检索结果-南通市图书馆

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Artificial Intelligence Based Smart Routing in Software Defined Networks

在线全文

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第2期44卷 1279-1293页

作者： C.Aswini m.l.Valarmathi Department of Information Technology Government College of TechnologyCoimbatore641013India Department of Computer Science and Engineering Dr.Mahalingam College of Engineering and TechnologyPollachi642003India

In a non-static information exchange network,routing is an overly com-plex task to perform,which has to satisfy all the needs of the *** Deﬁned Network(SDN)is the latest and widely used technology in the future communication networks,which would provide smart routing that is visible *** various features of routing are supported by the information centric network,which minimizes the congestion in the dataﬂow in a network and pro-vides the content awareness through its mined *** to the advantages of the information centric network,the concepts of the information-centric net-work has been used in the paper to enable an optimal routing in the software-deﬁned *** there are many advantages in the information-centric network,there are some disadvantages due to the non-static communication prop-erties,which affects the routing in *** this regard,artiﬁcial intelligence meth-odology has been used in the proposed approach to solve these difﬁculties.A detailed analysis has been conducted to map the content awareness with deep learning and deep reinforcement learning with *** novel aligned internet investigation technique has been proposed to process the deep reinforcement *** performance evaluation of the proposed systems has been con-ducted among various existing approaches and results in optimal load balancing,usage of the bandwidth,and maximization in the throughput of the network.

关键词： Content aware routing software deﬁned networks deep learning load balancing

Is the possible fine-structure constant drift also a test of a time-dependent Planck constant?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,mechanics & Astronomy) 2011年第12期54卷 2191-2195页

作者： ZTAS A. m. SmITH m. l. Engineering Physics Hacettepe University Jannek Fuel Inc. Phoenix

The recent publication of spatial and distance variation of the fine-structure constant, α, derived from astronomical data of quasar emissions (QE) is exciting. The decreasing value of α over time, derived from data obtained from the Very large Telescope (VlT) in Chile, encourages the search for other possible running constants. We surmise that emissions from distant supernovae, type Ia (SNe Ia), which are more blue than predictions are best explained by a decreasing Planck constant with increasing lookback time. We present some results from our theoretical work and comparison to the astronomical observations and suggest that both α and h might be running constants. more data are required to answer several questions about the origin of the "drifting" α and the possible time dependence of h. Astronomical tools such as SNe and QE may be the best means to secure the exacting data needed to confirm or deny these hypotheses.

关键词： alpha quasars distance measurement supernovae CmB

Geometrical Scale-Sensitive Fatigue Properties of Ti-6.5Al-3.5mo-1.5Zr-0.3Si Alloys With α/β lamellar microstructures

在线全文

学校读者我要写书评

暂无评论

Journal of materials Science & Technology 2014年第12期30卷 1284-1288页

作者： B.Zhang Z.m.Song l.m.lei l.Kang G.P.Zhang Key laboratory for Anisotropy and Texture of materials Ministry of Education Northeastern University Shenyang National laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences AVIC Commercial Aircraft Engine Co. Ltd.

Fatigue properties of the Ti-6.5Al-3.5mo-1.5Zr-0.3Si alloy sheets containing different numbers of α/β Widmansttten colonies in the thickness direction of the sheets were investigated by tensionetension fatigue testing. It is found that fatigue properties of the Ti alloy either in low- or high-stress amplitude regimes become more sensitive to the sheet thickness of the Ti alloy as the sheet thickness is comparable to the length scale of the Widmansttten colonies. The basic mechanism of such length scale-sensitive fatigue properties in the Ti alloy was elucidated.

关键词： Fatigue Ti alloy microstructure Size effect

Preliminary Study of a Hybrid Helicon-ECR Plasma Source

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2016年第8期18卷 832-836页

作者： A.m.HAlA l.OKSUZ ZHU Ximing The National Center for Applied Physics Material Science Research InstituteKing Abdul Aziz City for Science and Technology(KACST) Süleyman Demirel University Science and Literature FacultyPhysics Department Institute for Plasma and Atomic Physics Ruhr University

A new type of hybrid discharge is experimentally investigated in this work. A helicon source and an electron cyclotron resonance（ECR） source were combined to produce plasma. As a preliminary study of this type of plasma, the optical emission spectroscopy（OES） method was used to obtain values of electron temperature and density under a series of typical conditions. Generally,it was observed that the electron temperature decreases and the electron density increases as the pressure increased. When increasing the applied power at a certain pressure, the average electron density at certain positions in the discharge does not increase significantly possibly due to the high degree of neutral depletion. Electron temperature increased with power in the hybrid *** mechanisms of these preliminary observations are discussed.

