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journal of Biosciences and medicines 2018年第8期6卷 1-14页

作者： m.j.rosales m.Ximenis A.Costa C.Rotger D.Romero F.Olmo E.Delgado m.P.Clares E.Garcia-Espana C.marin mSanchez Departamento de Parasitologia Facultad de CienciasUniversidad de GranadaGranadaSpain Universidad de las Islas Baleares Palma de MallorcaSpain Universidad de Valencia ValenciaSpain

Pathogenic strains of Acanthamoeba cause keratitis (AK), granulomatous amoebic encephalitis (GAE), amoebic pneumonitis (AP), and skin infection in human and animals. The treatment of an Acanthamoeba infection is invariably very difficult and not always effective, and compounds that are amebicidic or amebistatic are frequently toxic and/or irritating for humans. Squaramides and polyamine derivatives have been demonstrated to have antitumor and antiprotozoal activity. The aim of this study was to investigate the activity of 5 squaramides and 5 acyclic polyamines against trophozoites and cysts of A. castellanii Neff. Amoebicidal activity against the trophozoites and cytotoxicity against Vero cells were evaluated with a colorimetric assay, using Alamar Blue?, and chlorhexidine digluconate was assayed as the reference drug. The squaramides 3 and 5 and the acyclic polyamine 6 appeared to be the most active against the trophozoites and their cytotoxicity was low, showing selectivity indexes of 28.3, 26, and 25.7, respectively, similar to the control drug, chlorhexidine digluconate (27.6). But only the squaramide 3 showed complete cysticidal activity at the concentrations of 100 and 200 μm, as the chlorhexidine digluconate. Further studies of the mechanism of action and in vivo assays are needed, but squaramide 3 could be used for developing novel therapeutic approaches against Acanthamoeba infections.

关键词： Acanthamoeba Squaramides Acyclic Polyamines Amoebicidal Cysticidal

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Evaluating physical changes of iron oxide nanoparticles due to surface modification with oleic acid

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Chinese Physics B 2020年第10期29卷 186-194页

作者： S rosales N Casillas A Topete O Cervantes G González j A Paz m E Cano Centro Universitario de Ciencias Exactas e Ingenienas Universidad de GuadalajaraBlvd.Marcelino Garcia Burragan 1421C.P.44430GuadalajaraJaliscoMexico Centro Universitario de la Cienegu Universidad de GuadalajaraAv.Universidad 1115C.P.47820OcotlanJaliscoMexico Centro Universitario de Ciencias de In Salud Universidad de Guadalajara.Sierra Mojada 950C.P.44340GuadalajaraJaliscoMexico

The physical characterization of a colloidal system of superficially modified magnetic nanoparticles (mNPs) is presented. The system consists of oleic acid-coated iron oxide nanoparticles (OAmNP) suspended in water. A structural analysis is carried out by using standard physical techniques to determine the diameter and shape of the mNPs and also the width of the coating shell. The colloidal stability and the polydispersity index of this ferrofluid are determined by using Zeta potential measurements. Additionally, the magnetic characterization is conducted by obtaining the DC magnetization loops, and the blocking temperatures are determined according to the ZFC–FC protocol. Finally, the values of power absorption density P of the ferrofluid are estimated by using a magneto-calorimetric procedure in a wide range of magnetic field amplitude H and frequency f. The experimental results exhibit spherical-like shape of OAmNP with (20 ± 4) nm in diameter. Due to the use of coating process, the parameters of the magnetization loops and the blocking temperatures are significantly modified. Hence, while the uncoated mNPs show a blocking state of the magnetization, the OAmNP are superparamagnetic above room temperature (300 K). Furthermore, the reached dependence P versus f and P versus H of the ferrofluid with coated mNPs are clearly fitted to linear and quadratic correlations, respectively, showing their accordance with the linear response theory.

关键词： nanoparticles ferrofluid magnetic hyperthermia functionalization

FINITELY GENERATED COmmUTATIVE ARCHImEDEAN SEmIGROUPS

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Acta mathematica Scientia 2003年第4期23卷 503-511页

作者： j.C.rosales j.I.García-García Departamento de Algebra Universidad de Granada E-18071 Granada EspanaDepartamento de Algebra Universidad de Granada E-18071 Granada Espana

In this work commutative Archimedean finitely generated semigroups axe characterized in terms of ideal extensions.

