检索结果-南通市图书馆

Potential Health Benefits of the Consumption of Cocoa Products

Biomedical and Environmental Sciences 2001年第1期14卷 159-160页

作者： m.izquierdo－pulido YINGCHEN 等 COLACAOFOOD（TIANJIN）CO. Ltd.No20xingHuaStreetXiQingTEDATianjin300381China DepartmentofNutritionandFOodScience universityofBarcelonaAV.JoanXXIIIs／n08028BarcelonaSpain I

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel insights into the sexual dimorphism-associated immune response

引用

Cellular & molecular Immunology 2024年第8期21卷 804-806页

作者： José m.izquierdo Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

In their recent article in Science,Chi et al.[1]characterized a mechanism that regulates tissue/organ-specific immunity in *** findings revealed that the androgen type 2 innate lymphoid cell-dendritic cell axis played a prominent role in a microbiota-and sex hormone-dependent *** observations implicate sexual immune dimorphism as a molecular,cellular and tissue/organ-specific regulatory hub for the(im)balance between health and *** factors,including nutritional status,diet,vital light-dark rhythms(i.e.,circadian and infradian rhythms)and the microbiota,shape the development and function of the immune system differently in males and females,which can result in differences in susceptibility to autoimmune diseases,malignancies and infectious diseases and affect the outcome of vaccination[3](Fig.1).

关键词： immunity al. diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vitamin D-dependent microbiota-enhancing tumor immunotherapy

引用

Cellular & molecular Immunology 2024年第10期21卷 1083-1086页

作者： José m.izquierdo Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 128049MadridSpain

The antitumor immune response plays a crucial role in successful cancer *** a recent article in Science,Giampazolias et al.[1]reported a vitamin D(VitD)-mediated antitumor mechanism in murine intestinal epithelial cells(IECs)associated with a specific microbiota signature(Bacteroides fragilis)that enhances the antitumor immune *** strong positive association between VitD-dependent microbiota and the antitumor immune response provides a proof-of-concept for supplementing immunotherapy regimens with VitD to strengthen antitumor immunity and improve immunotherapysuccess.

关键词： immunotherapy immunity vitamin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SDHA: a key player in T cell-mediated intestinal disease severity

引用

Cellular & molecular Immunology 2022年第2期19卷 139-141页

作者： José m.izquierdo Centro de Biología molecular Severo Ochoa.Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent article in Nature Immunology,Fujiwara et *** reduced mitochondrial respiration and increased succinate levels in intestinal epithelial cells(IECs)from several distinct models of T cell-mediated *** observations point to a specific link between alterations in the mitochondrial complex II component SDHA and the severity of T cell-mediated intestinal diseases and suggest that SDHA dysfunction could be a diagnostic and/or prognostic biomarker in T cell-mediated immunopathology.

关键词： severity alterations mediated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Taurine as a possible therapy for immunosenescence and inflammaging

引用

Cellular & molecular Immunology 2024年第1期21卷 3-5页

作者： Josém.izquierdo Centro de Biología molecular Severo Ochoa(CBmSO).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular senescence: is the problem a solution for muscle repair?

引用

Cellular & molecular Immunology 2023年第5期20卷 429-431页

作者： Jose m.izquierdo Centro de Biologia molecular Severo Ochoa Consejo Superior de Investigaciones CientificasUniversidad Autonoma de Madrid(CSIC/UAM)C/Nicolas Cabrera 1Campus de Cantoblanco28049 MadridSpain

In their recent article in Nature,moiseeva et *** that senescent cells are integral components of the skeletal muscle regenerative niche,showing that they repress regeneration in response to different types of injuries in young mice and that this regeneration is even more profound in aged *** observations point to selective links between the conservation of cell identity traits and two universal senescence hallmarks(i.e.,inflammation and matrix remodeling/fibrosis)across cell types,regeneration times,and aging statuses.

关键词： showing injuries regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

引用

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Search for microglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：