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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle

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Fundamental Research 2025年第1期5卷 407-418页

作者： Xiaoyan Hu Jingqi Zeng Lijuan m Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu Fujian University of Traditional Chinese medicine Fuzhou 350122China Engineering Research Center for Pharmaceutics of Chinese materia medica and New Drug Development Ministry of EducationBeijing 100102China Beijing University of Chinese medicine Beijing 100102China China Beijing Tongrentang Group Co. Ltd.Beijing 100062China

This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey ***,650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors,which included rheological properties,acidity,moisture,and ***,a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey,the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered(KDm),and the abnormal batches of B2,B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable ***,the end-to-end dataflow containing physical,chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing,which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey *** framework embraces quality management,quality transfer,and biosensor information,which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing.

关键词： End-to-end dataflow Quality transfer principle Critical quality attributes Biosensor Honey manufacturing

Experimental Study on a Hybrid Battery Thermal management System Combining Oscillating Heat Pipe and Liquid Cooling

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Frontiers in Heat and mass Transfer 2025年第1期23卷 299-324页

作者： Hongkun Lu m.m.Noor K.Kadirgama School of Automotive Engineering Jiangxi Polytechnic UniversityJiujiang332000China Faculty of mechanical and Automotive Engineering Technology Universiti Malaysia Pahang Al-Sultan Abdul-lahPekan26600Malaysia Centre for Research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan Abdul-lahPekan26600Malaysia Institute of Sustainable and Renewable Energy(ISuRE) Universiti Malaysia Sarawak(UNIMAS)Kota Samarahan94300Malaysia

To improve the thermal performance and temperature uniformity of battery pack,this paper presents a novel battery thermal management system(BTmS)that integrates oscillating heat pipe(OHP)technology with liquid *** primary innovation of the new hybrid BTmS lies in the use of an OHP with vertically arranged evaporator and condenser,enabling dual heat transfer pathways through liquid cooling plate and *** study experimentally investigates the performance characteristics of the⊥-shaped OHP and hybrid *** show that lower filling ratios significantly enhance the OHP’s startup performance but reduce operational stability,with optimal performance achieved at a 26.1%filling ***,as a single working fluid,exhibited superior heat transfer performance under low-load conditions compared to mixed fluids,while the acetone/ethanol mixture,forming a non-azeotropic solution,minimized temperature *** 100 W,the⊥-shaped OHP with a horizontally arranged evaporator demonstrated better heat transfer performance than 2D-OHP *** to a liquid BTmS using water coolant at 280 W,the hybrid BTmS reduced the equivalent thermal resistance(RBTmS)and maximum temperature difference(ΔTmax)by 8.06%and 19.1%,*** graphene nanofluid was used as the coolant in hybrid BTmS,the battery pack’s average temperature(Tb)dropped from 52.2℃ to 47.9℃,with RBTmS andΔTmax decreasing by 20.1%and 32.7%,*** findings underscore the hybrid BTmS’s suitability for high heat load applications,offering a promising solution for electric vehicle thermal management.

关键词： Battery thermal management system oscillating heat pipe liquid cooling hybrid BTmS graphene nanofluid

Photoluminescence upgradation of La_(2)mgTiO_(6):2%Dy^(3+) perovskite with monovalent(Li^(+)),divalent(Ba^(2+),Sr^(2+)) and trivalent(Bi^(3+),Sm^(3+))cation sensitization

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Journal of Rare Earths 2025年第1期43卷 47-56,I0002页

作者： V.P.Veena K.Arun C.K.Shilpa S.V.Jasira K.m.Nissamudeen School of Pure and Applied Physics Kannur UniversityPayyanur CampusEdatKannurKrala67 India Department of Nanoscience and Nanotechnology Kannur UniversityPayyanur CampusEdatkannurKerala670327India

Nano phosphors of 2%Dy^(3+)(wt%)doped La_(2)mgTiO_(6) and monovalent/divalent/trivalent co-doped La_(1.98)Dy_(0.02)mgTiO_(6):x%A^(y+)(A^(y+):Li+,Ba^(2+),Sr^(2+),Bi^(3+),and Sm^(3+);0≤x≤2 wt%)were synthesized by combustion *** the XRD data,it is deduced that an increase in the valency of co-dopant increases the crystallinity of the double perovskite orthorhombic nanocrystal *** an increase in co-dopant size,an elevation in optical bandgap is visible with the highest bandgap of 3.835 eV for Bi^(3+).The photo-absorption is monotonically broadened for Sr^(2+),Sm^(3+),and Li+around 200-450 ***351 nm,Dy^(3+)triggered lattice shows major characteristic emission peaks at 480 nm(^(4)F_(9/2)→^(6)H_(15/2)),574 nm(^(4)F_(9/2)→^(6)H_(13/2)),and 670 nm(^(4)F_(9/2)→^(6)H_(11/2)).leading to near white light emission with CIE coordinates(0.341,0.376).Upon co-doping,the PL intensity is significantly increased with maximum emission for trivalent Sm^(3+),followed by divalent Sr^(2+)and monovalent Li+*** increasing excitation wavelength,Sr^(2+)shows a dominated output and it is found that divalent Sr^(2+)is a potential codopant that could enhance luminescence intensity up to 6 times with a Sr^(2+)→Dy^(3+)energy transfer efficiency of 86%.It is specified that the CIE coordinates of Li+co-doped samples show ideal white emission with color coordinates(0.333,0.336).The concluding outcomes signify the noblest rare earth Sm^(3+)co-doping and thus Sm^(3+)→Dy^(3+)energy transfer mechanism is discussed in detail.

