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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Eddy Calculation and Vacuum Field Reconstruction on EAST

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Plasma Science and Technology 2011年第2期13卷 145-152页

作者：罗正平肖炳甲 j.A.LEUER m.L.walker 袁旗平 Institute of Plasma Physics Chinese Academy of Sciences General Atomics DⅢ-D National Fusion Facility

A new method, by using eigenmodes to reduce the fitting parameters and precalculated eddy current based on a lump parameter circuit equation, is applied to reconstruct the vacuum field for EAST plasma startup.

关键词： EAST eddy calculation vacuum field reconstruction tokamak

Background removal from global auroral images:Data-driven dayglow modeling

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Earth and Planetary Physics 2024年第1期8卷 247-257页

作者： A.Ohma m.madelaire K.m.Laundal j.P.Reistad S.m.Hatch S.Gasparini S.j.walker Birkeland Centre for Space Science Department of Physics and TechnologyUniversity of BergenBergenNorway

Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth ***,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by *** emissions and scattered sunlight can contribute to the background *** fully utilize such images in space science,background contamination must be removed to isolate the auroral *** we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical *** approach is robust,flexible,and iteratively deselects outliers,such as auroral *** final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the *** demonstrate the model by using the three far ultraviolet cameras on the Imager for magnetopause-to-Aurora Global Exploration(ImAGE)*** method can be applied to historical missions and is relevant for upcoming missions,such as the Solar wind magnetosphere Ionosphere Link Explorer(SmILE)mission.

关键词： aurora dayglow modeling global auroral images far ultraviolet images dayglow removal

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi mātai medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

脊髓和周围神经系统中内源性大麻酚类花生四烯甘油的液相层析-质谱检测(英文)

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中国药理学报 1999年第12期20卷 1098-1102页

作者： Susan m HUANG Nicole m STRANGmAN j michael walker The Alan m Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 USAThe Alan M Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 USAThe Alan M Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 USA

AIm: To develop a sensitive method for measuring theputative endocannabinoid 2-arachidonylglycerol (2-AG)in the peripheral and ceatral nervous ***: A method using atmospheric pressurechemical ionization (APCI) liquid chromatography/mass spectrometry (LC/mS ) was developed todetermine the levels of 2-AG in methanol extracts of therat lumar spinal cord, dorsal root ganglion (DRG),and sciatic nerve. RESULTS: 2-AG was detectedwith high sensitivity and minimal sample *** levels in the tissues analyzed were ≤pmol/mg wetweight. Similar levels were found in the spinal

关键词：大麻酚类花生四烯甘油脊神经节脊髓镇痛

Stable isotope paleohydrology and chemostratigraphy of the Albian Wayan Formation from the wedge-top depozone,North American Western Interior Basin

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Science China Earth Sciences 2017年第1期60卷 44-57页

作者： jeffrey B.ROSS Greg A.LUDVIGSON Andreas mOLLER Luis A.GONZALEZ j.D.walker Department of Geology University of Kansas Kansas Geological Survey University of Kansas

Understanding of the role of atmospheric moisture and heat transport in the climate system of the Cretaceous greenhouse world represents a major challenge in Earth system science. Stable isotopic paleohydrologic data from mid-Cretaceous paleosols in North America, from paleoequatorial to paleoArctic latitudes, have been used to constrain the oxygen isotope mass balance of the Albian hydrologic cycle. Over the range from 40°-50°N paleolatitude, sideritic paleosols predominate, indicating paleoenvironments with positive precipitation-evaporation （P-E） balances. Local exceptions occur on leeward side of the Sevier Orogen, where calcic paleosols in the wedge-top depozone record paleoenvironments with negative P-E balances in the orographic rain shadow. Stratigraphic sections in the Wayan Formation of Idaho （WF） were sampled from the wedge-top depozone. The units consist of stacked m-scale mudstone paleosols separated by m-scale sandstone-siltstone beds. Sections were sampled for organic carbon isotope profiles, and B-horizons from 6 well-developed paleosols were sampled for detrital zircons to determine maximum depositional ages. The first of these from the WF has produced a U-Pb concordia age of 101.0±1.1 ma. This same WF section has produced a stratigraphic trend of upwardly decreasing δ18C values ranging from -24‰ upwards to -27‰ VPDB, suggesting correlation to the late Albian C15 C-isotope segment. Pedogenic carbonates from the WF principally consist of micritic calcite, with carbon-oxygen isotope values that array along meteoric calcite lines （mCLs） with δ18O values that range from -9.47‰ up to -8.39‰ VPDB. At approximately 42°N paleolatitude, these mCL values produce calculated paleoprecipitation values of-8.12‰ to -7.04‰ VSmOW, a range that is consistent with the estimates produced from other proxies at the same paleolatitudes across North America. These results indicate that despite the orographic rain shadow effect, the processes of meridional atmospheric moist

关键词： Cretaceous Paleoclimate Wayan Formation Pedogenic carbonates Geochronology