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EDSUCh:A robust ensemble data summarization method for effective medical diagnosis

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Digital Communications and Networks 2024年第1期10卷 182-189页

作者： mohiuddin Ahmed A.N.m.Bazlur Rashid School of Science Edith Cowan UniversityPerthAustralia

Identifying rare patterns for medical diagnosis is a challenging task due to heterogeneity and the volume of *** summarization can create a concise version of the original data that can be used for effective *** this paper,we propose an ensemble summarization method that combines clustering and sampling to create a summary of the original data to ensure the inclusion of rare *** the best of our knowledge,there has been no such technique available to augment the performance of anomaly detection techniques and simultaneously increase the efficiency of medical *** performance of popular anomaly detection algorithms increases significantly in terms of accuracy and computational complexity when the summaries are ***,the medical diagnosis becomes more effective,and our experimental results reflect that the combination of the proposed summarization scheme and all underlying algorithms used in this paper outperforms the most popular anomaly detection techniques.

关键词： Data summarization Ensemble medical diagnosis Sampling

Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie m.K.Verge Nataliya Tokarska Justin m.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco mS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

multiple sclerosis(mS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** mS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few mS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

Imaging mass spectrometry: a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-mai Jacob m.Samuel Boone m.Prentice Department of Neurology University of Florida Department of Chemistry University of Florida

Parkinson’s disease–A lipidopathy? The histopathological hallmark of Parkinson’s disease(PD) and dementia with Lewy bodies are inclusions enriched in α-synuclein(α-syn), known as Lewy bodies, which are not only composed of proteins, but also a core of lipid species. PD has been thus far principally thought of as a “proteinopathy” caused by the misfolding of α-syn. However,

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Embracing substrate multispecificity in plant ABC transporters

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molecular Plant 2024年第7期17卷 990-992页

作者： markus m.Geisler Department of Biology University of Fribourg1700 FribourgSwitzerland

By analogy,the first plant ATP-binding cassette(ABC)transporters were identified as vacuolar detoxifiers transporting glutathione conjugates into the vacuole(martinoia et al.,1993).This somewhat negative image as"unspecific detoxifiers"still clings to plant ABC transporters today,although they have since been described to be involved in completely different programs,including development and defense(Park et al.,2017).In this context,some key plant ABC transporters have been shown to own exceptionally high substrate *** example,the transporter of the native auxin indole-3-acetic acid(IAA),Arabidopsis ABCB1,has been shown to also export the synthetic auxin 1-naphtaleneacetic acid but is even able to distinguish this substrate from its structural isomer,2-naphtaleneacetic acid(Geisler et al.,2005).Likewise,ABCG36 and ABCG37,which are known to have a broader substrate portfolio(Park et al.,2017;Aryal et al.,2023),export IBA but do not touch IAA(Aryal et al.,2023).Recently,several reports have challenged our current view on the reported high substrate specificity of plant ABCs,which requires clarification.

关键词： specificity analogy exceptional

Direct microwave leaching conditions of rare earth elements in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol m.N.Saridede S.S.Kaplan m.S.Sonmez Department of metallurgical and materials Engineering Yildiz Technical UniversityIstanbulTurkey Department of Chemical Engineering and materials Science Stevens Institute of TechnologyNew JereyUSA Department of metallurgical and materials Engineering Istanbul Technical UniversityIstanbulTurkey

The luminescent phosphor powder in the fluorescent lamp constitutes 2%of the lamp’s *** can be mentioned that fluorescent wastes are a crucial raw material to produce rare earth *** the present study,microwave leaching process was conducted to dissolve rare earth elements yttrium(Y),europium(Eu),and remaining rare earth elements(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the microwave leaching process,the effects of the temperature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HNO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 mol/L),solid to liquid ratio(0.1:10-0.5:10)and reaction time(5-90 min)parameters on leaching efficiencies of varying rare earth elements and calcium were *** highest yield was obtained in the direct microwave leaching of fluorescent waste with the experimental conditions of 6 mol/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations were made,and kinetic models of the reactions were obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum(La),cerium(Ce),and terbium(Tb)were examined to be chemical reaction ***,calcium(Ca)and gadolinium(Gd)seem coherent with the mixed ***,mathematical models of all experimental studies are created with the response surface Box-Behnken method and the correlation coefficients of all the models are over 90%.

关键词： Rare earth elements(REEs) Direct microwave leaching Fluorescent waste Kinetic models Response surface method

The role of N-glycosylation in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1098-1110页

作者： Yu Lin David m.Lubman Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer *** play an important role in medicine and are involved in various human disease conditions including ***-moieties participate in fundamental cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly impacts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tumor is essential for comprehending disease progression and discovering anti-cancer targets and biomarkers for therapy monitoring and *** review presents the fundamental process of protein N-glycosylation and summarizes glycosylation changes in tumor cells,including increased terminal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tumor signaling pathways,migration,and metabolism are *** and glycopeptides as potential biomarkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteome,along with its role in medicine,implication in cancer and other human diseases,highlights the significance of N-glycosylation in tumor processes,necessitating further research for potential anticancer targets and biomarkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers

A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHm FOR CONSTRUCTING THE PARETO FRONT OF mULTIOBJECTIVE OPTImIZATION PROBLEmS

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Acta mathematica Scientia 2024年第2期44卷 702-720页

作者： N.HOSEINPOOR m.GHAZNAVI Faculty of mathematical Sciences Shahrood University of TechnologyShahroodIran

In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.

关键词： multiobjective optimization Pareto front scalarization objective-constraint approach proper efficient solution

The Triple Helix of innovation as a double game involving domestic and foreign actors

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Journal of Data and Information Science 2024年第1期9卷 82-100页

作者： Eustache mêgnigbêto University of Antwerp Antwerpen 2000Belgium

Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the *** the level of each layer,the relationships and the actors involved constitute a Triple Helix *** paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner ***/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game *** core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between ***:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West *** limitations:Research data are limited to publication records;techniques and methods used may be extended to other research *** implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign ***,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign ***/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area *** proposes an indicator to this end.

关键词： Triple Helix Game theory Core Shapley value Nucleolus South Korea West Africa

Validation of adherence prediction system for lifestyle interventions in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2629-2632页

作者： meer m Chisthi Department of General Surgery Government Medical College PathanamthittaKonni 689691KeralaIndia

This editorial delves into the research article by Zeng et al published in the latest issue of World Journal of *** manuscript contributes significantly to addressing the global health issue of nonalcoholic fatty liver disease(NAFLD)by introducing and validating the Exercise and Diet Adherence Scale(EDAS).The article effectively conveys the importance of the study,highlighting the prevalence of NAFLD,the lack of approved drugs for its treatment,and the crucial role of lifestyle *** use of the Delphi method for scale development and the subsequent evaluation of its reliability add scientific rigor to the *** results demonstrate that the scale is correlated with key lifestyle indicators,which makes it a promising tool for assessing patient adherence to *** identification of specific score thresholds for predicting adherence to daily calorie intake and exercise adds practical value to the *** differentiation among scores indicative of good,average,and poor adherence enhances its clinical *** conclusion,the manuscript introduces EDAS,a valuable instrument that can contribute substantially to the field of NAFLD research and clinical practice.

关键词： Nonalcoholic fatty liver disease Lifestyle interventions Adherence assessment Exercise and Diet Adherence Scale Delphi method