关键词： helicon plasma ECR hybrid discharge

Effects of thermophoresis particle deposition and of the thermal conductivity in a porous plate with dissipative heat and mass transfer

在线全文

学校读者我要写书评

暂无评论

Acta mechanica Sinica 2011年第3期27卷 389-398页

作者： Joaquín Zueco O.Anwar Bég l.m.lpez-Ochoa Thermal Engineering and Fluids Department Technical University of CartagenaETSII Campus Muralla del Mar Aerospace Engineering Department of Engineering and MathematicsSheaf BuildingSheffield Hallam University mechanical Engineering Departament University of RiojaC/Luís de UlloaLogrono (La Rioja)20E-26004Spain

Network simulation method（NSm） is used to solve the laminar heat and mass transfer of an electricallyconducting,heat generating/absorbing fluid past a perforated horizontal surface in the presence of viscous and Joule heating problem. The governing partial differential equations are non-dimensionalized and transformed into a system of nonlinear ordinary differential similarity equations,in a single independent variable,畏. The resulting coupled,nonlinear equations are solved under appropriate transformed boundary conditions. Computations are performed for a wide range of the governing flow parameters,viz Prandtl number,thermophoretic coeffcient（a function of Knudsen number）,thermal conductivity parameter,wall transpiration parameter and Schmidt number. The numerical details are discussed with relevant applications. The present problem finds applications in optical fiber fabrication,aerosol filter precipitators,particle deposition on hydronautical blades,semiconductor wafer design,thermo-electronics and problems including nuclear reactor safety.

关键词： Thermophoresis . mHD . Network simulation model . Heat and mass transfer- Hartmann number

Dendritic cells in cancer immunology

在线全文

学校读者我要写书评

暂无评论

Cellular & molecular Immunology 2022年第1期19卷 3-13页

作者： Theresa l.murphy Kenneth m.murphy Department of Pathology and Immunology Washington University in St.LouisSchool of MedicineSt.LouisMO 63110USA

The clinical success of immune checkpoint therapy(ICT)has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune *** of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTlA4 or PD1/PD-l1 blockade and are solidly developed on the basis of currently accepted *** these principles through continuous basic research may help broaden translational *** this mindset,we focused this review on three threads of basic research directly relating to mechanisms underlying ***,this review covers three aspects of dendritic cell(DC)biology connected with antitumor immune responses but are not specifically oriented toward therapeutic ***,we review recent advances in the development of the cDC1 subset of DCs,identifying important features distinguishing these cells from other types of ***,we review the antigen-processing pathway called cross-presentation,which was discovered in the mid-1970s and remains an *** pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic ***,we review the longstanding field of helper cells and the related area of DC licensing,in which CD4 T cells influence the strength or quality of CD8 T cell *** topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.

关键词： Dendritic cells transcription factors cross-presentation tumor rejection CD4 help

Chemically reactive and radiative von Kármán swirling flow due to a rotating disk

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2018年第9期39卷 1295-1310页

作者： m.KHAN J.AHmED l.AHmAD Department of mathematics Quaid-i-Azam UniversityIslamabad 44000Pakistan Department of Basic Sciences University of Engineering and TechnologyTaxila 47050Pakistan Department of mathematics Shaheed Benazir Bhutto UniversitySheringal Upper Dir 18000Pakistan

A new mathematical model is presented to study the heat and mass transfer characteristics of magnetohydrodynamic(mHD) maxwell fluid flow over a convectively heated stretchable rotating disk. To regulate the fluid temperature at the surface, a simple isothermal model of homogeneous-heterogeneous reactions is employed. The impact of nonlinear thermal radiative heat flux on thermal transport features is studied. The transformed nonlinear system of ordinary differential equations is solved numerically with an efficient method, namely, the Runge-Kutta-Felberg fourth-order and fifth-order(RKF45)integration scheme using the mAPlE software. Achieved results are validated with previous studies in an excellent way. major outcomes reveal that the magnetic flux reduces the velocity components in the radial, angular, and axial directions, and enhances the fluid temperature. Also, the presence of radiative heat flux is to raise the temperature of fluid. Further, the strength of homogeneous-heterogeneous reactions is useful to diminish the concentration of reaction.

关键词： rotating stretchable disk magnetic field nonlinear radiative heat flux homogeneous-heterogeneous chemical reaction

Bianchi type I in f(T) gravitational theories

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2016年第5期25卷 58-64页

作者： m I Wanas G G l Nashed O A Ibrahim Astronomy Department Faculty of Science Cairo University Cairo Egypt Centre for Theoretical Physics The British University in Egypt El-Sherouk City Egypt mathematics Department Faculty of Science Ain Shams University Cairo Egypt Egyptian Relativity Group (ERG) Giza Egypt

A tetrad field that is homogeneous and anisotropic which contains two unknown functions A（t） and B（t） of cosmic time is applied to the field equations of f（T）, where T is the torsion scalar, T = T~μ_（νρ）S_μ^（νρ）. We calculate the equation of continuity and rewrite it as a product of two brackets, the first is a function of f（T） and the second is a function of the two unknowns A（t） and B（t）. We use two different relations between the two unknown functions A（t） and B（t） in the second bracket to solve it. Both of these relations give constant scalar torsion and solutions coincide with the de Sitter one. So,another assumption related to the contents of the matter fields is postulated. This assumption enables us to drive a solution with a non-constant value of the scalar torsion and a form of f（T） which represents ΛCDm.

关键词： f(T) gravitational theory Bianchi type I special solutions