关键词： Commutative semigroups Archimedean

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review

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World journal of Critical Care medicine 2025年第1期14卷 49-59页

作者： Angajendra N Ghosh Calum j Walsh matthew j maiden Tim P Stinear Adam m Deane Department of Intensive Care The Northern HospitalEpping 3076VictoriaAustralia Department of microbiology and Immunology The Peter Doherty Institute for Infection and ImmunityMelbourne 3052VictoriaAustralia Department of Intensive Care The Royal Melbourne HospitalThe University of MelbourneParkville 3050VictoriaAustralia Department of Intensive Care medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly *** strategies to modulate the GI microbiota during chronic diseases have demonstrated *** changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain *** fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI *** aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical *** controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were *** show dietary fibres have an impact on faecal microbiota in health and *** fibre,inulin,has a marked and specific effect on increasing the abundance of faecal *** chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient *** few trials have evaluated the effect of dietary fibre on the GI microbiota during critical *** research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关键词： Gastrointestinal microbiota Dietary fibre Health Critical illness Short chain fatty acids

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan m Isa marwa j Abdulnabi Nawra S Naser Fatema N Lahmda Noor m AlAnsari Zahra H Isa Afaf m mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CmPA).AIm To evaluate CmPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CmPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya medical Complex,Bahrain,between 2014 and 2022,and assessed CmPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CmPA and 595(96.3%)were included;CmPA prevalence was 2%.most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CmPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pmore cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pmediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CmPA was associated with a longer follow-up duration than non-IgE-mediated CmPA(17.3 months±14.0 mo

关键词： Children milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

Phase separation and coarsening of NiAl(β′)intermetallic in quench-aged Fe-Ni-Al alloys

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journal of Iron and Steel Research International 2020年第11期27卷 1331-1338页

作者： C.Ferreira-Palma j.A.Rosas-Barrios V.m.Lopez-Hirata D.I.Rivas-Lopez H.j.Dorantes-rosales Faculty of Chemical Sciences Universidad VeracruzanaVeracruz 94294Mexico ESIQIE Instituto Politecnico Nacional.UPALMMexico City 07738Mexico

The coarsening behavior of four quench-aged Fe-Ni-AI alloys with different Ni and Al con tents is *** alloys were solubilized at 1100℃for 24 h,water-quenched and aged at 850℃for periods ranging from 1 to 100 h to promote phase separation and *** two alloys with the highest combined Ni and Al contents(>35 at.%)showed signs of spinodal decomposition,while the alloys with lower Ni and Al contents followed a classical nucleation *** Ni and Al contents promoted an increase in NiAl(β′)phase fraction in concordance with phase equilibrium *** alloy with the highest[3'fraction presented a completely interconnected *** coarsening ofβ′particles in the other three alloys followed the predictions of the Lifshitz-Slyozov-Wagner(LSW)*** general trend was an increase in the coarsening kinetics with higher Ni and Al *** highest hardness was found in the alloys with higher fraction albeit these compositions are less resistant to coarsening and have been reported to present a low room-temperature ductility.

关键词： Precipitation Spinodal decomposition Coarsening Aging Fe-Ni-Al alloy

Immune therapy for human papillomaviruses-related cancers

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World journal of Clinical Oncology 2014年第5期5卷 1002-1019页

作者： Ricardo rosales Carlos rosales Virolab S de RL de CV Cuernavaca Morelos 17007 Mexico Carlos Departamento de Inmunología Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City DF 04510 Mexico

Human papillomaviruses(HPVs) are a large family of double strand DNA viruses comprising more than 180 types. Infection with HPV is very common and it is associated with benign and malignant proliferation of skin and squamous mucosae. many HPVs, considered lowrisk such as HPV 6 and 11, produce warts; while highrisk viruses, such as HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58, induce tumors. About 5% of all cancers in men and women are associated with HPV infection. Because there are not antiviral drugs for HPV infection, current therapies for low-risk HPV infections involve physical removal of the lesion by cryotherapy, trichloracetic acid, laser, or surgical removal. Surgical procedures are effective in the treatment of precancerous lesions, however after these procedures, many recurrences appear due to new re-infections, or to failure of the procedure to eliminate the HPV. In addition, HPV can inhibit recognition of malignant cellsby the immune system, leading to the development of cancer lesions. When this occurs, radiotherapy and chemotherapy are then used. Unfortunately, about 50% of the HPV-cancer patients still die. In the past decade, a better knowledge of the natural history of the virushost interaction and of the immune response against this viral infection has brought new therapeutic strategies geared to modulate the immune system to generate an efficient virus-specific cytotoxic response. Novel HPV protein-expressing vaccines have shown some significant clinical efficacy and systemic HPV-specific cytotoxic T cell responses. This review will describe the current status of the several therapeutic strategies used to treat HPV-induced lesions, and discuss the various new therapies now being tested.

关键词： Human papillomavirus T cell Immunoglobulin Antibody Vaccinia virus