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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Biology of tooth replacement in amniotes

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International Journal of Oral Science 2013年第2期5卷 66-70页

作者： John A Whitlock joy m Richman Department of Oral Health Sciences Faculty of DentistryLife Sciences InstituteUniversity of British Columbia

Tooth replacement is a common trait to most vertebrates, including mammals. mammals, however, have lost the capacity for continuous tooth renewal seen in most other vertebrates, and typically have only 1-2 generations of teeth. Here, we review the mechanisms of tooth replacement in reptiles and mammals, and discuss in detail the current and historical theories on control of timing and pattern of tooth replacement and development.

关键词： dental lamina growth factor signalling mammal epithelial stem cells diphyodonty polyphyodonty reptile successional lamina tooth replacement Zahnreihen, zone of inhibition

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

mining diversity of the natural biorefinery housed within Tipula abdominalis larvae for use in an industrial biorefinery for production of lignocellulosic ethanol

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Insect Science 2010年第3期17卷 303-312页

作者： Dana m. Cook joy Doran-Peterson microbiology Department University of Georgia Athens Georgia USA

Although they are the largest taxonomic group of animals, relatively few insects have been examined for symbiotic relationships with micro-organisms. However, this is rapidly changing because of the potential for examination of the natural insectmicrobe-lignocellulose interactions to provide insights for biofuel technology. micro-organisms associated with lignocellulose-consuming insects often facilitate the digestion of the recalcitrant plant diet; therefore these microbial communities may be mined for novel lignocellulose-degrading microbes, or for robust and inexpensive biocatalysts necessary for economically feasible biofuel production from lignocellulose. These insect-microbe interactions are influenced by the ecosystem and specific lignocellulose diet, and appre- ciating the whole ecosystem-insect-microbiota-lignocellulose as a natural biorefinery provides a rich and diverse framework from which to design novel industrial processes. One such natural biorefinery, the Tipula abdominalis larvae in riparian ecosystems, is reviewed herein with applications for biochemical processes and overcoming challenges involved in conversion of lignocellulosic biomass to fuel ethanol. From the dense and diverse T. abdominalis larval hindgut microbial community, a cellulolytic bacterial isolate, 27C64, demonstrated enzymatic activity toward many model plant polymers and also produced a bacterial antibiotic. 27C64 was co-cultured with yeast in fermentation of pine to ethanol, which allowed for a 20% reduction of commercial enzyme. In this study, a micro-organism from a lignocellulose-consuming insect was successfully applied for improvement of biomass-to-biofuel technology.

关键词： ethanol hydrolytic enzymes insect-associated microorganisms lignocellulose

lithium-ion mobility in layered oxides li_(2)Ca_(1.5)Nb_(3)O_(10),li_(2)Ca_(1.5)TaNb_(2)O_(10)and li_(2)Ca_(1.5)Ta_(2)NbO_(10),enhanced by supercell formation

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Journal of Energy Chemistry 2021年第9期30卷 75-84页

作者： Selorm joy Fanah Farshid Ramezanipour Department of Chemistry University of LouisvilleLouisvilleKY 40292USA

The formation of a supercell and its impact on lithium-ion conductivity have been studied through synthesis of three layered oxides,li_(2)Ca_(1.5)Nb_(3)O_(10),li_(2)Ca_(1.5)TaNb_(2)O_(10)and li_(2)Ca_(1.5)Ta_(2)NbO_(10),related to Ruddlesden-Popper *** diffraction experiments show that these materials feature a supercell,which is significantly larger(√2a×√2b×1c)than that of a typical RuddlesdenPopper *** impedance spectroscopy shows that the formation of the new supercell is associated with enhanced lithium-ion conductivity of these materials as compared with the Sranalogue,li_(2)Sr_(1.5)Nb_(3)O_(10),which lacks the *** addition,a systematic trend is observed in the ionic conductivity:li_(2)Ca_1.5Ta_(2)NbO10li_(2)Ca_(1.5)TaNb_(2)O_(10)li_(2)Ca_(1.5)Nb_(3)O_(10).The Arrhenius analysis in the temperature range 25–400°C shows that activation energy for the temperature-dependent rise in conductivity follows a similar *** analyses of real and imaginary components of impedance,dielectric properties,tangent loss,and complex modulus show the systematic increase in lithium-ion *** dielectric values mirror the same trend as ionic conductivity,where the most conductive material shows the highest dielectric *** addition,the same trend is observed in the peak and dispersion of dielectric loss and complex modulus as a function of angular frequency,indicating a systematic rise in lithium-ion *** fundamental study is aimed at exploring the impact of structural modifications on ionic conductivity in solids.

关键词： lithium-ion Conductivity Supercell Impedance Dielectric analyses

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOlAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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lepton and quark mixing patterns with generalized CP transformations

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Chinese Physics C 2022年第10期46卷 25-42页

作者： joy Ganguly Raghavendra Srikanth Hundi Department of Physics Indian Institute of Technology HyderabadKandi-502284India

In this study,we modify a scenario,originally proposed by Grimus and lavoura,in order to obtain maximal values for the atmospheric mixing angle and CP,violating the Dirac phase of the lepton *** achieve this,we employ CP and some discrete symmetries in a type Ⅱ seesaw *** make predictions about the neutrino mass ordering and smallness of the reactor angle,we establish some conditions on the elements of the neutrino mass matrix of our ***,we study the quark masses and mixing pattern within the framework of our model.

关键词： neutrino physics nuetrino mass and mixing model quark mass and mixing analysis of scalar potential

The biological stress of early weaned piglets

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Journal of Animal Science and Biotechnology 2013年第2期4卷 124-127页

作者： joy m Campbell Joe D Crenshaw Javier Polo APC Inc. 2425 SE Oak Tree CourtAnkenyIA USA

Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig＇s life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality.

关键词： Biological stress Intestine Pig Weaning