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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

The effect of adsorbent textural and functional properties on model naphthenic acid adsorption

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journal of Environmental Sciences 2025年第2期148卷 27-37页

作者： Tyler m.Roy Elmira Nazari Oliver K.L.Strong Paul R.Pede Andrew j.Vreugdenhil material Science Department of ChemistryTrent University1600 West BankPeterboroughOntario K9L 0G2Canada Carbonix 690 Mountain RdSuite 200Fort William First NationOntario P7J 1G8Canada

Naphthenic acids,NAs,are a major contaminant of concern and a focus of much research around remediation of oil sand process affected waters,*** activated carbon adsorbents are an attractive option given their low cost of fabrication and implementation.A deeper evaluation of the effect NA structural differences have on uptake affinity is *** we provide an in-depth exploration of NA adsorption including many more model NA species than have been assessed previously with evaluation of adsorption kinetics and isotherms at the relevant alkaline pH of OSPW using several different carbon adsorbents with pH buffering to simulate the behaviour of real *** for the NA varied considerably regardless of the activated carbon used,ranging from 350 mg/g to near zero highlighting recalcitrant *** equilibrium data was explored to identify structural features of these species and key physiochemical properties that influence *** found that certainNAwill be resistant to adsorptionwhen hydrophobic adsorbents are *** isotherm modelling helped explore interactions occurring at the interface between NA and adsorbent *** identified the importance of NA hydrophobicity for activated carbon *** is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups,demonstrating the importance of adsorbent surface functionality for NA *** research highlights the challenges associated with removing NAs from OSPW through adsorption and also identifies howadsorbent surface chemistry modification can be used to increase the removal efficiency of recalcitrant NA species.

关键词： Adsorption Activated carbon model naphthenic acids Isotherm modelling

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan m Isa marwa j Abdulnabi Nawra S Naser Fatema N Lahmda Noor m AlAnsari Zahra H Isa Afaf m mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CmPA).AIm To evaluate CmPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CmPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya medical Complex,Bahrain,between 2014 and 2022,and assessed CmPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CmPA and 595(96.3%)were included;CmPA prevalence was 2%.most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CmPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pmore cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pmediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CmPA was associated with a longer follow-up duration than non-IgE-mediated CmPA(17.3 months±14.0 mo

关键词： Children milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

Effect of divalent cations(Co^(2+) and Ni^(2+)) on microstructure,physical properties and application of NdFeO_(3)

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journal of Rare Earths 2025年第1期43卷 89-97,I0004页

作者： m.m.Arman materials Science Lab(1) Physics DepartmentFaculty of ScienceCairo UniversityGiza12613Egypt

The nanocrystalline samples Nd_(1-x)m_(x)FeO_(3)(x=0.0 and 0.1;m:Co^(2+)and Ni^(2+))were prepared using the citrate combustion *** X-ray diffraction(XRD)pattern confirmed that the nanoparticles were synthesized in an orthorhombic *** particle size of Nd_(1-x)m_(x)FeO_(3) is in the range of 29-59 *** selected area electron diffraction(SAED)indicates the samples were prepared in a polycrystalline *** samples Nd_(1-x)m_(x)FeO_(3)(x=0.0 and 0.1;m:Co^(2+)and Ni^(2+))have anti ferromagnetic *** Fe^(3+)spins are aligned antiparallel,forming the antiferromagnetic(AFm)properties,which are affected by many factors such as the bond angle between the Fe^(3+)(Fe^(3+)-O_(2)--Fe^(3+))and the Dzyaloshinskii-moriya(D-m)*** doping of Co^(2+)and Ni^(2+)ions in NdFeO_(3) enhances the magnetic properties of the NdFeO_(3).The saturation magnetization(ms)of Nd_(0.90)Co_(0.10)FeO_(3) increases 1.8times more than that of NdFeO_(3).The exchange bias field(HEX)of the Co-doped sample is two times greater than that of NdFeO_(3).The magnetic anisotropy constant(K)of the 10%Co-doped sample increases by 11 factors compared to that of NdFeO_(3).The Tauc plot illustrates that the samples have a direct optical *** divalent cation substitution(Co^(2+)and Ni^(2+))decreases the optical band gap of NdFeO_(3),leading to the recommendation of using the samples Nd_(0.90)Co_(0.10)FeO_(3) and Nd_(0.90)Ni_(0.10)FeO_(3) in photocatalysis of dye degradation from *** removal efficiencies of Cr6+at pH=6 are 88.06%,85.54%,and 85.52%for the samples NdFeO_(3),Nd_(0.90)Co_(0.10)FeO_(3),and Nd_(0.90)Ni_(0.10)FeO_(3),*** Freundlich isotherm mode is the best-fit model for NdFeO_(3) to adsorb Cr6+ions from aqueous solutions.

关键词： Optical properties Nanoparticles magnetic properties Perovskites Removal efficiency Rareearths

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词： functionally graded material (FGm) pipe conveying fluid O175.2 porosity primary resonance retaining clip subcritical regime

First Search for Pulsed CH maser Emission Stimulated by a Pulsar

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Research in Astronomy and Astrophysics 2025年第2期25卷 62-71页

作者： mengting Liu Di Li j.R.Dawson joel m.Weisberg George Hobbs Ningyu Tang Gan Luo Duo Xu Donghui Quan Research Center for Astronomical Computing Zhejiang Laboratory Department of Astronomy Tsinghua University National Astronomical Observatories Chinese Academy of Sciences CSIRO Astronomy & Space Science Australia Telescope National Facility School of mathematical and Physical Sciences and Astrophysics and Space Technologies Research Centre Macquarie University Department of Physics and Astronomy Carleton College Department of Physics Anhui Normal University Institut de Radioastronomie millimetrique 300 Rue de la Piscine Canadian Institute for Theoretical Astrophysics University of Toronto 60 St.George Street

We present the first search for pulsed CH maser emission potentially stimulated by PSR j1644-4559,conducted using the ultra-wide-bandwidth low-frequency receiver on murriyang,CSIRO's Parkes Radio *** targeted three CHΛ-doublet transitions at 3264,3335,and 3349 mHz,with a variability timescale of78 *** detected ten CH emission features at 3335 and 3349 mHz,and seven features at 3264 mHz,during both pulsar-ON and pulsar-OFF *** observed velocities align with the OH emission and absorption reported by a previous study,suggesting a close spatial association between CH and OH *** derived column densities for CH clouds within the Parkes beam range from 0.05 to 9.8×1013cm-2,indicating that these clouds are likely in diffuse and translucent *** limits for CH column densities within the pulsar beam ranged from 0.3 to 9.8×*** of these column densities suggests that CH clouds may exhibit clumpiness and *** significant stimulated emission feature was detected in the optical depth ***,as part of our search for pulsed stimulated emission,we investigated the potential CH absorption of the pulsar signal and found none,in agreement with astrophysical *** upper limits for the potential maser amplification factors towards PSR j1644-4559 at 3264,3335,and 3349 mHz are 1.014,1.009,and 1.009,*** study demonstrates the feasibility of detecting pulsed CH maser emission in the interstellar medium stimulated by pulsar photons.

关键词： (stars:) pulsars: general ISm: molecules masers

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic