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适用于GSm1800移动通信基站前端的高温超导滤波器和子系统原理样机

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中国科学（E辑） 2002年第4期32卷 479-484页

作者：何豫生黎红何艾生李顺洲李春光张雪强袁鹍阎令文朱文秀周远梁惊涛李顺洲何艾生张太平洪嘉生 m.j.lancaster 中国科学院物理研究所超导国家重点实验室北京100080 北方工业大学基础学院北京100041 中国科学院声学研究所北京100080 中国科学院理化研究所北京100080 北京大学微电子中心北京100871

研制成功可用于移动通信基站接收机前端的高温超导子系统原理样机.该子系统以GSm1800移动通信基站系统为应用背景.它由高温超导滤波器、低噪声放大器、脉冲管制冷机和相关电路组成.工作频段 1710～1785 mHz,增益 18 dB,工作温度70K.

关键词： GSm1800移动通信基站高温超导滤波器微波子系统原理样机高温超导子系统脉冲管制冷机

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Behavioral interactions between a coexisting rodent micaelamys namaquensis and macroscelid Elephantulus myurus

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Current Zoology 2010年第4期56卷 395-400页

作者： jennifer lancaster Neville PILLAY School of Animal Plant and Environmental Sciences University of the Witwatersrand

A number of mechanisms are known to influence coexistence in small mammal communities. However, the role ofbehavioral interactions in promoting species coexistence is under-represented in the literature. We studied the behavioral interactionsof two coexisting small mammals, the Namaqua rock mouse micaelamys namaquensis (Rodentia) and the Rock sengi Elephantulusmyurus (macroscelidae), which have high dietary and microhabitat overlap. Using wild-caught individuals, intra- andinterspecific dyadic encounters were staged in tanks on a neutral rocky outcrop. Interspecific dyads displayed significantly moreactive avoidance behavior. There was no support for the prediction that the larger, more specialist species, E. myurus, is behaviorallydominant over m. namaquensis. Intraspecific encounters of E. myurus showed significantly more passive avoidance andamicable behavior, whereas the behavior of m. namaquensis did not differ between intra- and inter-specific encounters, both ofwhich were characterized by low levels of aggression and amicability. Thus, due to the lack of aggression, direct competition appearsweak and instead mutual avoidance may reduce or minimize interspecific interactions, potentially promoting coexistence.

关键词： Avoidance Coexistence Elephantulus myurus Intraspecific behavior Interspecific behavior micaelamys namaquensis

Emulsion cold mix asphalt in the UK: A decade of site and laboratory experience

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journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 359-365页

作者： Dennis Day Ian michael lancaster Dougie mcKay Nynas UK AB Ellesmere Port CH651AJUK Tayside Contracts Dundee DD38SSUK

Cold mix asphalt manufactured using bitumen emulsion, by its very nature, has struggled to gain market penetration in the UK due to lack of design guidance and specifications and the need to comply with prevailing hot mix asphalt specification requirements. Despite this, a number of contractors have successfully utilized emulsion cold mix asphalt materials containing recycled asphalt planings on various categories of road. Whilst the majority of schemes in the UK have been on lower category traffic roads, in this paper we discuss the use of one material which has been used on a strategic highway(trunk road) in2008 which saved 43 t of CO2 during construction and is still performing well in situ to this day. Site construction details along with an analysis of traffic loading are presented. Laboratory simulations of in-situ curing of material supplied to site demonstrated an indirect tensile stiffness modulus at 10℃ of 5 GPa was achieved within 6 months. Binder recovered from site cores was found to be in line with comparable hot mix materials, whilst wheel tracking of site cores demonstrated excellent deformation resistance which has been borne out by site performance over the last decade. The continued development of standards enabling engineers to design and specify cold mix asphalt in the UK is also reviewed.

关键词： Cold mix Bitumen emulsion Specifications Carbon savings

Growth mechanisms of Ag and Cu nanodendrites via Galvanic replacement reactions

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Progress in Natural Science:materials International 2021年第1期31卷 141-151页

作者： jialu Chen jemima j.Davies Alister S.Goodfellow Sarah m.D.Hall Helena G.lancaster Xinyu Liu Cameron j.Rhodes Wuzong Zhou School of Chemistry University of St Andrews

Dendritic silver and copper crystals were produced via Galvanic replacement reactions on zinc and aluminum plates, respectively. The growth orientations of these metals were determined using electron microscopy. The results showed that a fast crystal growth associated with a high concentration of metal cations led to kinetically controlled growth along the axes of the cubic close-packed structures. However, a slow growth rate resulted in thermodynamically controlled growth along the [111] axis. The crystal growth was not found to rely upon the direct deposition of metal cations at crystallographic sites on crystal facets, but instead, hydrated metal cations deposited on the crystal surface to form an amorphous coating layer, followed by the reduction of metal cations and crystallization at the crystal/coating interface. Twin defects and stacking faults were often observed across the whole particle and commonly observed1/3{422} diffraction spots were explained by stacking faults rather than by the possible presence of any superstructures. The present work offers evidences to claim that both the crystal growth rate and Coulomb interaction between negatively charged crystal surface and metal cations play an important role in the formation of metal dendrites in replacement reactions.

关键词： Silver nanodendrite Copper nanodendrite Electron microscopy Stacking fault Crystal growth

The influence of metabolic disorders on adaptive immunity

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Cellular & molecular Immunology 2024年第10期21卷 1109-1119页

作者： Thomas j.C.Collins Pooranee K.morgan Kevin man Graeme I.lancaster Andrew j.murphy Division of Immunometabolism Baker Heart and Diabetes InstituteMelbourneVIC3004Australia Department of Immunology Monash UniversityMelbourneVIC3004Australia Peter Doherty Institute for Infection and Immunity MelbourneVIC3000Australia Department of microbiology and Immunology University of MelbourneParkvilleVIC3052Australia

The immune system plays a crucial role in protecting the body from invading pathogens and maintaining tissue *** homoeostatic lipid metabolism is an important aspect of efficient immune cell function and when disrupted immune cell function is *** are numerous metabolic diseases whereby systemic lipid metabolism and cellular function is *** the context of metabolic disorders,chronic inflammation is suggested to be a major contributor to disease progression.A major contributor to tissue dysfunction in metabolic disease is ectopic lipid deposition,which is generally caused by diet and genetic ***,we propose the idea,that similar to tissue and organ damage in metabolic disorders,excessive accumulation of lipid in immune cells promotes a dysfunctional immune system(beyond the classical foam cell)and contributes to disease ***,we review the evidence that lipid accumulation through diet can modulate the production and function of immune cells by altering cellular lipid *** can impact immune cell signalling,activation,migration,and death,ultimately affecting key aspects of the immune system such as neutralising pathogens,antigen presentation,effector cell activation and resolving inflammation.

关键词： Immunity metabolic Disorders Lipid metabolism Cell metabolism Immunometabolism Cancer

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate