定耕地集中整治区、时序联动治理、创新耕地恢复地类多功能管理、实施网格化协同管理等路径,为规范引导耕地恢复工作及耕地“进出平衡”夯实基础,也为进一步完善广东省耕地恢复配套政策做好研究支撑。

关键词：耕地恢复耕地恢复模式实施路径

菇渣有机肥配施脱硫石膏对黄河三角洲盐碱土活性有机碳及其敏感性的影响

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水土保持学报 2024年第2期38卷 387-397页

作者：李传福徐家林明玉飞高舒吕欣杨宇轩李永强焦树英山东农业大学资源与环境学院土肥高效利用国家工程研究中心山东泰安271018 德州市园林绿化服务中心山东德州253000

[目的]为探讨菇渣有机肥与脱硫石膏对盐碱土有机碳组分及碳库管理指数的影响。[方法]以黄河三角洲新垦殖小麦-玉米轮作地为研究对象,采用随机区组试验方法,设置不施肥(CK)、农民常用施肥(CN)、菇渣有机肥(mCOF)、菇渣有机肥+脱硫石膏(mC... 详细信息

[目的]为探讨菇渣有机肥与脱硫石膏对盐碱土有机碳组分及碳库管理指数的影响。[方法]以黄河三角洲新垦殖小麦-玉米轮作地为研究对象,采用随机区组试验方法,设置不施肥(CK)、农民常用施肥(CN)、菇渣有机肥(mCOF)、菇渣有机肥+脱硫石膏(mCOG)4个处理,通过3年田间施肥处理。[结果]菇渣有机肥与脱硫石膏配施显著降低0-20 cm土壤盐碱度,提高土壤氮磷钾养分含量和阳离子交换量(pm土层总有机碳(TOC)、易氧化有机碳(EOC)、微生物量碳(mBC)含量高于20-40 cm土层,而水溶性有机碳(WSOC)含量则相反;与CN处理相比,mCOG处理0-20 cm土层TOC、EOC、WSOC、mBC分别显著提高15.48%,23.50%,18.98%,51.40%,EOC和mBC有效率分别提高13.94%,30.49%,且mCOG处理较CN和CK处理的土壤碳库管理指数(CPmI)显著提高15.38%和20.00%;mBC的敏感性指数均高于其他有机碳组分,mCOG处理mBC值最高。相关性分析表明,土壤TOC含量取决于其活性组分,而影响盐碱土有机碳活性组分含量及其有效率、碳库管理指数的主要因素为pH、CEC和EC。[结论]菇渣有机肥与脱硫石膏配施能显著降低土壤盐碱含量,提高土壤肥力并增强固碳效率,研究结果为拓展盐碱地土壤有机改良方法提供理论依据和数据支撑。

关键词：盐碱地菇渣有机肥脱硫石膏活性有机碳碳库管理指数

热处理方式对大豆脂肪氧合酶活力和构象的影响

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中国食品学报 2024年第7期24卷 111-118页

作者：孔月孙立娜李妍慧康子孟何甜吕文彪徐福张爽谢凤英东北农业大学食品学院哈尔滨150030

通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)、圆二色谱、表面疏水性、荧光光谱以及分子对接等方法,研究不同热处理方式对大豆脂肪氧合酶(lOX)活力和构象的影响。结果表明:高温短时热处理可以显著降低lOX活力,其中120℃80 s+140℃... 详细信息

通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)、圆二色谱、表面疏水性、荧光光谱以及分子对接等方法,研究不同热处理方式对大豆脂肪氧合酶(lOX)活力和构象的影响。结果表明:高温短时热处理可以显著降低lOX活力,其中120℃80 s+140℃15 s和100℃10 min热处理后,lOX活力分别降低了67.47%和60.53%。SDS-PAGE电泳结果显示高温热处理后lOX蛋白条带的分子质量并未发生明显变化,而条带强度减弱;热处理迫使lOX蛋白的α-螺旋和β-折叠相对含量降低,表面疏水性和内源性荧光强度增强,说明其二级结构和三级结构发生变化,lOX活力降低;通过分子对接模拟预测lOX活性中心非血红色铁周围的微环境,其在热处理过程中发生改变。推断高温热处理是通过破坏维持酶蛋白结构稳定的非共价相互作用力,促使lOX活性丧失,其中高温短时升温钝化lOX活性是较为合适的热处理方式。试验结果为大豆产品加工中lOX活性控制提供了数据参考。

关键词：脂肪氧合酶热处理酶活力构象

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Cavity optomechanical chaos

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Fundamental Research 2023年第1期3卷 63-74页

作者： Gui-lei Zhu Chang-Sheng Hu Ying Wu Xin-You lü School of Physics Huazhong University of Science and TechnologyWuhan 430074China

Cavity optomechanics provides a powerful platform for observing many interesting classical and quantum nonlinear phenomena due to the radiation-pressure coupling between its optical and mechanical *** particular,the chaos induced by optomechanical nonlinearity has been of great concern because of its importance both in fundamental physics and potential applications ranging from secret information processing to optical *** review focuses on the chaotic dynamics in optomechanical *** basic theory of general nonlinear dynamics and the fundamental properties of chaos are *** nonlinear dynamical effects in optomechanical systems are ***,recent remarkable theoretical and experimental efforts in manipulating optomechanical chaotic motions are *** perspectives of chaos in hybrid systems are also discussed.

关键词： Cavity optomechanics Chaos Nonlinear dynamics Bistability Period-doubling bifurcation

大菱鲆类胰岛素生长因子3基因的克隆和表达分析

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渔业科学进展 2024年第2期45卷 220-232页

作者：张家荣秦宏宇谢婷张效宇李飞霞吕俊贤贾玉东上海海洋大学水产与生命学院上海201306 中国水产科学研究院黄海水产研究所山东青岛266071 崂山实验室海洋渔业科学与食物产出过程功能实验室山东青岛266237

类胰岛素生长因子3 (insulin-like growth factor 3, IGF3)在硬骨鱼类性别分化过程中扮演重要角色,但其是否影响卵巢发育尚不明确。本研究以欧亚养殖良种大菱鲆(Scophthalmus maximus)为实验材料,通过RACE (rapid-amplification of cDNA... 详细信息

类胰岛素生长因子3 (insulin-like growth factor 3, IGF3)在硬骨鱼类性别分化过程中扮演重要角色,但其是否影响卵巢发育尚不明确。本研究以欧亚养殖良种大菱鲆(Scophthalmus maximus)为实验材料,通过RACE (rapid-amplification of cDNA ends)克隆技术,获得了IGF3全长cDNA序列,分析了其生物信息学特征,预测了其与IGF特异性受体(IGF receptors, IGF-1R, IGF-2R)结合情况,查明了其组织和卵巢不同发育时期表达规律。结果显示,大菱鲆IGF3 cDNA全长为1 255 bp,编码259个氨基酸。生物信息学分析发现,IGF3为亲水性蛋白,具有典型的IGF特异性结构域和信号肽序列,同狭鳞庸鲽(Hippoglossus stenolepis)同源性最高;蛋白质三级结构域由3个α螺旋串联而成,同IGF-1R和IGF-2R紧密结合。组织表达分析显示,igf3在大菱鲆各个组织中均有分布,雌、雄大菱鲆表达规律显著不同,但皆在脑组织中表达最高。在卵巢发育过程中,igf3在卵黄生成后期表达量显著上升,在核迁移期达到最高,在闭锁期显著下降。以上结果表明,大菱鲆IGF3具有典型的IGFs家族结构特征,作为局域性内分泌因子,在组织中广泛分布且具有显著的性别二态性,同时参与调控了卵巢发育和成熟。相关结果为深入解析IGF3对大菱鲆卵巢发育和卵母细胞成熟的影响及其作用机制奠定了基础,也为探究鱼类IGF3新功能提供了重要思路。

关键词：大菱鲆 IGF3 基因克隆组织表达卵巢发育