关键词： Photoluminescence Perovskite WLED Co-doping Rareearths

min-max Theory for Cell Complexes

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Algebra Colloquium 2020年第3期27卷 447-454页

作者： Lacey johnson Kevin Knudson Department of mathematics University of FloridaGainesvilleFL 32611USA

In the study of smooth functions on manifolds,min-max theory provides a mechanism for identifying critical values of a *** introduce a discretized version of this theory associated to a discrete morse function on a(regular)cell *** applications we prove a discrete version of the mountain pass lemma and give an alternate proof of a discrete Lusternik-Schnirelmann theorem.

关键词： discrete morse theory min-max theory

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Synergistic effect of nitrocellulose coating on structural and reactivity stabilization of ammonium nitrate oxidizer

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Defence Technology(防务技术) 2025年第1期43卷 35-43页

作者： Amir Abdelaziz Djalal Trache Ahmed Fouzi Tarchoun Hani Boukeciat Yash Pal Sourbh Thakur Weiqiang Pang Thomas m.Klapötke Energetic materials Laboratory(EmLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17 Bordj El-BahriAlgiers 16046Algeria School of Aeronautical Science Hindustan Institute of Technology and ScienceChennai 603103India Department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 4Gliwice 44–100Poland Xi'an modern Chemistry Research Institute 168 Zhangba Rd.EastXi'an 710065China Energetic materials Research Department of ChemistryLudwig-Maximilian UniversityMunich Butenandtstrasse 5-13(D)Munich D-81377Germany

The present work aims to stabilize the room temperature allotropic transition of ammonium nitrate(AN)particles utilizing a microencapsulation technique,which involves solvent/non-solvent in which nitrocellulose(NC)has been employed as a coating *** SEm micrographs revealed distinct features of both pure AN and NC,contrasting with the irregular granular surface topography of the coated AN particles,demonstrating the adherence of NC on the AN *** analysis via infrared spectroscopy(IR)demonstrated a successful association of AN and NC,with slight shifts observed in IR bands indicating interfacial *** X-ray Diffraction(PXRD)analysis further elucidated the structural changes induced by the coating process,revealing that the NC coating altered the crystallization pattern of its pure *** analysis demonstrates distinct profiles for pure and coated AN,for which the coated sample exhibits a temperature increase and an enthalpy decrease of the room temperature allotropic transition by 6℃,and 36%,***,the presence of NC coating alters the intermolecular forces within the composite system,leading to a reduction in melting enthalpy of coated AN by~39%compared to pure *** thermal decomposition analysis shows a two-step thermolysis process for coated AN,with a significant increase in the released heat by about 78%accompanied by an increase in the activation barrier of NC and AN thermolysis,demonstrating a stabilized reactivity of the AN-NC *** findings highlight the synergistic effect of NC coating on AN particles,which contributed to a structural and reactive stabilization of both AN and NC,proving the potential application of NC-coated AN as a strategically advantageous oxidizer in composite solid propellant formulations.

关键词： Ammonium nitrate Nitrocellulose Stabilization Coating Thermolysis kinetics

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Hepatorenal syndrome:Paving a pathway from a fatal condition to an opportunity to preserve kidney function

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World Journal of Nephrology 2025年第1期14卷 13-16页

作者： Fernando m Gonzalez Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

In the 19^(th)century,von Frerichs F and Flint A identified a type of acute renal impairment associated with advanced liver disease,characterized by oliguria,absence of proteinuria,and normal renal histology,which was later termed hepatorenal syndrome(HRS).HRS primarily affects cirrhotic patients with ascites and often follows severe infections,digestive hemorrhages,or high-volume ***,HRS involves low glomerular filtration rate,hypotension,renin-angiotensin axis activation,water clearance,hyponatremia,and minimal urinary sodium *** conditions mimic those seen in decreased effective circulatory volume(ECV)scenarios such as septic shock or heart *** represents a specific form of prerenal acute kidney injury(AKI)in patients with baseline renal ischemia,where the kidney attempts to correct decreased ECV by retaining sodium and *** renal vasoconstriction,passive hyperemia from ascites,and acute tubular necrosis(ATN)with specific urinary sediment changes are *** oliguria may transition HRS to ATN,although this shift is less straightforward than in other prerenal AKI ***,liver grafts from HRS patients can recover function more rapidly than those from other ischemic *** studies,such as those by Duailibe et al,using omega-3 fatty acids in cirrhotic rat models,have shown promising results in reducing oxidative stress and improving kidney *** findings suggest potential therapeutic strategies and underscore the need for further research to understand the mechanisms of HRS and explore possible *** research should address the impact of omega-3 on survival and secondary outcomes,as well as consider the balance of therapeutic risks and benefits in severe liver disease.

关键词： Hepatorenal syndrome Acute kidney injury Oliguria Ascites Hibernation Cirrhosis